Molecular aspects of arsenic stress

Journal of Toxicology and Environmental Health - Part B: Critical Reviews

Volumn 3, Issue 4, 2000, Pages 293-322

  Bernstam, Luda ^a   Nriagu, Jerome ^a  

^a UNIVERSITY OF MICHIGAN   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ARSENIC;

APOPTOSIS; CHEMICAL CARCINOGENESIS; CHROMOSOME ABERRATION; CYTOSKELETON; DNA DAMAGE; ENVIRONMENTAL EXPOSURE; GENOTOXICITY; HEAT SHOCK; HUMAN; HUMAN CELL; MITOSIS SPINDLE; OXIDATIVE STRESS; REVIEW; SKIN CANCER; SQUAMOUS CELL CARCINOMA; TRANSCRIPTION REGULATION;

ANIMAL; ARSENIC; ARSENITES; CELL LINE; CHROMOSOMES; ENVIRONMENTAL POLLUTANTS; HEAT-SHOCK RESPONSE; HUMAN; MITOTIC SPINDLE APPARATUS; OXIDATIVE STRESS; SKIN; STRESS;

MAMMALIA;

EID: 0033787794     PISSN: 10937404     EISSN: 15216950     Source Type: Journal    
DOI: 10.1080/109374000436355     Document Type: Article

References (170)

1. Abello, P. A., and Buchman, T. G. 1994. Heat shock-induced cell death in murine microvascular endothelial cells depends on priming with tumor necrosis factor-alpha or interferon-gamma. Shock 2: 320-323.
2. Abello, P. A., Fidler, S. A., and Buchman, T. G. 1994. Thiol reducing agents modulate induced apoptosis in porcine endothelial cells. Shock 2: 79-83.
3. Ahmad, A., Bondaranayake, D., Khan, A. W., Hadi, A., Uddin, G., and Halim, A. 1997. Arsenic contamination in groundwater and arsenicosis in Bangladesh. Int. J. Environ. Health Res. 7: 271-276.
4. Akao, Y., Mizoguchi, H., Kojima, S., Naoe, T., Ohishi, N., and Yagi, K. 1998. Arsenic induces apoptosis in B-cell leukaemic cell lines in vitro: Activation of caspases and down-regulation of Bcl-2 protein. Br. J. Haematol. 102: 1055-1060.
5. Albores, A., Cebrian, M. E., Garcia-Vargas, G. G., Connelly, J. C., Price, S. C., Hinton, R. H., Bach, P. H., and Bridges, J. W. 1996. Enhanced arsenite-induced hepatic morphological and biochemical changes in phenobarbital-pretreated rats. Toxicol. Pathol. 24: 172-180.
6. Ali, A., Krone, P. H., Pearson, D. S., and Heikkila, J. J. 1996. Evaluation of stress-inducible hsp90 gene expression as a potential molecular biomarker in Xenopus laevis. Cell Stress Chaperones 1: 62-69.
7. Amici, C., Giorgi, C., Rossi, A., and Santoro, M. G. 1994. Selective inhibition of virus protein synthesis by prostaglandin A1: A translational block associated with HSP70 synthesis. J. Virol. 68: 6890-6899.
8. Aposhian, H. V., Zakharyan, R., Wu, Y., Healy, S. and Aposhian, M. M. 1997. Enzymatic methyla-tion of arsenic compounds. In Arsenic exposure and health effects, eds. C. O. Abernathy, R. L. Calderon, and W. R. Chappell, pp. 296-321. New York: Chapman & Hall.
9. Aposhian, H. V., Zakharyan, R. A., Healy, S. M., Wildfang, E. K., Radabaugh, T. R., Badghisi, H., and Aposhian, M. M. 1999a. Biodiversity of inorganic arsenite methyltransferases. Toxicol. Sci. 49: 7-8.
10. Aposhian, H. V., Zakharyan, R. A., Wildfang, E. K., Healy, S. M., Gailer, J., Radabaugh, T. R., Bogdan, G. M., Powell, L. A., Aposhian, M. M. 1999b. How is inorganic arsenic detoxified? In Arsenic exposure and health effects, eds. W. R. Chappell, C. O. Abernathy, and R. L. Calderon, pp. 289-297. New York: Elsevier Science.
11. Bazarbachi, A., EI-Sabban, M. E., Nasr, R., Quignon, F., Awaraji, C., Kersual, J., Dianoux, L., Zermati, Y., Haidar, J. H., Hermine, O., and de The, H. 1999. Arsenic trioxide and interferon-alpha synergize to induce cell cycle arrest and apoptosis in human T-cell lymphotropic virus type I-transformed cells. Blood 93: 278-283.
12. Biedermann, K. A., and Landolph, J. R. 1987. Induction of anchorage independence in human diploid foreskin fibroblasts by carcinogenic metal salts. Cancer Res. 47: 3815-3823.
13. Bittel, D., Dalton, T., Samson, S.L.-A., Gedamu, L., and Andrews, G. K. 1998. The DNA binding activity of metal response element-binding transcription factor-1is activated in vivo and in vitro by zinc, but not by other transition metals. J. Biol. Chem. 273: 7127-7133.
14. Brostrom, C. O., and Brostrom, M. A. 1998. Regulation of translational initiation during cellular responses to stress. Prog. Nucleic Acid Res. Mol. Biol. 58: 79-125.
15. Brostrom, C. O., Prostko, C. R., Kaufman, R. J., and Brostrom, M. A. 1996. Inhibition of translational initiation by activators of the glucose-regulated stress protein and heat shock protein stress response systems. Role of the interferon-inducible double-stranded RNA-activated eukaryotic initiation factor 2alpha. kinase. J. Biol. Chem. 271: 24995-25002.
