메뉴 건너뛰기




Volumn 5, Issue 4, 2014, Pages 429-441

Iron and Intracerebral Hemorrhage: From Mechanism to Translation

Author keywords

Brain iron metabolism; Hepcidin; Intracerebral hemorrhage; Iron; Iron handling proteins

Indexed keywords

IRON; IRON REGULATORY FACTOR; MESSENGER RNA;

EID: 84890412095     PISSN: 18684483     EISSN: 1868601X     Source Type: Journal    
DOI: 10.1007/s12975-013-0317-7     Document Type: Review
Times cited : (128)

References (113)
  • 1
    • 77956545744 scopus 로고    scopus 로고
    • Preclinical and clinical research on inflammation after intracerebral hemorrhage
    • PID: 20713126, COI: 1:CAS:528:DC%2BC3cXhsVGntrvO
    • Wang J. Preclinical and clinical research on inflammation after intracerebral hemorrhage. Prog Neurobiol. 2010;92(4):463–77.
    • (2010) Prog Neurobiol , vol.92 , Issue.4 , pp. 463-477
    • Wang, J.1
  • 2
    • 24944508139 scopus 로고    scopus 로고
    • Treatment of intracerebral haemorrhage
    • PID: 16168935
    • Mayer SA, Rincon F. Treatment of intracerebral haemorrhage. Lancet Neurol. 2005;4(10):662–72.
    • (2005) Lancet Neurol , vol.4 , Issue.10 , pp. 662-672
    • Mayer, S.A.1    Rincon, F.2
  • 3
    • 33744913322 scopus 로고    scopus 로고
    • Primary intracerebral hemorrhage
    • PID: 16769513
    • Sutherland GR, Auer RN. Primary intracerebral hemorrhage. J Clin Neurosci. 2006;13(5):511–7.
    • (2006) J Clin Neurosci , vol.13 , Issue.5 , pp. 511-517
    • Sutherland, G.R.1    Auer, R.N.2
  • 5
    • 34748899552 scopus 로고    scopus 로고
    • Brain iron metabolism: neurobiology and neurochemistry
    • PID: 17870230, COI: 1:CAS:528:DC%2BD2sXhtFSntrnJ
    • Ke Y, Qian ZM. Brain iron metabolism: neurobiology and neurochemistry. Prog Neurobiol. 2007;83(3):149–73.
    • (2007) Prog Neurobiol , vol.83 , Issue.3 , pp. 149-173
    • Ke, Y.1    Qian, Z.M.2
  • 6
    • 33644518386 scopus 로고    scopus 로고
    • Long-term effects of experimental intracerebral hemorrhage: the role of iron
    • PID: 16509506, COI: 1:CAS:528:DC%2BD28XhslOis7g%3D
    • Hua Y, Nakamura T, Keep RF, Wu J, Schallert T, Hoff JT, et al. Long-term effects of experimental intracerebral hemorrhage: the role of iron. J Neurosurg. 2006;104(2):305–12.
    • (2006) J Neurosurg , vol.104 , Issue.2 , pp. 305-312
    • Hua, Y.1    Nakamura, T.2    Keep, R.F.3    Wu, J.4    Schallert, T.5    Hoff, J.T.6
  • 7
    • 0345599222 scopus 로고    scopus 로고
    • Iron and iron-handling proteins in the brain after intracerebral hemorrhage
    • PID: 14615611, COI: 1:CAS:528:DC%2BD3sXpt1Kru78%3D
    • Wu J, Hua Y, Keep RF, Nakamura T, Hoff JT, Xi G. Iron and iron-handling proteins in the brain after intracerebral hemorrhage. Stroke. 2003;34(12):2964–9.
    • (2003) Stroke , vol.34 , Issue.12 , pp. 2964-2969
    • Wu, J.1    Hua, Y.2    Keep, R.F.3    Nakamura, T.4    Hoff, J.T.5    Xi, G.6
  • 8
    • 34250782407 scopus 로고    scopus 로고
    • Heme oxygenase-1 exacerbates early brain injury after intracerebral haemorrhage
    • PID: 17525142
    • Wang J, Doré S. Heme oxygenase-1 exacerbates early brain injury after intracerebral haemorrhage. Brain. 2007;130(6):1643–52.
    • (2007) Brain , vol.130 , Issue.6 , pp. 1643-1652
    • Wang, J.1    Doré, S.2
  • 9
    • 0030923630 scopus 로고    scopus 로고
    • The heme oxygenase system: a regulator of second messenger gases
    • PID: 9131263, COI: 1:CAS:528:DyaK2sXisl2qt7Y%3D
    • Maines MD. The heme oxygenase system: a regulator of second messenger gases. Annu Rev Pharmacol Toxicol. 1997;37(1):517–54.
    • (1997) Annu Rev Pharmacol Toxicol , vol.37 , Issue.1 , pp. 517-554
    • Maines, M.D.1
  • 10
    • 29044441975 scopus 로고    scopus 로고
    • Mechanisms of brain injury after intracerebral haemorrhage
    • PID: 16361023
    • Xi G, Keep RF, Hoff JT. Mechanisms of brain injury after intracerebral haemorrhage. Lancet Neurol. 2006;5(1):53–63.
    • (2006) Lancet Neurol , vol.5 , Issue.1 , pp. 53-63
    • Xi, G.1    Keep, R.F.2    Hoff, J.T.3
  • 11
    • 84863863921 scopus 로고    scopus 로고
    • Intracerebral haemorrhage: mechanisms of injury and therapeutic targets
    • PID: 22698888, COI: 1:CAS:528:DC%2BC38XhtV2gtbrM
    • Keep RF, Hua Y, Xi G. Intracerebral haemorrhage: mechanisms of injury and therapeutic targets. Lancet Neurol. 2012;11(8):720–31.
    • (2012) Lancet Neurol , vol.11 , Issue.8 , pp. 720-731
    • Keep, R.F.1    Hua, Y.2    Xi, G.3
  • 12
    • 84881365016 scopus 로고    scopus 로고
    • T2 and T2* magnetic resonance imaging sequences predict brain injury after intracerebral hemorrhage in rats
    • Jin H, Wu G, Hu S, Hua Y, Keep RF, Wu J, et al. T2 and T2* magnetic resonance imaging sequences predict brain injury after intracerebral hemorrhage in rats. Acta Neurochir Suppl. 2013;18:151–5.
    • (2013) Acta Neurochir Suppl , vol.18 , pp. 151-155
    • Jin, H.1    Wu, G.2    Hu, S.3    Hua, Y.4    Keep, R.F.5    Wu, J.6
  • 13
    • 34548307253 scopus 로고    scopus 로고
    • Excess capacity of the iron regulatory protein system
    • PID: 17604281, COI: 1:CAS:528:DC%2BD2sXpt1SlsL0%3D
    • Wang W, Di X, D'Agostino RB, Torti SV, Torti FM. Excess capacity of the iron regulatory protein system. J Biol Chem. 2007;282(34):24650–9.
    • (2007) J Biol Chem , vol.282 , Issue.34 , pp. 24650-24659
    • Wang, W.1    Di, X.2    D'Agostino, R.B.3    Torti, S.V.4    Torti, F.M.5
  • 14
    • 0037173578 scopus 로고    scopus 로고
    • Molecular and cellular mechanisms of iron homeostasis and toxicity in mammalian cells
    • PID: 12121757, COI: 1:CAS:528:DC%2BD38Xlt12msr8%3D
    • Crichton RR, Wilmet S, Legssyer R, Ward RJ. Molecular and cellular mechanisms of iron homeostasis and toxicity in mammalian cells. J Inorg Biochem. 2002;91(1):9–18.
    • (2002) J Inorg Biochem , vol.91 , Issue.1 , pp. 9-18
    • Crichton, R.R.1    Wilmet, S.2    Legssyer, R.3    Ward, R.J.4
  • 15
    • 84861355868 scopus 로고    scopus 로고
    • Hepcidin and iron homeostasis
    • PID: 22306005, COI: 1:CAS:528:DC%2BC38XitFyjtLY%3D
    • Ganz T, Nemeth E. Hepcidin and iron homeostasis. Biochimica et biophysica acta. 2012;1823(9):1434–43.
