The endoplasmic reticulum is a target organelle for trivalent dimethylarsinic acid (DMA III)-induced cytotoxicity

Toxicology and Applied Pharmacology

Volumn 260, Issue 3, 2012, Pages 241-249

  Naranmandura, Hua ^a   Xu, Shi ^a   Koike, Shota ^b   Pan, Li Qiang ^a   Chen, Bin ^c   Wang, Yan Wei ^a   Rehman, Kanwal ^a   Wu, Bin ^a   Chen, Zhe ^d   Suzuki, Noriyuki ^b  

^a ZHEJIANG UNIVERSITY   (China)

^b CHIBA UNIVERSITY   (Japan)

^c HUAZHONG UNIVERSITY OF SCIENCE AND TECHNOLOGY   (China)

^d ZHEJIANG CHINESE MEDICAL UNIVERSITY   (China)

Author keywords

Arsenic; Arsenite; Dimethylarsinous acid; ER stress; Reactive oxygen species

Indexed keywords

ACTIVATING TRANSCRIPTION FACTOR 4; ARSENIC DERIVATIVE; ARSENIC TRIOXIDE; CACODYLIC ACID; CCAAT ENHANCER BINDING PROTEIN; CYCLOHEXIMIDE; GLUCOSE REGULATED PROTEIN 78; GROWTH ARREST AND DNA DAMAGE INDUCIBLE PROTEIN 153; MESSENGER RNA; METHYLARSONOUS ACID; PROTEIN KINASE; PROTEIN KINASE LIKE ENDOPLASMIC RETICULUM KINASE; REACTIVE OXYGEN METABOLITE; UNCLASSIFIED DRUG;

ANIMAL CELL; ARSENIC POISONING; ARTICLE; CONTROLLED STUDY; CYTOTOXICITY; ENDOPLASMIC RETICULUM STRESS; ENVIRONMENTAL EXPOSURE; ENZYME PHOSPHORYLATION; LIVER CELL CULTURE; NONHUMAN; OXIDATIVE STRESS; PROTEIN FOLDING; RAT;

ACTIVATING TRANSCRIPTION FACTOR 4; ANIMALS; ARSENITES; CACODYLIC ACID; CELL LINE; EIF-2 KINASE; ENDOPLASMIC RETICULUM; ENDOPLASMIC RETICULUM STRESS; HEAT-SHOCK PROTEINS; LIVER; ORGANOMETALLIC COMPOUNDS; PHOSPHORYLATION; PROTEIN FOLDING; RATS; REACTIVE OXYGEN SPECIES; RNA, MESSENGER; TRANSCRIPTION FACTOR CHOP;

RATTUS;

EID: 84859993160     PISSN: 0041008X     EISSN: 10960333     Source Type: Journal    
DOI: 10.1016/j.taap.2012.02.017     Document Type: Article

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