16. Burgdorf, W., Kurvink, K., and Cervenka, J. 1977. Elevated sister chromatid exchange rate in lymphocytes of subjects treated with arsenic. Hum. Genet. 36: 69-72.
17. Cai, J., Salmon, K., and DuBow, M. S. 1998. A chromosomal ars operon homologue of Pseudomonas aeruginosa confers increased resistance to arsenic and antimony in Escherichia coli. Microbiology 144(part 10): 2705-2713.
18. Cavigelli, M., Li, W. W., Lin, A., Su, B., Yoshioka, K., and Karin, M. 1996. The tumor promoter arsenite stimulates AP-1activity by inhibiting a JNK phosphatase. EMBO J. 15: 6269-6279.
19. Chai, C. Y., Yu, H. S., Yen, H. T., Tsai, K. B., Chen, G. S., and Yu, C. L. 1997. The inhibitory effect of UVB irradiation on the expression of p53 and Ki-67 proteins in arsenic-induced Bowen's disease. J. Cutan. Pathol. 24: 8-13.
20. Chen, C., Xie, Y., Stevenson, M. A., Auron, P. E., and Calderwood, S. K. 1997. Heat shock factor 1represses ras-induced transcriptional activation of the c-fos gene. J. Biol. Chem. 272: 26803-26806.
21. 3) in the treatment of acute promyelocytic leukemia. Blood 88: 1052-1061.
22. Chen, C.-J., Hsu, L.-I., Tseng, C.-H., Hsueh, Y.-M., and Chiou, H.-Y. 1999. Emerging epidemics of arseniasis in Asia. In Arsenic exposure and health effects, eds. W. R. Chappel l, C. O. Abernathy, and R. L. Calderon, pp. 113-121. Amsterdam: Elsevier Science.
23. Choudhury, A. R., Das, T., and Sharma, A. 1997a. Mustard oil and garlic extract as inhibitors of sodium arsenite-induced chromosomal breaks in vivo. Cancer Lett. 121: 45-52.
24. Choudhury, A. R., Das, T., Sharma, A., and Talukder, G. 1997b. Inhibition of clastogenic effects of arsenic through continued oral administration of garlic extract in mice in vivo. Mutat. Res. 392: 23 7-242.
25. Chowdhury, U. K., Biswas, B. K., Dhar, R. K., Samanta, G., Mandal, B. K., Chowdhury, T. R., Chakraborti, D., Kabir, S., and Roy, S. 1999. Ground water arsenic contamination and suffering of people in Bangladesh. In Arsenic exposure and health effects, eds. W. R. Chappell, C. O. Abernathy, and R. L. Calderon, pp. 165-182. Amsterdam: Elsevier Science.
26. Chu, W. A., Moehlenkamp, J. D., Bittel, D., Andrews, G. K., and Johnson, J. A. 1999. Cadmium-mediated activation of the metal response element in human neuroblastoma cells lacking functional metal response element-binding transcription factor-1. J. Biol. Chem. 274: 5279-5284.
27. Clarkson, T. W. 1987. Metal toxicity in the central nervous system. Environ. Health Perspect. 75: 59-64.
28. Corton, J. M., Gillespie, J. G., and Hardie, D. G. 1994. Role of the AMP-activated protein kinase in the cellular stress response. Curr. Biol. 4: 315-324.
29. Crameri, A., Dawes, G., Rodriguez, E., Jr., Silver, S., and Stemmer, W. P. 1997. Molecular evolution of an arsenate detoxification pathway by DNA shuffling. Nat. Biotechnol. 15: 436-438.
30. Cullen, K. E., and Sarge, K. D. 1997. Characterization of hypothermia-induced cellular stress response in mouse tissues. J. Biol. Chem. 272: 1742-1746.
31. DeMeester, S. L., Buchman, T. G., Qiu, Y., Dunnigan, K., Hotchkiss, R. S., Karl, I. E., and Cobb, J. P. 1997. Heat shock induces IkappaB-alpha and prevents stress-induced endothelial cell apoptosis. Arch. Surg. 132: 1283-1288.
32. DeMeester, S. L., Cobb, J. P., Hotchkiss, R. S., Osborne, D. F., Karl, I. E., Tinsley, K. W., and Buchman, T. G. 1998a. Stress-induced fractal rearrangement of the endothelial cell cytoskeleton causes apoptosis. Surgery 124: 362-371.
33. DeMeester, S. L., Buchman, T. G., Qiu, Y., Dunnigan, K., Hotchkiss, R. S., Karl, I. E., and Cobb, J. P. 1998b. Pyrrolidine dithiocarbamate activates the heat shock response and thereby induces apoptosis in primed endothelial cells. Shock 10: 1-6.
34. de Vera, M. E., Kim, Y. M., Wong, H. R., Wang, Q., Billiar, T. R., and Geller, D. A. 1996a. Heat shock response inhibits cytokine-inducible nitric oxide synthase expression in rat hepatocytes. Hepatology 24: 1238-1245.
35. de Vera, M. E., Wong, J. M., Zhou, J. Y., Tzeng, E., Wong, H. R., Billiar, T. R., and Geller, D. A. 1996b. Cytokine-induced nitric oxide synthase gene transcription is blocked by the heat shock response in human liver cells. Surgery 120: 144-149.
36. Dewji, N. N., and Do, C. 1996. Heat shock factor-1mediates the transcriptional activation of Alzheimer's beta-amyloid precursor protein gene in response to stress. Brain Res. Mol. Brain Res. 35: 325-328.
