Deferoxamine reduces brain swelling in a rat model of hippocampal intracerebral hemorrhage

Acta Neurochirurgica, Supplementum

Volumn , Issue 105, 2008, Pages 13-18

  Song, S ^a,b   Hua, Y ^a   Keep, R F ^a   He, Y ^a   Wang, J ^b   Wu, J ^a,b   Xi, G ^a  

^a UNIVERSITY OF MICHIGAN MEDICAL SCHOOL   (United States)

^b ZHEJIANG UNIVERSITY SCHOOL OF MEDICINE   (China)

Author keywords

Brain edema; cerebral hemorrhage; deferoxamine; hemo globin; iron

Indexed keywords

DEFEROXAMINE; FERROUS ION; HEMOGLOBIN; SODIUM CHLORIDE; IRON; SIDEROPHORE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BRAIN EDEMA; BRAIN HEMORRHAGE; BRAIN SIZE; CELL DEATH; CONTROLLED STUDY; DNA DAMAGE; DRUG EFFECT; ERYTHROCYTE CONCENTRATE; ERYTHROCYTE TRANSFUSION; HEMOLYSATE; HEMOLYSIS; HISTOPATHOLOGY; MALE; NICK END LABELING; NONHUMAN; RAT; ANALYSIS OF VARIANCE; ANIMAL; CHEMICALLY INDUCED DISORDER; DISEASE MODEL; HEMISPHERIC DOMINANCE; HIPPOCAMPUS; METHODOLOGY; PATHOLOGY; SPRAGUE DAWLEY RAT;

ANALYSIS OF VARIANCE; ANIMALS; BRAIN EDEMA; CELL DEATH; CEREBRAL HEMORRHAGE; DEFEROXAMINE; DISEASE MODELS, ANIMAL; FUNCTIONAL LATERALITY; HEMOGLOBINS; HIPPOCAMPUS; IN SITU NICK-END LABELING; IRON; MALE; RATS; RATS, SPRAGUE-DAWLEY; SIDEROPHORES;

EID: 85052609094     PISSN: 00651419     EISSN: None     Source Type: Book Series    
DOI: 10.1007/978-3-211-09469-3_3     Document Type: Article

References (38)

