-
1
-
-
0034733635
-
A novel mammalian iron-regulated protein involved in intracellular iron metabolism
-
Abboud S., and Haile D.J. A novel mammalian iron-regulated protein involved in intracellular iron metabolism. J. Biol. Chem. 275 (2000) 19906-19912
-
(2000)
J. Biol. Chem.
, vol.275
, pp. 19906-19912
-
-
Abboud, S.1
Haile, D.J.2
-
2
-
-
13744254990
-
Duodenal ascorbate and ferric reductase in human iron deficiency
-
Atanasova B.D., Li A.C., Bjarnason I., Tzatchev K.N., and Simpson R.J. Duodenal ascorbate and ferric reductase in human iron deficiency. Am. J. Clin. Nutr. 81 (2005) 130-133
-
(2005)
Am. J. Clin. Nutr.
, vol.81
, pp. 130-133
-
-
Atanasova, B.D.1
Li, A.C.2
Bjarnason, I.3
Tzatchev, K.N.4
Simpson, R.J.5
-
3
-
-
33646370235
-
Bone morphogenetic protein signaling by hemojuvelin regulates hepcidin expression
-
Babitt J.L., Huang F.W., Wrighting D.M., Xia Y., Sidis Y., Samad T.A., Campagna J.A., Chung R.T., Schneyer A.L., Woolf C.J., et al. Bone morphogenetic protein signaling by hemojuvelin regulates hepcidin expression. Nat. Genet. 38 (2006) 531-539
-
(2006)
Nat. Genet.
, vol.38
, pp. 531-539
-
-
Babitt, J.L.1
Huang, F.W.2
Wrighting, D.M.3
Xia, Y.4
Sidis, Y.5
Samad, T.A.6
Campagna, J.A.7
Chung, R.T.8
Schneyer, A.L.9
Woolf, C.J.10
-
4
-
-
34447137331
-
Modulation of bone morphogenetic protein signaling in vivo regulates systemic iron balance
-
Babitt J.L., Huang F.W., Xia Y., Sidis Y., Andrews N.C., and Lin H.Y. Modulation of bone morphogenetic protein signaling in vivo regulates systemic iron balance. J. Clin. Invest. 117 (2007) 1933-1939
-
(2007)
J. Clin. Invest.
, vol.117
, pp. 1933-1939
-
-
Babitt, J.L.1
Huang, F.W.2
Xia, Y.3
Sidis, Y.4
Andrews, N.C.5
Lin, H.Y.6
-
5
-
-
0038542813
-
The HFE Cys282Tyr mutation as a necessary but not sufficient cause of clinical hereditary hemochromatosis
-
Beutler E. The HFE Cys282Tyr mutation as a necessary but not sufficient cause of clinical hereditary hemochromatosis. Blood 101 (2003) 3347-3350
-
(2003)
Blood
, vol.101
, pp. 3347-3350
-
-
Beutler, E.1
-
6
-
-
41949108403
-
Epidermal sensing of oxygen is essential for systemic hypoxic response
-
Boutin A.T., Weidemann A., Fu Z., Mesropian L., Gradin K., Jamora C., Wiesener M., Eckardt K.U., Koch C.J., Ellies L.G., et al. Epidermal sensing of oxygen is essential for systemic hypoxic response. Cell 133 (2008) 223-234
-
(2008)
Cell
, vol.133
, pp. 223-234
-
-
Boutin, A.T.1
Weidemann, A.2
Fu, Z.3
Mesropian, L.4
Gradin, K.5
Jamora, C.6
Wiesener, M.7
Eckardt, K.U.8
Koch, C.J.9
Ellies, L.G.10
-
7
-
-
33745685879
-
Role of hypoxia-inducible factor (HIF)-1alpha versus HIF-2alpha in the regulation of HIF target genes in response to hypoxia, insulin-like growth factor-I, or loss of von Hippel-Lindau function: implications for targeting the HIF pathway
-
Carroll V.A., and Ashcroft M. Role of hypoxia-inducible factor (HIF)-1alpha versus HIF-2alpha in the regulation of HIF target genes in response to hypoxia, insulin-like growth factor-I, or loss of von Hippel-Lindau function: implications for targeting the HIF pathway. Cancer Res. 66 (2006) 6264-6270
-
(2006)
Cancer Res.
, vol.66
, pp. 6264-6270
-
-
Carroll, V.A.1
Ashcroft, M.2
-
8
-
-
0037174609
-
C/EBPalpha regulates hepatic transcription of hepcidin, an antimicrobial peptide and regulator of iron metabolism. Cross-talk between C/EBP pathway and iron metabolism
-
Courselaud B., Pigeon C., Inoue Y., Inoue J., Gonzalez F.J., Leroyer P., Gilot D., Boudjema K., Guguen-Guillouzo C., Brissot P., et al. C/EBPalpha regulates hepatic transcription of hepcidin, an antimicrobial peptide and regulator of iron metabolism. Cross-talk between C/EBP pathway and iron metabolism. J. Biol. Chem. 277 (2002) 41163-41170
-
(2002)
