Iron and neurodegenerative disorders

Brain Research Bulletin

Volumn 55, Issue 2, 2001, Pages 155-164

  Thompson, Khristy J ^a   Shoham, Shai ^b   Connor, James R ^a  

^a PENN STATE COLLEGE OF MEDICINE   (United States)

^b HERZOG HOSPITAL   (Israel)

Author keywords

Alzheimer's disease; CNS; Iron homeostasis; Iron proteins; Oxidative damage

Indexed keywords

CERULOPLASMIN; FERRITIN; IRON; LACTOFERRIN; PROTEIN; TRANSFERRIN;

AGE; ALZHEIMER DISEASE; CELL DEATH; COGNITIVE DEFECT; CONFERENCE PAPER; DEGENERATIVE DISEASE; HOMEOSTASIS; HUMAN; IRON STORAGE; IRON TRANSPORT; NEUROLOGIC DISEASE; OXIDATIVE STRESS; PARKINSON DISEASE; PATHOGENESIS; PRIORITY JOURNAL; REGULATORY MECHANISM; SIGNAL TRANSDUCTION;

ANIMALS; BRAIN; HOMEOSTASIS; HUMANS; IRON; IRON METABOLISM DISORDERS; METALLOPROTEINS; NEURODEGENERATIVE DISEASES; OXIDATIVE STRESS;

EID: 0035872428     PISSN: 03619230     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0361-9230(01)00510-X     Document Type: Conference Paper

References (161)

