-
1
-
-
0033599057
-
Medical progress: Disorders of iron metabolism
-
Andrews N.C. Medical progress: disorders of iron metabolism. N Engl J Med. 341:1999;1986-1995.
-
(1999)
N Engl J Med
, vol.341
, pp. 1986-1995
-
-
Andrews, N.C.1
-
2
-
-
0034572933
-
Iron homeostasis: Insights from genetics and animal models
-
Andrews N.C. Iron homeostasis: insights from genetics and animal models. Nat Rev Genet. 1:2000;208-217.
-
(2000)
Nat Rev Genet
, vol.1
, pp. 208-217
-
-
Andrews, N.C.1
-
3
-
-
0002371305
-
Clinical consequences of new insights in the pathophysiology of disorders of iron and heme metabolism
-
Brittenham G.M., Weiss G., Brissot P., et al. Clinical consequences of new insights in the pathophysiology of disorders of iron and heme metabolism. Hematology. 1:2000;39-50.
-
(2000)
Hematology
, vol.1
, pp. 39-50
-
-
Brittenham, G.M.1
Weiss, G.2
Brissot, P.3
-
4
-
-
0034006860
-
Genetic disorders affecting proteins of iron metabolism: Clinical implications
-
Sheth S., Brittenham G.M. Genetic disorders affecting proteins of iron metabolism: clinical implications. Annu Rev Med. 51:2000;443-464.
-
(2000)
Annu Rev Med
, vol.51
, pp. 443-464
-
-
Sheth, S.1
Brittenham, G.M.2
-
5
-
-
0035474950
-
Recent advances in disorders of iron metabolism: Mutations, mechanisms and modifiers
-
Roy C.N., Andrews N.C. Recent advances in disorders of iron metabolism: mutations, mechanisms and modifiers. Human Mol Genet. 10:2001;2181-2186.
-
(2001)
Human Mol Genet
, vol.10
, pp. 2181-2186
-
-
Roy, C.N.1
Andrews, N.C.2
-
6
-
-
0034839086
-
Systemic iron metabolism: A review and implications for brain iron metabolism
-
Rouault T.A. Systemic iron metabolism: a review and implications for brain iron metabolism. Pediatr Neurol. 25:2001;130-137.
-
(2001)
Pediatr Neurol
, vol.25
, pp. 130-137
-
-
Rouault, T.A.1
-
8
-
-
0034889214
-
Deficiency and excess of iron in brain function and dysfunction
-
Youdim M.B. Deficiency and excess of iron in brain function and dysfunction. Nutr Rev. 59:(suppl):2001;S83-S85.
-
(2001)
Nutr Rev
, vol.59
, Issue.SUPPL.
-
-
Youdim, M.B.1
-
9
-
-
0036118607
-
The iron metabolism of neoplastic cells: Alterations that facilitate proliferation?
-
Kwok J.C., Richardson D.R. The iron metabolism of neoplastic cells: alterations that facilitate proliferation? Crit Rev Oncol Hematol. 42:2002;65-78.
-
(2002)
Crit Rev Oncol Hematol
, vol.42
, pp. 65-78
-
-
Kwok, J.C.1
Richardson, D.R.2
-
10
-
-
0035880488
-
Domain homologues of dopamine beta-hydroxylase and ferric reductase: Roles for iron metabolism in neurodegenerative disorders?
-
Ponting C.P. Domain homologues of dopamine beta-hydroxylase and ferric reductase: roles for iron metabolism in neurodegenerative disorders? Hum Mol Genet. 10:2001;1853-1858.
-
(2001)
Hum Mol Genet
, vol.10
, pp. 1853-1858
-
-
Ponting, C.P.1
-
11
-
-
0010487727
-
Expression of iron transport proteins and excessive iron accumulation in the brain in neurodegenerative disorders
-
Qian Z.M., Wang Q. Expression of iron transport proteins and excessive iron accumulation in the brain in neurodegenerative disorders. Brain Res Rev. 27:1998;257-267.
-
(1998)
Brain Res Rev
, vol.27
, pp. 257-267
-
-
Qian, Z.M.1
Wang, Q.2
-
12
-
-
0035095564
-
Brain iron transport and neurodegeneration
-
Qian Z.M., Shen X. Brain iron transport and neurodegeneration. Trend Mol Med. 7:2001;103-108.
-
(2001)
Trend Mol Med
, vol.7
, pp. 103-108
-
-
Qian, Z.M.1
Shen, X.2
-
13
-
-
0034935074
-
Iron on the brain
-
Rouault T.A. Iron on the brain. Nat Genet. 28:2001;299-300.
-
(2001)
Nat Genet
, vol.28
, pp. 299-300
-
-
Rouault, T.A.1
-
14
-
-
0034941118
-
Mutation in the gene encoding ferritin light polypeptide causes dominant adult-onset basal ganglia disease
-
Curtis A.R.J., Fey C., Morris C.M., et al. Mutation in the gene encoding ferritin light polypeptide causes dominant adult-onset basal ganglia disease. Nat Genet. 28:2001;350-354.
-
(2001)
Nat Genet
, vol.28
, pp. 350-354
-
-
Curtis, A.R.J.1
Fey, C.2
Morris, C.M.3
-
15
-
-
0030608152
-
The ferritins: Molecular properties, iron storage function and cellular regulation
-
Harrison P.M., Arosio P. The ferritins: molecular properties, iron storage function and cellular regulation. Biochim Biophys Acta. 1275:1996;161-203.
-
(1996)
Biochim Biophys Acta
, vol.1275
, pp. 161-203
-
-
Harrison, P.M.1
Arosio, P.2
-
16
-
-
0034964604
-
A mutation, in the iron-responsive element of H ferritin mRNA, causing autosomal dominant iron overload
-
Kato J., Fujikawa K., Kanda M., et al. A mutation, in the iron-responsive element of H ferritin mRNA, causing autosomal dominant iron overload. Am J Hum Genet. 69:2001;191-197.
-
(2001)
Am J Hum Genet
, vol.69
, pp. 191-197
-
-
Kato, J.1
Fujikawa, K.2
Kanda, M.3
-
17
-
-
0034603062
-
Early embryonic lethality of H ferritin gene deletion in mice
-
Ferreira C., Bucchini D., Martin M.E., et al. Early embryonic lethality of H ferritin gene deletion in mice. J Biol Chem. 275:2000;3021-3024.