J. Biol. Chem.
, vol.277
, pp. 41163-41170
-
-
Courselaud, B.1
Pigeon, C.2
Inoue, Y.3
Inoue, J.4
Gonzalez, F.J.5
Leroyer, P.6
Gilot, D.7
Boudjema, K.8
Guguen-Guillouzo, C.9
Brissot, P.10
-
9
-
-
0034677467
-
Positional cloning of zebrafish ferroportin1 identifies a conserved vertebrate iron exporter
-
Donovan A., Brownlie A., Zhou Y., Shepard J., Pratt S.J., Moynihan J., Paw B.H., Drejer A., Barut B., Zapata A., et al. Positional cloning of zebrafish ferroportin1 identifies a conserved vertebrate iron exporter. Nature 403 (2000) 776-781
-
(2000)
Nature
, vol.403
, pp. 776-781
-
-
Donovan, A.1
Brownlie, A.2
Zhou, Y.3
Shepard, J.4
Pratt, S.J.5
Moynihan, J.6
Paw, B.H.7
Drejer, A.8
Barut, B.9
Zapata, A.10
-
10
-
-
20444416123
-
The iron exporter ferroportin/Slc40a1 is essential for iron homeostasis
-
Donovan A., Lima C.A., Pinkus J.L., Pinkus G.S., Zon L.I., Robine S., and Andrews N.C. The iron exporter ferroportin/Slc40a1 is essential for iron homeostasis. Cell Metab. 1 (2005) 191-200
-
(2005)
Cell Metab.
, vol.1
, pp. 191-200
-
-
Donovan, A.1
Lima, C.A.2
Pinkus, J.L.3
Pinkus, G.S.4
Zon, L.I.5
Robine, S.6
Andrews, N.C.7
-
11
-
-
0038332156
-
Novel roles for iron regulatory proteins in the adaptive response to iron deficiency
-
Eisenstein R.S., and Ross K.L. Novel roles for iron regulatory proteins in the adaptive response to iron deficiency. J. Nutr. 133 (2003) 1510S-1516S
-
(2003)
J. Nutr.
, vol.133
-
-
Eisenstein, R.S.1
Ross, K.L.2
-
12
-
-
0029000839
-
Immune system impairment and hepatic fibrosis in mice lacking the dioxin-binding Ah receptor
-
Fernandez-Salguero P., Pineau T., Hilbert D.M., McPhail T., Lee S.S., Kimura S., Nebert D.W., Rudikoff S., Ward J.M., and Gonzalez F.J. Immune system impairment and hepatic fibrosis in mice lacking the dioxin-binding Ah receptor. Science 268 (1995) 722-726
-
(1995)
Science
, vol.268
, pp. 722-726
-
-
Fernandez-Salguero, P.1
Pineau, T.2
Hilbert, D.M.3
McPhail, T.4
Lee, S.S.5
Kimura, S.6
Nebert, D.W.7
Rudikoff, S.8
Ward, J.M.9
Gonzalez, F.J.10
-
13
-
-
0032477866
-
Nramp2 is mutated in the anemic Belgrade (b) rat: evidence of a role for Nramp2 in endosomal iron transport
-
Fleming M.D., Romano M.A., Su M.A., Garrick L.M., Garrick M.D., and Andrews N.C. Nramp2 is mutated in the anemic Belgrade (b) rat: evidence of a role for Nramp2 in endosomal iron transport. Proc. Natl. Acad. Sci. USA 95 (1998) 1148-1153
-
(1998)
Proc. Natl. Acad. Sci. USA
, vol.95
, pp. 1148-1153
-
-
Fleming, M.D.1
Romano, M.A.2
Su, M.A.3
Garrick, L.M.4
Garrick, M.D.5
Andrews, N.C.6
-
14
-
-
0030763856
-
Microcytic anaemia mice have a mutation in Nramp2, a candidate iron transporter gene
-
Fleming M.D., Trenor III C.C., Su M.A., Foernzler D., Beier D.R., Dietrich W.F., and Andrews N.C. Microcytic anaemia mice have a mutation in Nramp2, a candidate iron transporter gene. Nat. Genet. 16 (1997) 383-386
-
(1997)
Nat. Genet.