37. Ding, X. Z., Tsokos, G. C., and Kiang, J. G. 1998. Overexpression of HSP-70 inhibits the phosphorylation of HSF1by activating protein phosphatase and inhibiting protein kinase C activity. FASEB J. 12: 451-459.
38. Dix, D. J., Garges, J. B., and Hong, R. L. 1998. Inhibition of hsp70-1and hsp70-3 expression disrupts preimplantation embryogenesis and heightens embryo sensitivity to arsenic. Mol. Reprod. Dev. 51: 373-380.
39. Dubois, M. F., Bellier, S., Seo, S. J., and Bensaude, O. 1994. Phosphorylation of the RNA polymerase II largest subunit during heat shock and inhibition of transcription in HeLa cells. J. Cell. Physiol. 158: 417-426.
40. Eguchi, N., Kuroda, K., and Endo, G. 1997. Metabolites of arsenic induced tetraploids and mitotic arrest in cultured cells. Arch. Environ. Contam. Toxicol. 32: 141-145.
41. Elbirt, K. K., Whitmarsh, A. J., Davis, R. J., and Bonkovsky, H. L. 1998. Mechanism of sodium arsen-ite-mediated induction of heme oxygenase-1in hepatoma cells. Role of mitogen-activated protein kinases. J. Biol. Chem. 273: 8922-8931.
42. El ia, G., De Marco, A., Rossi, A., and Santoro, M. G. 1996. Inhibition of HSP70 expression by calcium ionophore A23187 in human cells. An effect independent of the acquisition of DNA-binding activity by the heat shock transcription factor. J. Biol. Chem. 271: 16111-16118.
43. Feder, M. E., and Hofmann, G. E. 1999. Heat-shock proteins, molecular chaperones and the stress response: evolutionary and ecological physiology. Annu. Rev. Physiol. 61: 243-282.
44. Gabai, V. L., Meriin, A. B., Mosser, D. D., Caron, A. W., Rits, S., Shifrin, V. I., and Sherman, M. Y. 1997. Hsp70 prevents activation of stress kinases. J. Biol. Chem. 272: 18033-18037
45. Gebel, T., Birkenkamp, P., Luthin, S., and Dunkelberg, H. 1998. Arsenic(III), but not antimony(III), induces DNA-protein crosslinks. Anticancer Res. 18: 4253-4257.
46. Germolec, D. R., Yoshida, T., Gaido, K., Wilmer, J. L., Simeonova, P. P., Kayama, F., Burleson, F., Dong, W., Lange, R. W., and Luster, M. I. 1996. Arsenic induces overexpression of growth factors in human keratinocytes. Toxicol. Appl. Pharmacol. 141: 308-318.
47. Ghoshal, K., Wang, Y., Sheridan, J. F., and Jacob, S. T. 1998. Metallothionein induction in response to restraint stress. Transcriptional control, adaptation to stress, and role of glucocorticoid. J. Biol. Chem. 273: 27904-27910.
48. Goering, P. L., Aposhian, H. V., Mass, M. J., Cebrian, M., Beck, B. D., and Waalkes, M. P. 1999. The enigma of arsenic carcinogenesis: Role of metabolism. Toxicol. Sci. 49: 5-14.
49. Gomer, C. J., Ryter, S. W., Ferrario, A., Rucker, N., Wong, S., and Fisher, A. M. 1996. Photodynamic therapy-mediated oxidative stress can induce expression of heat shock proteins. Cancer Res. 56: 2355-2360.
50. Gordon, S., Bharadwaj, S., Hnatov, A., Ali, A., and Ovsenek, N. 1997a. Distinct stress-inducible and developmentally regulated heat shock transcription factors in Xenopus oocytes. Dev. Biol. 181: 47-63.
51. Gordon, S. A., Hoffman, R. A., Simmons, R. L., and Ford, H. R. 1997b. Induction of heat shock protein 70 protects thymocytes against radiation-induced apoptosis. Arch. Surg. 132: 1277-1282.
52. Gurr, J. R., Liu, F., Lynn, S., and Jan, K. Y. 1998. Calcium-dependent nitric oxide production is involved in arsenite-induced micronuclei. Mutat. Res. 416: 137-148.
53. Hatayama, T., Takahashi, H., and Yamagishi, N. 1997. Reduced induction of HSP70 in PC12 cells during neuronal differentiation. J. Biochem. (Tokyo) 122: 904-910.
54. Hauser, G. J., Dayao, E. K., Wasserloos, K., Pitt, B. R., and Wong, H. R. 1996. HSP induction inhibits iNOS mRNA expression and attenuates hypotension in endotoxin-challenged rats. Am. J. Physiol. 271: H2529-H2535.
55. Haynes, J. I. 2nd, Duncan, M. K., and Piatigorsky, J. 1996. Spatial and temporal activity of the alpha B-crystallin/small heat shock protein gene promoter in transgenic mice. Dev. Dyn. 207: 75-88.
56. Henle, K. J., Wang, S. Y., Nagle, W. A., and Lumpkin, C. K. 1994. Heat shock glycoprotein GP50: Product of the retinoic acid-inducible J6 gene. Exp. Cell Res. 210: 185-191.
57. Henriksson, J., Johannisson, A., Bergqvist, P. A., and Norrgren, L. 1996. The toxicity of organo-arsenic-based warfare agents: In vitro and in vivo studies. Arch. Environ. Contam. Toxicol. 30: 213-219.
58. Holmberg, C. I., Leppa, S., Eriksson, J. E., and Sistonen, L. 1997. The phorbol ester 12-O-tetradeca-noylphorbol 13-acetate enhances the heat-induced stress response. J. Biol. Chem. 272: 6792-6798.