-
(2000)
J Biol Chem
, vol.275
, pp. 3021-3024
-
-
Ferreira, C.1
Bucchini, D.2
Martin, M.E.3
-
18
-
-
0026317374
-
Hallervorden-Spatz and brain iron metabolism
-
Swaiman K.F. Hallervorden-Spatz and brain iron metabolism. Arch Neurol. 48:1991;1285-1293.
-
(1991)
Arch Neurol
, vol.48
, pp. 1285-1293
-
-
Swaiman, K.F.1
-
19
-
-
0034935036
-
A novel pantothenate kinase gene (PANK2) is defective in Hallervorden-Spatz syndrome
-
Zhou B., Westaway S.K., Levinson B., Johnson M.A., Gitschier J., Hayflick S.J. A novel pantothenate kinase gene (PANK2) is defective in Hallervorden-Spatz syndrome. Nat Genet. 28:2001;345-349.
-
(2001)
Nat Genet
, vol.28
, pp. 345-349
-
-
Zhou, B.1
Westaway, S.K.2
Levinson, B.3
Johnson, M.A.4
Gitschier, J.5
Hayflick, S.J.6
-
20
-
-
0026738649
-
Hallervorden-Spatz disease: Clinical and MRI study of 11 cases diagnosed in life
-
Angelini L., Nardocci N., Rumi V., Zorzi C., Strada L., Savoiardo M. Hallervorden-Spatz disease: clinical and MRI study of 11 cases diagnosed in life. J Neurol. 239:1992;417-425.
-
(1992)
J Neurol
, vol.239
, pp. 417-425
-
-
Angelini, L.1
Nardocci, N.2
Rumi, V.3
Zorzi, C.4
Strada, L.5
Savoiardo, M.6
-
21
-
-
0034838767
-
Hallervorden-Spatz syndrome
-
Swaiman K.F. Hallervorden-Spatz syndrome. Pediatr Neurol. 25:2001;102-108.
-
(2001)
Pediatr Neurol
, vol.25
, pp. 102-108
-
-
Swaiman, K.F.1
-
22
-
-
0034850470
-
Cranial MRI changes may precede symptoms in Hallervorden-Spatz syndrome
-
Hayflick S.J., Penzien J.M., Michl W., Sharif U.M., Rosman N.P., Wheeler P.G. Cranial MRI changes may precede symptoms in Hallervorden-Spatz syndrome. Pediatr Neurol. 25:2001;166-169.
-
(2001)
Pediatr Neurol
, vol.25
, pp. 166-169
-
-
Hayflick, S.J.1
Penzien, J.M.2
Michl, W.3
Sharif, U.M.4
Rosman, N.P.5
Wheeler, P.G.6
-
23
-
-
0022381482
-
Hallervorden-Spatz disease: Cysteine accumulation and cysteine dioxygenase deficiency in the globus pallidus
-
Perry T.L., Norman M.G., Yong V.W., et al. Hallervorden-Spatz disease: cysteine accumulation and cysteine dioxygenase deficiency in the globus pallidus. Ann Neurol. 18:1985;482-489.
-
(1985)
Ann Neurol
, vol.18
, pp. 482-489
-
-
Perry, T.L.1
Norman, M.G.2
Yong, V.W.3
-
24
-
-
0025165272
-
Plasma cysteine and sulphate levels in patients with motor neurone, Parkinson's and Alzheimer's disease
-
Heafield M.T., Fearn S., Steventon G.B., Waring R.H., Williams A.C., Sturman S.G. Plasma cysteine and sulphate levels in patients with motor neurone, Parkinson's and Alzheimer's disease. Neurosci Lett. 110:1990;216-220.
-
(1990)
Neurosci Lett
, vol.110
, pp. 216-220
-
-
Heafield, M.T.1
Fearn, S.2
Steventon, G.B.3
Waring, R.H.4
Williams, A.C.5
Sturman, S.G.6
-
25
-
-
0037062571
-
HARP syndrome is allelic with pantothenate kinase-associated neurodegeneration
-
Ching K.H., Westaway S.K., Gitschier J., Higgins J.J., Hayflick S.J. HARP syndrome is allelic with pantothenate kinase-associated neurodegeneration. Neurology. 58:2002;1673-1674.
-
(2002)
Neurology
, vol.58
, pp. 1673-1674
-
-
Ching, K.H.1
Westaway, S.K.2
Gitschier, J.3
Higgins, J.J.4
Hayflick, S.J.5
-
26
-
-
0028903259
-
Aceruloplasminemia: Molecular characterization of this disorder of iron metabolism
-
Harris Z.L., Takahashi Y., Miyajima H., Serizawa M., MacGillivray R.T., Gitlin J.D. Aceruloplasminemia: molecular characterization of this disorder of iron metabolism. Proc Natl Acad Sci USA. 92:1995;2539-2543.
-
(1995)
Proc Natl Acad Sci USA
, vol.92
, pp. 2539-2543
-
-
Harris, Z.L.1
Takahashi, Y.2
Miyajima, H.3
Serizawa, M.4
Macgillivray, R.T.5
Gitlin, J.D.6
-
27
-
-
0028895749
-
Mutation in the ceruloplasmin gene is associated with systemic hemosiderosis in humans
-
Yoshida K., Furihata K., Takeda S., et al. Mutation in the ceruloplasmin gene is associated with systemic hemosiderosis in humans. Nat Genet. 9:1995;267-272.
-
(1995)
Nat Genet
, vol.9
, pp. 267-272
-
-
Yoshida, K.1
Furihata, K.2
Takeda, S.3
-
28
-
-
0030014701
-
Familial dementia due to a frameshift mutation in ceruloplasmin gene
-
Harris Z.L., Migas M.C., Hughes A.E., Logan J.I., Gitlin J.D. Familial dementia due to a frameshift mutation in ceruloplasmin gene. Q J Med. 89:1996;355-359.
