Iron-chelating activity of tetracyclines and its impact on the susceptibility of Actinobacillus actinomycetemcomitans to these antibiotics

Antimicrobial Agents and Chemotherapy

Volumn 44, Issue 3, 2000, Pages 763-766

  Grenier, Daniel ^a   Huot, Marie Pierre ^a   Mayrand, Denis ^a  

^a NONE

Author keywords

[No Author keywords available]

Indexed keywords

CLINDAMYCIN; DOXYCYCLINE; GENTAMICIN; METRONIDAZOLE; MINOCYCLINE; PENICILLIN G; SPIRAMYCIN; TETRACYCLINE;

ACTINOBACILLUS ACTINOMYCETEMCOMITANS; ANTIBACTERIAL ACTIVITY; ANTIBIOTIC SENSITIVITY; ARTICLE; BACTERIUM CULTURE; DRUG POTENCY; IRON CHELATION; MINIMUM INHIBITORY CONCENTRATION; NONHUMAN; PRIORITY JOURNAL;

ACTINOBACILLUS ACTINOMYCETEMCOMITANS; ANTI-BACTERIAL AGENTS; CULTURE MEDIA; HUMANS; IRON; IRON CHELATING AGENTS; MICROBIAL SENSITIVITY TESTS; PERIODONTAL DISEASES; TETRACYCLINES;

EID: 0033996306     PISSN: 00664804     EISSN: None     Source Type: Journal    
DOI: 10.1128/AAC.44.3.763-766.2000     Document Type: Article

References (29)

1. Arnow, L. E. 1937. Colorimetric determination of the compounds of 3,4-dihydroxyphenylalanine-tyrosine mixture. J. Biol. Chem. 118:531-537.
2. Boelaert, J. R. 1996. Iron and infection. Acta Clin. Belg. 51:213-220.
3. Csaky, T. Z. 1948. On the estimation of bound hydroxylamine in biological materials. Acta Chem. Scand. 2:450-454.
4. Emery, T. 1971. Role of ferrichrome as a ferric ionophore in Ustilago sphaerogena. Biochemistry 10:1483-1488.
5. Golub, L. M., H. M. Lee, G. Lehrer, A. Nemiroff, T. F. McNamara, R. Kaplan, and N. S. Ramamurthy. 1983. Minocycline reduces gingival collagenolytic activity during diabetes: preliminary observations and a proposed new mechanism of action. J. Periodontal Res. 18:516-526.
6. Golub, L. M., N. S. Ramamurthy, T. F. McNamara, R. A Greenwald, and B. R Rifkin. 1991. Tetracyclines inhibit connective tissue breakdown: new therapeutic implications for an old family of drugs. Crit. Rev. Oral Biol. Med. 2:297-322.
7. Golub, L. M., M. Wolff, S. Roberts, H. M. Lee, M. Leung, and G. S. Payonk. 1994. Treating periodontal diseases by blocking tissue destructive enzymes. J. Am. Dent. Assoc. 125:163-171.
8. Golub, L. M., T. Sorsa, H. M. Lee, S. Ciancio, D. Sorbi, and N. Ramamurthy. 1995. Doxycycline inhibits neutrophil (PMN)-type matrix metalloproteinases in human adult periodontitis gingiva. J. Clin. Periodontol. 21:1-9.
9. Greenwald, R. A., L. M. Golub, B. Lavietes, N. S. Ramamurthy, B. Guber, and R. S. Laskin. 1987. Tetracyclines inhibit human synovial collagenase in vivo and in vitro. J. Rheumatol. 14:28-32.
10. Haffajee, A. D., and S. S. Socransky. 1994. Microbial etiological agents of destructive periodontal diseases. Periodontol. 2000 5:78-111.
11. Makey, D. G., and U. S. Seal. 1976. The detection of four molecular forms of human transferring during the iron binding process. Biochim. Biophys. Acta 453:250-256.
12. Meyer, D. H., and P. M. Fives-Taylor. 1997. The role of Actinobacillus actinomycetemcomitans in the pathogenesis of periodontal disease. Trends Microbiol. 5:224-228.
13. Miles, A A., and J. P. Maskell. 1985. The antagonism of tetracyclines and ferric iron in vivo. J. Med. Microbiol. 20:17-26.
14. Miles, A. A., and J. P. Maskell. 1986. The neutralization of antibiotic action by metallic cations and iron chelators. J. Antimicrob. Chemother. 17:481-487.
15. Miyake, Y., K. Tsuruda, K. Okuda, Widomati, Y. Iwamoto, and H. Suginaka. 1995. In vitro activity of tetracyclines, macrolides, quinolones, clindamycin and metronidazole against periodontopathic bacteria. J. Periodontal Res. 30: 290-293.
16. Mukherjee, S. 1985. The role of crevicular fluid iron in periodontal disease. J. Periodontol. 56:22-27.
17. Olsvik, B., B. F. Hansen, F. C. Tenover, and L. Olsen. 1995. Tetracycline-resistant microorganisms recovered from patients with refractory periodontal disease. J. Clin. Periodontol. 22:391-396.
18. Otto, B. R., A. M. J. J. Verweij-van Vught, and D. M. MacLaren. 1992. Transferrins and heme-compounds as iron sources for pathogenic bacteria. Crit. Rev. Microbiol. 18:217-233.
19. Rajagopalan, S., X. P. Mang, S. Ramasamy, D. G. Harrison, and Z. S. Galis. 1996. Reactive oxygen species produced by macrophage-derived foam cells regulate the activity of vascular matrix metalloproteinases in vitro. J. Clin. Investig. 98:2572-2579.
20. Riaz, M., and N. Pilpel. 1984. Complexation of tetracyclines with metal ions in relation to photosensitization. J. Pharm. Pharmacol. 36:153-156.
21. Rifkin, B. R., A. T. Vernillo, and L. M. Golub. 1993. Blocking periodontal disease progression by inhibiting tissue-destructive enzymes: a potential therapeutic role for tetracyclines and their chemically-modified analogs. J. Periodontol. 64:819-827.
22. Schwyn, B., and J. B. Neilands. 1987. Universal chemical assay for the detection and determination of siderophores. Anal. Biochem. 160:47-56.
23. Seymour, R. A., and P. A. Heasman. 1995. Tetracyclines in the management of periodontal diseases. J. Clin. Periodontol. 22:22-35.
24. Wang, H.-L., H. Greenwell, and N. F. Bissada. 1990. Crevicular fluid iron changes in treated and untreated periodontically diseased sites. Oral Surg. Oral Med. Oral Pathol. 69:450-456.
25. Weinberg, E. D. 1957. The mutual effects of antimicrobial compounds and metallic cations. Bacteriol. Rev. 21:46-68.
26. Weinberg, E. D. 1971. Roles of iron in host-parasite interactions. J. Infect. Dis. 24:401-410.
27. Weinberg, E. D. 1995. Acquisition of iron and other nutrients in vivo, p. 79-93. In S. A. Roth et al. (ed.), Virulence mechanisms of bacterial pathogens, 2nd ed. American Society for Microbiology, Washington, D.C.
28. Weiss, S. J. 1989. Tissue destruction by neutrophils. N. Engl. J. Med. 320: 365-376.
29. Wooldridge, K. G., and P. H. Williams. 1993. Iron uptake mechanisms of pathogenic bacteria. FEMS Microbiol. Rev. 12:325-348.