Desferrioxamine, an iron chelator, upregulates cyclooxygenase-2 expression and prostaglandin production in a human macrophage cell line

Biochimica et Biophysica Acta - Molecular and Cell Biology of Lipids

Volumn 1530, Issue 2-3, 2001, Pages 227-235

  Tanji, Kunikazu ^a   Imaizumi, Tadaatsu ^a   Matsumiya, Tomoh ^a   Itaya, Hiroyuki ^a   Fujimoto, Koji ^a   Cui, Xue Fan ^a   Toki, Tsutomu ^a   Ito, Etsuro ^a   Yoshida, Hidemi ^a   Wakabayashi, Koichi ^a   Satoh, Kei ^a  

^a HIROSAKI UNIVERSITY   (Japan)

Author keywords

Cyclooxygenase; Inflammation; Iron chelator; Macrophage; Prostaglandin; U937

Indexed keywords

CYCLOOXYGENASE 2; DEFEROXAMINE; IRON; MESSENGER RNA; MITOGEN ACTIVATED PROTEIN KINASE; PROSTAGLANDIN; PROSTAGLANDIN E2;

ARTICLE; CONTROLLED STUDY; ENZYME IMMUNOASSAY; HUMAN; HUMAN CELL; IMMUNOBLOTTING; INFLAMMATION; IRON METABOLISM; MACROPHAGE; PRIORITY JOURNAL; PROSTAGLANDIN SYNTHESIS; PROTEIN EXPRESSION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION;

BINDING SITES; CELL LINE; CYCLOOXYGENASE 2; DEFEROXAMINE; DINOPROSTONE; ENZYME STABILITY; GENES, REPORTER; HUMANS; IRON CHELATING AGENTS; ISOENZYMES; MACROPHAGES; MEMBRANE PROTEINS; MITOGEN-ACTIVATED PROTEIN KINASES; PROMOTER REGIONS (GENETICS); PROSTAGLANDIN-ENDOPEROXIDE SYNTHASES; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER; UP-REGULATION;

EID: 0035952330     PISSN: 13881981     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1388-1981(01)00089-0     Document Type: Article

References (36)

1. In vitro modulation of T-cell surface molecules by iron
2. Iron augments macrophage-mediated killing of Brucella abortus alone and in conjunction with interferon-γ
3. Contrasting effects of lactoferrin on human lymphocyte and monocyte natural killer activity and antibody-dependent cell-mediated cytotoxicity
4. Iron modulates interferon-γ effects in the human myelomonocytic cell line THP-1
5. Iron regulates microglia cell-mediated secretory and effector functions
6. Central role of transcription factor NF-IL6 for cytokine and iron-mediated regulation of murine inducible nitric oxide synthase expression
7. Differential regulation of human alveolar macrophage-derived interleukin-1β and tumor necrosis factor-α by iron
8. Pathways for the regulation of macrophage iron metabolism by the anti-inflammatory cytokines IL-4 and IL-13
9. Novel regulation of cyclooxygenase-2 expression and prostaglandin E2 production by IFN-γ in human macrophages
10. Down regulation by iron of prostaglandin E2 production by human synovial fibroblasts
11. Differential effect on U937 cell differentiation by targeting transcriptional factors implicated in tissue- or stage-specific induced integrin expression
12. A p38 MAP kinase inhibitor regulates stability of interleukin-1-induced cyclooxygenase-2 mRNA
13. Inhibition of MAP kinase kinase prevents cytokine and prostaglandin E2 production in lipopolysaccharide-stimulated monocytes
14. Induction of cyclooxygenase-2 expression in human myometrial smooth muscle cells by interleukin-1β: Involvement of p38 mitogen-activated protein kinase
15. Evidence for involvement of NF-κB in the transcriptional control of COX-2 gene expression by IL-1beta
16. Hypoxia induces cyclooxygenase-2 via the NF-κB p65 transcription factor in human vascular endothelial cells
17. Transcriptional role of the nuclear factor κB site in the induction by lipopolysaccharide and suppression by dexamethasone of cyclooxygenase-2 in U937 cells
18. Chelation therapy in beta-thalassemia: The benefits and limitations of desferrioxamine
19. Deferoxamine followed by cyclophosphamide, etoposide, carboplatin, thiotepa, induction regimen inadvanced neuroblastoma: Preliminary results
20. Intramuscular desferrioxamine in patients with Alzheimer's disease
21. A predictor for side effects in patients with Alzheimer's disease treated with deferoxamine mesylate
22. Desferoxamine blocks IL 2 receptor expression on human T lymphocytes
23. Effect of iron deficiency and desferrioxamine on DNA synthesis in human cells
24. Antiviral and immunomodulatory effects of desferrioxamine in cytomegalovirus-infected rat liver allografts with rejection
25. Effect of deferoxamine and allopurinol on non-protein-bound iron concentrations in plasma and cortical brain tissue of newborn lambs following hypoxia-ischemia
26. Functional requirement of the hypoxia-responsive element in the activation of the inducible nitric oxide synthase promoter by the iron chelator desferrioxamine
27. Iron regulates nitric oxide synthase activity by controlling nuclear transcription
28. Nitric oxide activates cyclooxygenase enzymes
29. Transcriptional regulation of the cyclooxygenase-2 gene by diverse ligands in murine osteoblasts
30. Expression of cyclooxygenase-2 in rat vascular smooth muscle cells is unrelated to nuclear factor-κB activation
31. c-Jun N-terminal kinase phosphorylates peroxisome proliferator-activated receptor-γ1 and negatively regulates its transcriptional activity
32. Cell stress and MKK6b-mediated p38 MAP kinase activation inhibit tumor necrosis factor-induced IκB phosphorylation and NF-κB activation
33. Cobalt chloride-induced signaling in endothelium leading to the augmented adherence of sickle red blood cells and transendothelial migration of monocyte-like HL-60 cells is blocked by PAF-receptor antagonist
34. Phosphorylation at threonine-235 by a ras-dependent mitogen-activated protein kinase cascade is essential for transcription factor NF-IL6
35. Effect of iron and retinoic acid on the control of transferrin receptor and ferritin in the human promonocytic cell line U937