-
(1996)
Q J Med
, vol.89
, pp. 355-359
-
-
Harris, Z.L.1
Migas, M.C.2
Hughes, A.E.3
Logan, J.I.4
Gitlin, J.D.5
-
29
-
-
0030584404
-
Iron metabolism in Eukaryotes: Mars and Venus at it again
-
Kaplan J., O'Halloran T.V. Iron metabolism in Eukaryotes: Mars and Venus at it again. Science. 271:1996;1510-1512.
-
(1996)
Science
, vol.271
, pp. 1510-1512
-
-
Kaplan, J.1
O'halloran, T.V.2
-
30
-
-
0029850401
-
Hereditary caeruloplasmin deficiency: Clinicopathological study of a patient
-
Kawanami T., Kato T., Daimon M., et al. Hereditary caeruloplasmin deficiency: clinicopathological study of a patient. J Neurol Neurosurg Psychiatry. 61:1996;506-509.
-
(1996)
J Neurol Neurosurg Psychiatry
, vol.61
, pp. 506-509
-
-
Kawanami, T.1
Kato, T.2
Daimon, M.3
-
31
-
-
0029851871
-
Hereditary deficiency of ferroxidase (aka caeruloplasmin)
-
Logan J.I. Hereditary deficiency of ferroxidase (aka caeruloplasmin). J Neurol Neurosurg Psychiatry. 61:1996;431-432.
-
(1996)
J Neurol Neurosurg Psychiatry
, vol.61
, pp. 431-432
-
-
Logan, J.I.1
-
32
-
-
0030027565
-
Characterization of a nonsense mutation in the ceruloplasmin gene resulting in diabetes and neurodegenerative diseases
-
Takahashi Y., Miyajima H., Shirabe S., Nagataki S., Suenaga A., Gitlin J.D. Characterization of a nonsense mutation in the ceruloplasmin gene resulting in diabetes and neurodegenerative diseases. Hum Mol Genet. 5:1996;81-84.
-
(1996)
Hum Mol Genet
, vol.5
, pp. 81-84
-
-
Takahashi, Y.1
Miyajima, H.2
Shirabe, S.3
Nagataki, S.4
Suenaga, A.5
Gitlin, J.D.6
-
33
-
-
0033546624
-
Estimation of the gene frequency of aceruloplasminemia in Japan
-
Miyajima H., Kohno S., Takahashi Y., Yonekawa O., Kanno T. Estimation of the gene frequency of aceruloplasminemia in Japan. Neurology. 53:1999;617-619.
-
(1999)
Neurology
, vol.53
, pp. 617-619
-
-
Miyajima, H.1
Kohno, S.2
Takahashi, Y.3
Yonekawa, O.4
Kanno, T.5
-
34
-
-
0037059741
-
Biochemical analysis of a missense mutation in aceruloplasminemia
-
Hellman N.E., Kono S., Miyajima H., Gitlin J.D. Biochemical analysis of a missense mutation in aceruloplasminemia. J Biol Chem. 277:2002;1375-1380.
-
(2002)
J Biol Chem
, vol.277
, pp. 1375-1380
-
-
Hellman, N.E.1
Kono, S.2
Miyajima, H.3
Gitlin, J.D.4
-
35
-
-
0036221829
-
A case of aceruloplasminaemia: Abnormal serum ceruloplasmin protein without ferroxidase activity
-
Takeuchi Y., Yoshikawa M., Tsujino T., et al. A case of aceruloplasminaemia: abnormal serum ceruloplasmin protein without ferroxidase activity. J Neurol Neurosurg Psychiatry. 72:2002;543-545.
-
(2002)
J Neurol Neurosurg Psychiatry
, vol.72
, pp. 543-545
-
-
Takeuchi, Y.1
Yoshikawa, M.2
Tsujino, T.3
-
36
-
-
0031981976
-
Aceruloplasminemia: An inherited neurodegenerative disease with impairment of iron homeostasis
-
Harris Z.L., Klomp L.W., Gitlin J.D. Aceruloplasminemia: an inherited neurodegenerative disease with impairment of iron homeostasis. Am J Clin Nutr. 67:(suppl 5):1998;S972-S977.
-
(1998)
Am J Clin Nutr
, vol.67
, Issue.5 SUPPL.
-
-
Harris, Z.L.1
Klomp, L.W.2
Gitlin, J.D.3
-
37
-
-
0031816970
-
Aceruloplasminemia
-
Gitlin J.D. Aceruloplasminemia. Pediatr Res. 44:1998;271-276.
-
(1998)
Pediatr Res
, vol.44
, pp. 271-276
-
-
Gitlin, J.D.1
-
38
-
-
0014027719
-
The possible role of the ferrous oxidase activity of ceruloplasmin in normal human serum
-
Osaki S., Johnson D.A., Frieden E. The possible role of the ferrous oxidase activity of ceruloplasmin in normal human serum. J Biol Chem. 241:1966;11490-11491.
-
(1966)
J Biol Chem
, vol.241
, pp. 11490-11491
-
-
Osaki, S.1
Johnson, D.A.2
Frieden, E.3
-
39
-
-
0033231215
-
Role of ceruloplasmin and ascorbate in cellular iron release
-
Richardson D.R. Role of ceruloplasmin and ascorbate in cellular iron release. J Lab Clin Med. 134:1999;454-465.
-
(1999)
J Lab Clin Med
, vol.134
, pp. 454-465
-
-
Richardson, D.R.1
-
40
-
-
0033230121
-
The sky blue protein
-
Gitlin J.D. The sky blue protein. J Lab Clin Med. 134:1999;431-432.
-
(1999)
J Lab Clin Med
, vol.134
, pp. 431-432
-
-
Gitlin, J.D.1
-
41
-
-
0034672639
-
The physiopathological significance of ceruloplasmin: A possible therapeutic approach
-
Floris G., Medda R., Padiglia A., Musci G. The physiopathological significance of ceruloplasmin: a possible therapeutic approach. Biochem Pharmacol. 60:2000;1735-1741.
-
(2000)
Biochem Pharmacol
, vol.60
, pp. 1735-1741
-
-
Floris, G.1
Medda, R.2
Padiglia, A.3
Musci, G.4
-
42
-
-
0033665697
-
Hepatic iron overload in aceruloplasminaemia
-
Hellman N.E., Schaefer M., Gehrke S., et al. Hepatic iron overload in aceruloplasminaemia. Gut. 47:2000;858-860.