, vol.16
, pp. 383-386
-
-
Fleming, M.D.1
Trenor III, C.C.2
Su, M.A.3
Foernzler, D.4
Beier, D.R.5
Dietrich, W.F.6
Andrews, N.C.7
-
15
-
-
0036678091
-
Targeted mutagenesis of the murine transferrin receptor-2 gene produces hemochromatosis
-
Fleming R.E., Ahmann J.R., Migas M.C., Waheed A., Koeffler H.P., Kawabata H., Britton R.S., Bacon B.R., and Sly W.S. Targeted mutagenesis of the murine transferrin receptor-2 gene produces hemochromatosis. Proc. Natl. Acad. Sci. USA 99 (2002) 10653-10658
-
(2002)
Proc. Natl. Acad. Sci. USA
, vol.99
, pp. 10653-10658
-
-
Fleming, R.E.1
Ahmann, J.R.2
Migas, M.C.3
Waheed, A.4
Koeffler, H.P.5
Kawabata, H.6
Britton, R.S.7
Bacon, B.R.8
Sly, W.S.9
-
16
-
-
58149158220
-
Regulation of the divalent metal ion transporter DMT1 and iron homeostasis by a ubiquitin-dependent mechanism involving Ndfips and WWP2
-
Foot N.J., Dalton H.E., Shearwin-Whyatt L.M., Dorstyn L., Tan S.S., Yang B., and Kumar S. Regulation of the divalent metal ion transporter DMT1 and iron homeostasis by a ubiquitin-dependent mechanism involving Ndfips and WWP2. Blood 112 (2008) 4268-4275
-
(2008)
Blood
, vol.112
, pp. 4268-4275
-
-
Foot, N.J.1
Dalton, H.E.2
Shearwin-Whyatt, L.M.3
Dorstyn, L.4
Tan, S.S.5
Yang, B.6
Kumar, S.7
-
17
-
-
0036727925
-
Hepcidin expression inversely correlates with the expression of duodenal iron transporters and iron absorption in rats
-
Frazer D.M., Wilkins S.J., Becker E.M., Vulpe C.D., McKie A.T., Trinder D., and Anderson G.J. Hepcidin expression inversely correlates with the expression of duodenal iron transporters and iron absorption in rats. Gastroenterology 123 (2002) 835-844
-
(2002)
Gastroenterology
, vol.123
, pp. 835-844
-
-
Frazer, D.M.1
Wilkins, S.J.2
Becker, E.M.3
Vulpe, C.D.4
McKie, A.T.5
Trinder, D.6
Anderson, G.J.7
-
18
-
-
37449009448
-
Iron regulatory proteins are essential for intestinal function and control key iron absorption molecules in the duodenum
-
Galy B., Ferring-Appel D., Kaden S., Grone H.J., and Hentze M.W. Iron regulatory proteins are essential for intestinal function and control key iron absorption molecules in the duodenum. Cell Metab. 7 (2008) 79-85
-
(2008)
Cell Metab.
, vol.7
, pp. 79-85
-
-
Galy, B.1
Ferring-Appel, D.2
Kaden, S.3
Grone, H.J.4
Hentze, M.W.5
-
19
-
-
0030755366
-
Cloning and characterization of a mammalian proton-coupled metal-ion transporter
-
Gunshin H., Mackenzie B., Berger U.V., Gunshin Y., Romero M.F., Boron W.F., Nussberger S., Gollan J.L., and Hediger M.A. Cloning and characterization of a mammalian proton-coupled metal-ion transporter. Nature 388 (1997) 482-488
-
(1997)
Nature
, vol.388
, pp. 482-488
-
-
Gunshin, H.1
Mackenzie, B.2
Berger, U.V.3
Gunshin, Y.4
Romero, M.F.5
Boron, W.F.6
Nussberger, S.7
Gollan, J.L.8
Hediger, M.A.9
-
20
-
-
18244389488
-
Iron-dependent regulation of the divalent metal ion transporter
-
Gunshin H., Allerson C.R., Polycarpou-Schwarz M., Rofts A., Rogers J.T., Kishi F., Hentze M.W., Rouault T.A., Andrews N.C., and Hediger M.A. Iron-dependent regulation of the divalent metal ion transporter. FEBS Lett. 509 (2001) 309-316
-
(2001)
FEBS Lett.
, vol.509
, pp. 309-316
-
-
Gunshin, H.1
Allerson, C.R.2
Polycarpou-Schwarz, M.3
Rofts, A.4
Rogers, J.T.5
Kishi, F.6
Hentze, M.W.7
Rouault, T.A.8
Andrews, N.C.9
Hediger, M.A.10
-
21
-
-
18244399587
-
Slc11a2 is required for intestinal iron absorption and erythropoiesis but dispensable in placenta and liver
-
Gunshin H., Fujiwara Y., Custodio A.O., Direnzo C., Robine S., and Andrews N.C. Slc11a2 is required for intestinal iron absorption and erythropoiesis but dispensable in placenta and liver. J. Clin. Invest. 115 (2005) 1258-1266
-
(2005)
J. Clin. Invest.
, vol.115
, pp. 1258-1266
-
-
Gunshin, H.1
Fujiwara, Y.2
Custodio, A.O.3
Direnzo, C.4
Robine, S.5
Andrews, N.C.6
-
22
-
-
27144507493
-
Cybrd1 (duodenal cytochrome b) is not necessary for dietary iron absorption in mice
-
Gunshin H., Starr C.N., Direnzo C., Fleming M.D., Jin J., Greer E.L., Sellers V.M., Galica S.M., and Andrews N.C. Cybrd1 (duodenal cytochrome b) is not necessary for dietary iron absorption in mice. Blood 106 (2005) 2879-2883
-
(2005)
Blood
, vol.106
, pp. 2879-2883
-
-
Gunshin, H.1
Starr, C.N.2
Direnzo, C.3
Fleming, M.D.4
Jin, J.5
Greer, E.L.6
Sellers, V.M.7
Galica, S.M.8
Andrews, N.C.9
-
23
-
-
24344452947
-
The VHL tumor suppressor in development and disease: functional studies in mice by conditional gene targeting
-
Haase V.H. The VHL tumor suppressor in development and disease: functional studies in mice by conditional gene targeting. Semin. Cell Dev. Biol. 16 (2005) 564-574
-
(2005)
Semin. Cell Dev. Biol.
