Malignant cells can be sensitized to undergo growth inhibition and apoptosis by arsenic trioxide through modulation of the glutathione redox system

Blood

Volumn 93, Issue 1, 1999, Pages 268-277

  Dai, Jie ^a   Weinberg, Rona S ^a   Waxman, Samuel ^a,b   Jing, Yongkui ^a  

^a MOUNT SINAI MEDICAL CENTER   (United States)

^b MOUNT SINAI SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ACETYLCYSTEINE; ARSENIC TRIOXIDE; ASCORBIC ACID; BUTHIONINE SULFOXIMINE; CATALASE; GLUTATHIONE; THIOCTIC ACID;

ACUTE MYELOBLASTIC LEUKEMIA; ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; CANCER CELL; CANCER INHIBITION; CELL STRAIN HL 60; CONTROLLED STUDY; DRUG CYTOTOXICITY; DRUG POTENTIATION; HUMAN; HUMAN CELL; LEUKEMIA REMISSION; OXIDATION REDUCTION REACTION; PRIORITY JOURNAL; SENSITIZATION;

EID: 0032933610     PISSN: 00064971     EISSN: None     Source Type: Journal    
DOI: 10.1182/blood.v93.1.268     Document Type: Article

References (51)

1. Sun HD, Ma L, Hu XC, Zhang TD: Ai-ling 1 treated 32 cases of acute promyelocytic leukemia. Chung Kuo Chung Hsi I Chieh Ho Tsa Chih 12:170, 1992
2. Zhang P, Wang SY, Hu XH: Arsenic trioxide treated 72 cases of acute promyelocytic leukemia. Chin J Hematol 17:58, 1996
3. 3) in the treatment of acute promyelocytic leukemia (APL): II. Clinical efficacy and pharmacokinetics in relapsed patients. Blood 89:3354, 1997
4. 3) in acute promyelocytic leukemia (APL). Proc Am Soc Clin Oncol 17:6a, 1998 (abstr 19)
5. 3 induces NB4 cell apoptosis with downregulation of Bcl-2 expression and modulation of PML-RAR α/PML proteins. Blood 88:1052, 1996
6. 3 exerts dose-dependent dual effects on APL cells. Blood 89:3345, 1997
7. de The H, Lavau C, Marchio A, Chomienne C, Degos L, Dejean A: The PML-RAR α fusion mRNA generated by the t(15;17) translocation in acute promyelocytic leukemia encodes a functionally altered RAR. Cell 66:675, 1991
8. Tong JH, Dong S, Geng JP, Huang W, Wang ZY, Sun GL, Chen SJ, Chen Z, Larsen CJ, Berger R: Molecular rearrangements of the MYL gene in acute promyelocytic leukemia (APL, M3) define a breakpoint cluster region as well as some molecular variants. Oncogene 7:311, 1992
9. Knowles FC, Benson AA: The biochemistry of arsenic. TIPS 8:178, 1983
10. Konig A, Wrazel L, Warrell RP Jr, Rivi R, Pandolfi PP, Jakubowski A, Gabrilove JL: Comparative activity of melarsoprol and arsenic trioxide in chronic B-cell leukemia lines. Blood 90:562, 1997
11. Cavigelli M, Liww, Lin A, Su B, Yoshioka K, Karin M: The tumor promoter arsenite stimulates AP-1 activity by inhibiting a JUK phosphatase. EMBO J 15:6269, 1996
12. Ludwig S, Hoff-meyer A, Goebeler M, Kilian K, Kilian K, Hafner H, Neufeld B, Han H, Rapp UP: The stress inducer arsenite activates mitogen-activated protein kinases extracellular signal-regulated kinases 1 and 2 via a MAPK kinase 6/p38-dependent pathway. J Biol Chem 273:1917, 1998
13. Watson RW, Redmond HP, Wang JH, Bouchier-Hayes D: Mechanism involved in sodium arsenite-induced apoptosis of human neutrophils. J Leukoc Biol 60:625, 1996
14. Lee TC, Wei ML, Chang WJ, Ho IC, Lo JF, Jan KY, Huang H: Elevation of glutathione levels and glutathione S-transferase activity in arsenic-resistant Chinese hamster ovary cells. In Vitro Cell Dev Biol 25:442, 1989