-
(2000)
Gut
, vol.47
, pp. 858-860
-
-
Hellman, N.E.1
Schaefer, M.2
Gehrke, S.3
-
43
-
-
0036400025
-
Ceruloplasmin metabolism and function
-
Hellman N.E., Gitlin J.D. Ceruloplasmin metabolism and function. Annu Rev Nutr. 22:2002;439-458.
-
(2002)
Annu Rev Nutr
, vol.22
, pp. 439-458
-
-
Hellman, N.E.1
Gitlin, J.D.2
-
44
-
-
0032875387
-
Targeted gene disruption reveals an essential role for ceruloplasmin in cellular iron efflux
-
Harris Z.L., Durley A.P., Man T.K., Gitlin J.D. Targeted gene disruption reveals an essential role for ceruloplasmin in cellular iron efflux. Proc Natl Acad Sci USA. 96:1999;10812-10817.
-
(1999)
Proc Natl Acad Sci USA
, vol.96
, pp. 10812-10817
-
-
Harris, Z.L.1
Durley, A.P.2
Man, T.K.3
Gitlin, J.D.4
-
45
-
-
0032579397
-
Role of ceruloplasmin in cellular iron uptake
-
Mukhopadhyay C.K., Attieh Z.K., Fox A.P. Role of ceruloplasmin in cellular iron uptake. Science. 279:1998;714-717.
-
(1998)
Science
, vol.279
, pp. 714-717
-
-
Mukhopadhyay, C.K.1
Attieh, Z.K.2
Fox, A.P.3
-
46
-
-
0033534589
-
Ceruloplasmin ferroxidase activity stimulates cellular iron uptake by a trivalent cation-specific transport mechanism
-
Attieh Z.K., Mukhopadhyay C.K., Seshadri V., Tripoulas N.A., Fox P.L. Ceruloplasmin ferroxidase activity stimulates cellular iron uptake by a trivalent cation-specific transport mechanism. J Biol Chem. 274:1999;1116-1123.
-
(1999)
J Biol Chem
, vol.274
, pp. 1116-1123
-
-
Attieh, Z.K.1
Mukhopadhyay, C.K.2
Seshadri, V.3
Tripoulas, N.A.4
Fox, P.L.5
-
47
-
-
0034857231
-
Ceruloplasmin promotes iron uptake rather than release in BT325 cells
-
Qian Z.M., Tsoi Y.K., Ke Y., Wong M.S. Ceruloplasmin promotes iron uptake rather than release in BT325 cells. Exp Brain Res. 140:2001;369-374.
-
(2001)
Exp Brain Res
, vol.140
, pp. 369-374
-
-
Qian, Z.M.1
Tsoi, Y.K.2
Ke, Y.3
Wong, M.S.4
-
48
-
-
0037186463
-
Effects of ferroxidase activity and species on ceruloplasmin mediated iron uptake by BT325 cells
-
Xie J.X., Tsoi Y.K., Chang Y.Z., Ke Y., Qian Z.M. Effects of ferroxidase activity and species on ceruloplasmin mediated iron uptake by BT325 cells. Mol Brain Res. 99:2002;12-16.
-
(2002)
Mol Brain Res
, vol.99
, pp. 12-16
-
-
Xie, J.X.1
Tsoi, Y.K.2
Chang, Y.Z.3
Ke, Y.4
Qian, Z.M.5
-
50
-
-
0029800745
-
Expression of the ceruloplasmin gene in the human retina and brain: Implications for a pathogenic model in aceruloplasminemia
-
Klomp L.W.J., Gitlin J.D. Expression of the ceruloplasmin gene in the human retina and brain: implications for a pathogenic model in aceruloplasminemia. Hum Mol Genet. 5:1996;1989-1996.
-
(1996)
Hum Mol Genet
, vol.5
, pp. 1989-1996
-
-
Klomp, L.W.J.1
Gitlin, J.D.2
-
51
-
-
0034984521
-
Rethinking the role of ceruloplasmin in brain iron metabolism
-
Qian Z.M., Ke Y. Rethinking the role of ceruloplasmin in brain iron metabolism. Brain Res Rev. 35:2001;287-294.
-
(2001)
Brain Res Rev
, vol.35
, pp. 287-294
-
-
Qian, Z.M.1
Ke, Y.2
-
52
-
-
0031684169
-
CSF abnormalities in patients with aceruloplasminemia
-
Miyajima H., Fujimoto M., Kohno S., Kaneko E., Gitlin J.D. CSF abnormalities in patients with aceruloplasminemia. Neurology. 51:1998;1188-1190.
-
(1998)
Neurology
, vol.51
, pp. 1188-1190
-
-
Miyajima, H.1
Fujimoto, M.2
Kohno, S.3
Kaneko, E.4
Gitlin, J.D.5
-
53
-
-
0034891099
-
Increased oxysterols associated with iron accumulation in the brains and visceral organs of acaeruloplasminaemia patients
-
Miyajima H., Adachi J., Kohno S., Takahashi Y., Ueno Y., Naito T. Increased oxysterols associated with iron accumulation in the brains and visceral organs of acaeruloplasminaemia patients. Q J Med. 94:2001;417-512.
-
(2001)
Q J Med
, vol.94
, pp. 417-512
-
-
Miyajima, H.1
Adachi, J.2
Kohno, S.3
Takahashi, Y.4
Ueno, Y.5
Naito, T.6
-
54
-
-
0036212028
-
Glucose and oxygen hypometabolism in aceruloplasminemia brains
-
Miyajima H., Takahashi Y., Kono S., et al. Glucose and oxygen hypometabolism in aceruloplasminemia brains. Intern Med. 41:2002;186-190.
-
(2002)
Intern Med
, vol.41
, pp. 186-190
-
-
Miyajima, H.1
Takahashi, Y.2
Kono, S.3
-
55
-
-
0034656236
-
Increased lipid peroxidation in the brains of aceruloplasminemia patients
-
Yoshida K., Kaneko K., Miyajima H., et al. Increased lipid peroxidation in the brains of aceruloplasminemia patients. J Neurol Sci. 175:2000;91-95.