    • (2012) Biochimica et biophysica acta , vol.1823 , Issue.9 , pp. 1434-1443
    • Ganz, T.1    Nemeth, E.2
  • 16
    • 84875805891 scopus 로고    scopus 로고
    • Iron regulatory proteins control a mucosal block to intestinal iron absorption
    • PID: 23523353, COI: 1:CAS:528:DC%2BC3sXksFOgt78%3D
    • Galy B, Ferring-Appel D, Becker C, Gretz N, Gröne H-J, Schümann K, et al. Iron regulatory proteins control a mucosal block to intestinal iron absorption. Cell Rep. 2013;3(3):844–57.
    • (2013) Cell Rep , vol.3 , Issue.3 , pp. 844-857
    • Galy, B.1    Ferring-Appel, D.2    Becker, C.3    Gretz, N.4    Gröne, H.-J.5    Schümann, K.6
  • 17
  • 18
    • 77955610477 scopus 로고    scopus 로고
    • Iron-sensing proteins that regulate hepcidin and enteric iron absorption
    • PID: 20415583, COI: 1:CAS:528:DC%2BC3cXhsVWgsbrM
    • Knutson MD. Iron-sensing proteins that regulate hepcidin and enteric iron absorption. Annu Rev Nutr. 2010;30:149–71.
    • (2010) Annu Rev Nutr , vol.30 , pp. 149-171
    • Knutson, M.D.1
  • 19
    • 0033106390 scopus 로고    scopus 로고
    • Iron regulatory protein as an endogenous sensor of iron in rat intestinal mucosa
    • Schümann K, Moret R, Künzle H, Kühn LC. Iron regulatory protein as an endogenous sensor of iron in rat intestinal mucosa. EurJ Biochem. 1999;260(2):362–72.
    • (1999) EurJ Biochem , vol.260 , Issue.2 , pp. 362-372
    • Schümann, K.1    Moret, R.2    Künzle, H.3    Kühn, L.C.4
  • 21
    • 58749094789 scopus 로고    scopus 로고
    • Intestinal hypoxia-inducible transcription factors are essential for iron absorption following iron deficiency
    • PID: 19147412, COI: 1:CAS:528:DC%2BD1MXnt12quro%3D
    • Shah YM, Matsubara T, Ito S, Yim S-H, Gonzalez FJ. Intestinal hypoxia-inducible transcription factors are essential for iron absorption following iron deficiency. Cell Metab. 2009;9(2):152–64.
    • (2009) Cell Metab , vol.9 , Issue.2 , pp. 152-164
    • Shah, Y.M.1    Matsubara, T.2    Ito, S.3    Yim, S.-H.4    Gonzalez, F.J.5
  • 22
    • 79958146087 scopus 로고    scopus 로고
    • Hypoxia-inducible factor-2α mediates the adaptive increase of intestinal ferroportin during iron deficiency in mice
    • PID: 21419768, COI: 1:CAS:528:DC%2BC3MXntlGlt74%3D
    • Taylor M, Qu A, Anderson ER, Matsubara T, Martin A, Gonzalez FJ, et al. Hypoxia-inducible factor-2α mediates the adaptive increase of intestinal ferroportin during iron deficiency in mice. Gastroenterology. 2011;140(7):2044–55.
    • (2011) Gastroenterology , vol.140 , Issue.7 , pp. 2044-2055
    • Taylor, M.1    Qu, A.2    Anderson, E.R.3    Matsubara, T.4    Martin, A.5    Gonzalez, F.J.6
  • 23
    • 10844258104 scopus 로고    scopus 로고
    • Hepcidin regulates cellular iron efflux by binding to ferroportin and inducing its internalization
    • PID: 15514116, COI: 1:CAS:528:DC%2BD2cXhtVOjsL3K
    • Nemeth E, Tuttle MS, Powelson J, Vaughn MB, Donovan A, Ward DM, et al. Hepcidin regulates cellular iron efflux by binding to ferroportin and inducing its internalization. Science. 2004;306(5704):2090–3.
    • (2004) Science , vol.306 , Issue.5704 , pp. 2090-2093
    • Nemeth, E.1    Tuttle, M.S.2    Powelson, J.3    Vaughn, M.B.4    Donovan, A.5    Ward, D.M.6
  • 24
    • 0033166706 scopus 로고    scopus 로고
    • Metal ion transporters in mammals: structure, function and pathological implications
    • PID: 10373684, COI: 1:CAS:528:DyaK1MXkvV2ns7Y%3D
    • Rolfs A, Hediger MA. Metal ion transporters in mammals: structure, function and pathological implications. J Physiol. 1999;518(1):1–12.
    • (1999) J Physiol , vol.518 , Issue.1 , pp. 1-12
    • Rolfs, A.1    Hediger, M.A.2
  • 25
    • 0035003422 scopus 로고    scopus 로고
    • ABC transporters associated with cytochrome c biogenesis
    • PID: 11421279, COI: 1:CAS:528:DC%2BD3MXks12js7c%3D
    • Goldman BS, Kranz RG. ABC transporters associated with cytochrome c biogenesis. Res microbiol. 2001;152(3):323–9.
    • (2001) Res microbiol , vol.152 , Issue.3 , pp. 323-329
    • Goldman, B.S.1    Kranz, R.G.2
  • 26
    • 0033134765 scopus 로고    scopus 로고
    • Existing and emerging mechanisms for transport of iron and manganese to the brain
    • PID: 10777372, COI: 1:CAS:528:DyaK1MXivVKltL4%3D
    • Malecki EA, Devenyi AG, Beard JL, Connor JR. Existing and emerging mechanisms for transport of iron and manganese to the brain. J Neurosci Res. 1999;56(2):113.
    • (1999) J Neurosci Res , vol.56 , Issue.2 , pp. 113
    • Malecki, E.A.1    Devenyi, A.G.2    Beard, J.L.3    Connor, J.R.4
  • 27
    • 0033961913 scopus 로고    scopus 로고
    • Transferrin and transferrin receptor function in brain barrier systems
    • PID: 10690503, COI: 1:CAS:528:DC%2BD3cXhtV2ltL8%3D
    • Moos T, Morgan EH. Transferrin and transferrin receptor function in brain barrier systems. Cell Mol Neurobiol. 2000;20(1):77–95.
    • (2000) Cell Mol Neurobiol , vol.20 , Issue.1 , pp. 77-95
    • Moos, T.1    Morgan, E.H.2
  • 28
    • 0030739637 scopus 로고    scopus 로고
    • Transport of iron in the blood–brain–cerebrospinal fluid system
    • PID: 9231702, COI: 1:CAS:528:DyaK2sXkvFGktL4%3D
    • Bradbury M. Transport of iron in the blood–brain–cerebrospinal fluid system. J Neurochem. 1997;69(2):443–54.
    • (1997) J Neurochem , vol.69 , Issue.2 , pp. 443-454
    • Bradbury, M.1
  • 29
    • 1542754636 scopus 로고    scopus 로고
    • Receptor-mediated transport of lactoferrin into the cerebrospinal fluid via plasma in young calves
    • PID: 14532686, COI: 1:CAS:528:DC%2BD3sXos12msbo%3D
    • Talukder M, Takeuchi T, Harada E. Receptor-mediated transport of lactoferrin into the cerebrospinal fluid via plasma in young calves. J Vet Med Sci. 2003;65(9):957–64.
    • (2003) J Vet Med Sci , vol.65 , Issue.9 , pp. 957-964
    • Talukder, M.1    Takeuchi, T.2    Harada, E.3
  • 30
    • 30544448179 scopus 로고    scopus 로고
    • Pharmacokinetics and brain uptake of lactoferrin in rats
    • PID: 16165165, COI: 1:CAS:528:DC%2BD28XjvVymtA%3D%3D
    • Ji B, Maeda J, Higuchi M, Inoue K, Akita H, Harashima H, et al. Pharmacokinetics and brain uptake of lactoferrin in rats. Life Sci. 2006;78(8):851–5.
    • (2006) Life Sci , vol.78 , Issue.8 , pp. 851-855
    • Ji, B.1    Maeda, J.2    Higuchi, M.3    Inoue, K.4    Akita, H.5    Harashima, H.6
  • 31
    • 0026516293 scopus 로고
    • Changes in the uptake of transferrin-free and transferrin-bound iron during reticulocyte maturation in vivo and in vitro
    • PID: 1591271, COI: 1:CAS:528:DyaK38Xkt1eku7s%3D
    • Qian ZM, Morgan EH. Changes in the uptake of transferrin-free and transferrin-bound iron during reticulocyte maturation in vivo and in vitro. Biochim Biophys Acta. 1992;1135(1):35–43.
