Mechanisms of arsenic biotransformation

Toxicology

Volumn 181-182, Issue , 2002, Pages 211-217

  Vahter, Marie ^a  

^a KAROLINSKA INSTITUTE   (Sweden)

Author keywords

Arsenic methylation; Arsenic species; Metabolism; Toxicity

Indexed keywords

ARSENIC; ARSENIC ACID; CACODYLIC ACID; CARCINOGEN; GLUTATHIONE; INORGANIC COMPOUND; METHANEARSONIC ACID; METHYL GROUP; S ADENOSYLMETHIONINE; THIOL DERIVATIVE;

ABSORPTION; ARSENIC POISONING; BIOTRANSFORMATION; BLOOD; EXPOSURE; HUMAN; INDIVIDUALITY; INGESTION; LIVER; LIVER METABOLISM; MAMMAL; METABOLITE; METHYLATION; MOLECULAR MECHANICS; NONHUMAN; POPULATION; PRIORITY JOURNAL; REDUCTION; REVIEW; SPECIES DIFFERENCE; TOXICITY; URINALYSIS; URINARY EXCRETION; URINE LEVEL;

MAMMALIA;

EID: 0037184792     PISSN: 0300483X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0300-483X(02)00285-8     Document Type: Article

References (55)

1. Aposhian H.V., Gurzau E.S., Le X.C., Gurzau A., Healy S.M., Lu X., Ma M., Yip L., Zakharyan R.A., Maiorino R.M., Dart R.C., Tircus M.G., Gonzalez-Ramirez D., Morgan D.L., Avram D., Aposhian M.M. Occurrence of monomethylarsonous acid in urine of humans exposed to inorganic arsenic. Chem. Res. Toxicol. 13:2000a;693-697.
2. Aposhian H.V., Zheng B., Aposhian M.M., Le X.C., Cebrian M.E., Cullen W., Zakharyan R.A., Ma M., Dart R.C., Cheng Z., Andrewes P., Yip L., O'Malley G.F., Maiorino R.M., Van Voorhies W., Healy S.M., Titcomb A. DMPS - arsenic challenge test. II. Modulation of arsenic species, including monomethylarsonous acid (MMAIII), excreted in human urine. Toxicol.Appl. Pharmacol. 165:2000b;74-83.
3. Buchet J.P., Lauwerys R., Roels H. Comparison of the urinary excretion of arsenic metabolites after a single dose of sodium arsenite, monomethylarsonate or dimethylarsinate in man. Int. Arch. Occup. Environ. Health. 48:1981a;71-79.
4. Buchet J.P., Lauwerys R., Roels H. Urinary excretion of inorganic arsenic and its metabolites after repeated ingestion of sodium metaarsenite by volunteers. Int. Arch. Occup. Environ. Health. 48:1981b;111-118.
5. Buchet J.P., Lauwerys R. Role of thiols in the in-vitro methylation of inorganic arsenic by rat liver cytosol. Biochem. Pharmacol. 37:1988;3149-3153.
6. Chiou H.Y., Hsueh Y.M., Hsieh L.L., Hsu L.I., Hsu Y.H., Hsieh F.I., Wei M.L., Chen H.C., Yang H.T., Leu L.C., Chu T.H., Chen-Wu C., Yang M.H., Chen C.J. Arsenic methylation capacity, body retention, and null genotypes of glutathione S-transferase M1 and T1 among current arsenic-exposed residents in Taiwan. Mutat. Res. 386:1997;197-207.
7. Concha G., Vogler G., Nermell B., Vahter M. Metabolism of inorganic arsenic in children with chronic high arsenic exposure in northern Argentina. Environ. Health Perspect. 106:(6):1998a;355-359.
8. Concha G., Vogler G., Lezcano D., Nermell B., Vahter M. Exposure to inorganic arsenic metabolites during early human development. Toxicol. Sci. 44:(2):1998b;185-190.
9. Concha, C., Vogler, G., Nermell, B., Vachter, M., 2002. Intra-individual variation in the metabolism of inorganic arsenic. Int. Arch. Occup. Environ. Health (in press).
10. Crecelius E.A. Changes in the chemical speciation of arsenic following ingestion by man. Environ. Health Perspect. 19:1977;147-150.
11. Cullen W.R., McBride B.C., Reglinski J. The reaction of methyl arsenicals with thiols: some biological implications. J. Inorg. Biochem. 21:1984;179-193.
12. Delnomdedieu M., Basti M.M., Otvos J.D., Thomas D.J. Reduction and binding of arsenate and dimethylarsinate by glutathione: a magnetic resonance study. Chem. -Biol. Interact. 90:1994;139-155.
13. Del Razo L.M., García-Vargas G.G., Vargas H., Albores A., Gonsebatt M.E., Montero R., Ostrosky-Wegman P., Kelsh M., Cebrián M.E. Altered profile of urinary arsenic metabolites in adults with chronic arsenicism. Arch. Toxicol. 71:1997;211-217.