-
(2000)
J Neurol Sci
, vol.175
, pp. 91-95
-
-
Yoshida, K.1
Kaneko, K.2
Miyajima, H.3
-
56
-
-
0031058837
-
Use of desferrioxamine in the treatment of aceruloplasminemia
-
Miyajima H., Takahashi Y., Kamata T., Shimizu H., Sakai N., Gitlin J.D. Use of desferrioxamine in the treatment of aceruloplasminemia. Ann Neurol. 41:1997;404-407.
-
(1997)
Ann Neurol
, vol.41
, pp. 404-407
-
-
Miyajima, H.1
Takahashi, Y.2
Kamata, T.3
Shimizu, H.4
Sakai, N.5
Gitlin, J.D.6
-
57
-
-
0035138456
-
Targeted deletion of the gene encoding iron regulatory protein-2 causes misregulation of iron metabolism and neurodegenerative disease in mice
-
LaVaute T., Smith S., Cooperman S., et al. Targeted deletion of the gene encoding iron regulatory protein-2 causes misregulation of iron metabolism and neurodegenerative disease in mice. Nat Genet. 27:2001;209-214.
-
(2001)
Nat Genet
, vol.27
, pp. 209-214
-
-
Lavaute, T.1
Smith, S.2
Cooperman, S.3
-
58
-
-
0027452550
-
Regulating the fate of mRNA: The control of cellular iron metabolism
-
Klausner R.D., Rouault T.A., Harford J.B. Regulating the fate of mRNA: the control of cellular iron metabolism. Cell. 72:1993;19-28.
-
(1993)
Cell
, vol.72
, pp. 19-28
-
-
Klausner, R.D.1
Rouault, T.A.2
Harford, J.B.3
-
59
-
-
0029665281
-
An update on iron metabolism: Summary of the fifth international conference on disorders on iron metabolism
-
Bonkovsky H., Ponka P., Bacon B.R., Drysdale J., Grace N.D., Tavill A.S. An update on iron metabolism: summary of the fifth international conference on disorders on iron metabolism. Hepatology. 24:1996;718-729.
-
(1996)
Hepatology
, vol.24
, pp. 718-729
-
-
Bonkovsky, H.1
Ponka, P.2
Bacon, B.R.3
Drysdale, J.4
Grace, N.D.5
Tavill, A.S.6
-
60
-
-
0029758487
-
Molecular control of vertebrate iron metabolism: MRNA-based regulatory circuits operated by iron, nitric oxide, and oxidative stress
-
Hentze M.W., Kuhn L.C. Molecular control of vertebrate iron metabolism: mRNA-based regulatory circuits operated by iron, nitric oxide, and oxidative stress. Proc Natl Acad Sci USA. 93:1996;8175-8182.
-
(1996)
Proc Natl Acad Sci USA
, vol.93
, pp. 8175-8182
-
-
Hentze, M.W.1
Kuhn, L.C.2
-
61
-
-
0030057235
-
Demonstration and characterization of the iron regulatory protein in human brain
-
Hu J., Connor J.R. Demonstration and characterization of the iron regulatory protein in human brain. J Neurochem. 67:1996;838-844.
-
(1996)
J Neurochem
, vol.67
, pp. 838-844
-
-
Hu, J.1
Connor, J.R.2
-
62
-
-
0034531651
-
Iron regulatory proteins in pathobiology
-
Cairo G., Pietrangelo A. Iron regulatory proteins in pathobiology. Biochem J. 352:2000;241-250.
-
(2000)
Biochem J
, vol.352
, pp. 241-250
-
-
Cairo, G.1
Pietrangelo, A.2
-
63
-
-
0033826764
-
Iron regulatory proteins and the molecular control of mammalian iron metabolism
-
Eisenstein R.S. Iron regulatory proteins and the molecular control of mammalian iron metabolism. Annu Rev Nutr. 20:2000;627-662.
-
(2000)
Annu Rev Nutr
, vol.20
, pp. 627-662
-
-
Eisenstein, R.S.1
-
64
-
-
0036069457
-
An oxidative stress-mediated positive-feedback iron uptake loop in neuronal cells
-
Nunez-Millacura C., Tapia V., Munoz P., Maccioni R.B., Nunez M.T. An oxidative stress-mediated positive-feedback iron uptake loop in neuronal cells. J Neurochem. 82:2002;240-248.
-
(2002)
J Neurochem
, vol.82
, pp. 240-248
-
-
Nunez-Millacura, C.1
Tapia, V.2
Munoz, P.3
Maccioni, R.B.4
Nunez, M.T.5
-
65
-
-
0036135887
-
Increased IRP1 and IRP2 RNA binding activity accompanies a reduction of the labile iron pool in HFE-expressing cells
-
Roy C.N., Blemings K.P., Deck K.M., et al. Increased IRP1 and IRP2 RNA binding activity accompanies a reduction of the labile iron pool in HFE-expressing cells. J Cell Physiol. 190:2002;218-226.
-
(2002)
J Cell Physiol
, vol.190
, pp. 218-226
-
-
Roy, C.N.1
Blemings, K.P.2
Deck, K.M.3
-
66
-
-
0037096190
-
The iron regulatory proteins: Targets and modulators of free radical reactions and oxidative damage
-
Cairo G., Recalcati S., Pietrangelo A., Minotti G. The iron regulatory proteins: targets and modulators of free radical reactions and oxidative damage. Free Radic Biol Med. 32:2002;1237-1243.
-
(2002)
Free Radic Biol Med
, vol.32
, pp. 1237-1243
-
-
Cairo, G.1
Recalcati, S.2
Pietrangelo, A.3
Minotti, G.4
-
67
-
-
0036889760
-
Targeted drug delivery via the transferrin receptor-mediated endocytosis pathway
-
Qian Z.M., Li H., Sun H., Ho K. Targeted drug delivery via the transferrin receptor-mediated endocytosis pathway. Pharmacol Rev. 54:2002;561-587.