    • (1992) Biochim Biophys Acta , vol.1135 , Issue.1 , pp. 35-43
    • Qian, Z.M.1    Morgan, E.H.2
  • 32
    • 0029875023 scopus 로고    scopus 로고
    • Effect of lipid peroxidation on transferrin-free iron uptake by rabbit reticulocytes
    • PID: 8599607
    • Qian ZM, Tang PL, Morgan EH. Effect of lipid peroxidation on transferrin-free iron uptake by rabbit reticulocytes. Biochim Biophys Acta. 1996;1310(3):293–302.
    • (1996) Biochim Biophys Acta , vol.1310 , Issue.3 , pp. 293-302
    • Qian, Z.M.1    Tang, P.L.2    Morgan, E.H.3
  • 33
    • 1042301280 scopus 로고    scopus 로고
    • Brain capillary endothelium and choroid plexus epithelium regulate transport of transferrin-bound and free iron into the rat brain
    • PID: 14756801, COI: 1:CAS:528:DC%2BD2cXhs1Kmsrs%3D
    • Deane R, Zheng W, Zlokovic BV. Brain capillary endothelium and choroid plexus epithelium regulate transport of transferrin-bound and free iron into the rat brain. J Neurochem. 2004;88(4):813–20.
    • (2004) J Neurochem , vol.88 , Issue.4 , pp. 813-820
    • Deane, R.1    Zheng, W.2    Zlokovic, B.V.3
  • 34
    • 0036238011 scopus 로고    scopus 로고
    • Transferrin/transferrin receptor-mediated drug delivery
    • PID: 11933019, COI: 1:CAS:528:DC%2BD38XjslGru78%3D
    • Li H, Qian ZM. Transferrin/transferrin receptor-mediated drug delivery. Med Res Rev. 2002;22(3):225–50.
    • (2002) Med Res Rev , vol.22 , Issue.3 , pp. 225-250
    • Li, H.1    Qian, Z.M.2
  • 36
    • 4644293303 scopus 로고    scopus 로고
    • Disruption of ceruloplasmin and hephaestin in mice causes retinal iron overload and retinal degeneration with features of age-related macular degeneration
    • PID: 15365174, COI: 1:CAS:528:DC%2BD2cXotVygtbw%3D
    • Hahn P, Qian Y, Dentchev T, Chen L, Beard J, Harris ZL, et al. Disruption of ceruloplasmin and hephaestin in mice causes retinal iron overload and retinal degeneration with features of age-related macular degeneration. Proc Natl Acad Sci U S A. 2004;101(38):13850–5.
    • (2004) Proc Natl Acad Sci U S A , vol.101 , Issue.38 , pp. 13850-13855
    • Hahn, P.1    Qian, Y.2    Dentchev, T.3    Chen, L.4    Beard, J.5    Harris, Z.L.6
  • 37
    • 36849003552 scopus 로고    scopus 로고
    • Development and iron‐dependent expression of hephaestin in different brain regions of rats
    • PID: 17516501, COI: 1:CAS:528:DC%2BD2sXhsValsb7L
    • Qian ZM, Chang YZ, Zhu L, Yang L, Du JR, Ho KP, et al. Development and iron‐dependent expression of hephaestin in different brain regions of rats. J Cell Biochem. 2007;102(5):1225–33.
    • (2007) J Cell Biochem , vol.102 , Issue.5 , pp. 1225-1233
    • Qian, Z.M.1    Chang, Y.Z.2    Zhu, L.3    Yang, L.4    Du, J.R.5    Ho, K.P.6
  • 38
    • 0036861639 scopus 로고    scopus 로고
    • Brain iron homeostasis
    • PID: 12553165, COI: 1:CAS:528:DC%2BD3sXhtVGgs7o%3D
    • Moos T. Brain iron homeostasis. Dan Med Bull. 2002;49(4):279.
    • (2002) Dan Med Bull , vol.49 , Issue.4 , pp. 279
    • Moos, T.1
  • 40
    • 0032533743 scopus 로고    scopus 로고
    • Evidence for low molecular weight, non-transferrin-bound iron in rat brain and cerebrospinal fluid
    • PID: 9822159, COI: 1:CAS:528:DyaK1cXnt1Gjtbg%3D
    • Moos T, Morgan EH. Evidence for low molecular weight, non-transferrin-bound iron in rat brain and cerebrospinal fluid. J Neurosci Res. 1998;54(4):486–94.
    • (1998) J Neurosci Res , vol.54 , Issue.4 , pp. 486-494
    • Moos, T.1    Morgan, E.H.2
  • 41
    • 0035095564 scopus 로고    scopus 로고
    • Brain iron transport and neurodegeneration
    • PID: 11286780, COI: 1:CAS:528:DC%2BD3MXivVGls7g%3D
    • Qian ZM, Shen X. Brain iron transport and neurodegeneration. Trends Mol Med. 2001;7(3):103–8.
    • (2001) Trends Mol Med , vol.7 , Issue.3 , pp. 103-108
    • Qian, Z.M.1    Shen, X.2
  • 42
    • 0033534589 scopus 로고    scopus 로고
    • Ceruloplasmin ferroxidase activity stimulates cellular iron uptake by a trivalent cation-specific transport mechanism
    • PID: 9873059, COI: 1:CAS:528:DyaK1MXmtFGktw%3D%3D
    • Attieh ZK, Mukhopadhyay CK, Seshadri V, Tripoulas NA, Fox PL. Ceruloplasmin ferroxidase activity stimulates cellular iron uptake by a trivalent cation-specific transport mechanism. J Biol Chem. 1999;274(2):1116–23.
    • (1999) J Biol Chem , vol.274 , Issue.2 , pp. 1116-1123
    • Attieh, Z.K.1    Mukhopadhyay, C.K.2    Seshadri, V.3    Tripoulas, N.A.4    Fox, P.L.5
  • 43
    • 0032956629 scopus 로고    scopus 로고
    • Characterization and distribution of ferritin binding sites in the adult mouse brain
    • PID: 9930764, COI: 1:CAS:528:DyaK1MXmt1yksQ%3D%3D
    • Hulet S, Hess E, Debinski W, Arosio P, Bruce K, Powers S, et al. Characterization and distribution of ferritin binding sites in the adult mouse brain. J Neurochem. 1999;72(2):868–74.
    • (1999) J Neurochem , vol.72 , Issue.2 , pp. 868-874
    • Hulet, S.1    Hess, E.2    Debinski, W.3    Arosio, P.4    Bruce, K.5    Powers, S.6
  • 44
    • 0034235751 scopus 로고    scopus 로고
    • Oligodendrocyte progenitor cells internalize ferritin via clathrin-dependent receptor mediated endocytosis
    • PID: 10861799, COI: 1:CAS:528:DC%2BD3cXksF2iu7o%3D
    • Hulet S, Heyliger S, Powers S, Connor J. Oligodendrocyte progenitor cells internalize ferritin via clathrin-dependent receptor mediated endocytosis. J Neurosci Res. 2000;61(1):52–60.
    • (2000) J Neurosci Res , vol.61 , Issue.1 , pp. 52-60
    • Hulet, S.1    Heyliger, S.2    Powers, S.3    Connor, J.4
  • 45
    • 0345714885 scopus 로고    scopus 로고
    • Iron misregulation in the brain: a primary cause of neurodegenerative disorders
    • PID: 12849213, COI: 1:CAS:528:DC%2BD3sXkvVKqt7o%3D
    • Ke Y, Qian ZM. Iron misregulation in the brain: a primary cause of neurodegenerative disorders. Lancet Neurol. 2003;2(4):246–53.
    • (2003) Lancet Neurol , vol.2 , Issue.4 , pp. 246-253
    • Ke, Y.1    Qian, Z.M.2
  • 46
    • 0034839086 scopus 로고    scopus 로고
    • Systemic iron metabolism: a review and implications for brain iron metabolism
    • PID: 11551743, COI: 1:STN:280:DC%2BD3Mrgtlaqsg%3D%3D
    • Rouault TA. Systemic iron metabolism: a review and implications for brain iron metabolism. Pediatr Neurol. 2001;25(2):130–7.
    • (2001) Pediatr Neurol , vol.25 , Issue.2 , pp. 130-137
    • Rouault, T.A.1
  • 47
    • 0026779690 scopus 로고
    • Iron and transferrrin uptake by brain and cerebrospinal fluid in the rat
    • PID: 1450923, COI: 1:CAS:528:DyaK38XmtlSrs7o%3D
    • Crowe A, Morgan EH. Iron and transferrrin uptake by brain and cerebrospinal fluid in the rat. Brain Res. 1992;592(1):8–16.
