Brain Iron Metabolism

Seminars in Pediatric Neurology

Volumn 13, Issue 3, 2006, Pages 142-148

  Rouault, Tracey A ^a   Cooperman, Sharon ^a  

^a EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH AND HUMAN DEVELOPMENT   (United States)

Author keywords

blood brain barrier; ferroportin; GPI linked ceruloplasmin; Parkinson disease; transferrin receptor

Indexed keywords

IRON;

BLOOD BRAIN BARRIER; BRAIN METABOLISM; CENTRAL NERVOUS SYSTEM; DISEASE ASSOCIATION; IRON DEFICIENCY; IRON METABOLISM; IRON TRANSPORT; NERVE DEGENERATION; NEUROLOGIC DISEASE; NONHUMAN; PATHOLOGY; REVIEW;

ANIMALS; BLOOD-BRAIN BARRIER; BRAIN; CENTRAL NERVOUS SYSTEM; HUMANS; IRON; IRON METABOLISM DISORDERS; NERVE DEGENERATION;

EID: 33750709690     PISSN: 10719091     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.spen.2006.08.002     Document Type: Review

References (86)

1. Andrews N.C. Metal transporters and disease. Curr Opin Chem Biol 6 (2002) 181-186
2. Gunshin H., Mackenzie B., Berger U.V., et al. Cloning and characterization of a mammalian proton-coupled metal-ion transporter. Nature 388 (1997) 482-488
3. Fleming M.D., Trenor C.C., Su M.A., et al. Microcytic anaemia mice have a mutation in Nramp2, a candidate iron transporter gene. Nat Genet 16 (1997) 383-386
4. McKie A.T., Barrow D., Latunde-Dada G.O., et al. An iron-regulated ferric reductase associated with the absorption of dietary iron. Science 291 (2001) 1755-1759
5. Donovan A., Brownlie A., Zhou Y., et al. Positional cloning of zebrafish ferroportin1 identifies a conserved vertebrate iron exporter. Nature 403 (2000) 776-781
6. McKie A.T., Marciani P., Rolfs A., et al. A novel duodenal iron-regulated transporter, IREG1, implicated in the basolateral transfer of iron to the circulation. Mol Cell 5 (2000) 299-309
7. Abboud S., and Haile D.J. A novel mammalian iron-regulated protein involved in intracellular iron metabolism. J Biol Chem 275 (2000) 19906-19912
8. Vulpe C.D., Kuo Y.M., Murphy T.L., et al. Hephaestin, a ceruloplasmin homologue implicated in intestinal iron transport, is defective in the sla mouse. Nat Genet 21 (1999) 195-199
9. Shayeghi M., Latunde-Dada G.O., Oakhill J.S., et al. Identification of an intestinal heme transporter. Cell 122 (2005) 789-801
10. Quigley J.G., Yang Z., Worthington M.T., et al. Identification of a human heme exporter that is essential for erythropoiesis. Cell 118 (2004) 757-766
11. Latunde-Dada G.O., Simpson R.J., and McKie A.T. Recent advances in mammalian haem transport. Trends Biochem Sci 31 (2006) 182-188
12. Rouault T.A. The intestinal heme transporter revealed. Cell 122 (2005) 649-651
13. Aisen P. Transferrin, the transferrin receptor, and the uptake of iron by cells. Met Ions Biol Syst 35 (1998) 585-631
14. Aisen P. Transferrin receptor 1. Int J Biochem Cell Biol 36 (2004) 2137-2143
15. Ohgami R.S., Campagna D.R., Greer E.L., et al. Identification of a ferrireductase required for efficient transferrin-dependent iron uptake in erythroid cells. Nat Genet 37 (2005) 1264-1269
16. Napier I., Ponka P., and Richardson D.R. Iron trafficking in the mitochondrion: novel pathways revealed by disease. Blood 105 (2005) 1867-1874
17. Pantopoulos K. Iron metabolism and the IRE/IRP regulatory system: An update. Ann N Y Acad Sci 1012 (2004) 1-13
18. Hentze M.W., Muckenthaler M.U., and Andrews N.C. Balancing acts: Molecular control of mammalian iron metabolism. Cell 117 (2004) 285-297
19. Rouault T.A. The role of iron regulatory proteins in mammalian iron homeostasis and disease. Nat Chem Biol 2 (2006) 406-414
20. Donovan A., Lima C.A., Pinkus J.L., et al. The iron exporter ferroportin/Slc40a1 is essential for iron homeostasis. Cell Metab 1 (2005) 191-200