-
(2002)
Pharmacol Rev
, vol.54
, pp. 561-587
-
-
Qian, Z.M.1
Li, H.2
Sun, H.3
Ho, K.4
-
68
-
-
0028786932
-
Expression of lactoferrin receptors in increased in the mesencephalon of patients with Parkinson disease
-
Faucheux B.A., Nillesse N., Damier P., et al. Expression of lactoferrin receptors in increased in the mesencephalon of patients with Parkinson disease. Proc Natl Acad Sci USA. 92:1995;9603-9607.
-
(1995)
Proc Natl Acad Sci USA
, vol.92
, pp. 9603-9607
-
-
Faucheux, B.A.1
Nillesse, N.2
Damier, P.3
-
69
-
-
0028321575
-
The iron binding protein lactotransferrin is present in pathologic lesions in a variety of neurodegenerative disorders: A comparative immunohistochemical analysis
-
Leveugle B., Spik G., Perl D.P., Bouras C., Fillit H.M., Hof P.R. The iron binding protein lactotransferrin is present in pathologic lesions in a variety of neurodegenerative disorders: a comparative immunohistochemical analysis. Brain Res. 650:1994;20-31.
-
(1994)
Brain Res
, vol.650
, pp. 20-31
-
-
Leveugle, B.1
Spik, G.2
Perl, D.P.3
Bouras, C.4
Fillit, H.M.5
Hof, P.R.6
-
70
-
-
0029997918
-
Cellular distribution of the iron-binding protein lactoferrin in the mesencephalon of Parkinson's disease cases
-
Leveugle B., Faucheux B.A., Bouras C., et al. Cellular distribution of the iron-binding protein lactoferrin in the mesencephalon of Parkinson's disease cases. Acta Neuropathol. 91:1996;566-572.
-
(1996)
Acta Neuropathol
, vol.91
, pp. 566-572
-
-
Leveugle, B.1
Faucheux, B.A.2
Bouras, C.3
-
71
-
-
0029896313
-
Pumping iron in the '90s
-
Jefferies W.A., Gabathuler R., Rotherberger S., Food M., Kennard M.L. Pumping iron in the '90s. Trend Cell Biol. 6:1996;223-228.
-
(1996)
Trend Cell Biol
, vol.6
, pp. 223-228
-
-
Jefferies, W.A.1
Gabathuler, R.2
Rotherberger, S.3
Food, M.4
Kennard, M.L.5
-
72
-
-
0029955035
-
Serum levels of the iron binding protein p97 are elevated in Alzheimer's disease
-
Kennard M.L., Feldman H., Yamada T., Jefferies W.A. Serum levels of the iron binding protein p97 are elevated in Alzheimer's disease. Nat Med. 2:1996;1230-1235.
-
(1996)
Nat Med
, vol.2
, pp. 1230-1235
-
-
Kennard, M.L.1
Feldman, H.2
Yamada, T.3
Jefferies, W.A.4
-
73
-
-
0029935613
-
Reactive microglia specifically associated with amyloid plaques in Alzheimer's disease brain tissue express melanotransferrin
-
Jefferies W.A., Food M.R., Gabathuler R., et al. Reactive microglia specifically associated with amyloid plaques in Alzheimer's disease brain tissue express melanotransferrin. Brain Res. 712:1996;122-126.
-
(1996)
Brain Res
, vol.712
, pp. 122-126
-
-
Jefferies, W.A.1
Food, M.R.2
Gabathuler, R.3
-
74
-
-
0032822823
-
Melanotransferrin is produced by senile plaque-associated reactive microglia in Alzheimer's disease
-
Yamada T., Tsujioka Y., Taguchi J., et al. Melanotransferrin is produced by senile plaque-associated reactive microglia in Alzheimer's disease. Brain Res. 845:1999;1-5.
-
(1999)
Brain Res
, vol.845
, pp. 1-5
-
-
Yamada, T.1
Tsujioka, Y.2
Taguchi, J.3
-
75
-
-
0035024825
-
Serum melanotransferrin, p97 as a biochemical marker of Alzheimer's disease
-
Kim D.K., Seo M.Y., Lim S.W., et al. Serum melanotransferrin, p97 as a biochemical marker of Alzheimer's disease. Neuropsychopharmacology. 25:2001;84-90.
-
(2001)
Neuropsychopharmacology
, vol.25
, pp. 84-90
-
-
Kim, D.K.1
Seo, M.Y.2
Lim, S.W.3
-
77
-
-
0006905039
-
Differential distribution of lactoferrin and Alz-50 immunoreactivities in neuritic plaques and neurofibrillary tangles in Alzheimer's disease
-
K. Iqbal, R.C. McLachlan, B. Winblad, & H.M. Wisniewski. New York: Wiley
-
Osmand A.P., Switzer R.C. III. Differential distribution of lactoferrin and Alz-50 immunoreactivities in neuritic plaques and neurofibrillary tangles in Alzheimer's disease. Iqbal K., McLachlan R.C., Winblad B., Wisniewski H.M. Alzheimer's disease: basic mechanisms, diagnosis and therapeutic strategies. 1991;219-227 Wiley, New York.
-
(1991)
Alzheimer's disease: Basic mechanisms, diagnosis and therapeutic strategies
, pp. 219-227
-
-
Osmand, A.P.1
Switzer III, R.C.2
-
78
-
-
0027723591
-
Lacto-transferrin immunocytochemistry in Alzheimer and normal human brain
-
Kawamata T., Tooyama I., Yamada T., Walker D.G., McGeer P.L. Lacto-transferrin immunocytochemistry in Alzheimer and normal human brain. Am J Pathol. 142:1993;1574-1585.
-
(1993)
Am J Pathol
, vol.142
, pp. 1574-1585
-
-
Kawamata, T.1
Tooyama, I.2
Yamada, T.3
Walker, D.G.4
Mcgeer, P.L.5
-
79
-
-
0028894661
-
Multiple, diverse senile plaque-associated proteins are ligands of an apolipoprotein E receptor, the alpha-macroglobulin receptor/low density lipoprotein receptor-related protein
-
Rebeck G.W., Harr S.D., Strickland D.K., Hyman B.T. Multiple, diverse senile plaque-associated proteins are ligands of an apolipoprotein E receptor, the alpha-macroglobulin receptor/low density lipoprotein receptor-related protein. Ann Neurol. 37:1995;211-217.