59. Hopenhayn-Rich, C., Biggs, M. L., Fuchs, A., Bergoglio, R., Tello, E. E., Nicolli, H., and Smith, A. H. 1996. Bladder cancer mortality associated with arsenic in drinking water in Argentina. Epidemiology 7: 117-124.
60. Hsieh, L. L., Chen, H. J., Hsieh, J. T., Jee, S. H., Chen, G. S., and Chen, C. J. 1994. Arsenic-related Bowen's disease and paraquat-related skin cancerous lesions show no detectable ras and p53 gene alterations. Cancer Lett. 86: 59-65.
61. Hsueh, Y. M., Cheng, G. S., Wu, M. M., Yu, H. S., Kuo, T. L., and Chen, C. J. 1995. Multiple risk factors associated with arsenic-induced skin cancer: Effects of chronic liver disease and malnutri-tional status. Br. J. Cancer 71: 109-114.
62. Hu, J. L., Guan, X. J., and Sanchez, E. R. 1996. Enhancement of glucocorticoid receptor-mediated gene expression by cellular stress: Evidence for the involvement of a heat shock-initiated factor or process during recovery from stress. Cell Stress Chaperones 1: 197-205.
63. Hu, Y., Su, L., and Snow, E. T. 1998. Arsenic toxicity is enzyme specific and its affects on ligation are not caused by the direct inhibition of DNA repair enzymes. Mutat. Res. 408: 203-218.
64. Huang, R. N., Ho, I. C., Yih, L. H., and Lee, T. C. 1995. Sodium arsenite induces chromosome endoreduplication and inhibits protein phosphatase activity in human fibroblasts. Environ. Mol. Mutagen. 25: 188-196.
65. Huang, S. C., and Lee, T. C. 1998. Arsenite inhibits mitotic division and perturbs spindle dynamics in HeLa S3 cells. Carcinogenesis 19: 889-896.
66. Hung, J.-J., Cheng, T.-J., Lai, Y.-K., and Chang, M.D.-T. 1998. Differential activation of p38 mitogen-activated protein kinase and extracellular signal-regulated protein kinases confers cadmium-induced HSP70 expression in 9L rat brain tumor cells. J. Biol. Chem. 273: 31924-31931.
67. Huot, J., Lambert, H., Lavoie, J. N., Guimond, A., Houle, F., and Landry, J. 1995. Characterization of 45-kDa/54-kDa HSP27 kinase, a stress-sensitive kinase which may activate the phosphorylation-dependent protective function of mammalian 27-kDa heat shock protein HSP27. Eur. j. Biochem. 22 7: 416-427.
68. Ishikawa, T., Igarashi, T., Hata, K., and Fujita, T. 1999. c-fos Induction by heat, arsenite, and cadmium is mediated by a heat shock element in its promoter. Biochem. Biophys. Res. Commun. 254: 566-571.
69. Ito, H., Okamoto, K., Nakayama, H., Isobe, T., and Kato, K. 1997. Phosphorylation of alphaB-crys-tallin in response to various types of stress. j. Biol. Chem. 272: 29934-29941.
70. Jaafar, R., Omar, I., Jidon, A. J., Wan-Khamizar, B. W., Siti-Aishah, B. M., and Sharifah-Noor-Akmal, S. H. 1993. Skin cancer caused by chronic arsenical poisoning-A report of three cases. Med. J. Malaysia 48: 86-92.
71. Jacob, A. K., Hotchkiss, R. S., DeMeester, S. L., Hiramatsu, M., Karl, I. E., Swanson, P. E., Cobb, J. P., and Buchman, T. G. 1997. Endothelial cell apoptosis is accelerated by inorganic iron and heat via an oxygen radical dependent mechanism. Surgery 122: 243-253.
72. Ju, W. D., Schiller, J. T., Kazempour, M. K., and Lowy, D. R. 1993. TGF alpha enhances locomotion of cultured human keratinocytes. J. Invest. Dermatol. 100: 628-632.
73. Jurivich, D. A., Pachetti, C., Qiu, L., and Welk, J. F. 1995. Salicylate triggers heat shock factor differently than heat. J. Biol. Chem. 270: 24489-24495.
74. Kampinga, H. H., Brunsting, J. F., Stege, G. J., Burgman, P. W., and Konings, A. W. 1995. Thermal protein denaturation and protein aggregation in cells made thermotolerant by various chemicals: role of heat shock proteins. Exp. Cell Res. 219: 536-546.
75. Kato, K., Ito, H., and Okamoto, K. 1997a. Modulation of the arsenite-induced expression of stress proteins by reducing agents. Cell Stress Chaperones 2: 199-209.
76. Kato, K., Yamanaka, K., Nakano, M., Hasegawa, A., Oku, N., and Okada, S. 1997b. Cell-nuclear accumulation of 72-kDa stress protein induced by dimethylated arsenics. Biol. Pharm. Bull. 20: 364-369.
77. Kawasaki, H., Moriguchi, T., Matsuda, S., Li, H. Z., Nakamura, S., Shimohama, S., Kimura, J., Gotoh, Y., and Nishida, E. 1996. Ras-dependent and Ras-independent activation pathways for the stress-activated-protein-kinase cascade. Eur. J. Biochem. 241: 315-321.
78. Kim, S. H., Yeo, G. S., Lim, Y. S., Kang, C. D., Kim, C. M., and Chung, B. S. 1998. Suppression of multidrug resistance via inhibition of heat shock factor by quercetin in MDR cells. Exp. Mol. Med. 30: 87-92.