, vol.16
, pp. 564-574
-
-
Haase, V.H.1
-
24
-
-
0035852668
-
Vascular tumors in livers with targeted inactivation of the von Hippel-Lindau tumor suppressor
-
Haase V.H., Glickman J.N., Socolovsky M., and Jaenisch R. Vascular tumors in livers with targeted inactivation of the von Hippel-Lindau tumor suppressor. Proc. Natl. Acad. Sci. USA 98 (2001) 1583-1588
-
(2001)
Proc. Natl. Acad. Sci. USA
, vol.98
, pp. 1583-1588
-
-
Haase, V.H.1
Glickman, J.N.2
Socolovsky, M.3
Jaenisch, R.4
-
25
-
-
0345491599
-
Differential roles of hypoxia-inducible factor 1alpha (HIF-1alpha) and HIF-2alpha in hypoxic gene regulation
-
Hu C.J., Wang L.Y., Chodosh L.A., Keith B., and Simon M.C. Differential roles of hypoxia-inducible factor 1alpha (HIF-1alpha) and HIF-2alpha in hypoxic gene regulation. Mol. Cell. Biol. 23 (2003) 9361-9374
-
(2003)
Mol. Cell. Biol.
, vol.23
, pp. 9361-9374
-
-
Hu, C.J.1
Wang, L.Y.2
Chodosh, L.A.3
Keith, B.4
Simon, M.C.5
-
26
-
-
0037126002
-
Previously uncharacterized isoforms of divalent metal transporter (DMT)-1: implications for regulation and cellular function
-
Hubert N., and Hentze M.W. Previously uncharacterized isoforms of divalent metal transporter (DMT)-1: implications for regulation and cellular function. Proc. Natl. Acad. Sci. USA 99 (2002) 12345-12350
-
(2002)
Proc. Natl. Acad. Sci. USA
, vol.99
, pp. 12345-12350
-
-
Hubert, N.1
Hentze, M.W.2
-
27
-
-
34447117473
-
Dietary phytochemicals regulate whole-body CYP1A1 expression through an arylhydrocarbon receptor nuclear translocator-dependent system in gut
-
Ito S., Chen C., Satoh J., Yim S., and Gonzalez F.J. Dietary phytochemicals regulate whole-body CYP1A1 expression through an arylhydrocarbon receptor nuclear translocator-dependent system in gut. J. Clin. Invest. 117 (2007) 1940-1950
-
(2007)
J. Clin. Invest.
, vol.117
, pp. 1940-1950
-
-
Ito, S.1
Chen, C.2
Satoh, J.3
Yim, S.4
Gonzalez, F.J.5
-
28
-
-
0035917313
-
HIFalpha targeted for VHL-mediated destruction by proline hydroxylation: implications for O2 sensing
-
Ivan M., Kondo K., Yang H., Kim W., Valiando J., Ohh M., Salic A., Asara J.M., Lane W.S., and Kaelin Jr. W.G. HIFalpha targeted for VHL-mediated destruction by proline hydroxylation: implications for O2 sensing. Science 292 (2001) 464-468
-
(2001)
Science
, vol.292
, pp. 464-468
-
-
Ivan, M.1
Kondo, K.2
Yang, H.3
Kim, W.4
Valiando, J.5
Ohh, M.6
Salic, A.7
Asara, J.M.8
Lane, W.S.9
Kaelin Jr., W.G.10
-
29
-
-
0035917808
-
Targeting of HIF-alpha to the von Hippel-Lindau ubiquitylation complex by O2-regulated prolyl hydroxylation
-
Jaakkola P., Mole D.R., Tian Y.M., Wilson M.I., Gielbert J., Gaskell S.J., Kriegsheim A., Hebestreit H.F., Mukherji M., Schofield C.J., et al. Targeting of HIF-alpha to the von Hippel-Lindau ubiquitylation complex by O2-regulated prolyl hydroxylation. Science 292 (2001) 468-472
-
(2001)
Science
, vol.292
, pp. 468-472
-
-
Jaakkola, P.1
Mole, D.R.2
Tian, Y.M.3
Wilson, M.I.4
Gielbert, J.5
Gaskell, S.J.6
Kriegsheim, A.7
Hebestreit, H.F.8
Mukherji, M.9
Schofield, C.J.10
-
30
-
-
40949136438
-
The VHL tumor suppressor and HIF: insights from genetic studies in mice
-
Kapitsinou P.P., and Haase V.H. The VHL tumor suppressor and HIF: insights from genetic studies in mice. Cell Death Differ. 15 (2008) 650-659
-
(2008)
Cell Death Differ.