21. Nemeth E., Tuttle M.S., Powelson J., et al. Hepcidin regulates cellular iron efflux by binding to ferroportin and inducing its internalization. Science 306 (2004) 2090-2093
22. Ganz T., and Nemeth E. Iron imports.IV. Hepcidin and regulation of body iron metabolism. Am J Physiol Gastrointest Liver Physiol 290 (2006) G199-G203
23. Kawabata H., Yang R., Hirama T., et al. Molecular cloning of transferrin receptor 2. A new member of the transferrin receptor-like family. J Biol Chem 274 (1999) 20826-20832
24. Fleming R.E., and Britton R.S. Iron Imports. VI. HFE and regulation of intestinal iron absorption. Am J Physiol Gastrointest Liver Physiol 290 (2006) G590-G594
25. Papanikolaou G., Samuels M.E., Ludwig E.H., et al. Mutations in HFE2 cause iron overload in chromosome 1q-linked juvenile hemochromatosis. Nat Genet 36 (2004) 77-82
26. Babitt J.L., Huang F.M., Wrighting D.M., et al. Bone morphogenetic protein signaling by hemojuvelin regulates hepcidin expression. Nat Genet 38 (2006) 531-539
27. Beutler E. Hemochromatosis: Genetics and pathophysiology. Annu Rev Med 57 (2006) 331-347
28. Wang R.H., Li C., Xu X., et al. A role of SMAD4 in iron metabolism through the positive regulation of hepcidin expression. Cell Metab 2 (2005) 399-409
29. Abbott N.J., Ronnback L., and Hansson E. Astrocyte-endothelial interactions at the blood-brain barrier. Nat Rev Neurosci 7 (2006) 41-53
30. Lai C.H., and Kuo K.H. The critical component to establish in vitro BBB model: Pericyte. Brain Res Brain Res Rev 50 (2005) 258-265
31. Hellstrom M., Gerhardt H., Kalen M., et al. Lack of pericytes leads to endothelial hyperplasia and abnormal vascular morphogenesis. J Cell Biol 153 (2001) 543-553
32. Bradbury M.W. Transport of iron in the blood-brain-cerebrospinal fluid system. J Neurochem 69 (1997) 443-454
33. Moos T., and Morgan E.H. Transferrin and transferrin receptor function in brain barrier systems. Cell Mol Neurobiol 20 (2000) 77-95
34. Enerson B.E., and Drewes L.R. The rat blood-brain barrier transcriptome. J Cereb Blood Flow Metab 26 (2005) 959-973
35. Burdo J.R., Antonetti D.A., Wolpert E.B., et al. Mechanisms and regulation of transferrin and iron transport in a model blood-brain barrier system. Neuroscience 121 (2003) 883-890
36. Beard J.L., Wiesinger J.A., Li N., et al. Brain iron uptake in hypotransferrinemic mice: Influence of systemic iron status. J Neurosci Res 79 (2005) 254-261
37. Burdo J.R., Menzies S.L., Simpson I.A., et al. Distribution of divalent metal transporter 1 and metal transport protein 1 in the normal and Belgrade rat. J Neurosci Res 66 (2001) 1198-1207
38. Moos T., and Morgan E.H. The significance of the mutated divalent metal transporter (DMT1) on iron transport into the Belgrade rat brain. J Neurochem 88 (2004) 233-245
39. Wu L.J., Leenders A.G., Cooperman S., et al. Expression of the iron transporter ferroportin in synaptic vesicles and the blood-brain barrier. Brain Res 1001 (2004) 108-117
40. Jeong S.Y., and David S. Glycosylphosphatidylinositol-anchored ceruloplasmin is required for iron efflux from cells in the central nervous system. J Biol Chem 278 (2003) 27144-27148
41. Oide T., Yoshida K., Kaneko K., et al. Iron overload and antioxidative role of perivascular astrocytes in aceruloplasminemia. Neuropathol Appl Neurobiol 32 (2006) 170-176
42. Brightman M.W., and Kaya M. Permeable endothelium and the interstitial space of brain. Cell Mol Neurobiol 20 (2000) 111-130
43. Takeda A., Devenyi A., and Connor J.R. Evidence for non-transferrin-mediated uptake and release of iron and manganese in glial cell cultures from hypotransferrinemic mice. J Neurosci Res 51 (1998) 454-462
