The accumulation and toxicity of methylated arsenicals in endothelial cells: Important roles of thiol compounds

Toxicology and Applied Pharmacology

Volumn 198, Issue 3, 2004, Pages 458-467

  Hirano, Seishiro ^a   Kobayashi, Yayoi ^a   Cui, Xing ^a   Kanno, Sanae ^a   Hayakawa, Toru ^a,b   Shraim, Amjad ^a,c  

^a NATIONAL INSTITUTE FOR ENVIRONMENTAL STUDIES   (Japan)

^b CHIBA UNIVERSITY   (Japan)

^c UNIVERSITY OF QUEENSLAND   (Australia)

Author keywords

Arsenic; Buthionine sulfoximine; Cytotoxicity; Endothelial cell; Glutathione; Heme oxygenase 1; N Acetyl L cysteine; Thiol

Indexed keywords

ACETYLCYSTEINE; ARSENIC ACID; ARSENIC DERIVATIVE; ARSENIC TRIOXIDE; BUTHIONINE SULFOXIMINE; CACODYLIC ACID; GLUTATHIONE; HEME OXYGENASE 1; MESSENGER RNA; METHANEARSONIC ACID; MONOMETHYLARSONOUS ACID DIGLUTATHIONE; ORGANOARSENIC DERIVATIVE; PEPTIDE; THIOL DERIVATIVE; TRIMETHYLARSINE OXIDE; UNCLASSIFIED DRUG;

ANIMAL CELL; BIOACCUMULATION; CARCINOGENICITY; CARDIOTOXICITY; CELL TRANSPORT; CELL VIABILITY; CHEMICAL MODIFICATION; CONTROLLED STUDY; CYTOTOXICITY; ENDOTHELIUM CELL; ENVIRONMENTAL EXPOSURE; HEART BLOOD VESSEL; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; MASS SPECTROMETRY; METHYLATION; MICROVASCULATURE; NONHUMAN; PATHOPHYSIOLOGY; RAT; REVIEW;

ANIMALS; ARSENIC POISONING; CELLS, CULTURED; HUMANS; LETHAL DOSE 50; MUSCLE, SMOOTH, VASCULAR; RATS;

EID: 3242804525     PISSN: 0041008X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.taap.2003.10.023     Document Type: Review

References (54)