79. Kodym, R., Calkins, P., and Story, M. 1999. The cloning and characterization of a new stress response protein. A mammalian member of a family of theta class glutathione-S-transferase-like proteins. J. Biol. Chem. 274: 5131-5137.
80. Konishi, H., Matsuzaki, H., Tanaka, M., Takemura, Y., Kuroda, S., Ono, Y., and Kikkawa, U. 1997. Activation of protein kinase B (Akt/RAC-protein kinase) by cellular stress and its association with heat shock protein Hsp27. FEBS Lett. 410: 493-498.
81. Korber, P., Zander, T., Herschlag, D., and Bardwell, J. C. A. 1999. A new heat shock protein that binds nucleic acids. J. Biol. Chem. 274: 249-256.
82. Kovacs, A., Yonemoto, K., Katsuoka, K., Nishiyama, S., and Harhai, I. 1996. Bowen's disease: Statistical study of a 10 year period. J. Dermatol. 23: 267-274.
83. Kultz, D., and Csonka, L. 1999. What sets the TonE during osmotic stress? Proc. Natl. Acad. Sci. USA 96: 1814-1816.
84. Lambert, H., Charette, S. J., Bernier, A. F., Guimond, A., and Landry, J. 1999. HSP27 multimerization mediated by phosphorylation-sensitive intermolecular interactions at the amino terminus. J. Biol. Chem. 274: 9378-9385.
85. Lappas, G. D., Karl, I. E., and Hotchkiss, R. S. 1994. Effect of ethanol and sodium arsenite on HSP-72 formation and on survival in a murine endotoxin model. Shock 2: 34-39.
86. Lee, T. C., Tanaka, N., Lamb, P. W., Gilmer, T. M., and Barrett, J. C. 1988. Induction of gene amplification by arsenic. Science 241: 79-81.
87. 2-terminal kinase. J. Biol. Chem. 273: 29857-29863.
88. Leonard, A. 1991. Metals and metalloids and their ions and compounds. In Metals and their compounds in the environment, ed. E. Merian, pp. 751-774. Basel: VCH.
89. Lerda, D. 1994. Sister-chromatid exchange (SCE) among individuals chronically exposed to arsenic in drinking water. Mutat. Res. 312: 111-120.
90. Lim, C. P., Jain, N., and Cao, X. 1998. Stress-induced immediate-early gene, egr-1, involves activation of p3 8/JNK1. Oncogene 16: 2915-2926.
91. Liu, R. Y., Corry, P. M., and Lee, Y. J. 1995. Potential involvement of a constitutive heat shock element binding factor in the regulation of chemical stress-induced hsp70 gene expression. Mol. Cell. Biochem. 144: 27-34.
92. Lynn, S., Shiung, J. N., Gurr, J. R., and Jan, K. Y. 1998. Arsenite stimulates poly(ADP-ribosylation) by generation of nitric oxide. Free Radical Biol. Med. 24: 442-449.
93. Macfarlane, W. M., Smith, S. B., James, R. F., Clifton, A. D., Doza, Y. N., Cohen, P., and Docherty, K. 1997. The p38/reactivating kinase mitogen-activated protein kinase cascade mediates the activation of the transcription factor insulin upstream factor 1and insulin gene transcription by high glucose in pancreatic beta-cells. J. Biol. Chem. 272: 2 0936-20944.
94. Masuya, Y., Hioki, K., Tokunaga, R., and Taketani, S. 1998. Involvement of the tyrosine phosphorylation pathway in induction of human heme oxygenase-1by hemin, sodium arsenite, and cadmium chloride. J. Biochem. (Tokyo) 124: 628-633.
95. Maytin, E. V. 1992. Differential effects of heat shock and UVB light upon stress protein expression in epidermal keratinocytes. J. Biol. Chem. 267: 23189-23196.
96. McDowell, H. E., Eyers, P. A., and Hundal, H. S. 1998. Regulation of system A amino acid transport in L6 rat skeletal muscle cells by insulin, chemical and hyperthermic stress. FEBS Lett. 441: 1519.
97. Mirkes, P. E., Doggett, B., and Cornel, L. 1994. Induction of a heat shock response (HSP 72) in rat embryos exposed to selected chemical teratogens. Teratology 49: 135-142.
98. Mivechi, N. F., Koong, A. C., Giaccia, A. J., and Hahn, G. M. 1994. Analysis of HSF-1phosphorylation in A549 cells treated with a variety of stresses. Int. J. Hyperthermia 10: 371-379.
99. Miyakawa, H., Woo, S. K., Dahl, S. C., Handler, J. S., and Kwon, H. M. 1999. Tonicity-responsive enhancer binding protein, a Rel-like protein that stimulates transcription in response to hypertonicity. Proc. Natl. Acad. Sci. USA 96: 2538-2542.
100. Mizuno, S., Ishii, A., Murakami, Y., and Akagawa, H. 1997. Stress dose-dependent suppression of heat shock protein gene expression by inhibiting protein synthesis during heat shock treatment. Cell. Struct. Funct. 22: 7-13.
101. Moore, L. E., Smith, A. H., Hopenhayn-Rich, C., Biggs, M. L., Kalman, D. A., and Smith, M. T. 1997. Micronuclei in exfoliated bladder cells among individuals chronically exposed to arsenic in drinking water. Cancer Epidemiol. Biomarkers Prev. 6: 31-36.
102. Mosser, D. D., Duchaine, J., and Massie, B. 1993. The DNA-binding activity of the human heat shock transcription factor is regulated in vivo by hsp70. Mol. Cell. Biol. 13: 5427-5438.