44. Erikson K.M., and Aschner M. Increased manganese uptake by primary astrocyte cultures with altered iron status is mediated primarily by divalent metal transporter. Neurotoxicology 27 (2006) 125-130
45. Abbott N.J. Dynamics of CNS barriers: Evolution, differentiation, and modulation. Cell Mol Neurobiol 25 (2005) 5-23
46. Connor J.R., and Menzies S.L. Cellular management of iron in the brain. J Neurol Sci 134 Suppl (1995) 33-44
47. Moos T. Immunohistochemical localization of intraneuronal transferrin receptor immunoreactivity in the adult mouse central nervous system. J Comp Neurol 375 (1996) 675-692
48. Hoepken H.H., Korten T., Robinson S.R., et al. Iron accumulation, iron-mediated toxicity and altered levels of ferritin and transferrin receptor in cultured astrocytes during incubation with ferric ammonium citrate. J Neurochem 88 (2004) 1194-1202
49. Dickinson T.K., and Connor J.R. Immunohistochemical analysis of transferrin receptor: Regional and cellular distribution in the hypotransferrinemic (hpx) mouse brain. Brain Res 801 (1998) 171-181
50. Kaur C., and Ling E.A. Increased expression of transferrin receptors and iron in amoeboid microglial cells in postnatal rats following an exposure to hypoxia. Neurosci Lett 262 (1999) 183-186
51. Hahn P., Qian Y., Dentchev T., et al. Disruption of ceruloplasmin and hephaestin in mice causes retinal iron overload and retinal degeneration with features of age-related macular degeneration. Proc Natl Acad Sci U S A 101 (2004) 13850-13855
52. Rodriguez Martinez A., Niemela O., and Parkkila S. Hepatic and extrahepatic expression of the new iron regulatory protein hemojuvelin. Haematologica 89 (2004) 1441-1445
53. Golub M.S., Germann S.L., Araiza R.S., et al. Movement disorders in the Hfe knockout mouse. Nutr Neurosci 8 (2005) 239-244
54. Dekker M.C., Giesbergen P.C., Njajou O.T., et al. Mutations in the hemochromatosis gene (HFE), Parkinson's disease and parkinsonism. Neurosci Lett 348 (2003) 117-119
55. Costello D.J., Walsh S.L., Harrington H.J., et al. Concurrent hereditary haemochromatosis and idiopathic Parkinson's disease. J Neurol Neurosurg Psychiatry 75 (2004) 631-633
56. Park C.H., Valore E.V., Waring A.J., et al. Hepcidin, a urinary antimicrobial peptide synthesized in the liver. J Biol Chem 276 (2001) 7806-7810
57. Nicolas G., Chauvet C., Viatte L., et al. The gene encoding the iron regulatory peptide hepcidin is regulated by anemia, hypoxia, and inflammation. J Clin Invest 110 (2002) 1037-1044
58. Cardarelli G., and Anatra G.M. Hepcidin: A key peptide in iron metabolism. Minerva Med 94 (2003) 135-139
59. Moos T., and Morgan E.H. Evidence for low molecular weight, non-transferrin-bound iron in rat brain and cerebrospinal fluid. J Neurosci Res 54 (1998) 486-494
60. Bennett M.V., Contreras J.E., Bukauskas F.F., et al. New roles for astrocytes: gap junction hemichannels have something to communicate. Trends Neurosci 26 (2003) 610-617
61. Sloot W.N., and Gramsbergen J.B. Axonal transport of manganese and its relevance to selective neurotoxicity in the rat basal ganglia. Brain Res 657 (1994) 124-132
62. Tjalve H., and Henriksson J. Uptake of metals in the brain via olfactory pathways. Neurotoxicology 20 (1999) 181-195
63. Rao D.B., Wong B.A., McManus B.E., et al. Inhaled iron, unlike manganese, is not transported to the rat brain via the olfactory pathway. Toxicol Appl Pharmacol 193 (2003) 116-126
64. Hahn P., Dentchev T., Qian Y., et al. Immunolocalization and regulation of iron handling proteins ferritin and ferroportin in the retina. Mol Vis 10 (2004) 598-607