1. A novel mammalian iron-regulated protein involved in intracellular iron metabolism
2. Iron transport and storage proteins
3. Distribution of transferrin synthesis in brain and other tissues in the rat
4. Inhibitory effect of lactoferrin on the adhesion of actinobacillus actinomycetemcomitan and prevotella intermedia to fibroblasts and epithelial cells
5. Manganese transport across the blood-brain barrier: Relationship to iron homeostasis
6. Expression of transferrin mRNA in the CNS of normal and jimpy mice
7. Increased basal ganglia iron levels in Huntington Disease
8. MRI evaluation of brain iron in earlier- and later-onset Parkinson's Disease and normal subjects
9. MRI evaluation of basal ganglia ferritin iron and neurotoxicity in Alzheimer's and Huntington's Disease
10. Iron in the brain
11. Limbic seizure and brain damage produced by kainic acid: Mechanisms and relevance to human temporal lobe epilepsy
12. Lactoferrin binds to neutrophilic membrane DNA
13. Are reactive oxygen species involved in Alzheimer's disease?
14. Receptor binding of lactoferrin by human monocytes
15. Transferrin gene expression visualized in oligodendrocytes of the rat brain using in situ hybridization and immunohistochemistry
16. Pumping iron in Parkinson's Disease
17. Iron absorption. I. Factors influencing absorption
18. Transcytosis of protein through the mammalian cerebral epithelium and endothelium. III. Receptor-mediated transcytosis through the blood-brain barrier of blood-borne transferrin and antibody against the transferrin receptor
19. Cellular distribution of iron in the brain of the Belgrade rat
20. Metals and neuroscience
21. Early-onset Alzheimer's disease caused by mutations at codon 717 of the beta-amyloid precursor protein gene
22. Dietary iron intake rapidly influences iron regulatory proteins, ferritin subunits and mitochondrial aconitase in rat liver
23. Oxidative stress and Alzheimer's Disease
24. The distribution of transferrin immunoreactivity in the rat central nervous system
25. Cellular management of iron in the brain
26. Cellular distribution of transferrin, ferritin, and iron in normal and aged human brains
27. A histochemical study of iron, transferrin, and ferritin in Alzheimer's diseased brains
28. Is hemochromatosis a risk factor for Alzheimer's disease?
29. A quantitative analysis of isoferritins in select regions of aged, Parkinsonian, and Alzheimer's diseased brains
30. Ceruloplasmin levels in the human superior temporal gyrus in aging and Alzheimer's Disease
31. Glutathione in the brain: Disorders of glutathione metabolism
32. Oxidative stress, glutamate, and neurodegenerative disorders
33. Stoichiometry of Fe(ii) oxidation during ceruloplasmin-catalyzed loading of ferritin
34. Expression of a constitutive mutant of iron regulatory protein 1 abolishes iron homeostasis in mammalian cells
35. Increased nigral iron content and alterations in other metal ions occurring in brain in Parkinson's disease
36. Immunohistochemical analysis of transferrin receptor: Regional and cellular distribution in the hypotransferrinemic (hpx) mouse brain
37. Distribution of injected iron 59 and manganese 54 in hypotransferrinemic mice
38. Reduced signal intensity on mr images of thalamus and putamen in multiple sclerosis: Increased iron content?
39. An obligate role for oxygen in the early stages of glutamate-induced, delayed neuronal death
40. Nonidentical distribution of transferrin and ferric iron in human brains
41. Abnormalities in CSF concentrations of ferritin and transferrin in restless legs syndrome
42. Applications of an immunoperoxidase method to a study of the central nervous system: Preliminary findings in a study of human formalin-fixed material
43. Distribution of 125i-ferrotransferrin binding sites in the mesencephalon of control subjects and patients with Parkinson's disease
44. Expression of lactoferrin receptors is increased in the mesencephalon of patients with Parkinson disease
45. Receptor-mediated transcytosis of lactoferrin through the blood-brain barrier
46. Ferritin: Isolation of aluminum-ferritin complex from brain
47. Iron as a vulnerability factor in nigrostriatal degeneration in aging and Parkinson's disease
48. Role of oxygen free radicals in carcinogenesis and brain ischemia
49. Regional distribution of iron, transferrin, ferritin, and oxidatively-modified proteins in young and aged Fischer 344 rat brains
50. Ferritin: Design and formation of an iron-storage molecule
51. Lactoferrin binding sites and nuclear localization in k562(s) cells
52. Transferrin receptors in rat central nervous system. An immunocytochemical study
53. Segregation of a missense mutation in the amyloid precursor protein gene with familial Alzheimer's disease
54. Changes in glial cell markers in recent and old demyelinated lesions in central pontine myelinolysis
55. Neuromelanin-containing neurons of the substantia nigra accumulate iron and aluminum in Parkinson's disease: A lamma study