103. Muramatsu, T., Tada, H., Kobayashi, N., Yamji, M., Shirai, T., and Ohnishi, T. 1992. Induction of the 72-kD heat shock protein in organ-cultured normal human skin. J. Invest. Dermatol. 98: 786-790.
104. Muramatsu, T., Kobayashi, N., Tada, H., Hatoko, M., and Shirai, T. 1995. Induction of the 72-kD heat shock protein in human skin melanoma and squamous cell carcinoma cell lines. J. Dermatol. 22: 907-912.
105. Nakamuro, K., and Sayato, Y. 1981. Comparative studies of chromosomal aberration induced by trivalent and pentavalent arsenic. Mutat. Res. 88: 73-80.
106. National Academy of Sciences. 1999. Arsenic in drinking water. Washington, DC: National Academy of Sciences Press.
107. Newman, D. K., Kennedy, E. K., Coates, J. D., Ahmann, D., Ellis, D. J., Lovley, D. R., and Morel, F. M. 1997. Dissimilatory arsenate and sulfate reduction in Desulfotomaculum auripigmentum sp. nov. Arch. Microbiol. 168: 380-388.
108. Ochi, T., Nakajima, F., and Fukumori, N. 1998. Different effects of inorganic and dimethylated arsenic compounds on cell morphology, cytoskeletal organization, and DNA synthesis in cultured Chinese hamster V79 cells. Arch. Toxicol. 72: 566-573.
109. Ohan, N. W., Tam, Y., Fernando, P., and Heikkila, J. J. 1998. Characterization of a novel group of basic small heat shock proteins in Xenopus laevis A6 kidney epithelial cells. Biochem. Cell. Biol. 76: 665-671.
110. Ohnishi, Y., Murakami, S., Ohtsuka, H., Miyauchi, S., Shinmori, H., and Hashimoto, K. 1997. Merkel cell carcinoma and multiple Bowen's disease: Incidental association or possible relationship to inorganic arsenic exposure? J. Dermatol. 24: 310-316.
111. Ovelgonne, H., Bitorina, M., and Van Wijk, R. 1995. Stressor-specific activation of heat shock genes in H35 rat hepatoma cells. Toxicol. Appl. Pharmacol. 135: 100-109.
112. Petito, C. T., and Beck, B. D. 1990. Evaluation of evidence of nonlinearities in the dose-response curve of arsenic carcinogenesis. Trace Subst. Environ. Health 24: 143-151.
113. Pontius, F. W., Brown, K. G., and Chen, C. J. 1994. Health implications of arsenic in drinking water. J. Am. Water Works Assoc. 86: 52-63.
114. Radha, S., and Natarajan, A. T. 1998. Sodium arsenite-induced chromosomal aberrations in the Xq arm of Chinese hamster cell lines. Mutagenesis 13: 229-234.
115. Ramirez, P., Eastmond, D. A., Laclette, J. P., and Ostrosky-Wegman, P. 1997. Disruption of microtubule assembly and spindle formation as a mechanism for the induction of aneuploid cells by sodium arsenite and vanadium pentoxide. Mutat. Res. 386: 291-298.
116. Rasmussen, R. E., and Menzel, D. B. 1997. Variation in arsenic-induced sister chromatid exchange in human lymphocytes and lymphoblastoid cell lines. Mutat. Res. 386: 299-306.
117. Ribeiro, S. P., Villar, J., Downey, G. P., Edelson, J. D., and Slutsky, A. S. 1994. Sodium arsenite induces heat shock protein-72 kilodalton expression in the lungs and protects rats against sepsis. Crit. Care Med. 22: 922-999.
118. Roat, J. W., Wald, A., Mendelow, H., and Pataki, K. I. 1982. Hepatic angiosarcoma associated with short-term arsenic ingestion. Am. J. Med. 73: 933-936.
119. Rossman, T. G., Goncharova, E. I., Rajah, T., and Wang, Z. 1997. Human cells lack the inducible tolerance to arsenite seen in hamster cells. Mutat. Res. 386: 307-314.
120. Rouse, J., Cohen, P., Trigon, S., Morange, M., Alonso-Llamazares, A., Zamanillo, D., Hunt, T., and Nebreda, A. R. 1994. A novel kinase cascade triggered by stress and heat shock that stimulates MAPKAP kinase-2 and phosphorylation of the small heat shock proteins. Cell 78: 1027-1037.
121. Sacco, M. G., Zecca, L., Bagnasco, L., Chiesa, G., Parolini, C., Bromley, P., Cato, E. M., Roncucci, R., Clerici, L. A., and Vezzoni, P. 1997. A transgenic mouse model for the detection of cellular stress induced by toxic inorganic compounds. Nat. Biotechnol. 15: 1392-1397.
122. Sanchez, E. R., Hu, J. L., Zhong, S., Shen, P., Greene, M. J., and Housley, P. R. 1994. Potentiation of glucocorticoid receptor-mediated gene expression by heat and chemical shock. Mol. Endocrinol. 8: 408-421.
123. Schett, G., Redlich, K., Xu, Q., Bizan, P., Groger, M., Tohidast-Akrad, M., Kiener, H., Smolen, J., and Steiner, G. 1998. Enhanced expression of heat shock protein 70 (hsp70) and heat shock factor 1(HSF1) activation in rheumatoid arthritis synovial tissue differential regulation of hsp70 expression and HSF1activation in synovial fibroblasts by proinflammatory cytokines, shear stress, and antiinflammatory drugs. J. Clin. Invest. 102: 302-311.
124. 2+-ATPase of sarcoplasmic reticulum by thiol-specific, heat shock inducers results in thermal denaturation at 37 degrees C. Biochemistry 36: 11002-11011.