    • (1992) Brain Res , vol.592 , Issue.1 , pp. 8-16
    • Crowe, A.1    Morgan, E.H.2
  • 48
    • 0029867619 scopus 로고    scopus 로고
    • Receptor-mediated transcytosis of transferrin through blood–brain barrier endothelial cells
    • PID: 8967351, COI: 1:CAS:528:DyaK28Xis1Klur0%3D
    • Descamps L, Dehouck M-P, Torpier G, Cecchelli R. Receptor-mediated transcytosis of transferrin through blood–brain barrier endothelial cells. Am J Physiol. 1996;270(4):H1149–58.
    • (1996) Am J Physiol , vol.270 , Issue.4 , pp. 1149-1158
    • Descamps, L.1    Dehouck, M.-P.2    Torpier, G.3    Cecchelli, R.4
  • 49
    • 15844427058 scopus 로고    scopus 로고
    • Hemoglobin potentiates excitotoxic injury in cortical cell culture
    • PID: 8860203, COI: 1:STN:280:DyaK2s%2FhtleltQ%3D%3D
    • REGAN RF, PANTER S. Hemoglobin potentiates excitotoxic injury in cortical cell culture. J Neurotrauma. 1996;13(4):223–31.
    • (1996) J Neurotrauma , vol.13 , Issue.4 , pp. 223-231
    • REGAN, R.F.1    PANTER, S.2
  • 50
    • 0037716283 scopus 로고    scopus 로고
    • Hemin induces an iron-dependent, oxidative injury to human neuron-like cells
    • PID: 12815715, COI: 1:CAS:528:DC%2BD3sXltlSqtL4%3D
    • Goldstein L, Teng ZP, Zeserson E, Patel M, Regan RF. Hemin induces an iron-dependent, oxidative injury to human neuron-like cells. J Neurosci Res. 2003;73(1):113–21.
    • (2003) J Neurosci Res , vol.73 , Issue.1 , pp. 113-121
    • Goldstein, L.1    Teng, Z.P.2    Zeserson, E.3    Patel, M.4    Regan, R.F.5
  • 51
    • 0032951905 scopus 로고    scopus 로고
    • Nitric oxide and iron proteins
    • PID: 10320664, COI: 1:CAS:528:DyaK1MXjsF2qtro%3D
    • Cooper CE. Nitric oxide and iron proteins. Biochim Biophys Acta. 1999;1411(2):290–309.
    • (1999) Biochim Biophys Acta , vol.1411 , Issue.2 , pp. 290-309
    • Cooper, C.E.1
  • 52
    • 15244357849 scopus 로고    scopus 로고
    • Oxidative DNA injury after experimental intracerebral hemorrhage
    • PID: 15781043, COI: 1:CAS:528:DC%2BD2MXisFGqsbw%3D
    • Nakamura T, Keep RF, Hua Y, Hoff JT, Xi G. Oxidative DNA injury after experimental intracerebral hemorrhage. Brain Res. 2005;1039(1):30–6.
    • (2005) Brain Res , vol.1039 , Issue.1 , pp. 30-36
    • Nakamura, T.1    Keep, R.F.2    Hua, Y.3    Hoff, J.T.4    Xi, G.5
  • 53
    • 0033571939 scopus 로고    scopus 로고
    • Protection from oxidative stress–induced apoptosis in cortical neuronal cultures by iron chelators is associated with enhanced dna binding of hypoxia-inducible factor-1 and atf-1/creb and increased expression of glycolytic enzymes, p21waf1/cip1, and erythropoietin
    • PID: 10559391, COI: 1:CAS:528:DyaK1MXnsValt7c%3D
    • Zaman K, Ryu H, Hall D, O'Donovan K, Lin K-I, Miller MP, et al. Protection from oxidative stress–induced apoptosis in cortical neuronal cultures by iron chelators is associated with enhanced dna binding of hypoxia-inducible factor-1 and atf-1/creb and increased expression of glycolytic enzymes, p21waf1/cip1, and erythropoietin. J Neurosci. 1999;19(22):9821–30.
    • (1999) J Neurosci , vol.19 , Issue.22 , pp. 9821-9830
    • Zaman, K.1    Ryu, H.2    Hall, D.3    O'Donovan, K.4    Lin, K.-I.5    Miller, M.P.6
  • 54
    • 0035952330 scopus 로고    scopus 로고
    • Desferrioxamine, an iron chelator, upregulates cyclooxygenase-2 expression and prostaglandin production in a human macrophage cell line
    • PID: 11239825, COI: 1:CAS:528:DC%2BD3MXhslWls74%3D
    • Tanji K, Imaizumi T, Matsumiya T, Itaya H, Fujimoto K, Cui X-F, et al. Desferrioxamine, an iron chelator, upregulates cyclooxygenase-2 expression and prostaglandin production in a human macrophage cell line. Biochim Biophys Acta. 2001;1530(2):227–35.
    • (2001) Biochim Biophys Acta , vol.1530 , Issue.2 , pp. 227-235
    • Tanji, K.1    Imaizumi, T.2    Matsumiya, T.3    Itaya, H.4    Fujimoto, K.5    Cui, X.-F.6
  • 55
    • 0018940991 scopus 로고
    • Dendritic alterations in rat isocortex within an iron-induced chronic epileptic focus
    • COI: 1:STN:280:DyaL3M%2FjtFWgtA%3D%3D
    • Willmore JL, Ballinger Jr WE, Boggs W, Sypert GW, Rubin JJ. Dendritic alterations in rat isocortex within an iron-induced chronic epileptic focus. Neurosurg. 1980;7(2):142–6.
    • (1980) Neurosurg , vol.7 , Issue.2 , pp. 142-146
    • Willmore, J.L.1    Ballinger, W.E.2    Boggs, W.3    Sypert, G.W.4    Rubin, J.J.5
  • 56
    • 0018722492 scopus 로고
    • Histopathology of the ferric-induced chronic epileptic focus in cat: a Golgi study
    • PID: 114405, COI: 1:STN:280:DyaL3c%2FisVGhtA%3D%3D
    • Reid SA, Sypert GW, Boggs WM, Willmore LJ. Histopathology of the ferric-induced chronic epileptic focus in cat: a Golgi study. Exp Neurol. 1979;66(2):205–19.
    • (1979) Exp Neurol , vol.66 , Issue.2 , pp. 205-219
    • Reid, S.A.1    Sypert, G.W.2    Boggs, W.M.3    Willmore, L.J.4
  • 57
    • 0030174825 scopus 로고    scopus 로고
    • Relationship of iron to oligondendrocytes and myelination
    • PID: 8776576, COI: 1:STN:280:DyaK28znt1OrsQ%3D%3D
    • Connor JR, Menzies SL. Relationship of iron to oligondendrocytes and myelination. Glia. 1996;17(2):83–93.
    • (1996) Glia , vol.17 , Issue.2 , pp. 83-93
    • Connor, J.R.1    Menzies, S.L.2
  • 58
    • 0028854932 scopus 로고
    • Regional differences in late-onset iron deposition, ferritin, transferrin, astrocyte proliferation, and microglial activation after transient forebrain ischemia in rat brain
    • PID: 7860655, COI: 1:CAS:528:DyaK2MXktlynu7w%3D
    • Kondo Y, Ogawa N, Asanuma M, Ota Z, Mori A. Regional differences in late-onset iron deposition, ferritin, transferrin, astrocyte proliferation, and microglial activation after transient forebrain ischemia in rat brain. J Cereb Blood Flow Metab. 1995;15(2):216–26.
    • (1995) J Cereb Blood Flow Metab , vol.15 , Issue.2 , pp. 216-226
    • Kondo, Y.1    Ogawa, N.2    Asanuma, M.3    Ota, Z.4    Mori, A.5
  • 59
    • 0023696821 scopus 로고
    • Nonidentical distribution of transferrin and ferric iron in human brain
    • PID: 3200444, COI: 1:CAS:528:DyaL1cXmt1OhsLY%3D
    • Dwork A, Schon E, Herbert J. Nonidentical distribution of transferrin and ferric iron in human brain. Neuroscience. 1988;27(1):333–45.
    • (1988) Neuroscience , vol.27 , Issue.1 , pp. 333-345
    • Dwork, A.1    Schon, E.2    Herbert, J.3
  • 61
    • 0029433318 scopus 로고
    • Cellular management of iron in the brain
    • PID: 8847543, COI: 1:CAS:528:DyaK28XhsFSltLs%3D
    • Connor JR, Menzies SL. Cellular management of iron in the brain. J Neurol Sci. 1995;134:33–44.