15. Lee TC, Ko JL, Jan KY: Differential cytotoxicity of sodium arsenite in human fibroblasts and Chinese hamster ovary cells. Toxicology 56:289, 1989
16. Ochi T, Raise T, Oya-Ohta Y: Glutathione plays different roles in the induction of the cytotoxic effects of inorganic and organic arsenic compounds in cultured BALB/c 3T3 cells. Experientia 50:115, 1994
17. Ochi T, Nakajima F, Sakurai T, Kaise T, Oya-Ohta Y: Dimethylarsinic acid causes apoptosis in HL-60 cells via interaction with glutathione. Arch Toxicol 70:815, 1996
18. Scott N, Hatlelid KM, MacKenzie NE, Carter DE: Reactions of arsenic(III) and arsenic(V) species with glutathione. Chem Res Toxicol 6:102, 1993
19. Kitamura K, Yoshida H, Ohno R, Naoe T: Toxic effects of arsenic (As3+) and other metal ions on acute promyelocytic leukemia cells. Int J Hematol 65:179, 1997
20. Wang TS, Kuo CF, Jan KY, Huang H: Arsenite induces apoptosis in chinese hamster ovary cells by generation of reactive oxygen species. J Cell Physiol 169:256, 1996
21. Cantoni O, Hussain S. Guidarelli A, Cattabeni F: Cross-resistance to heavy metals in hydrogen peroxide-resistant CHO cell varients. Mutat Res 324:1, 1994
22. Lanotte M, Martin-Thouvenin V, Najman S, Balerini P, Valensi F, Berger R: NB4, a maturation inducible cell line with t(15;17) marker isolated from a human acute promyelocytic leukemia (M3). Blood 77:1080, 1991
23. Cleary ML, Smith SD, Sklar J: Cloning and structural analysis of cDNA for Bcl-2 and a hybrid bcl-2/immunoglobulin transcript resulting from the t(14;18) translocation. Cell 47:19, 1986
24. Jing Y, Zhang J, Bleiweiss IJ, Waxman S, Zelent A, Mira-Y-Lopez R: Defective expression of cellular retinol binding protein type 1 and retinoic acid receptors αt2, β2, and γ2 in human breast cancer cells. FASEB J 10:1064, 1996
25. Huang Y, Waxman S: Enhanced apoptosis in leukemia cells following treatment with combination fluoropyrimidines and differentiation inducers. Mol Cell Diff 2:83, 1994
26. Weinberg RS, Thomson JC, Lao R, Chen G, Alter BP: Stem cell factor amplifies newborn and sickle erythropoiesis in liquid cultures. Blood 81:2591, 1993
27. Coligan JE, Kruisbeek AM, Margulies DH, Sheva EM, Strober W: Current Protocols in Immunology, vol 2. National Institutes of Health. New York, NY, Wiley International Science, 1991, p 3.12.1
28. Droge W, Eck HP, Mihm S: HIV-induced cysteine deficiency and T-cell dysfunction - A rationale for treatment with N-acetylcysteine. Immunol Today 13:211, 1992
29. Han D, Handelman G, Marcocci L, Sen CK, Roy S, Kobuchi H, Tritschler HJ, Flohe L, Packer L: Lipoic acid increases de novo synthesis of cellular glutathione by improving cystine utilization. Biofactors 6:321, 1997
30. Griffith OW, Meister: Potent and specific inhibition of glutathione synthesis by buthione sulfoximine (S-n-butyl homocyteine sulfoximine). J Biol Chem 254:7558, 1979
31. Alcain FJ, Buron MI, Rodriguez-Aguilera JC, Villalba JM, Navas P: Ascorbate free radical stimulates the growth of a human promyelocytic leukemia cell line. Cancer Res 50:5887, 1990
32. Zhu J, Koken MHM, Quignon F, Chelbi-Alix M, Degos L, Wang ZY, Chen Z, de The H: Arsenic-induced PML targeting onto nuclear bodies: implications for the treatment of acute promyelocytic leukemia. Proc Natl Acad Sci USA 94:3978, 1997
