Minocycline attenuates iron neurotoxicity in cortical cell cultures

Biochemical and Biophysical Research Communications

Volumn 386, Issue 2, 2009, Pages 322-326

  Chen Roetling, Jing ^a   Chen, Lifen ^a   Regan, Raymond F ^a  

^a THOMAS JEFFERSON UNIVERSITY   (United States)

Author keywords

Cell culture; Free radical; Hemoglobin toxicity; Inflammation; Intracerebral hemorrhage; Mouse; Oxidative stress; Stroke

Indexed keywords

DEFEROXAMINE; DOXYCYCLINE; FERROUS SULFATE; MACROPHAGE MIGRATION INHIBITION FACTOR; MALONALDEHYDE; MINOCYCLINE; SIDEROPHORE;

ANIMAL CELL; ANIMAL CELL CULTURE; ARTICLE; BRAIN CELL; BRAIN HEMORRHAGE; CELL ACTIVATION; COLORIMETRY; CONTROLLED STUDY; DRUG EFFICACY; DRUG MECHANISM; FETUS; IRON CHELATION; IRON OVERLOAD; LIPID PEROXIDATION; MICROGLIA; MOUSE; NERVE CELL; NERVE CELL LESION; NEUROPROTECTION; NEUROTOXICITY; NONHUMAN; OXIDATION; OXIDATIVE STRESS; PRIORITY JOURNAL; STROKE;

ANIMALS; CEREBRAL CORTEX; CEREBRAL HEMORRHAGE; CYTOPROTECTION; DEFEROXAMINE; IRON; IRON CHELATING AGENTS; MICE; MICE, INBRED STRAINS; MINOCYCLINE; NEURONS; NEUROPROTECTIVE AGENTS; NEUROTOXICITY SYNDROMES;

EID: 67649444192     PISSN: 0006291X     EISSN: 10902104     Source Type: Journal    
DOI: 10.1016/j.bbrc.2009.06.026     Document Type: Article

References (36)