, vol.15
, pp. 650-659
-
-
Kapitsinou, P.P.1
Haase, V.H.2
-
31
-
-
44449108683
-
Duodenal cytochrome B expression stimulates iron uptake by human intestinal epithelial cells
-
Latunde-Dada G.O., Simpson R.J., and McKie A.T. Duodenal cytochrome B expression stimulates iron uptake by human intestinal epithelial cells. J. Nutr. 138 (2008) 991-995
-
(2008)
J. Nutr.
, vol.138
, pp. 991-995
-
-
Latunde-Dada, G.O.1
Simpson, R.J.2
McKie, A.T.3
-
32
-
-
33845357105
-
Role of HIF-1 in iron regulation: potential therapeutic strategy for neurodegenerative disorders
-
Lee D.W., and Andersen J.K. Role of HIF-1 in iron regulation: potential therapeutic strategy for neurodegenerative disorders. Curr. Mol. Med. 6 (2006) 883-893
-
(2006)
Curr. Mol. Med.
, vol.6
, pp. 883-893
-
-
Lee, D.W.1
Andersen, J.K.2
-
33
-
-
0034062537
-
Genes that modify the hemochromatosis phenotype in mice
-
Levy J.E., Montross L.K., and Andrews N.C. Genes that modify the hemochromatosis phenotype in mice. J. Clin. Invest. 105 (2000) 1209-1216
-
(2000)
J. Clin. Invest.
, vol.105
, pp. 1209-1216
-
-
Levy, J.E.1
Montross, L.K.2
Andrews, N.C.3
-
35
-
-
0033861745
-
A novel duodenal iron-regulated transporter, IREG1, implicated in the basolateral transfer of iron to the circulation
-
McKie A.T., Marciani P., Rolfs A., Brennan K., Wehr K., Barrow D., Miret S., Bomford A., Peters T.J., Farzaneh F., et al. A novel duodenal iron-regulated transporter, IREG1, implicated in the basolateral transfer of iron to the circulation. Mol. Cell 5 (2000) 299-309
-
(2000)
Mol. Cell
, vol.5
, pp. 299-309
-
-
McKie, A.T.1
Marciani, P.2
Rolfs, A.3
Brennan, K.4
Wehr, K.5
Barrow, D.6
Miret, S.7
Bomford, A.8
Peters, T.J.9
Farzaneh, F.10
-
36
-
-
0035793856
-
An iron-regulated ferric reductase associated with the absorption of dietary iron
-
McKie A.T., Barrow D., Latunde-Dada G.O., Rolfs A., Sager G., Mudaly E., Mudaly M., Richardson C., Barlow D., Bomford A., et al. An iron-regulated ferric reductase associated with the absorption of dietary iron. Science 291 (2001) 1755-1759
-
(2001)
Science
, vol.291
, pp. 1755-1759
-
-
McKie, A.T.1
Barrow, D.2
Latunde-Dada, G.O.3
Rolfs, A.4
Sager, G.5
Mudaly, E.6
Mudaly, M.7
Richardson, C.8
Barlow, D.9
Bomford, A.10
-
37
-
-
0000723465
-
Studies on iron absorption. I. The relationships between the rate of erythropoiesis, hypoxia and iron absorption
-
Mendel G.A. Studies on iron absorption. I. The relationships between the rate of erythropoiesis, hypoxia and iron absorption. Blood 18 (1961) 727-736
-
(1961)
Blood
, vol.18
, pp. 727-736
-
-
Mendel, G.A.1
-
38
-
-
10844258104
-
Hepcidin regulates cellular iron efflux by binding to ferroportin and inducing its internalization
-
Nemeth E., Tuttle M.S., Powelson J., Vaughn M.B., Donovan A., Ward D.M., Ganz T., and Kaplan J. Hepcidin regulates cellular iron efflux by binding to ferroportin and inducing its internalization. Science 306 (2004) 2090-2093
-
(2004)
Science
, vol.306
, pp. 2090-2093
-
-
Nemeth, E.1
Tuttle, M.S.2
Powelson, J.3
Vaughn, M.B.4
Donovan, A.5
Ward, D.M.6
Ganz, T.7
Kaplan, J.8
-
39
-
-
0035902605
-
Lack of hepcidin gene expression and severe tissue iron overload in upstream stimulatory factor 2 (USF2) knockout mice
-
Nicolas G., Bennoun M., Devaux I., Beaumont C., Grandchamp B., Kahn A., and Vaulont S. Lack of hepcidin gene expression and severe tissue iron overload in upstream stimulatory factor 2 (USF2) knockout mice. Proc. Natl. Acad. Sci. USA 98 (2001) 8780-8785
-
(2001)
Proc. Natl. Acad. Sci. USA
, vol.98
, pp. 8780-8785
-
-
Nicolas, G.1
Bennoun, M.2
Devaux, I.3
Beaumont, C.4
Grandchamp, B.5
Kahn, A.6
Vaulont, S.7
-
40
-
-
0037007064
-
Severe iron deficiency anemia in transgenic mice expressing liver hepcidin
-
Nicolas G., Bennoun M., Porteu A., Mativet S., Beaumont C., Grandchamp B., Sirito M., Sawadogo M., Kahn A., and Vaulont S. Severe iron deficiency anemia in transgenic mice expressing liver hepcidin. Proc. Natl. Acad. Sci. USA 99 (2002) 4596-4601
-
(2002)
Proc. Natl. Acad. Sci. USA
, vol.99
, pp. 4596-4601
-
-
Nicolas, G.1
Bennoun, M.2
Porteu, A.3
Mativet, S.4
Beaumont, C.5
Grandchamp, B.6
Sirito, M.7
Sawadogo, M.8
Kahn, A.9
Vaulont, S.10
-
41
-
-
0036791486
-
The gene encoding the iron regulatory peptide hepcidin is regulated by anemia, hypoxia, and inflammation
-
Nicolas G., Chauvet C., Viatte L., Danan J.L., Bigard X., Devaux I., Beaumont C., Kahn A., and Vaulont S. The gene encoding the iron regulatory peptide hepcidin is regulated by anemia, hypoxia, and inflammation. J. Clin. Invest. 110 (2002) 1037-1044
-
(2002)