56. Selective accumulation of aluminum and iron in the neurofibrillary tangles of Alzheimer's disease: A laser microprobe (lamma) study
57. Evidence of neuronal oxidative damage in Alzheimer's disease
58. Cloning and characterization of a mammalian proton-coupled metal-ion transporter
59. Expression and loading of recombinant heavy and light chain homopolymers of rat liver ferritin
60. Free radicals in CNS injury
61. The effect of age on the nonhaemin iron in the human brain
62. Reactive oxygen species and the central nervous system
63. Oxygen toxicity, oxygen radicals, transition metals and disease
64. Aceruloplasminemia: An inherited neurodegenerative disease with impairment of iron homeostasis
65. The ferritins: Molecular properties, iron storage function and cellular regulation
66. The location of exon boundaries in the multimeric iron-storage protein ferritin
67. Cell culture assay of biological activity of lactoferrin and transferrin
68. The role of alterations in membrane lipid composition in enabling physiological adaptation of organisms to their physical environment
69. Molecular control of vertebrate iron metabolism: mRNA-based regulatory circuits operated by iron, nitric oxide, and oxidative stress
70. Huntingtin: An iron-related protein essential for normal nuclear and perinuclear organelles
71. Iron concentration reduced in ventral pallidum, globus pallidus, and substancia nigra by gaba-transaminase inhibitor, gamma-vinyl GABA
72. Transferrin receptors in rat brain: Neuropeptide-like pattern and relationship to iron distribution
73. Iron metabolism and Parkinson's disease
74. Alzheimer's disease, beta-amyloid protein and zinc
75. Distribution of transferrin and ferritin binding in normal and multiple sclerotic human brains
76. Comparative study of different iron-chelating agents in cold-induced brain edema
77. Transferrin receptor on endothelium of brain capillaries
78. Iron-melanin complex in substantia nigra of Parkinsonian brains: An x-ray microanalysis
79. Chemical evidence for 6-hydroxydopamine to be an endogenous toxic factor in the pathogenesis of Parkinson's disease
80. The role of iron in neurodegeneration: Prospects for pharmacotherapy of Parkinson's disease
81. Loading of iron into recombinant rat liver ferritin heteropolymers by ceruloplasmin
82. Melatonin inhibits iron-induced epileptic discharges in rats by suppressing peroxidation
83. Immunohistochemical localization of the murine transferrin receptor (TfR) on blood-tissue barriers using a novel anti-TfR monoclonal antibody
84. From receptors to genes - Insights from molecular iron metabolism
85. Ceruloplasmin gene expression in the murine central nervous system
86. Expression of the ceruloplasmin gene in the human retina and brain: Implications for a pathogenic model in aceruloplasminemia
87. Brain hemosiderin and superficial siderosis of the central nervous system
88. Targeted deletion of the gene encoding iron regulatory protein-2 causes misregulation of iron metabolism and neurodegenerative disease in mice
89. Oligodendrocytes and myelin sheaths in normal, quaking and shiverer brains are enriched in iron
90. Iron-enriched oligodendrocytes: A reexamination of their spatial distribution
91. Transferrin receptor is necessary for development of erythrocytes and the nervous system
92. The H(+)-ATPase from reticulocyte endosomes reconstituted into liposomes acts as an iron transporter
93. Translation inhibition by an mRNA coding region secondary structure is determined by its proximity to the aug initiation codon
94. Transferrin and iron in normal, Alzheimer's disease, and Parkinson's disease brain regions
95. Increased regional brain concentrations of ceruloplasmin in neurodegenerative disorders
96. Lactoferrin: Molecular structure and biological function
97. Transferrin is required for normal distribution of 59Fe and 54Mn in mouse brain
98. Existing and emerging mechanisms for transport of iron and manganese to the brain
99. Characterization and distribution of transferrin receptors in the rat brain
100. Immunohistochemical localization of intraneuronal transferrin receptor immunoreactivity in the adult mouse central nervous system
101. Expression of the neuronal transferrin receptor is age dependent and susceptible to iron deficiency
102. Hereditary ceruloplasmin deficiency with hemosiderosis: A clinicopathological study of a Japanese family
103. Transferrin receptors in the normal human hippocampus and in Alzheimer's disease
104. Histochemical distribution of non-haem iron in the human brain
105. Comparison of the regional distribution of transferrin receptors and aluminium in the forebrain of chronic renal dialysis patients
106. Non-ferritin, non-heme iron pools in rat tissues
107. The size of small molecular weight iron pools in rat tissues
108. A mutation in the amyloid precursor protein associated with hereditary Alzheimer's disease