125. Shannon, R. L., and Strayer, D. S. 1989. Arsenic-induced skin toxicity. Hum. Toxicol. 8: 99-104.
126. 2 or heat shock is mediated by phosphoinositide 3-kinase and not by mitogen-activated protein kinase-activated protein kinase-2. Biochem. J. 336: 241-246.
127. Shen, P., Xie, Z. J., Li, H., and Sanchez, E. R. 1993. Glucocorticoid receptor conversion to high affinity nuclear binding and transcription enhancement activity in Chinese hamster ovary cells subjected to heat and chemical stress. J. Steroid Biochem. Mol. Biol. 47: 55-64.
128. Shi, B., and Isseroff, R. R. 1996. Thapsigargin induces phosphorylation of the 27-kDa heat shock protein in human keratinocytes. J. Invest. Dermatol. 107: 749-754.
129. Silver, S. 1998. Genes for all metals-A bacterial view of the periodic table. The 1996 Thom Award Lecture. J. Ind. Microbiol. Biotechnol. 20: 1-12.
130. Smith, A. H., Hopenhayn-Rich, C., Warner, M., Biggs, M. L., Moore, L., and Smith, M. T. 1993. Rationale for selecting exfoliated bladder cell micronuclei as potential biomarkers for arsenic genotoxicity. J. Toxicol. Environ. Health 40: 223-234.
131. Suzuki, A., Kozawa, O., Oiso, Y., and Kato, K. 1996. Protein kinase C activation inhibits stress-induced synthesis of heat shock protein 27 in osteoblast-like cells: Function of arachidonic acid. J. Cell. Biochem. 62: 69-75.
132. Suzuki, K., Wakao, N., Sakurai, Y., Kimura, T., Sakka, K., and Ohmiya, K. 1997. Transformation of Escherichia coli with a large plasmid of Acidiphilium multivorum AIU 301encoding arsenic resistance. Appl. Environ. Microbiol. 63: 2089-2091.
133. Takechi, H., Hosokawa, N., Hirayoshi, K., and Nagata, K. 1994. Alternative 5' splice site selection induced by heat shock. Mol. Cell. Biol. 14: 567-575.
134. Tamura, Y., Tsuboi, N., Sato, N., and Kikuchi, K. 1993. 70 kDa heat shock cognate protein is a transformation-associated antigen and a possible target for the host's anti-tumor immunity. J. Immunol. 151: 5516-5524.
135. Tanabe, M., Nakai, A., Kawazoe, Y., and Nagata, K. 1997. Different thresholds in the responses of two heat shock transcription factors, HSF1and HSF3. J. Biol. Chem. 272: 15389-15395.
136. Tanabe, M., Kawazoe, Y., Takeda, S., Morimoto, R. I., Nagata, K., and Nakai, A. 1998. Disruption of HSF3 gene results in the severe reduction of heat shock gene expression and loss of thermotolerance. EMBO J. 17: 1750-1758.
137. Tello, E. E. 1988. [Carcinomas of internal organs and their relationship to arsenical drinking water in the Republic of Argentina]. Med. Cutan. Ibero Lat. Am. 16: 497-501.
138. Thornton, I. 1996. Sources and pathways of arsenic in the geochemical environment: Health implications. In Environmental geochemistry and health, eds. J. D. Appleton, R. Fuge, and G. J. H. McCal l, pp. 153-161. London: Geological Society Special Publications No. 113.
139. Tsuda, T., Babazono, A., Yamamoto, E., Kurumatani, N., Mino, Y., Ogawa, T., Kishi, Y., and Aoyama, H. 1995. Ingested arsenic and internal cancer: A historical cohort study followed for 33 years. Am. J. Epidemiol. 141: 198-209.
140. U.S Environmental Protection Agency. 1988. Special Report on Ingested Inorganic Arsenic, Skin Cancer; Nutritional Essentiality. Washington, DC: U.S Environmental Protection Agency, Report No. EPA/62 5/3-87/013.
141. Vahter, M. 1981. Biotransformation of trivalent and pentavalent inorganic arsenic in mice and rats. Environ. Res. 25: 286-293.
142. van Delft, S., Coffer, P., Kruijer, W., and van Wijk, R. 1993. c-fos Induction by stress can be mediated by the SRE. Biochem. Biophys. Res. Commun. 197: 542-548.
143. Vietor, I., and Vilcek, J. 1994. Pathways of heat shock protein 28 phosphorylation by TNF in human fibroblasts. Lymphokine Cytokine Res. 13: 315-323.
144. Vig, B. K., Figueroa, M. L., Cornforth, M. N., and Jenkins, S. H. 1984. Chromosome studies in human subjects chronically exposed to arsenic in drinking water. Am. J. Ind. Med. 6: 325-338.
145. Wang, B. J., Lee, Y. Y., Mak, C. P., Kao, H. F., Hsu, M. L., and Hsien, J. R. 1991. Quantitative and morphological changes of Langerhans cells in Bowen's disease from patients with chronic arsenicism. J. Formos. Med. Assoc. 90: 1093-1098.
146. Wang, J. H., Redmond, H. P., Watson, R. W., and Bouchier-Hayes, D. 1997. Induction of human endothelial cell apoptosis requires both heat shock and oxidative stress responses. Am. J. Physiol. 272: C1543-C1551.
147. Wang, J. H., Redmond, H. P., Watson, R. W., Condron, C., and Bouchier-Hayes, D. 1995. Induction of heat shock protein 72 prevents neutrophil-mediated human endothelial cell necrosis. Arch. Surg. 130: 1260-1265.
