Effect of phosphate transporter and methylation inhibitor drugs on the disposition of arsenate and arsenite in rats

Toxicological Sciences

Volumn 63, Issue 1, 2001, Pages 29-36

  Csanaky, Iván ^a   Gregus, Zoltán ^a  

^a UNIVERSITY OF PÉCS   (Hungary)

Author keywords

Arsenic; Biliary excretion; Cathechol O methyltransferase (COMT); Entacapone; Foscarnet (fosfonoformic acid); Fosfomycin; Methylation; Methylcobalamin; Monomethylarsonous acid; Nitrous oxide (N2O); Urinary excretion

Indexed keywords

ADENOSINE; ARSENIC ACID; ARSENIC TRIOXIDE; CARRIER PROTEIN; CATECHOL METHYLTRANSFERASE; CATECHOL METHYLTRANSFERASE INHIBITOR; ENTACAPONE; FOSCARNET; FOSCARNET SODIUM; FOSFOMYCIN; MECOBALAMIN; METHYLTRANSFERASE; MONOMETHYLARSONOUS ACID; NITROUS OXIDE; PERIODATE; PHOSPHATE; PHOSPHORUS DERIVATIVE; S ADENOSYLMETHIONINE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ARTICLE; BILE; BILIARY EXCRETION; BIOTRANSFORMATION; CONTROLLED STUDY; DRUG STRUCTURE; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; INJECTION; KIDNEY CLEARANCE; KIDNEY TUBULE ABSORPTION; MALE; METABOLITE; METHYLATION; NONHUMAN; PHOSPHATE TRANSPORT; RAT; URINARY EXCRETION; URINE;

ARSENATES; ARSENITES; BIOTRANSFORMATION; CARRIER PROTEINS; CATECHOLS; FOSCARNET; FOSFOMYCIN; METHYLATION; NITROUS OXIDE; PHOSPHATES; TISSUE DISTRIBUTION;

EID: 0034865564     PISSN: 10966080     EISSN: None     Source Type: Journal    
DOI: 10.1093/toxsci/63.1.29     Document Type: Article

References (50)

1. Enzymatic methylation of arsenic species and other new approaches to arsenic toxicity
2. Occurrence of monomethylarsonous acid in urine of humans exposed to inorganic arsenic
3. DMPS-arsenic challenge test. II. Modulation of arsenic species, including monomethylarsonous acid (MMA(III), excreted in human urine
4. Alterations in tissue levels of S-adenosylmethionine
5. Pharmacokinetic comparison between fosfomycin and other phosphonic acid derivatives
6. Phosphate transport into brush-border membrane vesicles isolated from rat small intestine
7. Role of thiols in the in vitro methylation of inorganic arsenic by rat liver cytosol
8. i transporter
9. 3 induces NB4 cell apoptosis with down-regulation of Bcl-2 expression and PML-RARα/PML proteins
10. The metabolism of methylarsine oxide and sulfide
11. Inactivation of methionine sythase by nitrous oxide
12. In vitro methylation of arsenite by rabbit liver cytosol: Effect of metal ions, metal chelating agents, methyltransferase inhibitors, and uremic toxins
13. The biochemical action of arsonic acids, especially as phosphate analogues
14. Ontogeny of phosphate transport by rat liver plasma membrane vesicles
15. Renal mechanism for excretion and transformation of arsenic in the dog
16. Interrelations of arsenate and phosphate transport in the dog kidney
17. Evaluation of atomic fluorescence spectrometry as a sensitive detection technique for arsenic speciation
18. Biliary and urinary excretion of inorganic arsenic. Monomethylarsonous acid as a major biliary metabolite in rats
19. Enhancement of selenium excretion in bile by sulfobromophthalein: Elucidation of the mechanism
20. The rate of transmethylation in mouse liver as measured by trapping S-adenosylhomocysteine
21. Phosphate transport by isolated renal brush border vesicles
22. Cellular uptake of trivalent arsenite and pentavalent arsenate in KB cells cultured in phosphate-free medium
23. Effect of a carrier-mediated transport system on intestinal fosfomycin absorption in situ and in vivo
24. Mechanisms of intestinal absorption of the antibiotic, fosfomycin, in brush-border membrane vesicles in rabbits and humans
25. Sodium- and pH-dependent carrier-mediated transport of the antibiotic, fosfomycin, in the rat intestinal brush-border membrane
26. The MRP2/cMOAT transporter and arsenic-glutathione complex formation are required for biliary excretion of arsenic
27. Arsenate substitutes for phosphate in the human red cell sodium pump and anion exchanger
28. The biochemistry of arsenic
29. Speciation of key arsenic metabolic intermediates in human urine
30. The metabolism of arsenite and arsenate by the rat
31. i cotransporter in small gut brush border by phosponocarboxylic acids
32. Effects of nitrous oxide-induced inactivation of cobalamin on methionine and S-adenosylmethionine metabolism in the rat
33. Biochemical and pharmacological properties of peripherically acting catechol-O-methyltransferase inhibitor entacapone
34. Monomethylarsonous acid (MMA(III) is more toxic than arsenite in Chang human hepatocytes
35. Enzymatic reduction of arsenic compounds in mammalian systems: Reduction of arsenate to arsenite by human liver arsenate reductase
36. Comparative toxicity of trivalent and pentavalent inorganic and methylated arsenicals in rat and human cells
37. Carrier-mediated transport mechanism of foscarnet (trisodium phosphonoformate hexahydrate) in rat intestinal tissue
38. +-dependent transport of phosphate across renal brush border membrane
39. The stimulation and inhibition of the exhalation of volatile selenium
40. Phosphate transport by the human renal cotransporter NaPi-3 expressed in HEK-293 cells
41. +- and pH-dependent transport of foscarnet via the phosphate-carrier system across intestinal brush-border membrane
42. Metabolism and renal handling of sodium arsenate in dogs
43. Mechanism of phosphaturia elicited by administration of phosphonoformate in vivo
44. On the role of O-methylation in the metabolism of S-adenosylmethionine in rat brain
45. Phosphate transport process in eukaryotic cells
46. Metabolite profiles of two [14C]-labelled catechol O-methyltransferase inhibitors, nitecapone and entacapone, in rat and mouse urine and rat bile
47. Enzymatic methylation of arsenic compounds: VI. Characterization of hamster liver arsenite and methylarsonic acid methyltransferase activities in vitro
48. +/Pi cotransport by phosphonoformic acid
49. 12 and glutathione does not require an enzyme
50. Enzymatic methylation of arsenic compounds: I. Assay, partial purification and properties of arsenite methyltransferase and monomethylarsonic acid methyltransferase of rabbit liver