1. Aposhian H.V. Enzymatic methylation of arsenic species and other new approaches to arsenic toxicity. Annu. Rev. Pharmacol. 1997;37397-37419
2. Aposhian H.V., Gurzau E.S., Le X.C., Gurzau A., Healy S.M., Lu X., Ma M., Yip L., Zakharyan R.A., Maiorino R.M., Dart R.C., Tircus M.G., Gonzalez Ramirez D., Morgan D.L., Avram D., Aposhian M.M. Occurrence of monomethylarsonous acid in urine of humans exposed to inorganic arsenic. Chem. Res. Toxicol. 13:2000;693-697
3. Barchowsky A., Roussel R.R., Klei L.R., James P.E., Ganju N., Smith K.R., Dudek E.J. Low levels of arsenic trioxide stimulate proliferative signals in primary vascular cells without activating stress effector pathways. Toxicol. Appl. Pharmacol. 159:1999;65-75
4. Bunderson M., Coffin J.D., Beall H.D. Arsenic induces peroxynitrite generation and cyclooxygenase-2 protein expression in aortic endothelial cells: possible role in atherosclerosis. Toxicol. Appl. Pharmacol. 184:2002;11-18
5. Chakravortty D., Kato Y., Sugiyama T., Koide N., Mu M.M., Yoshida T., Yokochi T. The inhibitory action of sodium arsenite on lipopolysaccharide- induced nitric oxide production in RAW 267.4 macrophage cells: a role of Raf-1 in lipopolysaccharide signaling. J. Immunol. 166:2001;2011-2017
6. Cohen S.M., Arnold L.L., Uzvolgyi E., Cano M., John M.S., Yamamoto S., Lu X.F., Le X.C. Possible role of dimethylarsinous acid in dimethylarsinic acid-induced urothelial toxicity and regeneration in the rat. Chem. Res. Toxicol. 15:2002;1150-1157
7. Csanaky L., Gregus Z. Species variations in the biliary and urinary excretion of arsenate, arsenite and their metabolites. Comp. Biochem. Physiol., C-Toxicol. Pharmacol. 131:2002;355-365
8. Cullen W.R., McBride B.C., Reglinski J. The reaction of methylarsenicals with thiols - Some biological implications. J. Inorg. Biochem. 21:1984;179-194
9. Del Razo L.M., Quintanilla Vega B., Brambila Colombres E., Calderon Aranda E.S., Manno M., Albores A. Stress proteins induced by arsenic. Toxicol. Appl. Pharmacol. 177:2001;132-148
10. Del Razo L.M., Styblo M., Cullen W.R., Thomas D.J. Determination of trivalent methylated arsenicals in biological matrices. Toxicol. Appl. Pharmacol. 174:2001;282-293
11. Eguchi N., Kuroda K., Endo G. Metabolites of arsenic induced tetraploids and mitotic arrest in cultured cells. Arch. Environ. Contam. Toxicol. 32:1997;141-145
12. Engel R.R., Smith A.H. Arsenic in drinking-water and mortality from vascular-disease - An ecologic analysis in 30 counties in the United-States. Arch. Environ. Health. 49:1994;418-427
13. Engel R.R., Hopenhayn Rich C., Receveur O., Smith A.H. Vascular effects of chronic arsenic exposure: a review. Epidemiol. Rev. 16:1994;184-209
14. Gregus Z., Nemeti B. Purine nucleoside phosphorylase as a cytosolic arsenate reductase. Toxicol. Sci. 70:2002;13-19
15. Harvey C.F., Swartz C.H., Badruzzaman A.B.M., Keon-Blute N., Yu W., Ali M.A., Jay J., Beckie R., Niedan V., Brabander D., Oates P.M., Ashfaque K.N., Islam S., Hemond H.F., Ahmed M.F. Arsenic mobility and groundwater extraction in Bangladesh. Science. 298:2002;1602-1606
16. Hirano S., Cui X., Li S., Kanno S., Hayakawa T., Shraim A. Difference in uptake and toxicity of trivalent and pentavalent inorganic arsenics in rat microvessel endothelial cells. Arch. Toxicol. 77:2003;305-312
17. Hirano S., Furuyama A., Koike E., Kobayashi T. Oxidative-stress potency of organic extracts of diesel exhaust and urban fine particles in rat heart microvessel endothelial cells. Toxicology. 187:2003;161-170
18. IPCS Arsenic. 1981;World Health Organization, Geneva
