Increased expression of transferrin receptors and iron in amoeboid microglial cells in postnatal rats following an exposure to hypoxia

Neuroscience Letters

Volumn 262, Issue 3, 1999, Pages 183-186

  Kaur, C ^a   Ling, E A ^a  

^a NATIONAL UNIVERSITY OF SINGAPORE   (Singapore)

Author keywords

Amoeboid microglial cells; Hypoxia; Iron; Rat brain; Transferrin receptors

Indexed keywords

IRON; MONOCLONAL ANTIBODY; TRANSFERRIN RECEPTOR;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; CORPUS CALLOSUM; HYPOXIA; MICROGLIA; NEWBORN; NONHUMAN; OLIGODENDROGLIA; PRIORITY JOURNAL; RAT;

AGING; ANIMALS; ANIMALS, NEWBORN; ANOXIA; ANTIBODIES, MONOCLONAL; BRAIN; GENE EXPRESSION REGULATION, DEVELOPMENTAL; IMMUNOHISTOCHEMISTRY; IRON; MICROGLIA; RATS; RECEPTORS, TRANSFERRIN;

EID: 0033548410     PISSN: 03043940     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0304-3940(99)00075-0     Document Type: Article

References (19)

1. Adcock L.M., Yamashita Y., Goddard-Finegold J., Smith C.V. Cerebral hypoxia-ischemia increases microsomal iron in newborn piglets. Metab. Brain Res. 11:1996;359-367.
2. Aisen P., Listowski I. Iron transport and storage proteins. Annu. Rev. Biochem. 49:1980;357-393.
3. Connor J.R., Pavlick G., Karli D., Menzies S.L., Palmer C. A histochemical study of iron positive cells in the developing rat brain. J. Comp. Neurol. 355:1995;111-123.
4. Dietrich R.B., Bradley W.G. Iron accumulation in the basal ganglia following severe ischemic-anoxic insults in children. Radiology. 68:1998;203-206.
5. Gutteridge J.M. Iron and oxygen radicals in brain. Ann. Neurol. Suppl. 32:1992;S16-S21.
6. Hamilton T.A., Weid J.E., Adams D.O. Expression of the transferrin receptor in murine peritoneal macrophages is modulated in the different stages of activation. J. Immunobiol. 132:1984;2285-2290.
7. Hill J.M., Switzer R.C. The regional distribution and cellular localization of iron in the rat brain. Neuroscience. 11:1984;595-603.
8. Kaur C., Ling E.A. Transient expression of transferrin receptors and localisation of iron in amoeboid microglia in postnatal rats. J. Anat. 186:1995;165-173.
9. Kaur C., Ling E.A., Wong W.C. Labelling of amoeboid microglial cells in rats of various ages following an intravenous injection of horseradish peroxidase. Acta Anat. 125:1986;132-137.
10. Koshino T., Tsuyuki Y., Yokota A., Tsunoda Y., Araki T., Asano G. An ultrastructural investigation of changes in hypoxia in the subependymal layer of newborn rabbit. Nippon Ika Daigaku Zasshi. S7:1990;55-63.
11. Laskey J., Webb J., Shulman H.M., Ponka P. Evidence that transferrin supports cell proliferation by supplying iron for DNA synthesis. Exp. Cell Res. 176:1988;87-95.
12. Ling E.A., Wong W.C. Origin and nature of ramified and amoeboid microglia: a historical review and current concepts. Glia. 7:1993;9-18.
13. Ling E.A., Kaur C., Wong W.C. Immunocytochemical localization of CR3 complement receptors with OX-42 in the amoeboid microglia in postnatal rats. Anat. Embryol. 182:1990;481-486.
14. Lu J., Kaur C., Ling E.A. Expression and upregulation of transferrin receptors and iron uptake in the epiplexus cells of different aged rats injected with lipopolysaccharide and interferon-gamma. J. Anat. 187:1995;601-611.
15. Orita T., Akimura T., Nishizaki T., Kamiryo T., Ikeyama Y., Aoki H., Ito H. Transferrin receptors in injured brain. Acta Neuropathol. 79:1990;686-688.
16. Paller M.S., Hedlund B.E. Extracellular iron chelators protect kidney cells from hypoxia/reoxygenation. Free Rad. Biol. Med. 17:1994;597-603.
17. Qi Y., Jamindar T.M., Dawson G. Hypoxia alters iron homeostasis and induces ferritin synthesis in oligodendrocytes. J. Neurochem. 64:1995;2458-2464.
18. Rice J.E., Vannuci R.C., Brierley J.B. The influence of immaturity on hypoxic-ischemic brain damage. Ann. Neurol. 9:1981;131-141.
19. Robinson A.P., White T.M., Mason D.W. Macrophage heterogeneity in the rat as delineated by two monoclonal antibodies MRC OX-41 and MRC OX-42, the latter recognizing complement receptor type 3. Immunobiology. 57:1986;239-247.