-
(1995)
Ann Neurol
, vol.37
, pp. 211-217
-
-
Rebeck, G.W.1
Harr, S.D.2
Strickland, D.K.3
Hyman, B.T.4
-
80
-
-
0030763856
-
Microcytic anemia have a mutation in Nramp2, a candidate iron transporter
-
Fleming M.D., Trenor C.C.I., Su M.A., Foemzler D.R., Dietrich W.F., Andrews N.C. Microcytic anemia have a mutation in Nramp2, a candidate iron transporter. Nat Genet. 16:1997;383-386.
-
(1997)
Nat Genet
, vol.16
, pp. 383-386
-
-
Fleming, M.D.1
Trenor, C.C.I.2
Su, M.A.3
Foemzler, D.R.4
Dietrich, W.F.5
Andrews, N.C.6
-
81
-
-
0030755366
-
Cloning and characterization of a mammalian proton-coupled metal-ion transporter
-
Gunshin H., Mackenzie B., Berger U.V., et al. Cloning and characterization of a mammalian proton-coupled metal-ion transporter. Nature. 388:1997;482-488.
-
(1997)
Nature
, vol.388
, pp. 482-488
-
-
Gunshin, H.1
Mackenzie, B.2
Berger, U.V.3
-
82
-
-
0033044583
-
Iron transport across biological membranes
-
Andrews N.C., Fleming M.D., Gunshin H. Iron transport across biological membranes. Nutr Rev. 57:1999;114-123.
-
(1999)
Nutr Rev
, vol.57
, pp. 114-123
-
-
Andrews, N.C.1
Fleming, M.D.2
Gunshin, H.3
-
83
-
-
0032734745
-
Copper, ceruloplasmin, superoxide dismutase and iron parameters in Parkinson's disease
-
Torsdottir G., Kristinsson J., Sveinbjornsdottir S., Snaedal J., Johannesson T. Copper, ceruloplasmin, superoxide dismutase and iron parameters in Parkinson's disease. Pharmacol Toxicol. 85:1999;239-243.
-
(1999)
Pharmacol Toxicol
, vol.85
, pp. 239-243
-
-
Torsdottir, G.1
Kristinsson, J.2
Sveinbjornsdottir, S.3
Snaedal, J.4
Johannesson, T.5
-
84
-
-
0033597299
-
Reduced ferroxidase activity in the cerebrospinal fluid from patients with Parkinson's disease
-
Boll M.C., Sotelo J., Otero E., Alcaraz-Zubeldia M., Rios C. Reduced ferroxidase activity in the cerebrospinal fluid from patients with Parkinson's disease. Neurosci Lett. 265:1999;155-158.
-
(1999)
Neurosci Lett
, vol.265
, pp. 155-158
-
-
Boll, M.C.1
Sotelo, J.2
Otero, E.3
Alcaraz-Zubeldia, M.4
Rios, C.5
-
85
-
-
0034776216
-
Brain iron pathways and their relevance to Parkinson's disease
-
Berg D., Gerlach M., Youdim M.B., et al. Brain iron pathways and their relevance to Parkinson's disease. J Neurochem. 79:2001;225-236.
-
(2001)
J Neurochem
, vol.79
, pp. 225-236
-
-
Berg, D.1
Gerlach, M.2
Youdim, M.B.3
-
86
-
-
2142828035
-
Alterations in the interaction between iron regulatory proteins and their responsive element in normal and Alzheimer's diseased brains
-
Piñero D.J., Hu J., Connor J.R. Alterations in the interaction between iron regulatory proteins and their responsive element in normal and Alzheimer's diseased brains. Cell Mol Biol. 46:2000;761-776.
-
(2000)
Cell Mol Biol
, vol.46
, pp. 761-776
-
-
Piñero, D.J.1
Hu, J.2
Connor, J.R.3
-
87
-
-
0032735145
-
Stabilization of iron regulatory protein 2, IRP2, by aluminum
-
Yamanaka K., Minato N., Iwai K. Stabilization of iron regulatory protein 2, IRP2, by aluminum. FEBS Lett. 462:1999;216-220.
-
(1999)
FEBS Lett
, vol.462
, pp. 216-220
-
-
Yamanaka, K.1
Minato, N.2
Iwai, K.3
-
88
-
-
0033793044
-
Heme oxygenase-1: Role in brain aging and neurodegeneration
-
Schipper H.M. Heme oxygenase-1: role in brain aging and neurodegeneration. Exp Gerontol. 35:2000;821-830.
-
(2000)
Exp Gerontol
, vol.35
, pp. 821-830
-
-
Schipper, H.M.1
-
89
-
-
0033751421
-
Metabolic, metallic, and mitotic sources of oxidative stress in Alzheimer disease
-
Smith M.A., Nunomura A., Zhu X., Takeda A., Perry G. Metabolic, metallic, and mitotic sources of oxidative stress in Alzheimer disease. Antioxid Redox Signal. 2:2000;413-420.
-
(2000)
Antioxid Redox Signal
, vol.2
, pp. 413-420
-
-
Smith, M.A.1
Nunomura, A.2
Zhu, X.3
Takeda, A.4
Perry, G.5
-
90
-
-
0034796353
-
Role of free radicals in the neurodegenerative diseases: Therapeutic implications for antioxidant treatment
-
Halliwell B. Role of free radicals in the neurodegenerative diseases: therapeutic implications for antioxidant treatment. Drugs Aging. 18:2001;685-716.
-
(2001)
Drugs Aging
, vol.18
, pp. 685-716
-
-
Halliwell, B.1
-
91
-
-
0036623360
-
Aceruloplasminemia: New clinical, pathophysiological and therapeutic insights
-
Loreal O., Turlin B., Pigeon C., et al. Aceruloplasminemia: new clinical, pathophysiological and therapeutic insights. J Hepatol. 36:2002;851-856.
-
(2002)
J Hepatol
, vol.36
, pp. 851-856
-
-
Loreal, O.1
Turlin, B.2
Pigeon, C.3
-
92
-
-
0036113819
-
The role of iron and copper in the aetiology of neurodegenerative disorders: Therapeutic implications
-
Perry G., Sayre L.M., Atwood C.S., et al. The role of iron and copper in the aetiology of neurodegenerative disorders: therapeutic implications. CNS Drugs. 16:2002;339-352.
