Evidence for low molecular weight, non-transferrin-bound iron in rat brain and cerebrospinal fluid

Journal of Neuroscience Research

Volumn 54, Issue 4, 1998, Pages 486-494

  Moos, Torben ^a   Morgan, Evan H ^b  

^a UNIVERSITY OF COPENHAGEN   (Denmark)

^b UNIVERSITY OF WESTERN AUSTRALIA   (Australia)

Author keywords

Blood brain barrier; Choroid plexus; Interstitial fluid; Transferrin receptor; Uptake

Indexed keywords

DEFEROXAMINE; IRON; NITRILOTRIACETIC ACID; TRANSFERRIN;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BLOOD BRAIN BARRIER; CEREBROSPINAL FLUID; CHOROID PLEXUS; CONTROLLED STUDY; ENDOCYTOSIS; INTERSTITIAL FLUID; IRON TRANSPORT; MALE; NONHUMAN; PRIORITY JOURNAL; RAT; TRANSCYTOSIS;

AGING; ANIMALS; BINDING SITES; BIOLOGICAL TRANSPORT; BLOOD-BRAIN BARRIER; BODY WEIGHT; BRAIN; DEFEROXAMINE; FERRITINS; IRON; MALE; MICROPORE FILTERS; MOLECULAR WEIGHT; NITRILOTRIACETIC ACID; ORGAN SIZE; PRECIPITIN TESTS; RATS; RATS, WISTAR; TRANSFERRIN;

EID: 0032533743     PISSN: 03604012     EISSN: None     Source Type: Journal    
DOI: 10.1002/(SICI)1097-4547(19981115)54:4<486::AID-JNR6>3.0.CO;2-I     Document Type: Article

References (34)

1. Bloch B, Popovici T, Levin MJ, Tuil D, Kahn A (1985): Transferrin gene expression visualized in oligodendrocytes of the rat brain by using in situ hybridization and immunocytochemistry. Proc Natl Acad Sci USA 82:6706-6710.
2. Bloch B, Popovici T, Chouham S, Levin MJ, Tuil D, Kahn A (1987): Transferrin gene expression in choroid plexus of the adult rat brain. Brain Res Bull 18:573-576.
3. Bradbury MWB (1997): Transport of iron in the blood-brain-cerebrospinal fluid system. J Neurochem 69:443-454.
4. Broadwell RD, Baker-Cairns BJ, Frieden PM, Oliver C, Villegas JC (1996): Transcytosis of protein through the mammalian cerebral epithelium and endothelium. Exp Neurol 142:47-65.
5. Connor JR, Menzies SL (1996): Relationship of iron to oligodendrocytes and myelination. Glia 17:83-93.
6. Connor JR, Boeshore KL, Benkovic SA, Menzies SL (1994): Isoforms of ferritin have a specific cellular distribution in the brain. J Neurosci Res 37:461-465.
7. Crowe A, Morgan EH (1992): Iron and transferrin uptake by brain and cerebrospinal fluid in the rat. Brain Res 592:8-16.
8. 131I across the blood-brain barrier. J Physiol 233:327-347.
9. Descamps L, Dehouck M-P, Torpier G, Cecchelli R (1996): Receptor-mediated transcytosis of transferrin through blood-brain barrier endothelial cells. Am J Physiol 270:H1149-H1158.
10. Fishman JB, Rubin JB, Handrahan JV, Connor JR, Fine RE (1987): Receptor-mediated transcytosis of transferrin across the blood-brain barrier. J Neurosci Res 18:299-304.
11. Giometto B, Bozza F, Argentiero V, Gallo P, Pagni S, Grazia Piccinno M, Tavolato B (1990): Transferrin receptors in the rat central nervous system. J Neurol Sci 98:81-90.
12. Graeber MB, Raivich G, Kreutzberg GW (1989): Increase of transferrin receptors and iron uptake in regenerating motor neurons. J Neurosci Res 23:342-345.
13. Huebers H, Huebers E, Rummel W, Crichton RR (1976): Isolation and characterization of iron-binding proteins from rat intestinal mucosa. Eur J Biochem 66:447-455.
14. Ichimura T, Fraser PA, Cserr HF (1991): Distribution of extracellular tracers in perivascular spaces of the rat brain. Brain Res 545:103-113.
15. Jefferies WA, Brandon MR, Hunt SV, Williams AF, Gatter KC, Mason DY (1984): Transferrin receptor on endothelium of brain capillaries. Nature 312:162-163.
16. Kaldor I (1954): The measurement of non-heme tissue iron. Aust J Biol 32:795-800.
17. Leibold EA, Aziz N, Brown AJP, Monro HN (1984): Conservation in rat liver of light and heavy subunit sequences of mammalian ferritin. J Biol Chem 259:4327-4334.
18. Moos T (1996): Immunohistochemical distribution of intraneuronal transferrin receptor immunoreactivity in the adult mouse central nervous system. J Comp Neurol 374:675-692.
19. Morgan EH (1979): Studies on the mechanism of iron release from transferrin. Biochim Biophys Acta 580:312-326.
20. Morgan EH (1996): Iron metabolism and transport. In: Zakim D, Bayer T (eds): Hepatology. A Textbook of Liver Disease, 3rd edition. Philadelphia-Saunders, pp 526-554.
21. 125I-labelled transferrin by the liver. Biochem J 237:163-173.
22. Morris CM, Keith AB, Edwardson JA, Pullen RGL (1992): Uptake and distribution of iron and transferrin in the adult rat brain. J Neurochem 59:300-306.
23. Mulligan M, Althaus B, Linder MC (1986): Non-ferritin, non-heme iron pools in rat tissues. Int J Biochem 18:791-798.
24. Petroff OA, Yu RK, Ogino T (1986): High-resolution proton magnetic-resonance analysis of human cerebrospinal fluid. J Neurochem 47:1270-1276.
25. Roskams AJI, Connor JR (1994): Iron, transferrin and ferritin in the rat brain during development and aging. J Neurochem 83:709-716.
26. Singh S, Hider RC, Porter JB (1990): A direct method for quantification of non-transferrin-bound iron. Anal Biochem 186:320-323.
27. 125I]transferrin through the rat blood-brain barrier. Brain Res 683:164-171.
28. 13C]NMR spectroscopy of cultured neurons and astrocytes. Neurosci Lett 128:235-239.
29. Strahan ME, Crowe A, Morgan EH (1992): Iron uptake in relation to transferrin degradation in brain and other tissues of rats. Am J Physiol 263:R924-R929.
30. Szentistvanyi I, Patlak CS, Ellis RA, Cserr HF (1984): Drainage of interstitial fluid from different regions of rat brain. Am J Physiol 246:F835-F844.
31. Taylor EM, Morgan EH (1990): Development changes in transferrin and iron uptake by the brain in the rat. Dev Brain Res 55:35-42.
32. Taylor EM, Crowe A, Morgan EH (1991): Transferrin and iron uptake by the brain: Effects of altered iron status. J Neurochem 57:1584-1592.
33. 2+ of N-methyl-D-aspartate receptor-mediated channel current and neurotransmitter release. Proc Natl Acad Sci USA 92:3367-3370.
34. Willmore LJ, Triggs WJ, Gray JD (1986): The role of iron-induced hippocampal peroxidation in acute epileptogenesis. Brain Res 382:422-426.