J. Clin. Invest.
, vol.110
, pp. 1037-1044
-
-
Nicolas, G.1
Chauvet, C.2
Viatte, L.3
Danan, J.L.4
Bigard, X.5
Devaux, I.6
Beaumont, C.7
Kahn, A.8
Vaulont, S.9
-
42
-
-
1842608845
-
Iron metabolism and the IRE/IRP regulatory system: an update
-
Pantopoulos K. Iron metabolism and the IRE/IRP regulatory system: an update. Ann. N Y Acad. Sci. 1012 (2004) 1-13
-
(2004)
Ann. N Y Acad. Sci.
, vol.1012
, pp. 1-13
-
-
Pantopoulos, K.1
-
43
-
-
34447120059
-
Regulation of iron homeostasis by the hypoxia-inducible transcription factors (HIFs)
-
Peyssonnaux C., Zinkernagel A.S., Schuepbach R.A., Rankin E., Vaulont S., Haase V.H., Nizet V., and Johnson R.S. Regulation of iron homeostasis by the hypoxia-inducible transcription factors (HIFs). J. Clin. Invest. 117 (2007) 1926-1932
-
(2007)
J. Clin. Invest.
, vol.117
, pp. 1926-1932
-
-
Peyssonnaux, C.1
Zinkernagel, A.S.2
Schuepbach, R.A.3
Rankin, E.4
Vaulont, S.5
Haase, V.H.6
Nizet, V.7
Johnson, R.S.8
-
44
-
-
38349111676
-
Role of the hypoxia inducible factors HIF in iron metabolism
-
Peyssonnaux C., Nizet V., and Johnson R.S. Role of the hypoxia inducible factors HIF in iron metabolism. Cell Cycle 7 (2008) 28-32
-
(2008)
Cell Cycle
, vol.7
, pp. 28-32
-
-
Peyssonnaux, C.1
Nizet, V.2
Johnson, R.S.3
-
45
-
-
0035896581
-
A new mouse liver-specific gene, encoding a protein homologous to human antimicrobial peptide hepcidin, is overexpressed during iron overload
-
Pigeon C., Ilyin G., Courselaud B., Leroyer P., Turlin B., Brissot P., and Loreal O. A new mouse liver-specific gene, encoding a protein homologous to human antimicrobial peptide hepcidin, is overexpressed during iron overload. J. Biol. Chem. 276 (2001) 7811-7819
-
(2001)
J. Biol. Chem.
, vol.276
, pp. 7811-7819
-
-
Pigeon, C.1
Ilyin, G.2
Courselaud, B.3
Leroyer, P.4
Turlin, B.5
Brissot, P.6
Loreal, O.7
-
46
-
-
0032898369
-
Dual roles for glucokinase in glucose homeostasis as determined by liver and pancreatic beta cell-specific gene knock-outs using Cre recombinase
-
Postic C., Shiota M., Niswender K.D., Jetton T.L., Chen Y., Moates J.M., Shelton K.D., Lindner J., Cherrington A.D., and Magnuson M.A. Dual roles for glucokinase in glucose homeostasis as determined by liver and pancreatic beta cell-specific gene knock-outs using Cre recombinase. J. Biol. Chem. 274 (1999) 305-315
-
(1999)
J. Biol. Chem.
, vol.274
, pp. 305-315
-
-
Postic, C.1
Shiota, M.2
Niswender, K.D.3
Jetton, T.L.4
Chen, Y.5
Moates, J.M.6
Shelton, K.D.7
Lindner, J.8
Cherrington, A.D.9
Magnuson, M.A.10
-
47
-
-
0038037735
-
Regulation of angiogenesis by hypoxia: role of the HIF system
-
Pugh C.W., and Ratcliffe P.J. Regulation of angiogenesis by hypoxia: role of the HIF system. Nat. Med. 9 (2003) 677-684
-
(2003)
Nat. Med.