    • (1995) J Neurol Sci , vol.134 , pp. 33-44
    • Connor, J.R.1    Menzies, S.L.2
  • 62
    • 0034838768 scopus 로고    scopus 로고
    • Iron and iron management proteins in neurobiology
    • PID: 11551742, COI: 1:STN:280:DC%2BD3Mrgtlaruw%3D%3D
    • Connor JR, Menzies SL, Burdo JR, Boyer PJ. Iron and iron management proteins in neurobiology. Pediatr Neurol. 2001;25(2):118–29.
    • (2001) Pediatr Neurol , vol.25 , Issue.2 , pp. 118-129
    • Connor, J.R.1    Menzies, S.L.2    Burdo, J.R.3    Boyer, P.J.4
  • 63
    • 84856217346 scopus 로고    scopus 로고
    • Minocycline-induced attenuation of iron overload and brain injury after experimental intracerebral hemorrhage
    • PID: 21998050
    • Zhao F, Hua Y, He Y, Keep RF, Xi G. Minocycline-induced attenuation of iron overload and brain injury after experimental intracerebral hemorrhage. Stroke. 2011;42(12):3587–93.
    • (2011) Stroke , vol.42 , Issue.12 , pp. 3587-3593
    • Zhao, F.1    Hua, Y.2    He, Y.3    Keep, R.F.4    Xi, G.5
  • 64
    • 0033548410 scopus 로고    scopus 로고
    • Increased expression of transferrin receptors and iron in amoeboid microglial cells in postnatal rats following an exposure to hypoxia
    • PID: 10218886, COI: 1:STN:280:DyaK1M3jtlamtg%3D%3D
    • Kaur C, Ling E. Increased expression of transferrin receptors and iron in amoeboid microglial cells in postnatal rats following an exposure to hypoxia. Neurosci Lett. 1999;262(3):183–6.
    • (1999) Neurosci Lett , vol.262 , Issue.3 , pp. 183-186
    • Kaur, C.1    Ling, E.2
  • 65
    • 0028919152 scopus 로고
    • Cytokine-mediated regulation of transferrin synthesis in mouse macrophages and human T lymphocytes
    • PID: 7849292, COI: 1:CAS:528:DyaK2MXjs1Ojtb0%3D
    • Djeha A, Perez-Arellano J-L, Hayes SL, Oria R, Simpson RJ, Raja KB, et al. Cytokine-mediated regulation of transferrin synthesis in mouse macrophages and human T lymphocytes. Blood. 1995;85(4):1036–42.
    • (1995) Blood , vol.85 , Issue.4 , pp. 1036-1042
    • Djeha, A.1    Perez-Arellano, J.-L.2    Hayes, S.L.3    Oria, R.4    Simpson, R.J.5    Raja, K.B.6
  • 67
    • 41149126098 scopus 로고    scopus 로고
    • Association between serum ferritin level and perihematoma edema volume in patients with spontaneous intracerebral hemorrhage
    • PID: 18292378, COI: 1:CAS:528:DC%2BD1cXjtlSqsbc%3D
    • Mehdiratta M, Kumar S, Hackney D, Schlaug G, Selim M. Association between serum ferritin level and perihematoma edema volume in patients with spontaneous intracerebral hemorrhage. Stroke. 2008;39(4):1165–70.
    • (2008) Stroke , vol.39 , Issue.4 , pp. 1165-1170
    • Mehdiratta, M.1    Kumar, S.2    Hackney, D.3    Schlaug, G.4    Selim, M.5
  • 68
    • 77950263353 scopus 로고    scopus 로고
    • Iron-related brain damage in patients with intracerebral hemorrhage
    • de la Ossa NP, Sobrino T, Silva Y, Blanco M, Millán M, Gomis M, et al. Iron-related brain damage in patients with intracerebral hemorrhage. Stroke. 2010;41(4):810–3.
    • (2010) Stroke , vol.41 , Issue.4 , pp. 810-813
    • de la Ossa, N.P.1    Sobrino, T.2    Silva, Y.3    Blanco, M.4    Millán, M.5    Gomis, M.6
  • 69
    • 1542373644 scopus 로고    scopus 로고
    • Regulated secretion of glycosylated human ferritin from hepatocytes
    • PID: 14615366, COI: 1:CAS:528:DC%2BD2cXitlCjs7g%3D
    • Ghosh S, Hevi S, Chuck SL. Regulated secretion of glycosylated human ferritin from hepatocytes. Blood. 2004;103(6):2369–76.
    • (2004) Blood , vol.103 , Issue.6 , pp. 2369-2376
    • Ghosh, S.1    Hevi, S.2    Chuck, S.L.3
  • 70
    • 0031454793 scopus 로고    scopus 로고
    • Secretion of ferritin by rat hepatoma cells and its regulation by inflammatory cytokines and iron
    • PID: 9389717, COI: 1:CAS:528:DyaK2sXnvFWkt7s%3D
    • Tran TN, Eubanks SK, Schaffer KJ, Zhou CY, Linder MC. Secretion of ferritin by rat hepatoma cells and its regulation by inflammatory cytokines and iron. Blood. 1997;90(12):4979–86.
    • (1997) Blood , vol.90 , Issue.12 , pp. 4979-4986
    • Tran, T.N.1    Eubanks, S.K.2    Schaffer, K.J.3    Zhou, C.Y.4    Linder, M.C.5
  • 71
    • 0023912979 scopus 로고
    • Interactions between isolated hepatocytes and Kupffer cells in iron metabolism: a possible role for ferritin as an iron carrier protein
    • PID: 3356411, COI: 1:CAS:528:DyaL1cXitVahsrY%3D
    • Sibille JC, Kondo H, Aisen P. Interactions between isolated hepatocytes and Kupffer cells in iron metabolism: a possible role for ferritin as an iron carrier protein. Hepatology. 1988;8(2):296–301.
    • (1988) Hepatology , vol.8 , Issue.2 , pp. 296-301
    • Sibille, J.C.1    Kondo, H.2    Aisen, P.3
  • 72
    • 77956605615 scopus 로고    scopus 로고
    • Serum ferritin is derived primarily from macrophages through a nonclassical secretory pathway
    • PID: 20472835, COI: 1:CAS:528:DC%2BC3cXhtF2qsbzF
    • Cohen LA, Gutierrez L, Weiss A, Leichtmann-Bardoogo Y, Zhang D-L, Crooks DR, et al. Serum ferritin is derived primarily from macrophages through a nonclassical secretory pathway. Blood. 2010;116(9):1574–84.
    • (2010) Blood. , vol.116 , Issue.9 , pp. 1574-1584
    • Cohen, L.A.1    Gutierrez, L.2    Weiss, A.3    Leichtmann-Bardoogo, Y.4    Zhang, D.-L.5    Crooks, D.R.6
  • 73
    • 0028643643 scopus 로고
    • Hydroxyl radicals, iron, oxidative stress, and neurodegeneration
    • PID: 7832429, COI: 1:CAS:528:DyaK28XjvV2ksrw%3D
    • Gutteridge J. Hydroxyl radicals, iron, oxidative stress, and neurodegeneration. Ann NY Acad Sci. 1994;738(1):201–13.
    • (1994) Ann NY Acad Sci , vol.738 , Issue.1 , pp. 201-213
    • Gutteridge, J.1
  • 74
    • 0035872428 scopus 로고    scopus 로고
    • Iron and neurodegenerative disorders
    • PID: 11470311, COI: 1:CAS:528:DC%2BD3MXltlOitLo%3D
    • Thompson KJ, Shoham S, Connor JR. Iron and neurodegenerative disorders. Brain Res Bull. 2001;55(2):155–64.
    • (2001) Brain Res Bull , vol.55 , Issue.2 , pp. 155-164
    • Thompson, K.J.1    Shoham, S.2    Connor, J.R.3
  • 75
    • 8344265251 scopus 로고    scopus 로고
    • Iron, brain ageing and neurodegenerative disorders
    • PID: 15496864, COI: 1:CAS:528:DC%2BD2cXos1Ojtrc%3D
    • Zecca L, Youdim MB, Riederer P, Connor JR, Crichton RR. Iron, brain ageing and neurodegenerative disorders. Nat Rev Neurosci. 2004;5(11):863–73.
