Targeted deletion of the gene encoding iron regulatory protein-2 causes misregulation of iron metabolism and neurodegenerative disease in mice

Nature Genetics

Volumn 27, Issue 2, 2001, Pages 209-214

  LaVaute, Timothy ^a   Smith, Sophia ^a   Cooperman, Sharon ^a   Iwai, Kazuhiro ^a   Land, William ^a   Meyron Holtz, Esther ^a   Drake, Steven K ^a   Miller, Georgina ^b   Abu Asab, Mones ^c   Tsokos, Maria ^c   Switzer III, Robert ^d   Grinberg, Alexander ^a   Love, Paul ^a   Tresser, Nancy ^e   Rouault, Tracey A ^a  

^a EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH AND HUMAN DEVELOPMENT   (United States)

^b NATIONAL INSTITUTES OF HEALTH   (United States)

^c NATIONAL CANCER INSTITUTE   (United States)

^d NeuroScience Associates   (United States)

^e National Institute for Neurologic Diseases and Stroke   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

FERRIC ION; FERRITIN; IRON REGULATORY FACTOR; TRANSFERRIN RECEPTOR;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BRAIN; DEGENERATIVE DISEASE; EMBRYO; GENE DELETION; GENE EXPRESSION REGULATION; INTESTINE MUCOSA; IRON METABOLISM; IRON OVERLOAD; MOTOR DYSFUNCTION; MOUSE; NERVE CELL; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROTEIN BINDING;

ANIMALS; CEREBELLUM; DUODENUM; FERRITINS; GENE DELETION; INTESTINAL MUCOSA; IRON; IRON REGULATORY PROTEIN 1; IRON REGULATORY PROTEIN 2; IRON-REGULATORY PROTEINS; IRON-SULFUR PROTEINS; MICE; MICE, MUTANT STRAINS; MOLECULAR SEQUENCE DATA; MOVEMENT DISORDERS; NEURODEGENERATIVE DISEASES; NEURONS; OLIGODENDROGLIA; PURKINJE CELLS; PUTAMEN; RESPONSE ELEMENTS; RNA-BINDING PROTEINS; THALAMUS; UBIQUITINS;

ANIMALIA; ATAXIA; MAMMALIA;

EID: 0035138456     PISSN: 10614036     EISSN: None     Source Type: Journal    
DOI: 10.1038/84859     Document Type: Article

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