65. Dentchev T., Hahn P., and Dunaief J.L. Strong labeling for iron and the iron-handling proteins ferritin and ferroportin in the photoreceptor layer in age-related macular degeneration. Arch Ophthalmol 123 (2005) 1745-1746
66. Zhang P., Land W., Lee S., et al. Electron tomography of degenerating neurons in mice with abnormal regulation of iron metabolism. J Struct Biol 150 (2005) 144-153
67. Mackenzie B., Ujwal M.L., Change M.H., Romero M.F., and Hediger M.A. Divalent metal-ion transporter DMT1 mediates both H+-coupled Fe2+ transport and uncoupled fluxes. Pflugers Arch 451 (2006) 544-558
68. Dwork A.J., Lawler G., Zybert P.A., et al. An autoradiographic study of the uptake and distribution of iron by the brain of the young rat. Brain Res 518 (1990) 31-39
69. Dwork A.J. Effects of diet and development upon the uptake and distribution of cerebral iron. J Neurol Sci 134 Suppl (1995) 45-51
70. Malecki E.A., Cook B.M., Devenyi A.G., et al. Transferrin is required for normal distribution of 59Fe and 54Mn in mouse brain. J Neurol Sci 170 (1999) 112-118
71. de Arriba Zerpa G.A., Saleh M.C., Fernandez P.M., et al. Alternative splicing prevents transferrin secretion during differentiation of a human oligodendrocyte cell line. J Neurosci Res 61 (2000) 388-395
72. Bartzokis G., Tishler T.A., Shin I.S., et al. Brain ferritin iron as a risk factor for age at onset in neurodegenerative diseases. Ann N Y Acad Sci 1012 (2004) 224-236
73. Zecca L., Youdim M.B., Riederer P., et al. Iron, brain ageing and neurodegenerative disorders. Nat Rev Neurosci 5 (2004) 863-873
74. Beard J.L., Felt B., Schallert T., et al. Moderate iron deficiency in infancy: Biology and behavior in young rats. Behav Brain Res 170 (2006) 224-232
75. Xu X., Pin S., Gathinji M., et al. Aceruloplasminemia: an inherited neurodegenerative disease with impairment of iron homeostasis. Ann N Y Acad Sci 1012 (2004) 299-305
76. Gregory A., and Hayflick S.J. Neurodegeneration with brain iron accumulation. Folia Neuropathol 43 (2005) 286-296
77. Curtis A.R., Fey C., Morris C.M., et al. Mutation in the gene encoding ferritin light polypeptide causes dominant adult-onset basal ganglia disease. Nat Genet 28 (2001) 350-354
78. LaVaute T., Smith S., Cooperman S., et al. Targeted deletion of iron regulatory protein 2 causes misregulation of iron metabolism and neurodegenerative disease in mice. Nat Genet 27 (2001) 209-214
79. Cooperman S.S., Meyron-Holtz E.G., Olivierre-Wilson H., et al. Microcytic anemia, erythropoietic protoporphyria, and neurodegeneration in mice with targeted deletion of iron-regulatory protein 2. Blood 106 (2005) 1084-1091
80. Galy B., Ferring D., Minana B., et al. Altered body iron distribution and microcytosis in mice deficient in iron regulatory protein 2 (IRP2). Blood 106 (2005) 2580-2589
81. Frantom P.A., Seravalli J., Ragsdale S.W., et al. Reduction and oxidation of the active site iron in tyrosine hydroxylase: Kinetics and specificity. Biochemistry 45 (2006) 2372-2379
82. Perry T.L., Norman M.G., Yong V.W., et al. Hallervorden-Spatz disease: Cysteine accumulation and cysteine dioxygenase deficiency in the globus pallidus. Ann Neurol 18 (1985) 482-489
83. Beard J.L., Erikson K.M., and Jones B.C. Neurobehavioral analysis of developmental iron deficiency in rats. Behav Brain Res 134 (2002) 517-524
84. Levenson C.W., Cutler R.G., Ladenheim B., et al. Role of dietary iron restriction in a mouse model of Parkinson's disease. Exp Neurol 190 (2004) 506-514
85. Leapman R.D. Detecting single atoms of calcium and iron in biological structures by electron energy-loss spectrum-imaging. J Microsc 210 (2003) 5-15
86. Francis K., Van Beek J., Canova C., et al. Innate immunity and brain inflammation: the key role of complement. Expert Rev Mol Med 2003 (2003) 1-19