    • (2004) Nat Rev Neurosci , vol.5 , Issue.11 , pp. 863-873
    • Zecca, L.1    Youdim, M.B.2    Riederer, P.3    Connor, J.R.4    Crichton, R.R.5
  • 76
    • 66849099876 scopus 로고    scopus 로고
    • Deferoxamine reduces intracerebral hematoma-induced iron accumulation and neuronal death in piglets
    • PID: 19372448, COI: 1:CAS:528:DC%2BD1MXlvFWmurg%3D
    • Gu Y, Hua Y, Keep RF, Morgenstern LB, Xi G. Deferoxamine reduces intracerebral hematoma-induced iron accumulation and neuronal death in piglets. Stroke. 2009;40(6):2241–3.
    • (2009) Stroke , vol.40 , Issue.6 , pp. 2241-2243
    • Gu, Y.1    Hua, Y.2    Keep, R.F.3    Morgenstern, L.B.4    Xi, G.5
  • 77
    • 1642307312 scopus 로고    scopus 로고
    • Deferoxamine-induced attenuation of brain edema and neurological deficits in a rat model of intracerebral hemorrhage
    • PID: 15070122, COI: 1:CAS:528:DC%2BD2cXjsVWntbg%3D
    • Nakamura T, Keep RF, Hua Y, Schallert T, Hoff JT, Xi G. Deferoxamine-induced attenuation of brain edema and neurological deficits in a rat model of intracerebral hemorrhage. J Neurosurg. 2004;100(4):672–8.
    • (2004) J Neurosurg , vol.100 , Issue.4 , pp. 672-678
    • Nakamura, T.1    Keep, R.F.2    Hua, Y.3    Schallert, T.4    Hoff, J.T.5    Xi, G.6
  • 78
    • 72049095587 scopus 로고    scopus 로고
    • Failure of deferoxamine, an iron chelator, to improve outcome after collagenase-induced intracerebral hemorrhage in rats
    • PID: 19879860, COI: 1:CAS:528:DC%2BD1MXhsFams7nM
    • Warkentin LM, Auriat AM, Wowk S, Colbourne F. Failure of deferoxamine, an iron chelator, to improve outcome after collagenase-induced intracerebral hemorrhage in rats. Brain Res. 2010;1309:95–103.
    • (2010) Brain Res , vol.1309 , pp. 95-103
    • Warkentin, L.M.1    Auriat, A.M.2    Wowk, S.3    Colbourne, F.4
  • 79
    • 84857501921 scopus 로고    scopus 로고
    • Ferric iron chelation lowers brain iron levels after intracerebral hemorrhage in rats but does not improve outcome
    • PID: 22226595, COI: 1:CAS:528:DC%2BC38XjsVWhurk%3D
    • Auriat AM, Silasi G, Wei Z, Paquette R, Paterson P, Nichol H, et al. Ferric iron chelation lowers brain iron levels after intracerebral hemorrhage in rats but does not improve outcome. Exp Neurol. 2012;234(1):136–43.
    • (2012) Exp Neurol , vol.234 , Issue.1 , pp. 136-143
    • Auriat, A.M.1    Silasi, G.2    Wei, Z.3    Paquette, R.4    Paterson, P.5    Nichol, H.6
  • 80
    • 62949225543 scopus 로고    scopus 로고
    • Deferoxamine mesylate: a new hope for intracerebral hemorrhage: from bench to clinical trials
    • PID: 19064798, COI: 1:CAS:528:DC%2BD1MXitFKjur8%3D
    • Selim M. Deferoxamine mesylate: a new hope for intracerebral hemorrhage: from bench to clinical trials. Stroke. 2009;40(3 suppl 1):S90–1.
    • (2009) Stroke , vol.40 , pp. 90-91
    • Selim, M.1
  • 81
    • 0037263625 scopus 로고    scopus 로고
    • Delayed treatment of hemoglobin neurotoxicity
    • PID: 12614593
    • Regan RF, Rogers B. Delayed treatment of hemoglobin neurotoxicity. J neurotrauma. 2003;20(1):111–20.
    • (2003) J neurotrauma , vol.20 , Issue.1 , pp. 111-120
    • Regan, R.F.1    Rogers, B.2
  • 82
    • 65549127596 scopus 로고    scopus 로고
    • Effects of deferoxamine on intracerebral hemorrhage-induced brain injury in aged rats
    • PID: 19286595, COI: 1:CAS:528:DC%2BD1MXkvVWmt7Y%3D
    • Okauchi M, Hua Y, Keep RF, Morgenstern LB, Xi G. Effects of deferoxamine on intracerebral hemorrhage-induced brain injury in aged rats. Stroke. 2009;40(5):1858–63.
    • (2009) Stroke , vol.40 , Issue.5 , pp. 1858-1863
    • Okauchi, M.1    Hua, Y.2    Keep, R.F.3    Morgenstern, L.B.4    Xi, G.5
  • 83
    • 85052609094 scopus 로고    scopus 로고
    • Deferoxamine reduces brain swelling in a rat model of hippocampal intracerebral hemorrhage
    • PID: 19066074, COI: 1:STN:280:DC%2BD1cjps1yktw%3D%3D
    • Song S, Hua Y, Keep R, He Y, Wang J, Wu J. Deferoxamine reduces brain swelling in a rat model of hippocampal intracerebral hemorrhage. Acta Neurochir Suppl. 2008;105:13–8.
    • (2008) Acta Neurochir Suppl , vol.105 , pp. 13-18
    • Song, S.1    Hua, Y.2    Keep, R.3    He, Y.4    Wang, J.5    Wu, J.6
  • 84
    • 79959669623 scopus 로고    scopus 로고
    • Iron toxicity in mice with collagenase-induced intracerebral hemorrhage
    • PID: 21102602, COI: 1:CAS:528:DC%2BC3cXhsVOqtrvN
    • Wu H, Wu T, Xu X, Wang J, Wang J. Iron toxicity in mice with collagenase-induced intracerebral hemorrhage. J Cereb Blood Flow Metab. 2010;31(5):1243–50.
    • (2010) J Cereb Blood Flow Metab , vol.31 , Issue.5 , pp. 1243-1250
    • Wu, H.1    Wu, T.2    Xu, X.3    Wang, J.4    Wang, J.5
  • 85
    • 85052609073 scopus 로고    scopus 로고
    • Deferoxamine reduces CSF free iron levels following intracerebral hemorrhage
    • PID: 16671454, COI: 1:STN:280:DC%2BD283kslKlug%3D%3D
    • Wan S, Hua Y, Keep R, Hoff J, Xi G. Deferoxamine reduces CSF free iron levels following intracerebral hemorrhage. Acta Neurochir Suppl. 2006;96:199–202.
    • (2006) Acta Neurochir Suppl , vol.96 , pp. 199-202
    • Wan, S.1    Hua, Y.2    Keep, R.3    Hoff, J.4    Xi, G.5
  • 86
    • 0025314978 scopus 로고
    • Collagenase-induced intracerebral hemorrhage in rats
    • PID: 2160142, COI: 1:CAS:528:DyaK3cXksFKku70%3D
    • Rosenberg GA, Mun-Bryce S, Wesley M, Kornfeld M. Collagenase-induced intracerebral hemorrhage in rats. Stroke. 1990;21(5):801–7.
    • (1990) Stroke , vol.21 , Issue.5 , pp. 801-807
    • Rosenberg, G.A.1    Mun-Bryce, S.2    Wesley, M.3    Kornfeld, M.4
  • 87
    • 13644269314 scopus 로고    scopus 로고
    • Deferoxamine infusion during coronary artery bypass grafting ameliorates lipid peroxidation and protects the myocardium against reperfusion injury: immediate and long-term significance
    • PID: 15618054, COI: 1:CAS:528:DC%2BD2MXksFCgu7w%3D
    • Paraskevaidis IA, Iliodromitis EK, Vlahakos D, Tsiapras DP, Nikolaidis A, Marathias A, et al. Deferoxamine infusion during coronary artery bypass grafting ameliorates lipid peroxidation and protects the myocardium against reperfusion injury: immediate and long-term significance. Eur Heart J. 2005;26(3):263–70.
    • (2005) Eur Heart J , vol.26 , Issue.3 , pp. 263-270
    • Paraskevaidis, I.A.1    Iliodromitis, E.K.2    Vlahakos, D.3    Tsiapras, D.P.4    Nikolaidis, A.5    Marathias, A.6
  • 88
    • 80055001133 scopus 로고    scopus 로고
    • Deferoxamine Mesylate in Intracerebral Hemorrhage Investigators. Safety and tolerability of deferoxamine mesylate in patients with acute intracerebral hemorrhage
    • PID: 21868742, COI: 1:CAS:528:DC%2BC3MXhtlKrsbzO
    • Selim M, Yeatts S, Goldstein J, Gomes J, Greenberg S, Morgenstern L, et al. Deferoxamine Mesylate in Intracerebral Hemorrhage Investigators. Safety and tolerability of deferoxamine mesylate in patients with acute intracerebral hemorrhage. Stroke. 2011;42:3067–74.