33. Meister A: Glutathione, ascorbate, and cellular protection. Cancer Res 54:1969s, 1994 (suppl)
34. Zhang K, Mack P, Wong KP: Glutathione-related mechanisms in cellular resistance to anticancer drugs. Int J Oncol 12:871, 1998
35. Lo JF, Wang HF, Tam MF, Lee T-C: Glutathione S-transferase π in an arsenic-resistant Chinese hamster ovary cell line. Biochem J 288:977, 1992
36. Armstrong DK, Gordon GB, Hilton J, Streeper RT, Colvin OM, Davidson NE: Hepsulfam sensitivity in human breast cancer cell lines: The role of glutathione and glutathione S-transferase in resistance. Cancer Res 52:1416, 1992
37. Wang TS, Shu YF, Liu YC, Jan KY, Huang H: Glutathione peroxidase and catalase modulate the genotoxicity of arsenite. Toxicology 121:229, 1997
38. Lorico A, Rappa G, Flavell RA, Sartorelli AC: Double knockout of the MRP gene leads to increased drug sensitivity in vitro. Cancer Res 56:5351, 1996
39. Rappa G, Lorico A, Flavell RA, Sartorelli AC: Evidence that the multidrug resistance protein (MRP) functions as a co-transporter of glutathione and natural product toxins. Cancer Res 57:5232, 1997
40. Lazo JS, Basu A: Metallothionein expression and transient resistance to electrophilic antineoplastic drugs. Cancer Biol 2:267, 1991
41. Gasdaska JR, Gasdaska PY, Cochran S, Powis G: Cloning and sequencing of human thioredoxin reductase. FEBS Lett 373:7271, 1993
42. Delia D, Aiello A, Meroni L, Nicolini M, Reed JC, Pierotti MA: Role of antioxidants and interacellular free radicals in retinamide-induced cell death. Carcinogenesis 18:943, 1997
43. Kuo ML, Huang TS, Lin JK: Curcumin, an antioxidant and anti-tumor promoter, induces apoptosis in human leukemia cells. Biochim Biophys Acta 1317:95, 1996
44. Haendeler J, Zeiher AM, Dimmeler S: Vitamin C and E prevent lipopolysaccharide-induced apoptosis in human endothelial cells by modulation of Bcl-2 and Bax. Eur J Pharmacol 317:407, 1996
45. Barroso MP, Gomez-Diaz C, Lopez-Lluch G, Malagon MM, Crane FL, Navas P: Ascorbate and alpha-tocopherol prevent apoptosis induced by serum removal independent of Bcl-2. Arch Biochem Biophys 343:243, 1997
46. Sakagami H, Satoh K: Modulating factors of radical intensity and cytotoxic activity of ascorbate. Anticancer Res 17:3513, 1997
47. Gabbay M, Tauber M, Porat S, Simantov R: Selective role of glutathione in protecting human neuronal cells from dopamine-induced apoptosis. Neuropharmacol 35:571, 1996
48. Vera JC, Rivas Cl, Zhang RH, Farber CM, Golde DW: Human HL-60 myeloid leukemia cells transport dehydroascorbic acid via the glucose transporters and accumulate reduced ascorbic acid. Blood 84:1628, 1994
49. Bram S, Froussard P, Guichard M, Jasmin C, Augery Y, Sinoussi-Barre F, Wray W: Vitamin C preferential toxicity for malignant melanoma cells. Nature 284:629, 1980
50. Benade L, Howard T, Burk D: Synergistic killing of Ehrlich ascites carcinoma cells by ascorbate and 3-amino-1,2,4-triazole. Oncology 23:33, 1969
51. Jing Y, Ohizumi H, Kawazoe N, Hashimoto S, Masuda Y, Nakajo S, Yoshida T, Kuroiwa Y, Nakaya K: Selective inhibitory effect of bufalin on growth of human tumor cells in vitro: association with the induction of apoptosis in leukemia HL-60 cells. Jpn J Cancer Res 85:645, 1994