1. Andaluz N, Zuccarello M, Wagner KR (2002) Experimental animal models of intracerebral hemorrhage. Neurosurg Clin N Am 13:385-393
2. Aruoma OI, Halliwell B, Dizdaroglu M (1989) Iron ion-dependent modification of bases in DNA by the superoxide radicalgenerating system hypoxanthine/xanthine oxidase. J Biol Chem 264:13024-13028
3. Felberg RA, Grotta JC, Shirzadi AL, Strong R, Narayana P, Hill-Felberg SJ, Aronowski J (2002) Cell death in experimental intracerebral hemorrhage: the "black hole" model of hemorrhagic damage. Ann Neurol 51:517-524
4. Gong Y, Tian H, Xi G, Keep RF, Hoff JT, Hua Y (2006) Systemic zinc protoporphyrin administration reduces intracerebral hemorrhage-induced brain injury. Acta Neurochir Suppl 96:232-236
5. Graham SH, Chen J (2001) Programmed cell death in cerebral ischemia. J Cereb Blood Flow Metab 21:99-109
6. Gutteridge JM (1987) The antioxidant activity of haptoglobin towards haemoglobin-stimulated lipid peroxidation. Biochim Biophys Acta 917:219-223
7. Hua Y, Schallert T, Keep RF, Wu J, Hoff JT, Xi G (2002) Behavioral tests after intracerebral hemorrhage in the rat. Stroke 33:2478-2484
8. Hua Y, Nakamura T, Keep RF, Wu J, Schallert T, Hoff JT, Xi G (2006) Long-term effects of experimental intracerebral hemorrhage: the role of iron. J Neurosurg 104:305-312
9. Huang FP, Xi G, Keep RF, Hua Y, Nemoianu A, Hoff JT (2002) Brain edema after experimental intracerebral hemorrhage: role of hemoglobin degradation products. J Neurosurg 96:287-293
10. Kase CS, Caplan LR (1994) Intracerebral hemorrhage. Butterworth- Heinemann, Boston
11. Koeppen AH, Dickson AC, Smith J (2004) Heme oxygenase in experimental intracerebral hemorrhage: the benefit of tin-mesoporphyrin. J Neuropathol Exp Neurol 63:587-597
12. Nagayama T, Lan J, Henshall DC, Chen D, O'Horo C, Simon RP, Chen J (2000) Induction of oxidative DNA damage in the periinfarct region after permanent focal cerebral ischemia. J Neurochem 75:1716-1728
13. Nakamura T, Keep RF, Hua Y, Schallert T, Hoff JT, Xi G (2004) Deferoxamine-induced attenuation of brain edema and neurological deficits in a rat model of intracerebral hemorrhage. J Neurosurg 100:672-678
14. Nakamura T, Xi G, Hua Y, Schallert T, Hoff JT, Keep RF (2004) Intracerebral hemorrhage in mice: model characterization and application for genetically modified mice. J Cereb Blood Flow Metab 24:487-494
15. Nakamura T, Keep RF, Hua Y, Hoff JT, Xi G (2005) Oxidative DNA injury after experimental intracerebral hemorrhage. Brain Res 1039:30-36 (Pubitemid 40386824)
16. Ogihara K, Zubkov AY, Bernanke DH, Lewis AI, Parent AD, Zhang JH (1999) Oxyhemoglobin-induced apoptosis in cultured endothelial cells. J Neurosurg 91:459-465
17. Palmer C, Roberts RL, Bero C (1994) Deferoxamine posttreatment reduces ischemic brain injury in neonatal rats. Stroke 25:1039-1045
18. Prass K, Ruscher K, Karsch M, Isaev N, Megow D, Priller J, Scharff A, Dirnagl U, Meisel A (2002) Desferrioxamine induces delayed tolerance against cerebral ischemia in vivo and in vitro. J Cereb Blood Flow Metab 22:520-525
19. Qureshi AI, Wilson DA, Hanley DF, Traystman RJ (1999) No evidence for an ischemic penumbra in massive experimental intracerebral hemorrhage. Neurology 52:266-272
20. Qureshi AI, Tuhrim S, Broderick JP, Batjer HH, Hondo H, Hanley DF (2001) Spontaneous intracerebral hemorrhage. N Engl J Med 344:1450-1460
21. Regan RF, Panter SS (1993) Neurotoxicity of hemoglobin in cortical cell culture. Neurosci Lett 153:219-222
22. Regan RF, Rogers B (2003) Delayed treatment of hemoglobin neurotoxicity. J Neurotrauma 20:111-120
23. Rosenberg GA, Mun-Bryce S, Wesley M, Kornfeld M (1990) Collagenase-induced intracerebral hemorrhage in rats. Stroke 21:801-807
24. Song S, Hua Y, Keep RF, Hoff JT, Xi G (2007) A new hippocampal model for examining intracerebral hemorrhage-related neuronal death: effects of deferoxamine on hemoglobin-induced neuronal death. Stroke 38:2861-2863
25. Wagner KR, Xi G, Hua Y, Kleinholz M, de Courten-Myers GM, Myers RE, Broderick JP, Brott TG (1996) Lobar intracerebral hemorrhage model in pigs: rapid edema development in perihematomal white matter. Stroke 27:490-497
26. Wagner KR, Hua Y, de Courten-Myers GM, Broderick JP, Nishimura RN, Lu SY, Dwyer BE (2000) Tin-mesoporphyrin, a potent heme oxygenase inhibitor, for treatment of intracerebral hemorrhage: in vivo and in vitro studies. Cell Mol Biol (Noisy-le-grand) 46:597-608
27. Wagner KR, Sharp FR, Ardizzone TD, Lu A, Clark JF (2003) Heme and iron metabolism: role in cerebral hemorrhage. J Cereb Blood Flow Metab 23:629-652
28. Wan S, Hua Y, Keep RF, Hoff JT, Xi G (2006) Deferoxamine reduces CSF free iron levels following intracerebral hemorrhage. Acta Neurochir Suppl 96:199-202
29. Wang J, Tsirka SE (2005) Neuroprotection by inhibition of matrix metalloproteinases in a mouse model of intracerebral haemorrhage. Brain 128:1622-1633
30. Wang X, Mori T, Sumii T, Lo EH (2002) Hemoglobin-induced cytotoxicity in rat cerebral cortical neurons: caspase activation and oxidative stress. Stroke 33:1882-1888
31. Wu J, Hua Y, Keep RF, Schallert T, Hoff JT, Xi G (2002) Oxidative brain injury from extravasated erythrocytes after intracerebral hemorrhage. Brain Res 953:45-52
32. Wu J, Hua Y, Keep RF, Nakamura T, Hoff JT, Xi G (2003) Iron and iron-handling proteins in the brain after intracerebral hemorrhage. Stroke 34:2964-2969
33. Xi G, Keep RF, Hoff JT (1998) Erythrocytes and delayed brain edema formation following intracerebral hemorrhage in rats. J Neurosurg 89:991-996
34. Xi G, Hua Y, Bhasin RR, Ennis SR, Keep RF, Hoff JT (2001) Mechanisms of edema formation after intracerebral hemorrhage: effects of extravasated red blood cells on blood flow and blood-brain barrier integrity. Stroke 32:2932-2938
35. Xi G, Keep RF, Hoff JT (2002) Pathophysiology of brain edema formation. Neurosurg Clin N Am 13:371-383
36. Xi G, Keep RF, Hoff JT (2006) Mechanisms of brain injury after intracerebral haemorrhage. Lancet Neurol 5:53-63
37. Xue M, Del Bigio MR (2000) Intracortical hemorrhage injury in rats: relationship between blood fractions and brain cell death. Stroke 31:1721-1727
38. Zhao X, Zhang Y, Strong R, Grotta JC, Aronowski J (2006) 15d-Prostaglandin J2 activates peroxisome proliferator-activated receptorgamma, promotes expression of catalase, and reduces inflammation, behavioral dysfunction, and neuronal loss after intracerebral hemorrhage in rats. J Cereb Blood Flow Metab 26:811-820