    • (2011) Stroke , vol.42 , pp. 3067-3074
    • Selim, M.1    Yeatts, S.2    Goldstein, J.3    Gomes, J.4    Greenberg, S.5    Morgenstern, L.6
  • 89
    • 0033996306 scopus 로고    scopus 로고
    • Iron-chelating activity of tetracyclines and its impact on the susceptibility of Actinobacillus actinomycetemcomitans to these antibiotics
    • COI: 1:CAS:528:DC%2BD3cXhsVGgs70%3D
    • Grenier D, Huot M-P, Mayrand D. Iron-chelating activity of tetracyclines and its impact on the susceptibility of Actinobacillus actinomycetemcomitans to these antibiotics. Antimicrob Agents Ch. 2000;44(3):763–6.
    • (2000) Antimicrob Agents Ch , vol.44 , Issue.3 , pp. 763-766
    • Grenier, D.1    Huot, M.-P.2    Mayrand, D.3
  • 90
    • 67649444192 scopus 로고    scopus 로고
    • Minocycline attenuates iron neurotoxicity in cortical cell cultures
    • PID: 19523448, COI: 1:CAS:528:DC%2BD1MXotFKlsrg%3D
    • Chen-Roetling J, Chen L, Regan RF. Minocycline attenuates iron neurotoxicity in cortical cell cultures. Biochem Biophys Res Commun. 2009;386(2):322–6.
    • (2009) Biochem Biophys Res Commun , vol.386 , Issue.2 , pp. 322-326
    • Chen-Roetling, J.1    Chen, L.2    Regan, R.F.3
  • 91
    • 58149357102 scopus 로고    scopus 로고
    • Extension of the thrombolytic time window with minocycline in experimental stroke
    • PID: 18927459, COI: 1:CAS:528:DC%2BD1cXhtlylt7nE
    • Murata Y, Rosell A, Scannevin RH, Rhodes KJ, Wang X, Lo EH. Extension of the thrombolytic time window with minocycline in experimental stroke. Stroke. 2008;39(12):3372–7.
    • (2008) Stroke , vol.39 , Issue.12 , pp. 3372-3377
    • Murata, Y.1    Rosell, A.2    Scannevin, R.H.3    Rhodes, K.J.4    Wang, X.5    Lo, E.H.6
  • 92
    • 33745457705 scopus 로고    scopus 로고
    • Minocycline inhibits poly (ADP-ribose) polymerase-1 at nanomolar concentrations
    • PID: 16769901, COI: 1:CAS:528:DC%2BD28XmsVOnsbc%3D
    • Alano CC, Kauppinen TM, Valls AV, Swanson RA. Minocycline inhibits poly (ADP-ribose) polymerase-1 at nanomolar concentrations. Proc Natl Acad Sci U S A. 2006;103(25):9685–90.
    • (2006) Proc Natl Acad Sci U S A , vol.103 , Issue.25 , pp. 9685-9690
    • Alano, C.C.1    Kauppinen, T.M.2    Valls, A.V.3    Swanson, R.A.4
  • 93
    • 34548787358 scopus 로고    scopus 로고
    • Minocycline protects the blood–brain barrier and reduces edema following intracerebral hemorrhage in the rat
    • PID: 17698063, COI: 1:CAS:528:DC%2BD2sXhtVOmsbrN
    • Wasserman JK, Schlichter LC. Minocycline protects the blood–brain barrier and reduces edema following intracerebral hemorrhage in the rat. Exp Neurol. 2007;207(2):227–37.
    • (2007) Exp Neurol , vol.207 , Issue.2 , pp. 227-237
    • Wasserman, J.K.1    Schlichter, L.C.2
  • 94
    • 0038443057 scopus 로고    scopus 로고
    • Intracerebral hemorrhage induces macrophage activation and matrix metalloproteinases
    • PID: 12783419, COI: 1:CAS:528:DC%2BD3sXkslGhs7g%3D
    • Power C, Henry S, Del Bigio MR, Larsen PH, Corbett D, Imai Y, et al. Intracerebral hemorrhage induces macrophage activation and matrix metalloproteinases. Ann Neurol. 2003;53(6):731–42.
    • (2003) Ann Neurol , vol.53 , Issue.6 , pp. 731-742
    • Power, C.1    Henry, S.2    Del Bigio, M.R.3    Larsen, P.H.4    Corbett, D.5    Imai, Y.6
  • 95
    • 0037101879 scopus 로고    scopus 로고
    • Ferritin, iron homeostasis, and oxidative damage
    • COI: 1:CAS:528:DC%2BD38XlvVWmtbg%3D
    • Arosio P, Levi S. Ferritin, iron homeostasis, and oxidative damage. Free Radical Bio Med. 2002;33(4):457–63.
    • (2002) Free Radical Bio Med , vol.33 , Issue.4 , pp. 457-463
    • Arosio, P.1    Levi, S.2
  • 96
    • 10744223491 scopus 로고    scopus 로고
    • Genetic ablations of iron regulatory proteins 1 and 2 reveal why iron regulatory protein 2 dominates iron homeostasis
    • PID: 14726953, COI: 1:CAS:528:DC%2BD2cXhtVeqsLw%3D
    • Meyron-Holtz EG, Ghosh MC, Iwai K, LaVaute T, Brazzolotto X, Berger UV, et al. Genetic ablations of iron regulatory proteins 1 and 2 reveal why iron regulatory protein 2 dominates iron homeostasis. EMBO J. 2004;23(2):386–95.
    • (2004) EMBO J , vol.23 , Issue.2 , pp. 386-395
    • Meyron-Holtz, E.G.1    Ghosh, M.C.2    Iwai, K.3    LaVaute, T.4    Brazzolotto, X.5    Berger, U.V.6
  • 97
    • 0030057235 scopus 로고    scopus 로고
    • Demonstration and characterization of the iron regulatory protein in human brain
    • PID: 8764614, COI: 1:CAS:528:DyaK28XksFCjtb4%3D
    • Hu J, Connor JR. Demonstration and characterization of the iron regulatory protein in human brain. J Neurochem. 1996;67(2):838–44.
    • (1996) J Neurochem , vol.67 , Issue.2 , pp. 838-844
    • Hu, J.1    Connor, J.R.2
  • 98
    • 1842608845 scopus 로고    scopus 로고
    • Iron metabolism and the IRE/IRP regulatory system: an update
    • PID: 15105251, COI: 1:CAS:528:DC%2BD2cXjvVOnu78%3D
    • Pantopoulos K. Iron metabolism and the IRE/IRP regulatory system: an update. Ann N Y Acad Sci. 2004;1012(1):1–13.
    • (2004) Ann N Y Acad Sci , vol.1012 , Issue.1 , pp. 1-13
    • Pantopoulos, K.1
  • 99
    • 0023612118 scopus 로고
    • Identification of the iron-responsive element for the translational regulation of human ferritin mRNA
    • PID: 3685996, COI: 1:CAS:528:DyaL1cXltVGjsQ%3D%3D
    • Hentze MW, Caughman SW, Rouault TA, Barriocanal JG, Dancis A, Harford JB, et al. Identification of the iron-responsive element for the translational regulation of human ferritin mRNA. Science. 1987;238(4833):1570–3.
    • (1987) Science , vol.238 , Issue.4833 , pp. 1570-1573
    • Hentze, M.W.1    Caughman, S.W.2    Rouault, T.A.3    Barriocanal, J.G.4    Dancis, A.5    Harford, J.B.6
  • 100
    • 0023882711 scopus 로고
    • Iron-responsive elements: regulatory RNA sequences that control mRNA levels and translation
    • PID: 2452485, COI: 1:CAS:528:DyaL1cXktFyjtbk%3D
    • Casey JL, Hentze MW, Koeller DM, Caughman SW, Rouault TA, Klausner RD, et al. Iron-responsive elements: regulatory RNA sequences that control mRNA levels and translation. Science. 1988;240(4854):924–8.