, vol.9
, pp. 677-684
-
-
Pugh, C.W.1
Ratcliffe, P.J.2
-
48
-
-
34147124264
-
Hypoxia-inducible factor-2 (HIF-2) regulates hepatic erythropoietin in vivo
-
Rankin E.B., Biju M.P., Liu Q., Unger T.L., Rha J., Johnson R.S., Simon M.C., Keith B., and Haase V.H. Hypoxia-inducible factor-2 (HIF-2) regulates hepatic erythropoietin in vivo. J. Clin. Invest. 117 (2007) 1068-1077
-
(2007)
J. Clin. Invest.
, vol.117
, pp. 1068-1077
-
-
Rankin, E.B.1
Biju, M.P.2
Liu, Q.3
Unger, T.L.4
Rha, J.5
Johnson, R.S.6
Simon, M.C.7
Keith, B.8
Haase, V.H.9
-
49
-
-
0006908586
-
Influence of altitude changes on intestinal iron absorption
-
Reynafarje C., and Ramos J. Influence of altitude changes on intestinal iron absorption. J. Lab. Clin. Med. 57 (1961) 848-855
-
(1961)
J. Lab. Clin. Med.
, vol.57
, pp. 848-855
-
-
Reynafarje, C.1
Ramos, J.2
-
50
-
-
33746361251
-
The role of iron regulatory proteins in mammalian iron homeostasis and disease
-
Rouault T.A. The role of iron regulatory proteins in mammalian iron homeostasis and disease. Nat. Chem. Biol. 2 (2006) 406-414
-
(2006)
Nat. Chem. Biol.
, vol.2
, pp. 406-414
-
-
Rouault, T.A.1
-
51
-
-
0142166332
-
Targeting HIF-1 for cancer therapy
-
Semenza G.L. Targeting HIF-1 for cancer therapy. Nat. Rev. Cancer 3 (2003) 721-732
-
(2003)
Nat. Rev. Cancer
, vol.3
, pp. 721-732
-
-
Semenza, G.L.1
-
52
-
-
0026468180
-
A nuclear factor induced by hypoxia via de novo protein synthesis binds to the human erythropoietin gene enhancer at a site required for transcriptional activation
-
Semenza G.L., and Wang G.L. A nuclear factor induced by hypoxia via de novo protein synthesis binds to the human erythropoietin gene enhancer at a site required for transcriptional activation. Mol. Cell. Biol. 12 (1992) 5447-5454
-
(1992)
Mol. Cell. Biol.
, vol.12
, pp. 5447-5454
-
-
Semenza, G.L.1
Wang, G.L.2
-
53
-
-
44649179392
-
Hypoxia-inducible factor augments experimental colitis through an MIF-dependent inflammatory signaling cascade
-
2048.e1-3
-
Shah Y.M., Ito S., Morimura K., Chen C., Yim S.H., Haase V.H., and Gonzalez F.J. Hypoxia-inducible factor augments experimental colitis through an MIF-dependent inflammatory signaling cascade. Gastroenterology 134 (2008) 2036-2048 2048.e1-3
-
(2008)
Gastroenterology
, vol.134
, pp. 2036-2048
-
-
Shah, Y.M.1
Ito, S.2
Morimura, K.3
Chen, C.4
Yim, S.H.5
Haase, V.H.6
Gonzalez, F.J.7
-
54
-
-
0036566143
-
Expression of the two mRNA isoforms of the iron transporter Nramp2/DMTI in mice and function of the iron responsive element
-
Tchernitchko D., Bourgeois M., Martin M.E., and Beaumont C. Expression of the two mRNA isoforms of the iron transporter Nramp2/DMTI in mice and function of the iron responsive element. Biochem. J. 363 (2002) 449-455
-
(2002)
Biochem. J.
, vol.363
, pp. 449-455
-
-
Tchernitchko, D.1
Bourgeois, M.2
Martin, M.E.3
Beaumont, C.4
-
55
-
-
0031020884
-
Endothelial PAS domain protein 1 (EPAS1), a transcription factor selectively expressed in endothelial cells
-
Tian H., McKnight S.L., and Russell D.W. Endothelial PAS domain protein 1 (EPAS1), a transcription factor selectively expressed in endothelial cells. Genes Dev. 11 (1997) 72-82
-
(1997)
Genes Dev.
, vol.11
, pp. 72-82
-
-
Tian, H.1
McKnight, S.L.2
Russell, D.W.3
-
56
-
-
0033777202
-
Conditional disruption of the aryl hydrocarbon receptor nuclear translocator (Arnt) gene leads to loss of target gene induction by the aryl hydrocarbon receptor and hypoxia-inducible factor 1alpha
-
Tomita S., Sinal C.J., Yim S.H., and Gonzalez F.J. Conditional disruption of the aryl hydrocarbon receptor nuclear translocator (Arnt) gene leads to loss of target gene induction by the aryl hydrocarbon receptor and hypoxia-inducible factor 1alpha. Mol. Endocrinol. 14 (2000) 1674-1681
-
(2000)
Mol. Endocrinol.
, vol.14
, pp. 1674-1681
-
-
Tomita, S.1
Sinal, C.J.2
Yim, S.H.3
Gonzalez, F.J.4
-
57
-
-
0141669198
-
Defective brain development in mice lacking the Hif-1alpha gene in neural cells
-
Tomita S., Ueno M., Sakamoto M., Kitahama Y., Ueki M., Maekawa N., Sakamoto H., Gassmann M., Kageyama R., Ueda N., et al. Defective brain development in mice lacking the Hif-1alpha gene in neural cells. Mol. Cell. Biol. 23 (2003) 6739-6749
-
(2003)
Mol. Cell. Biol.
