Phosphate transport: Molecular basis, regulation and pathophysiology

Journal of Steroid Biochemistry and Molecular Biology

Volumn 103, Issue 3-5, 2007, Pages 572-577

  Tenenhouse, Harriet S ^a  

^a MCGILL UNIVERSITY   (Canada)

Author keywords

1,25 dihydroxyvitamin D; FGF 23; Hypophosphatemia; Kidney; NaPi IIa; NaPi IIc; Parathyroid hormone; PHEX; Pi wasting; Proximal tubule

Indexed keywords

FGF23 PROTEIN; FIBROBLAST GROWTH FACTOR 23; GENE PRODUCT; PARATHYROID HORMONE; PHEX PROTEIN; PHOSPHATE; SODIUM PHOSPHATE COTRANSPORTER 2A; SODIUM PHOSPHATE COTRANSPORTER 2C; UNCLASSIFIED DRUG;

ARTICLE; BRUSH BORDER; DIETARY INTAKE; GENE CONTROL; GENE DISRUPTION; GENE MUTATION; HOMEOSTASIS; HUMAN; HYPERCALCIURIA; HYPOPHOSPHATEMIA; KIDNEY CELL; KIDNEY PROXIMAL TUBULE; MINERALIZATION; MOLECULAR GENETICS; PATHOPHYSIOLOGY; PHOSPHATE TRANSPORT; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN INTERACTION; PROTEIN STRUCTURE; VITAMIN D RESISTANT RICKETS; WASTING SYNDROME;

ANIMALS; BIOLOGICAL TRANSPORT; FIBROBLAST GROWTH FACTORS; HUMANS; HYPERCALCIURIA; HYPOPHOSPHATEMIC RICKETS, X-LINKED DOMINANT; MICE; MICE, KNOCKOUT; PHOSPHATES; SODIUM-PHOSPHATE COTRANSPORTER PROTEINS, TYPE IIA;

MUS;

EID: 33947111420     PISSN: 09600760     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jsbmb.2006.12.090     Document Type: Article

References (46)