    • (1988) Science , vol.240 , Issue.4854 , pp. 924-928
    • Casey, J.L.1    Hentze, M.W.2    Koeller, D.M.3    Caughman, S.W.4    Rouault, T.A.5    Klausner, R.D.6
  • 101
    • 18244389488 scopus 로고    scopus 로고
    • Iron-dependent regulation of the divalent metal ion transporter
    • PID: 11741608, COI: 1:CAS:528:DC%2BD3MXovF2hs78%3D
    • Gunshin H, Allerson CR, Polycarpou-Schwarz M, Rofts A, Rogers JT, Kishi F, et al. Iron-dependent regulation of the divalent metal ion transporter. FEBS Lett. 2001;509(2):309–16.
    • (2001) FEBS Lett , vol.509 , Issue.2 , pp. 309-316
    • Gunshin, H.1    Allerson, C.R.2    Polycarpou-Schwarz, M.3    Rofts, A.4    Rogers, J.T.5    Kishi, F.6
  • 102
    • 0034677467 scopus 로고    scopus 로고
    • Positional cloning of zebrafish ferroportin1 identifies a conserved vertebrate iron exporter
    • PID: 10693807, COI: 1:CAS:528:DC%2BD3cXhsVWitrY%3D
    • Donovan A, Brownlie A, Zhou Y, Shepard J, Pratt SJ, Moynihan J, et al. Positional cloning of zebrafish ferroportin1 identifies a conserved vertebrate iron exporter. Nature. 2000;403(6771):776–81.
    • (2000) Nature , vol.403 , Issue.6771 , pp. 776-781
    • Donovan, A.1    Brownlie, A.2    Zhou, Y.3    Shepard, J.4    Pratt, S.J.5    Moynihan, J.6
  • 103
    • 0028982262 scopus 로고
    • Iron regulates the intracellular degradation of iron regulatory protein 2 by the proteasome
    • PID: 7665579, COI: 1:CAS:528:DyaK2MXotFaisr4%3D
    • Guo B, Phillips JD, Yu Y, Leibold EA. Iron regulates the intracellular degradation of iron regulatory protein 2 by the proteasome. J Biol Chem. 1995;270(37):21645–51.
    • (1995) J Biol Chem , vol.270 , Issue.37 , pp. 21645-21651
    • Guo, B.1    Phillips, J.D.2    Yu, Y.3    Leibold, E.A.4
  • 104
    • 37449009448 scopus 로고    scopus 로고
    • Iron regulatory proteins are essential for intestinal function and control key iron absorption molecules in the duodenum
    • PID: 18177727, COI: 1:CAS:528:DC%2BD1cXnsFSntA%3D%3D
    • Galy B, Ferring-Appel D, Kaden S, Gröne H-J, Hentze MW. Iron regulatory proteins are essential for intestinal function and control key iron absorption molecules in the duodenum. Cell Metab. 2008;7(1):79–85.
    • (2008) Cell Metab , vol.7 , Issue.1 , pp. 79-85
    • Galy, B.1    Ferring-Appel, D.2    Kaden, S.3    Gröne, H.-J.4    Hentze, M.W.5
  • 105
    • 33645307993 scopus 로고    scopus 로고
    • Complete loss of iron regulatory proteins 1 and 2 prevents viability of murine zygotes beyond the blastocyst stage of embryonic development
    • PID: 16480904, COI: 1:CAS:528:DC%2BD28XivVGrsbY%3D
    • Smith SR, Ghosh MC, Ollivierre-Wilson H, Hang Tong W, Rouault TA. Complete loss of iron regulatory proteins 1 and 2 prevents viability of murine zygotes beyond the blastocyst stage of embryonic development. Blood Cells Mol Dis. 2006;36(2):283–7.
    • (2006) Blood Cells Mol Dis , vol.36 , Issue.2 , pp. 283-287
    • Smith, S.R.1    Ghosh, M.C.2    Ollivierre-Wilson, H.3    Hang Tong, W.4    Rouault, T.A.5
  • 106
    • 77952544962 scopus 로고    scopus 로고
    • Iron regulatory protein-2 knockout increases perihematomal ferritin expression and cell viability after intracerebral hemorrhage
    • PID: 20399759, COI: 1:CAS:528:DC%2BC3cXmslWis7g%3D
    • Chen M, Awe OO, Chen-Roetling J, Regan RF. Iron regulatory protein-2 knockout increases perihematomal ferritin expression and cell viability after intracerebral hemorrhage. Brain Res. 2010;1337:95–103.
    • (2010) Brain Res , vol.1337 , pp. 95-103
    • Chen, M.1    Awe, O.O.2    Chen-Roetling, J.3    Regan, R.F.4
  • 107
    • 47149093139 scopus 로고    scopus 로고
    • Neurons lacking iron regulatory protein-2 are highly resistant to the toxicity of hemoglobin
    • PID: 18571425, COI: 1:CAS:528:DC%2BD1cXoslOhtrk%3D
    • Regan RF, Chen M, Li Z, Zhang X, Benvenisti-Zarom L, Chen-Roetling J. Neurons lacking iron regulatory protein-2 are highly resistant to the toxicity of hemoglobin. Neurobiol Dis. 2008;31(2):242–9.
    • (2008) Neurobiol Dis , vol.31 , Issue.2 , pp. 242-249
    • Regan, R.F.1    Chen, M.2    Li, Z.3    Zhang, X.4    Benvenisti-Zarom, L.5    Chen-Roetling, J.6
  • 108
  • 109
    • 0035138456 scopus 로고    scopus 로고
    • Targeted deletion of the gene encoding iron regulatory protein-2 causes misregulation of iron metabolism and neurodegenerative disease in mice
    • PID: 11175792, COI: 1:CAS:528:DC%2BD3MXhtFKqtro%3D
    • LaVaute T, Smith S, Cooperman S, Iwai K, Land W, Meyron-Holtz E, et al. Targeted deletion of the gene encoding iron regulatory protein-2 causes misregulation of iron metabolism and neurodegenerative disease in mice. Nat Genet. 2001;27(2):209–14.
    • (2001) Nat Genet , vol.27 , Issue.2 , pp. 209-214
    • LaVaute, T.1    Smith, S.2    Cooperman, S.3    Iwai, K.4    Land, W.5    Meyron-Holtz, E.6
  • 110
    • 0034212588 scopus 로고    scopus 로고
    • Oxalomalate, a competitive inhibitor of aconitase, modulates the RNA-binding activity of iron-regulatory proteins
    • PID: 10816424, COI: 1:CAS:528:DC%2BD3cXksF2msb0%3D
    • Festa M, Colonna A, Pietropaolo C, Ruffo A. Oxalomalate, a competitive inhibitor of aconitase, modulates the RNA-binding activity of iron-regulatory proteins. Biochem J. 2000;348:315–20.
    • (2000) Biochem J , vol.348 , pp. 315-320
    • Festa, M.1    Colonna, A.2    Pietropaolo, C.3    Ruffo, A.4
  • 111
    • 37149013678 scopus 로고    scopus 로고
    • Retinoic acid modulates hepatic iron homeostasis in rats by attenuating the RNA-binding activity of iron regulatory proteins
    • PID: 18029484, COI: 1:CAS:528:DC%2BD2sXhtlKqtr3L
    • Schroeder SE, Reddy MB, Schalinske KL. Retinoic acid modulates hepatic iron homeostasis in rats by attenuating the RNA-binding activity of iron regulatory proteins. J Nutr. 2007;137(12):2686–90.
    • (2007) J Nutr , vol.137 , Issue.12 , pp. 2686-2690
    • Schroeder, S.E.1    Reddy, M.B.2    Schalinske, K.L.3
  • 112
    • 65449176475 scopus 로고    scopus 로고
    • Intracerebral haemorrhage
    • PID: 19427958
    • Qureshi AI, Mendelow AD, Hanley DF. Intracerebral haemorrhage. Lancet. 2009;373(9675):1632–44.
    • (2009) Lancet , vol.373 , Issue.9675 , pp. 1632-1644
    • Qureshi, A.I.1    Mendelow, A.D.2    Hanley, D.F.3
  • 113
    • 4143062381 scopus 로고    scopus 로고
    • Acute and subacute intracerebral hemorrhages: comparison of MR imaging at 1.5 and 3.0 T—initial experience
    • PID: 15284437
    • Allkemper T, Tombach B, Schwindt W, Kugel H, Schilling M, Debus O, et al. Acute and subacute intracerebral hemorrhages: comparison of MR imaging at 1.5 and 3.0 T—initial experience. Radiology. 2004;232(3):874–81.
    • (2004) Radiology , vol.232 , Issue.3 , pp. 874-881
    • Allkemper, T.1    Tombach, B.2    Schwindt, W.3    Kugel, H.4    Schilling, M.5    Debus, O.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.