19. IPCS Arsenic and Arsenic Compounds. 2001;World Health Organization, Geneva
20. Kala S.V., Neely M.W., Kala G., Prater C.I., Atwood D.W., Rice J.S., Lieberman M.W. The MRP2/cMOAT transporter and arsenic-glutathione complex formation are required for biliary excretion of arsenic. J. Biol. Chem. 275:2000;33404-33408
21. Kitajima H., Hirano S., Suzuki K.T. Upregulation of heme oxygenase gene expression in rat lung epithelial cells following exposure to cadmium. Arch. Toxicol. 73:1999;410-412
22. Lewis D.R., Southwick J.W., Ouellet-Hellstrom R., Rench J., Calderon R.L. Drinking water arsenic in Utah: a cohort mortality study. Environ. Health Perspect. 107:1999;359-365
23. Lin S., Del Razo L.M., Styblo M., Wang C., Cullen W.R., Thomas D.J. Arsenicals inhibit thioredoxin reductase in cultured rat hepatocytes. Chem. Res. Toxicol. 14:2001;305-311
24. Lin S., Shi Q., Nix F.B., Styblo M., Beck M.A., Herbin-Davis K.M., Hall L.L., Simeonsson J.B., Thomas D.J. A novel S-adenosyl-L-methionine: arsenic (III) methyltransferase from rat liver cytosol. J. Biol. Chem. 277:2002;10795-10803
25. Liu F., Jan K.Y. DNA damage in arsenite- and cadmium-treated bovine aortic endothelial cells. Free Radical Biol. Med. 28:2000;55-63
26. Liu J., Kadiiska M.B., Liu Y., Lu T., Qu W., Waalkes M.P. Stress-related gene expression in mice treated with inorganic arsenicals. Toxicol. Sci. 61:2001;314-320
27. Maitani T., Saito N., Abe M., Uchiyama S., Saito Y. Chemical form-dependent induction of hepatic zinc-thionein by arsenic administration and effect of co-administered selenium in mice. Toxicol. Lett. 39:1987;63-70
28. Mandal B.K., Ogra Y., Suzuki K.T. Identification of dimethylarsinous and monomethylarsonous acids in human urine of the arsenic-affected areas in West Bengal, India. Chem. Res. Toxicol. 14:2001;371-378
29. Mass M.J., Tennant A., Roop B.C., Cullen W.R., Styblo M., Thomas D.J., Kligerman A.D. Methylated trivalent arsenic species are genotoxic. Chem. Res. Toxicol. 14:2001;355-361
30. Nemeti B., Gregus Z. Mitochondria work as reactors in reducing arsenate to arsenite. Toxicol. Appl. Pharmacol. 182:2002;208-218
31. Nemeti B., Gregus Z. Reduction of arsenate to arsenite in hepatic cytosol. Toxicol. Sci. 70:2002;4-12
32. Nesnow S., Roop B.C., Lambert G., Kadiiska M., Mason R.P., Cullen W.R., Mass M.J. DNA damage induced by methylated trivalent arsenicals is mediated by reactive oxygen species. Chem. Res. Toxicol. 15:2002;1627-1634
33. Ochi T., Kaise T., Oya Ohta Y. Glutathione plays different roles in the induction of the cytotoxic effects of inorganic and organic arsenic compounds in cultured BALB/c 3T3 cells. Experientia. 50:1994;115-120
34. Parrish A.R., Zheng X.H., Turney K.D., Younis H.S., Gandolfi A.J. Enhanced transcription factor DNA binding and gene expression induced by arsenite or arsenate in renal slices. Toxicol. Sci. 50:1999;98-105
35. Petrick J.S., Jagadish B., Mash E.A., Aposhian H.V. Monomethylarsonous acid (MMA(III)) and arsenite: LD(50) in hamsters and in vitro inhibition of pyruvate dehydrogenase. Chem. Res. Toxicol. 14:2001;651-656
36. Pi J., Kumagai Y., Sun G., Yamauchi H., Yoshida T., Iso H., Endo A., Yu L., Yuki K., Miyauchi T., Shimojo N. Decreased serum concentrations of nitric oxide metabolites among Chinese in an endemic area of chronic arsenic poisoning in inner Mongolia. Free Radical Biol. Med. 28:2000;1137-1142
37. Radabaugh T.R., Aposhian H.V. Enzymatic reduction of arsenic compounds in mammalian systems: reduction of arsenate to arsenite by human liver arsenate reductase. Chem. Res. Toxicol. 13:2000;26-30