-
(2002)
CNS Drugs
, vol.16
, pp. 339-352
-
-
Perry, G.1
Sayre, L.M.2
Atwood, C.S.3
-
93
-
-
0035993851
-
Therapeutic potential in Alzheimer disease
-
Cash A.D., Perry G., Smith M.A. Therapeutic potential in Alzheimer disease. Curr Med Chem. 9:2002;1605-1610.
-
(2002)
Curr Med Chem
, vol.9
, pp. 1605-1610
-
-
Cash, A.D.1
Perry, G.2
Smith, M.A.3
-
94
-
-
0035793856
-
An iron-regulated ferric reductase associated with the absorption of dietary iron
-
McKie A.T., Barrow D., Latunde-Dada G.O., et al. An iron-regulated ferric reductase associated with the absorption of dietary iron. Science. 291:2001;1755-1759.
-
(2001)
Science
, vol.291
, pp. 1755-1759
-
-
Mckie, A.T.1
Barrow, D.2
Latunde-Dada, G.O.3
-
95
-
-
0034677467
-
Positional cloning of zebrafish ferroportin 1 identifies a conserved vertebrate iron exporter
-
Donovan A., Brownlie A., Zhou Y., et al. Positional cloning of zebrafish ferroportin 1 identifies a conserved vertebrate iron exporter. Nature. 403:2000;776-781.
-
(2000)
Nature
, vol.403
, pp. 776-781
-
-
Donovan, A.1
Brownlie, A.2
Zhou, Y.3
-
96
-
-
0032909207
-
Hephaestin, a ceruloplasmin homologue implicated in intestinal iron transport, is defective in the sla mouse
-
Vulpe C.D., Kuo Y.M., Murphy T.L., et al. Hephaestin, a ceruloplasmin homologue implicated in intestinal iron transport, is defective in the sla mouse. Nat Genet. 21:1999;195-199.
-
(1999)
Nat Genet
, vol.21
, pp. 195-199
-
-
Vulpe, C.D.1
Kuo, Y.M.2
Murphy, T.L.3
-
97
-
-
0036972034
-
Distribution of ferroportin1 protein in different regions of developing rat brain
-
Jiang D.H., Ke Y., Cheng Y.Z., Ho K.P., Qian Z.M. Distribution of ferroportin1 protein in different regions of developing rat brain. Dev Neurosci. 24:2002;94-98.
-
(2002)
Dev Neurosci
, vol.24
, pp. 94-98
-
-
Jiang, D.H.1
Ke, Y.2
Cheng, Y.Z.3
Ho, K.P.4
Qian, Z.M.5
-
98
-
-
0034284595
-
LEAP-1, a novel highly disulfide-bonded human peptide, exhibits antimicrobial activity
-
Krause A., Neitz S., Magert H.J., et al. LEAP-1, a novel highly disulfide-bonded human peptide, exhibits antimicrobial activity. FEBS Lett. 480:2000;147-150.
-
(2000)
FEBS Lett
, vol.480
, pp. 147-150
-
-
Krause, A.1
Neitz, S.2
Magert, H.J.3
-
99
-
-
0035896642
-
Hepcidin, a urinary antimicrobial peptide synthesized in the liver
-
Park C.H., Valore E.V., Waring A.J., Ganz T. Hepcidin, a urinary antimicrobial peptide synthesized in the liver. J Biol Chem. 276:2001;7806-7810.
-
(2001)
J Biol Chem
, vol.276
, pp. 7806-7810
-
-
Park, C.H.1
Valore, E.V.2
Waring, A.J.3
Ganz, T.4
-
100
-
-
0035902605
-
Lack of hepcidin gene expression and severe tissue iron overload in upstream stimulatory factor 2 (USF2) knockout mice
-
Nicolas G., Bennoun M., Devaux I., et al. Lack of hepcidin gene expression and severe tissue iron overload in upstream stimulatory factor 2 (USF2) knockout mice. Proc Natl Acad Sci USA. 98:2001;8780-8785.
-
(2001)
Proc Natl Acad Sci USA
, vol.98
, pp. 8780-8785
-
-
Nicolas, G.1
Bennoun, M.2
Devaux, I.3
-
101
-
-
0036727925
-
Hepcidin expression inversely correlates with the expression of duodenal iron transporters and iron absorption in rats
-
Frazer D.M., Wilkins S.J., Becker E.M., et al. Hepcidin expression inversely correlates with the expression of duodenal iron transporters and iron absorption in rats. Gastroenterology. 123:2002;835-844.
-
(2002)
Gastroenterology
, vol.123
, pp. 835-844
-
-
Frazer, D.M.1
Wilkins, S.J.2
Becker, E.M.3
-
102
-
-
0037007064
-
Severe iron deficiency anemia in transgenic mice expressing liver hepcidin
-
Nicolas G., Bennoun M., Porteu A., et al. Severe iron deficiency anemia in transgenic mice expressing liver hepcidin. Proc Natl Acad Sci USA. 99:2002;4596-4601.
-
(2002)
Proc Natl Acad Sci USA
, vol.99
, pp. 4596-4601
-
-
Nicolas, G.1
Bennoun, M.2
Porteu, A.3
-
103
-
-
0035902586
-
Hepcidin: A putative iron-regulatory hormone relevant to hereditary hemochromatosis and the anemia of chronic disease
-
Fleming R.E., Sly W.S. Hepcidin: a putative iron-regulatory hormone relevant to hereditary hemochromatosis and the anemia of chronic disease. Proc Natl Acad Sci USA. 98:2001;8160-8162.
-
(2001)
Proc Natl Acad Sci USA
, vol.98
, pp. 8160-8162
-
-
Fleming, R.E.1
Sly, W.S.2
-
104
-
-
0036196205
-
Mechanisms of iron accumulation in hereditary hemochromatosis
-
Fleming R.E., Sly W.S. Mechanisms of iron accumulation in hereditary hemochromatosis. Annu Rev Physiol. 64:2002;663-680.
-
(2002)
Annu Rev Physiol
, vol.64
, pp. 663-680
-
-
Fleming, R.E.1
Sly, W.S.2
|