14. Geubel A.P., Mairlot M.C., Buchet J.P., Lauwerys R. Abnormal methylation capacity in human liver cirrhosis. Int. J. Clin. Pharmacol. Res. 8:1988;117-122.
15. Healy S.M., Casarez E.A., Ayala-Fierro F., Aposhian H.V. Enzymatic methylation of arsenic compounds V. arsenite methyltransferase activity in tissues of mice. Toxicol. Appl. Pharmacol. 148:1998;65-70.
16. Healy S.M., Wildfang E., Zakharyan R.A., Aposhian H.V. Diversity of inorganic arsenite biotransformation. Biol. Trace Elem. 68:1999;249-266.
17. Hirata M., Tanaka A., Hisanaga A., Ishinishi N. Effects of glutathione depletion on the acute nephrotoxic potential of arsenite and on the arsenic metabolism in the hamster. Toxicol. Appl. Pharmacol. 106:1990;469-481.
18. Hopenhayn-Rich C., Biggs M.L., Smith A.H., Kalman D.A., Moore L.E. Methylation study of a population environmentally exposed to arsenic in drinking water. Environ. Health Perspect. 104:1996;620-628.
19. Hsueh Y.-M., Huang Y.-L., Huang C.-C., Wu W.-L., Chen H.-M., Yang M.-H., Lue L.-C., Chen C.-J. Urinary levels of inorganic and organic arsenic metabolites among residents in an arseniasis-hyperendemic area in Taiwan. J. Toxicol. Environ. Health. 54:1998;431-444.
20. Hughes M.F., Kenyon E.M. Dose-dependent effects on the disposition of monomethylarsonic acid and dimethylarsinic acid in the mouse after intravenous administration. J. Toxicol. Environ. Health. 53:1998;95-112.
21. Johnson L.R., Farmer J.G. Use of human metabolic studies and urinary arsenic speciation in Assessing arsenic exposure. Bull. Environ. Contam. Toxicol. 46:1991;53-61.
22. Kurttio P., Komulainen H., Hakala E., Kahelin H., Pekkanen J. Urinary excretion of arsenic species after exposure to arsenic present in drinking water. Arch. Environ. Contam. Toxicol. 34:1998;297-305.
23. Lerman S.A., Clarkson T.W., Gerson R.J. Arsenic uptake and metabolism by liver cells is dependent on arsenic oxidation state. Chem.-Biol. Interact. 45:1983;401-406.
24. Mandal B.K., Ogra Y., Suzuki K.T. Indentification of dimethylarsinous and monomethylarsonous acids in human urine of the arsenic-affected areas in West Bengal, India. Chem. Res. Toxicol. 14:2001;371-378.
25. Marafante E., Vahter M., Envall J. The role of the methylation in the detoxication of arsenate in the rabbit. Chem.-Biol. Interact. 56:1985;225-238.
26. Marafante E., Vahter M., Norin H., Envall J., Sandström M., Christakopoulos A., Ryhage R. Biotransformation of dimethylarsinic acid in mouse, hamster and man. J. Appl. Toxicol. 7:1987;111-117.
27. Mass M.J., Tennant A., Roop B.C., Cullen W.R., Styblo M., Thomas D.J., Kligermann A.D. Methylated trivalent arsenic species are genotoxic. Chem. Res. Toxicol. 14:2001;355-361.
28. Mäki-Paakkanen J., Kurttio P., Paldy A., Pekkanen J. Association between the clastogenic effect in peripheral lymphocytes and human exposure to arsenic through drinking water. Environ. Mol. Mut. 32:1998;301-313.
29. Arsenic in Drinking Water. 1999;National Academy of Sciences, Washington, DC.
30. III ) is more toxic than arsenite in Chang human hepatocytes. Toxicol. Appl. Pharmacol. 163:2000;203-207.
31. Radabaugh T.R., Aposhian H.V. Enzymatic reduction of arsenic compounds in mammalian systems: Reduction of arsenate to arsenite by human liver arsenate reductase. Chem. Res. Toxicol. 13:2000;26-30.
32. Sampayo-Reyes A., Zakharyan R.A., Healy S.M., Aposhian H.V. Monomethylarsonic acid reductase and monomethylarsonous acid in hamster tissue. Chem. Res. Toxicol. 13:(11):2000;1181-1186.
33. Scott N., Hatlelid K.M., MacKenzie N.E., Carter D.E. Reactions of arsenic (III) species with glutathione. Chem. Res. Toxicol. 6:1993;102-106.
34. Styblo M., Yamauchi H., Thomas D. Comparative in vitro methylation of trivalent and pentavalent arsenicals. Toxicol. Appl. Pharmacol. 135:1995;172-178.