109. Iron uptake and utilization by mammalian cells. I. Cellular uptake of transferrin and iron
110. Immunocytochemical distribution of transferrin and its receptor in the developing chicken nervous system
111. A novel glycosylphosphatidylinositol-anchored form of ceruloplasmin is expressed by mammalian astrocytes
112. Alternative RNA splicing generates a glycosylphosphatidylinositol-anchored form of ceruloplasmin in mammalian brain
113. Alterations in the interaction between iron regulatory proteins and their responsive element in normal and Alzheimer's diseased brains
114. Heme oxygenase 1 is required for mammalian iron reutilization
115. Expression of iron transport proteins and excessive iron accumulation in the brain in neurodegenerative disorders
116. Peroxidation induced changes in synaptosomal transport of dopamine and gamma-aminobutyric acid
117. Ferritin as a source of iron for oxidative damage
118. Stimulation of the ferroxidase activity of ceruloplasmin during iron loading into ferritin
119. Oxidative stress-induced cell damage in the CNS: A proposal for a final common pathway
120. Translation of the Alzheimer amyloid precursor protein mRNA is up-regulated by interleukin-1 through 5′-untranslated region sequences
121. Lactoferrin-binding sites at the surface of HT29-D4 cells. Comparison with transferrin
122. Evidence of altered central nervous system development in infants with iron deficiency anemia at 6 mo: Delayed maturation of auditory brainstem responses
123. Aluminum access to the brain: A role for transferrin and its receptor
124. Differential localization of divalent metal transporter 1 with and without iron response element in rat PC12 and sympathetic neuronal cells
125. Time-dependent changes in iron levels and associated neuronal loss within the substantia nigra following lesions within the neostriatum/globus pallidus complex
126. Redox metals and neurodegenerative disease
127. 4-Hydroxynonenal-derived advanced lipid peroxidation end products are increased in Alzheimer's disease
128. Iron accumulation in the rat basal ganglia after excitatory amino acid injections - Dissociation from neuronal loss
129. Differential sensitivity of hippocampal subregions to iron deficiency and to iron and zinc in nutritional therapy
130. Iron involvement in neural damage and microgliosis in models of neurodegenerative diseases
131. Oxidative stress in closed-head injury: Brain antioxidant capacity as an indicator of functional outcome
132. Iron accumulation in Alzheimer disease is a source of redox-generated free radicals
133. Free radical damage, iron, and Alzheimer's Disease
134. Is Alzheimer's a disease of oxidative stress?
135. Abnormal localization of iron regulatory protein in Alzheimer's Disease
136. Selective increase of iron in substantia nigra zona compacta of Parkinsonian brains
137. Hallervorden-Spatz syndrome and brain iron metabolism
138. Characterization of a nonsense mutation in the ceruloplasmin gene resulting in diabetes and neurodegenerative disease
139. Alzheimer's mutation
140. Bacteriostatic effect of orally administered bovine lactoferrin on proliferation of clostridium species in the gut of mice fed bovine milk
141. Perterbations of H-ferritin in mice results in alterations in brain iron homeostasis
142. Rate of 59fe uptake into brain and cerebrospinal fluid and the influence thereon of antibodies against the transferrin receptor
143. The reflection of histology in mr imaging of Pelizaeus-Merzbacher disease
144. Intact human ceruloplasmin is required for the incorporation of iron into human ferritin
145. Review: Alzheimer's amyloid β-peptide-associated free radical oxidative stress and neurotoxicity
146. Purification of a specific repressor of ferritin mRNA translation from rabbit liver
147. Low molecular weight iron specied isolated from guinea pig reticulacytes as AMP-iron and ATP-iron complexes
148. Iron-dependent enzymes in the brain
149. Free manganese (ii) and iron (ii) cations can act as intracellular cell controls
150. Chronic focal epileptiform discharges induced by injection of iron into rat and cat cortex
151. Generation of hydroxyl radical from linoleic acid hydroperoxide in the presence of epinephrine and iron
152. Lactoferrin binding by leukemia cell lines
153. Stabilization of iron regulatory protein 2, IRP2, by aluminum
154. A mutation in the ceruloplasmin gene is associated with systemic hemosiderosis in humans
155. The role of monoamine oxidase, iron-melanin interaction, and intracellular calcium in Parkinson's disease
156. Neuropharmacological and neurobiochemical aspects of iron deficiency
157. The Menkes/Wilson disease gene homologue in yeast provides copper to a ceruloplasmin-like oxidase required for iron uptake
158. Lactoferrin uptake by the rat liver. Characterization of the recognition site and effect of selective modification of arginine residues
159. Clinically silent mutation in the putative iron-response element in exon 17 of the β-amyloid precursor protein gene