38. Rossi M.R., Somji S., Garrett S.H., Sens M.A., Nath J., Sens D.A. Expression of hsp 27, hsp 60, hsc 70, and hsp 70 stress response genes in cultured human urothelial cells (UROtsa) exposed to lethal and sublethal concentrations of sodium arsenite. Environ. Health Perspect. 110:2002;1225-1232
39. Sakurai T., Qu W., Sakurai M.H., Waalkes M.P. A major human arsenic metabolite, dimethylarsinic acid, requires reduced glutathione to induce apoptosis. Chem. Res. Toxicol. 15:2002;629-637
40. Samanta G., Chowdhury U.K., Mandal B.K., Chakraborti D., Sekaran N.C., Tokunaga H., Ando M. High performance liquid chromatography inductively coupled plasma mass spectrometry for speciation of arsenic compounds in urine. Microchem. J. 65:2001;113-127
41. Sampayo Reyes A., Zakharyan R.A., Healy S.M., Aposhian H.V. Monomethylarsonic acid reductase and monomethylarsonous acid in hamster tissue. Chem. Res. Toxicol. 13:2000;1181-1186
42. Shiobara Y., Ogra Y., Suzuki K.T. Animal species difference in the uptake of dimethylarsinous acid (dma(iii)) by red blood cells. Chem. Res. Toxicol. 14:2001;1446-1452
43. Shraim A., Sekaran N.C., Anuradha C.D., Hirano S. Speciation of arsenic in tube-well water samples collected from West Bengal, India, by high-performance liquid chromatography-inductively coupled plasma mass spectrometry. Appl. Organomet. Chem. 16:2002;202-209
44. Shraim A., Cui X., Li S., Ng J.C., Wang H.P., Jin Y.L., Liu Y.C., Guo L., Li D.S., Wang S.Q., Zhang R.Z., Hirano S. Arsenic speciation in the urine and hair of individuals exposed to airborne arsenic through coal-burning in Guizhou, PR China. Toxicol. Lett. 137:2003;35-48
45. Styblo M., Del Razo L.M., LeCluyse E.L., Hamilton G.A., Wang C., Cullen W.R., Thomas D.J. Metabolism of arsenic in primary cultures of human and rat hepatocytes. Chem. Res. Toxicol. 12:1999;560-565
46. Styblo M., Del Razo L.M., Vega L., Germolec D.R., LeCluyse E.L., Hamilton G.A., Reed W., Wang C., Cullen W.R., Thomas D.J. Comparative toxicity of trivalent and pentavalent inorganic and methylated arsenicals in rat and human cells. Arch. Toxicol. 74:2000;289-299
47. Styblo M., Drobna Z., Jaspers I., Lin S., Thomas D.J. The role of biomethylation in toxicity and carcinogenicity of arsenic: a research update. Environ. Health Perspect. 110:2002;767-771
48. Suzuki K.T., Tomita T., Ogra Y., Ohmichi M. Glutathione-conjugated arsenics in the potential hepato-enteric circulation in rats. Chem. Res. Toxicol. 14:2001;1604-1611
49. Trouba K.J., Glanzer J.G., Vorce R.L. Wild-type and Ras-transformed fibroblasts display differential mitogenic responses to transient sodium arsenite exposure. Toxicol. Sci. 50:1999;72-81
50. Vega L., Styblo M., Patterson R., Cullen W., Wang C., Germolec D. Differential effects of trivalent and pentavalent arsenicals on cell proliferation and cytokine secretion in normal human epidermal keratinocytes. Toxicol. Appl. Pharmacol. 172:2001;225-232
51. Yamanaka K., Okada S. Induction of lung-specific DNA-damage by metabolically methylated arsenics via the production of free-radicals. Environ. Health Perspect. 102(suppl. 3):1994;37-40
52. Yamauchi H., Yamamura Y. Metabolism and excretion of orally administrated arsenic trioxide in the hamster. Toxicology. 34:1985;113-121
53. Yoshida K., Chen H., Inoue Y., Wanibuchi H., Fukushima S., Kuroda K., Endo G. The urinary excretion of arsenic metabolites after a single oral administration of dimethylarsinic acid to rats. Arch. Environ. Contam. Toxicol. 32:1997;416-421
54. V) reductase is a member of the glutathione-S-transferase superfamily. Chem. Res. Toxicol. 14:2001;1051-1057