35. Styblo M., Serves S.V., Cullen W.R., Thomas D.J. Comparative inhibition of yeast glutathione reductase by arsenicals and arsenothiols. Chem. Res. Toxicol. 10:1997;27-33.
36. Styblo M., Del Razo L.M., LeCluyse E.L., Hamilton G.A., Wang C., Cullen W.R., Thomas D.J. Metabolism of arsenic in primary cultures of human and rat hepatocytes. Chem. Res. Toxicol. 12:1999;560-565.
37. Styblo M., Del Razo L.M., Vega L., Germolec D.R., LeCluyse E.L., Hamilton G.A., Reed W., Wang C., Cullen W.R., Thomas D.J. Comparative toxicity of trivalent and pentavalent inorganic and methylated arsenicals in rat and human cells. Arch. Toxicol. 74:2000;289-299.
38. 74 As) in humans following oral ingestion. Toxicol. Appl. Pharmacol. 50:1979;319-322.
39. Thompson D.J. A chemical hypothesis for arsenic methylation in mammals. Chem.-Biol. Interact. 88:1993;89-114.
40. 74 As-dimethylarsinic acid in mice and rats. Arch. Environ. Contam. Toxicol. 13:1984;259-264.
41. Vahter M., Marafante E. Reduction and binding of arsenate in marmoset monkeys. Arch. Toxicol. 57:1985;119-124.
42. Vahter M., Marafante E. Effects of low dietary intake of methionine, choline or proteins on the biotransformation of arsenite in the rabbit. Toxicol. Lett. 37:1987;41-46.
43. Vahter M., Couch R., Nermell B., Nilsson R. Lack of methylation of inorganic arsenic in the chimpanzee. Toxicol. Appl. Pharmacol. 133:1995a;262-268.
44. Vahter M., Concha G., Nermell B., Nilsson R., Dulout F., Natarajan N. A unique metabolism of inorganic arsenic in native Andean women. Eur. J. Pharmacol., Environ. Toxicol. Pharmacol. Section. 293:1995b;455-462.
45. Vahter M. Variation in human metabolism of arsenic. Chappell W.R., Abernathy C.O., Calderon R.L. Arsenic Exposure and Health Effects. 1999a;267-279 Elsevier Science Ltd, Oxford.
46. Vahter M. Methylation of inorganic arsenic in different mammalian species and population groups. Sci. Prog. 82:1999b;69-88.
47. Valentine J.L., Kang H.K., Spivey G. Arsenic levels in human blood, urine, and hair in response to exposure via drinking water. Environ. Res. 20:1979;24-32.
48. Vega L., Styblo M., Patterson R., Cullen W., Wang C., Germolec D. Differential effects of trivalent and pentavalent arsenicals on cell proliferation and cytokine secretion in normal human epidermal keratinocytes. Toxicol. Appl. Pharmacol. 172:2001;225-232.
49. Warner M.L., Moore L.E., Smith M.T., Kalman D.A., Fanning E., Smith A.H. Increased micronuclei in exfoliated bladder cells of individuals who chronically ingest arseni-contaminated water in Nevada. Cancer Epidemiol. Biomarkers Prev. 3:1994;583-590.
50. Weinshilboum R.M., Otterness D.M., Szumlanski C.L. Methylation pharmacogenetics: catecol O-methyltransferase, thiopurine methyltransferase, and histamine N-methyltransferase. Annu. Rev. Pharmacol. Toxicol. 39:1999;19-52.
51. Wildfang E., Zakharyan R.A., Aposhian H.V. Enzymatic methylation of arsenic compounds. VI. Characterization of hamster liver arsenite and methylarsonic acid methyltransferase activities in vitro. Toxicol. Appl. Pharmacol. 152:1998;366-375.
52. Yu R.C., Hsu K.H., Chen C.J., Froines J.R. Arsenic methylation capacity and skin cancer. Cancer Epidemiol. Biomarkers Prev. 9:2000;1259-1262.
53. Zakharyan R.A., Wu Y., Bogdan G.M., Aposhian H.V. Enzymatic methylation of arsenic compounds. I: Assay, partial purification, and properties of arsenite methyltransferase and monomethylarsonic acid methyltransferase of rabbit liver. Chem. Res. Toxicol. 8:1995;1029-1038.
54. Zakharyan R.A., Wildfang E., Aposhian H.V. Enzymatic methylation of arsenic compounds: III. The marmoset and tamarin, but not the rhesus, monkey are deficient in methyltransferases that methylate inorganic arsenic. Toxicol. Appl. Pharmacol. 140:1996;77-84.
55. v reductase. Chem. Res. Toxicol. 12:1999;1278-1283.