1. Wu J., Hua Y., Keep R.F., Nakemura T., Hoff J.T., and Xi G. Iron and iron-handling proteins in the brain after intracerebral hemorrhage. Stroke 34 (2003) 2964-2969
2. Hua Y., Nakamura T., Keep R.F., Wu J., Schallert T., Hoff J.T., and Xi G. Long-term effects of experimental intracerebral hemorrhage: the role of iron. J. Neurosurg. 104 (2006) 305-312
3. Gong Y., Tian H., Xi G., Keep R.F., Hoff J.T., and Hua Y. Systemic zinc protoporphyrin administration reduces intracerebral hemorrhage-induced brain injury. Acta Neurochir. Suppl. 96 (2006) 232-236
4. Qu Y., Chen-Roetling J., Benvenisti-Zarom L., and Regan R.F. Attenuation of oxidative injury after induction of experimental intracerebral hemorrhage in heme oxygenase-2 knockout mice. J. Neurosurg. 106 (2007) 428-435
5. Rogers B., Yakopson V., Teng Z.P., Guo Y., and Regan R.F. Heme oxygenase-2 knockout neurons are less vulnerable to hemoglobin toxicity. Free Rad. Biol. Med. 35 (2003) 872-881
6. Nakamura T., Keep R.F., Hua Y., Schallert T., Hoff J.T., and Xi G. Deferoxamine-induced attenuation of brain edema and neurological deficits in a rat model of intracerebral hemorrhage. J. Neurosurg. 100 (2004) 672-678
7. Wang J., and Dore S. Inflammation after intracerebral hemorrhage. J. Cereb. Blood Flow Metab. 27 (2007) 894-908
8. Power C., Henry S., Del Bigio M.R., Larsen P.H., Corbett D., Imai Y., Yong V.W., and Peeling J. Intracerebral hemorrhage induces macrophage activation and matrix metalloproteinases. Ann. Neurol. 53 (2003) 731-742
9. Wasserman J.K., and Schlichter L.C. Minocycline protects the blood-brain barrier and reduces edema following intracerebral hemorrhage in the rat. Exp. Neurol. 207 (2007) 227-237
10. Wu J., Yang S., Xi G., Fu G., Keep R.F., and Hua Y. Minocycline reduces intracerebral hemorrhage-induced brain injury. Neurol. Res. 31 (2009) 183-188
11. Elewa H.F., Hilali H., Hess D.C., Machado L.S., and Fagan S.C. Minocycline for short-term neuroprotection. Pharmacotherapy 26 (2006) 515-521
12. Grenier D., Huot M.P., and Mayrand D. Iron-chelating activity of tetracyclines and its impact on the susceptibility of Actinobacillus actinomycetemcomitans to these antibiotics. Antimicrob. Agents Chemother. 44 (2000) 763-766
13. Leyden J.J. Absorption of minocycline hydrochloride and tetracycline hydrochloride. Effect of food, milk, and iron. J. Am. Acad. Dermatol. 12 (1985) 308-312
14. Gordon G., Sparano B.M., and Iatropoulos M.J. Hyperpigmentation of the skin associated with minocycline therapy. Arch. Dermatol. 121 (1985) 618-623
15. Graf E., Mahoney J.R., Bryant R.G., and Eaton J.W. Iron-catalyzed hydroxyl radical formation. Stringent requirement for free iron coordination site. J. Biol. Chem. 259 (1984) 3620-3624
16. Halliwell B., and Gutteridge J.M.C. Free Radicals in Biology and Medicine (1999), Oxford University Press, Oxford pp. 54-55, 851
17. Saura J. Microglial cells in astroglial cultures: a cautionary note. J. Neuroinflammation 4 (2007) 26
18. Yoshida T., and Migita C.T. Mechanism of heme degradation by heme oxygenase. J. Inorg. Biochem. 82 (2000) 33-41
19. Chen J., and Regan R.F. Heme oxygenase-2 gene deletion increases astrocyte vulnerability to hemin. Biochem. Biophys. Res. Commun. 318 (2004) 88-94
20. Koh J.Y., and Choi D.W. Vulnerability of cultured cortical neurons to damage by excitotoxins: differential susceptibility of neurons containing NADPH-diaphorase. J. Neurosci. 8 (1988) 2153-2163
21. Regan R.F., Jasper E., Guo Y.P., and Panter S.S. The effect of magnesium on oxidative neuronal injury in vitro. J. Neurochem. 70 (1998) 77-85
22. Sadrzadeh S.M.H., Anderson D.K., Panter S.S., Hallaway P.E., and Eaton J.W. Hemoglobin potentiates central nervous system damage. J. Clin. Invest. 79 (1987) 662-664
23. Chen-Roetling J., and Regan R.F. Effect of heme oxygenase-1 on the vulnerability of astrocytes and neurons to hemoglobin. Biochem. Biophys. Res. Commun. 350 (2006) 233-237
24. Thanos S., Mey J., and Wild M. Treatment of the adult retina with microglia-suppressing factors retards axotomy-induced neuronal degradation and enhances axonal regeneration in vivo and in vitro. J. Neurosci. 13 (1993) 455-466
25. Lai A.Y., and Todd K.G. Hypoxia-activated microglial mediators of neuronal survival are differentially regulated by tetracyclines. Glia 53 (2006) 809-816
26. Tikka T., Fiebich B.L., Goldsteins G., Keinanen R., and Koistinaho J. Minocycline, a tetracycline derivative, is neuroprotective against excitotoxicity by inhibiting activation and proliferation of microglia. J. Neurosci. 21 (2001) 2580-2588
27. Alano C.C., Kauppinen T.M., Valls A.V., and Swanson R.A. Minocycline inhibits poly(ADP-ribose) polymerase-1 at nanomolar concentrations. Proc. Natl. Acad. Sci. USA 103 (2006) 9685-9690
28. Barza M., Brown R.B., Shanks C., Gamble C., and Weinstein L. Relation between lipophilicity and pharmacological behavior of minocycline, doxycycline, tetracycline, and oxytetracycline in dogs. Antimicrob. Agents Chemother. 8 (1975) 713-720
29. Kraus R.L., Pasieczny R., Lariosa-Willingham K., Turner M.S., Jiang A., and Trauger J.W. Antioxidant properties of minocycline: neuroprotection in an oxidative stress assay and direct radical-scavenging activity. J. Neurochem. 94 (2005) 819-827
30. Torti F.M., and Torti S.V. Regulation of ferritin genes and protein. Blood 99 (2002) 3505-3516
31. Meyron-Holtz E.G., Ghosh M.C., Iwai K., LaVaute T., Brazzolotto X., Berger U.V., Land W., Ollivierre-Wilson H., Grinberg A., Love P., and Rouault T.A. Genetic ablations of iron regulatory proteins 1 and 2 reveal why iron regulatory protein 2 dominates iron homeostasis. EMBO J. 23 (2004) 386-395
32. Regan R.F., Li Z., Chen M., Zhang X., and Chen-Roetling J. Iron regulatory proteins increase neuronal vulnerability to hydrogen peroxide. Biochem. Biophys. Res. Commun. 375 (2008) 6-10
33. Iwai K., Drake S.K., Wehr N.B., Weissman A.M., LaVaute T., Minato N., Klausner R.D., Levine R.L., and Rouault T.A. Iron-dependent oxidation, ubiquitination, and degradation of iron regulatory protein 2: implications for degradation of oxidized proteins. Proc. Natl. Acad. Sci. 95 (1998) 4924-4928
34. Kang D.K., Jeong J., Drake S.K., Wehr N.B., Rouault T.A., and Levine R.L. Iron regulatory protein 2 as iron sensor. Iron-dependent oxidative modification of cysteine. J. Biol. Chem. 278 (2003) 14857-14864
35. Regan R.F., Chen M., Li Z., Zhang X., Benvenisti-Zarom L., and Chen-Roetling J. Neurons lacking iron regulatory protein-2 are highly resistant to the toxicity of hemoglobin. Neurobiol. Dis. 31 (2008) 242-249
36. Xi G., Keep R.F., and Hoff J.T. Mechanisms of brain injury after intracerebral haemorrhage. Lancet Neurol. 5 (2006) 53-63