, vol.23
, pp. 6739-6749
-
-
Tomita, S.1
Ueno, M.2
Sakamoto, M.3
Kitahama, Y.4
Ueki, M.5
Maekawa, N.6
Sakamoto, H.7
Gassmann, M.8
Kageyama, R.9
Ueda, N.10
-
58
-
-
33845985236
-
STAT3 mediates hepatic hepcidin expression and its inflammatory stimulation
-
Verga Falzacappa M.V., Vujic Spasic M., Kessler R., Stolte J., Hentze M.W., and Muckenthaler M.U. STAT3 mediates hepatic hepcidin expression and its inflammatory stimulation. Blood 109 (2007) 353-358
-
(2007)
Blood
, vol.109
, pp. 353-358
-
-
Verga Falzacappa, M.V.1
Vujic Spasic, M.2
Kessler, R.3
Stolte, J.4
Hentze, M.W.5
Muckenthaler, M.U.6
-
59
-
-
0027427588
-
Characterization of hypoxia-inducible factor 1 and regulation of DNA binding activity by hypoxia
-
Wang G.L., and Semenza G.L. Characterization of hypoxia-inducible factor 1 and regulation of DNA binding activity by hypoxia. J. Biol. Chem. 268 (1993) 21513-21518
-
(1993)
J. Biol. Chem.
, vol.268
, pp. 21513-21518
-
-
Wang, G.L.1
Semenza, G.L.2
-
60
-
-
0029051439
-
Hypoxia-inducible factor 1 is a basic-helix-loop-helix-PAS heterodimer regulated by cellular O2 tension
-
Wang G.L., Jiang B.H., Rue E.A., and Semenza G.L. Hypoxia-inducible factor 1 is a basic-helix-loop-helix-PAS heterodimer regulated by cellular O2 tension. Proc. Natl. Acad. Sci. USA 92 (1995) 5510-5514
-
(1995)
Proc. Natl. Acad. Sci. USA
, vol.92
, pp. 5510-5514
-
-
Wang, G.L.1
Jiang, B.H.2
Rue, E.A.3
Semenza, G.L.4
-
61
-
-
33644876815
-
A role of SMAD4 in iron metabolism through the positive regulation of hepcidin expression
-
Wang R.H., Li C., Xu X., Zheng Y., Xiao C., Zerfas P., Cooperman S., Eckhaus M., Rouault T., Mishra L., and Deng C.X. A role of SMAD4 in iron metabolism through the positive regulation of hepcidin expression. Cell Metab. 2 (2005) 399-409
-
(2005)
Cell Metab.
, vol.2
, pp. 399-409
-
-
Wang, R.H.1
Li, C.2
Xu, X.3
Zheng, Y.4
Xiao, C.5
Zerfas, P.6
Cooperman, S.7
Eckhaus, M.8
Rouault, T.9
Mishra, L.10
Deng, C.X.11
-
62
-
-
0036845376
-
A possible link between hepcidin and regulation of dietary iron absorption
-
Wessling-Resnick M. A possible link between hepcidin and regulation of dietary iron absorption. Nutr. Rev. 60 (2002) 371-374
-
(2002)
Nutr. Rev.
, vol.60
, pp. 371-374
-
-
Wessling-Resnick, M.1
-
63
-
-
46749158788
-
Hemojuvelin regulates hepcidin expression via a selective subset of BMP ligands and receptors independently of neogenin
-
Xia Y., Babitt J.L., Sidis Y., Chung R.T., and Lin H.Y. Hemojuvelin regulates hepcidin expression via a selective subset of BMP ligands and receptors independently of neogenin. Blood 111 (2008) 5195-5204
-
(2008)
Blood
, vol.111
, pp. 5195-5204
-
-
Xia, Y.1
Babitt, J.L.2
Sidis, Y.3
Chung, R.T.4
Lin, H.Y.5
-
64
-
-
0001376313
-
HFE gene knockout produces mouse model of hereditary hemochromatosis
-
Zhou X.Y., Tomatsu S., Fleming R.E., Parkkila S., Waheed A., Jiang J., Fei Y., Brunt E.M., Ruddy D.A., Prass C.E., et al. HFE gene knockout produces mouse model of hereditary hemochromatosis. Proc. Natl. Acad. Sci. USA 95 (1998) 2492-2497
-
(1998)
Proc. Natl. Acad. Sci. USA
, vol.95
, pp. 2492-2497
-
-
Zhou, X.Y.1
Tomatsu, S.2
Fleming, R.E.3
Parkkila, S.4
Waheed, A.5
Jiang, J.6
Fei, Y.7
Brunt, E.M.8
Ruddy, D.A.9
Prass, C.E.10
-
65
-
-
0142126132
-
Mechanisms of iron mediated regulation of the duodenal iron transporters divalent metal transporter 1 and ferroportin 1
-
Zoller H., Theurl I., Koch R., Kaser A., and Weiss G. Mechanisms of iron mediated regulation of the duodenal iron transporters divalent metal transporter 1 and ferroportin 1. Blood Cells Mol. Dis. 29 (2002) 488-497
-
(2002)
Blood Cells Mol. Dis.
, vol.29
, pp. 488-497
-
-
Zoller, H.1
Theurl, I.2
Koch, R.3
Kaser, A.4
Weiss, G.5
|