148. Wang, T. S., Shu, Y. F., Liu, Y. C., Jan, K. Y., and Huang, H. 1997. Glutathione peroxidase and catalase modulate the genotoxicity of arsenite. Toxicology 121: 229-237.
149. Wang, X., Flynn, A., Waskiewicz, A. J., Webb, B. L., Vries, R. G., Baines, I. A., Cooper, J. A., and Proud, C. G. 1998. The phosphorylation of eukaryotic initiation factor eIF4E in response to phorbol esters, cell stresses, and cytokines is mediated by distinct MAP kinase pathways. J. Biol. Chem. 273: 9373-9377.
150. Wang, Z., Hou, G., and Rossman, T. G. 1994. Induction of arsenite tolerance and thermotolerance by arsenite occur by different mechanisms. Environ. Health Perspect. 102(suppl. 3): 97-100.
151. Wang, Z. G., Rivi, R., Delva, L., Konig, A., Scheinberg, D. A., Gambacorti-Passerini, C., Gabrilove, J. L., Warrell, R. P., Jr., and Pandolfi, P. P. 1998. Arsenic trioxide and melarsoprol induce programmed cell death in myeloid leukemia cell lines and function in a PML and PML-RARalpha independent manner. Blood 92: 1497-1504.
152. Watson, R. W., Redmond, H. P., Wang, J. H., and Bouchier-Hayes, D. 1996. Mechanisms involved in sodium arsenite-induced apoptosis of human neutrophils. J. Leukocyte Biol. 60: 625-632.
153. Wiegant, F. A., Souren, J. E., van Rijn, J., and van Wijk, R. 1994. Stressor-specific induction of heat shock proteins in rat hepatoma cells. Toxicology 94: 143-159.
154. Wiegant, F. A., Spieker, N., Van der Mast, C. A., and van Wijk, R. 1996. Is heat shock protein reinduction during tolerance related to the stressor-specific induction of heat shock proteins? J. Cell. Physiol. 169: 364-372.
155. Wiegant, F. A., Spieker, N., and van Wijk, R. 1998. Stressor-specific enhancement of hsp induction by low doses of stressors in conditions of self-and cross-sensitization. Toxicology 127: 107-119.
156. Wijeweera, J. B., Thomas, C. M., Gandolfi, A. J., and Brendel, K. 1995. Sodium arsenite and heat shock induce stress proteins in precision-cut rat liver slices. Toxicology 104: 3 5-45.
157. Wong, H. R., Finder, J. D., Wasserloos, K., and Pitt, B. R. 1995. Expression of iNOS in cultured rat pulmonary artery smooth muscle cells is inhibited by the heat shock response. Am. J. Physiol. 269: L843-L848.
158. Wong, H. R., Mannix, R. J., Rusnak, J. M., Boota, A., Zar, H., Watkins, S. C., Lazo, J. S., and Pitt, B. R. 1996. The heat-shock response attenuates lipopolysaccharide-mediated apoptosis in cultured sheep pulmonary artery endothelial cells. Am. J. Respir. Cell Mol. Biol. 15: 745-751.
159. Wong, S. S., Tan, K. C., and Goh, C. L. 1998. Cutaneous manifestations of chronic arsenicism: Review of seventeen cases. J. Am. Acad. Dermatol. 38: 179-185.
160. World Health Organization. 1994. Guidelines for drinking water quality, Vol. 1, Recommendations. Geneva: WHO.
161. Xu, C., Zhou, T., Kuroda, M., and Rosen, B. P. 1998. Metalloid resistance mechanisms in prokaryotes. J. Biochem. (Tokyo) 123: 16-23.
162. Yang, Y. L., Lu, K. T., Tsay, H. J., Lin, C. H., and Lin, M. T. 1998. Heat shock protein expression protects against death following exposure to heatstroke in rats. Neurosci. Lett. 252: 9-12.
163. Yasuda, K., Nakai, A., Hatayama, T., and Nagata, K. 1995. Cloning and expression of murine high molecular mass heat shock proteins, HSP105. J. Biol. Chem. 270: 29718-29723.
164. Yih, L. H., and Lee, T. C. 1999. Effects of exposure protocols on induction of kinetochore-plus and-minus micronuclei by arsenite in diploid human fibroblasts. Mutat. Res. 440: 75-82.
165. Yih, L. H., Ho, I. C., and Lee, T. C. 1997. Sodium arsenite, disturbs mitosis and induces chromosome loss in human fibroblasts. Cancer Res. 57: 5051-5059.
166. Yu, H. S., Chang, K. L., Wang, C. M., and Yu, C. L. 1992. Alterations of mitogenic responses of mononuclear cells by arsenic in arsenical skin cancers. J. Dermatol. 19: 710-714.
167. Yu, H. S., Chiou, K. S., Chen, G. S., Yang, R. C., and Chang, S. F. 1993. Progressive alterations of cytokeratin expressions in the process of chronic arsenism. J. Dermatol. 20: 741-745.
168. Zavialov, A., Benndorf, R., Ehrnsperger, M., Zav'yalov, V., Dudich, I., Buchner, J., and Gaestel, M. 1998. The effect of the intersubunit disulfide bond on the structural and functional properties of the small heat shock protein Hsp25. Int. J. Biol. Macromol. 22: 163-173.
169. Zhong, M., Orosz, A., and Wu, C. 1998. Direct sensing of heat and oxidation by Drosophila heat shock transcription factor. Mol. Cell. 2: 101-108.
170. Zou, J., Salminen, W. F., Roberts, S. M., and Voellmy, R. 1998. Correlation between glutathione oxidation and trimerization of heat shock factor 1, an early step in stress induction of the Hsp response. Cell Stress Chaperones 3: 130-141.