1. Murer H., Hernando N., Forster I., and Biber J. Proximal tubular phosphate reabsorption: molecular mechanisms. Physiol. Rev. 80 (2000) 1373-1409
2. Tenenhouse H.S., and Econs M.J. Mendelian hypophosphatemias. In: Scriver C.R., Beaudet A.L., Sly W.S., and Valle D. (Eds). The Metabolic and Molecular Bases of Inherited Disease (2001), McGraw Hill Book Co., New York 5039-5067
3. Murer H., Hernando N., Forster I., and Biber J. Regulation of Na/Pi transporter in the proximal tubule. Annu. Rev. Physiol. 65 (2003) 531-542
4. Tenenhouse H.S., and Murer H. Disorders of renal tubular phosphate transport. J. Am. Soc. Nephrol. 14 (2003) 240-247
5. Tenenhouse H.S. Regulation of phosphorus homeostasis by the type IIa Na/phosphate cotransporter. Annu. Rev. Nutr. 25 (2005) 197-214
6. Hernando N., Gisler S.M., Pribanic S., Deliot N., Capuano P., Wagner C.A., Moe O.W., Biber J., and Murer H. NaPi-IIa and interacting partners. J. Physiol. 567 (2005) 21-26
7. Hernando N., Biber J., Forster I., and Murer H. Recent advances in renal phosphate transport. Ther. Apher. Dial. 9 (2005) 323-327
8. Berndt T.J., Schiavi S., and Kumar R. "Phosphatonins" and the regulation of phosphorus homeostasis. Am. J. Physiol. Renal. Physiol. 289 (2005) F1170-F1182
9. Imel E.A., and Econs M.J. Fibroblast growth factor 23: roles in health and disease. J. Am. Soc. Nephrol. 16 (2005) 2565-2575
10. Biber J., Custer M., Werner A., Kaissling B., and Murer H. Localization of NaPi-1, a Na/Pi cotransporter, in rabbit kidney proximal tubules. II. Localization by immunohistochemistry. Pflügers Arch. 424 (1993) 210-215
11. Soumounou Y., Gauthier C., and Tenenhouse H.S. Murine and human type I Na-phosphate cotransporter genes: structure and promoter activity. Am. J. Physiol. Renal. Physiol. 281 (2001) F1082-F1091
12. Broer S., Schuster A., Wagner C.A., Broer A., Forster I., Biber J., Murer H., Werner A., Lang F., and Busch A.E. Chloride conductance and Pi transport are separate functions induced by the expression of NaPi-1 in Xenopus oocytes. J. Membr. Biol. 164 (1998) 71-77
13. Kavanaugh M.P., Miller D.G., Zhang W., Law W., Kozak S.L., Kabat D., and Miller A.D. Cell-surface receptors for gibbon ape leukemia virus and amphotropic murine retrovirus are inducible sodium-phosphate symporters. Proc. Natl. Acad. Sci. USA 91 (1994) 7071-7075
14. Custer M., Lötscher M., Biber J., Murer H., and Kaissling B. Expression of Na-Pi cotransport in rat kidney: localization by RT-PCR and immunohistochemistry. Am. J. Physiol. 266 (1994) F767-F774
15. Segawa H., Kaneko I., Takahashi A., Kuwahata M., Ito M., Ohkido I., Tatsumi S., and Miyamoto K. Growth-related renal type II Na/Pi cotransporter. J. Biol. Chem. 277 (2002) 19665-19672
16. Hilfiker H., Hattenhauer O., Traebert M., Forster I., Murer H., and Biber J. Characterization of a murine type II sodium-phosphate cotransporter expressed in mammalian small intestine. Proc. Natl. Acad. Sci. USA 95 (1998) 14564-14569
17. +-phosphate cotransporter genes in murine kidney. Am. J. Physiol. 44 (1998) F527-F534
18. Virkki L.V., Forster I.C., Bacconi A., Biber J., and Murer H. Functionally important residues in the predicted 3(rd) transmembrane domain of the type IIa sodium-phosphate co-transporter (NaPi-IIa). J. Membr. Biol. 206 (2005) 227-238
19. Bacconi A., Virkki L.V., Biber J., Murer H., and Forster I.C. Renouncing electroneutrality is not free of charge: switching on electrogenicity in a Na+-coupled phosphate cotransporter. Proc. Natl. Acad. Sci. USA 102 (2005) 12606-12611
20. Lambert G., Forster I.C., Stange G., Kohler K., Biber J., and Murer H. Cysteine mutagenesis reveals novel structure-function features within the predicted third extracellular loop of the type IIa Na(+)/P(i) cotransporter. J. Gen. Physiol. 117 (2001) 533-546
21. Kohler K., Forster I.C., Stange G., Biber J., and Murer H. Identification of functionally important sites in the first intracellular loop of the NaPi-IIa cotransporter. Am. J. Physiol. 282 (2002) F687-F696
22. de la Horra C., Hernando N., Lambert G., Forster I., Biber J., and Murer H. Molecular determinants of pH sensitivity of the type IIa Na/P(i) cotransporter. J. Biol. Chem. 275 (2000) 6284-6287
23. Karim-Jimenez Z., Hernando N., Biber J., and Murer H. A dibasic motif involved in parathyroid hormone-induced down-regulation of the type IIa NaPi cotransporter. Proc. Natl. Acad. Sci. USA 97 (2000) 12896-12901
24. Karim-Jimenez Z., Hernando N., Biber J., and Murer H. Molecular determinants for apical expression of the renal type IIa Na+/Pi-cotransporter. Pflugers Arch. 442 (2001) 782-790
25. Ehnes C., Forster I.C., Kohler K., Biber J., and Murer H. Functional studies on a split type II Na/Pi-cotransporter. J. Membr. Biol. 188 (2002) 227-236
26. Kohl B., Wagner C.A., Huelseweh B., Busch A.E., and Werner A. The Na+-phosphate cotransport system (NaPi-II) with a cleaved protein backbone: implications on function and membrane insertion. J. Physiol. 508 (1998) 341-350
27. Kohler K., Forster I.C., Lambert G., Biber J., and Murer H. The functional unit of the renal type IIa Na+/Pi cotransporter is a monomer. J. Biol. Chem. 275 (2000) 26113-26120
28. Beck L., Karaplis A.C., Amizuka N., Hewson A.S., Ozawa H., and Tenenhouse H.S. Targeted inactivation of Npt2 in mice leads to severe renal phosphate wasting, hypercalciuria and skeletal abnormalities. Proc. Natl. Acad. Sci. USA 95 (1998) 5372-5377
29. Tenenhouse H.S., Martel J., Gauthier C., Segawa H., and Miyamoto K. Differential effects of Npt2a gene ablation and the X-linked Hyp mutation on renal expression of type IIc Na/Pi cotransporter. Am. J. Physiol. 285 (2003) F1271-F1278
30. Tenenhouse H.S., Martel J., Gauthier C., Zhang M.Y.H., and Portale A.A. Renal expression of the sodium/phosphate cotransporter gene, Npt2, is not required for regulation of renal 1α-hydroxylase by phosphate. Endocrinology 142 (2001) 1124-1129
31. Chau H., El-Maadawy S., McKee M.D., and Tenenhouse H.S. Renal calcification in mice homozygous for the disrupted type IIa Na/Pi cotransporter gene, Npt2. J. Bone. Miner. Res. 18 (2003) 644-657
32. -/- mice. Bone 29 (2001) 467-476
33. Zhao N., and Tenenhouse H.S. Npt2 gene disruption confers resistance to the inhibitory action of PTH on renal Na-phosphate cotransport. Endocrinology 141 (2000) 2159-2165
34. Hoag H.M., Martel J., Gauthier C., and Tenenhouse H.S. Effects of Npt2 gene ablation and low-phosphate diet on renal Na/phosphate cotransport and cotransporter gene expression. J. Clin. Invest. 104 (1999) 679-686
35. Tieder M., Modai D., Samuel R., Arie R., Halabe A., Bab I., Gabizon D., and Lieberman U.A. Hereditary hypophosphatemic rickets with hypercalciuria. N. Engl. J. Med. 312 (1985) 611-617
36. Jones A.O., Tzenova J., Frappier D., Crumley M., Roslin N.M., Kos C.H., Tieder M., Langman C.B., Proesmans W., Carpenter T.O., Rice A., Anderson D., Morgan K., Fujiwara T.M., and Tenenhouse H.S. Hereditary hypophosphatemic rickets with hypercalciuria is not caused by mutations in the Na/Pi cotransporter NPT2 gene. J. Am. Soc. Nephrol. 12 (2001) 507-514
37. Bergwitz C., Roslin N.M., Tieder M., Loredo-Osti J.C., Bastepe M., Abu-Zahra H., Frappier D., Burkett K., Carpenter T.O., Anderson D., Garabedian M., Sermet I., Fujiwara T.M., Morgan K., Tenenhouse H.S., and Juppner H. SLC34A3 mutations in patients with hereditary hypophosphatemic rickets with hypercalciuria predict a key role for the sodium-phosphate cotransporter NaPi-IIc in maintaining phosphate homeostasis. Am. J. Hum. Genet. 78 (2006) 179-192
38. Lorenz-Depiereux B., Benet-Pages A., Eckstein G., Tenenbaum-Rakover Y., Wagenstaller J., Tiosano D., Gershoni-Baruch R., Albers N., Lichtner P., Schnabel D., Hochberg Z., and Strom T.M. Hereditary hypophosphatemic rickets with hypercalciuria is caused by mutations in the sodium-phosphate cotransporter gene SLC34A3. Am. J. Hum. Genet. 78 (2006) 193-201
39. Sabbagh Y., Carpenter T.O., and Demay M.B. Hypophosphatemia leads to rickets by impairing caspase-mediated apoptosis of hypertrophic chondrocytes. Proc. Natl. Acad. Sci. USA 102 (2005) 9637-9642
40. Shimada T., Mizutani S., Muto T., Yoneya T., Hino R., Takeda S., Takeuchi Y., Fujita T., Fukumoto S., and Yamashita T. Cloning and characterization of FGF23 as a causative factor of tumor-induced osteomalacia. Proc. Natl. Acad. Sci. USA 98 (2001) 6500-6505
41. Larsson T., Marsell R., Schipani E., Ohlsson C., Ljunggren O., Tenenhouse H.S., Juppner H., and Jonsson K.B. Transgenic mice expressing fibroblast growth factor 23 under the control of the alpha1(I) collagen promoter exhibit growth retardation, osteomalacia, and disturbed phosphate homeostasis. Endocrinology 145 (2004) 3087-3094
42. White K.E., Carn G., Lorenz-Depiereux B., Benet-Pages A., Strom T.M., and Econs M.J. Autosomal-dominant hypophosphatemic rickets (ADHR) mutations stabilize FGF-23. Kidney Int. 60 (2001) 2079-2086
43. Consortium H.Y.P. A gene (PEX) with homologies to endopeptidases is mutated in patients with X-linked hypophosphatemic rickets. Nat. Genet. 11 (1995) 130-136
44. Azam N., Zhang M.Y., Wang X., Tenenhouse H.S., and Portale A.A. Disordered regulation of renal 25-hydroxyvitamin D-1alpha-hydroxylase gene expression by phosphorus in X-linked hypophosphatemic (hyp) mice. Endocrinology 144 (2003) 3463-3468
45. Perwad F., Azam N., Zhang M.Y.H., Yamashita T., Tenenhouse H.S., and Portale A.A. Dietary and serum phosphorus regulate fibroblast growth factor 23 expression and 1,25-dihydroxyvitamin D metabolism in mice. Endocrinology 146 (2005) 5358-5364
46. Sitara D., Razzaque M.S., Hesse M., Yoganathan S., Taguchi T., Erben R.G., Juppner H., and Lanske B. Homozygous ablation of fibroblast growth factor-23 results in hyperphosphatemia and impaired skeletogenesis, and reverses hypophosphatemia in Phex-deficient mice. Matrix Biol. 23 (2004) 421-432