Role of Sirtuins in Stem Cell Differentiation

Genes and Cancer

Volumn 4, Issue 3-4, 2013, Pages 105-111

  Rodriguez, R M ^a   Fernandez, A F ^a   Fraga, M F ^a,b  

^a DEPARTAMENTO DE BIOQUÍMICA Y BIOLOGÍA MOLECULAR   (Spain)

^b CENTRO NACIONAL DE BIOTECNOLOGÍA   (Spain)

Author keywords

aging; development; sirtuins; stem cells

Indexed keywords

HISTONE DEACETYLASE 1; PROTAMINE; SIRTUIN; SIRTUIN 1; SIRTUIN 2; SIRTUIN 3; SIRTUIN 6;

ADULT STEM CELL; AGING; APOPTOSIS; BLASTOCYST; CARCINOGENESIS; CELL ACTIVITY; CELL AGING; CELL CYCLE ARREST; CELL DIFFERENTIATION; CELL FATE; CELL FUNCTION; CELL MATURATION; CELL METABOLISM; CELL SURVIVAL; CHROMOSOMAL INSTABILITY; DEACETYLATION; DNA REPAIR; EMBRYONIC STEM CELL; ENVIRONMENTAL STRESS; ENZYME LOCALIZATION; G2 PHASE CELL CYCLE CHECKPOINT; GENE EXPRESSION REGULATION; GENE SILENCING; HISTONE ACETYLATION; HUMAN; NONHUMAN; PRIORITY JOURNAL; PROTEIN FUNCTION; PROTEIN INTERACTION; PROTEIN TARGETING; REVIEW; SENESCENCE; STEM CELL; TARGET CELL; TELOMERE;

EID: 84887474201     PISSN: 19476019     EISSN: 19476027     Source Type: Journal    
DOI: 10.1177/1947601913479798     Document Type: Review

References (98)

1. de Ruijter AJ,van Gennip AH,Caron HN,Kemp S,van Kuilenburg AB.Histone deacetylases (HDACs): characterization of the classical HDAC family.Biochem J. 2003;370:737-49.
2. Gregoretti IV,Lee YM,Goodson HV.Molecular evolution of the histone deacetylase family: functional implications of phylogenetic analysis.J Mol Biol. 2004;338:17-31.
3. Shore D,Squire M,Nasmyth KA.Characterization of two genes required for the position-effect control of yeast mating-type genes.EMBO J. 1984;3:2817-23.
4. Guarente L.Diverse and dynamic functions of the Sir silencing complex.Nat Genet. 1999;23:281-5.
5. Landry J,Slama JT,Sternglanz R.Role of NAD(+) in the deacetylase activity of the SIR2-like proteins.Biochem Biophys Res Commun. 2000;278:685-90.
6. Saunders LR,Verdin E.Sirtuins: critical regulators at the crossroads between cancer and aging.Oncogene. 2007;26:5489-504.
7. Rodriguez RM,Fraga MF.Aging and cancer: are sirtuins the link?.Future Oncol. 2010;6:905-15.
8. Finkel T,Deng CX,Mostoslavsky R.Recent progress in the biology and physiology of sirtuins.Nature. 2009;460:587-91.
9. Bosch-Presegue L,Vaquero A.The dual role of sirtuins in cancer.Genes Cancer. 2012;2:648-62.
10. Carafa V,Nebbioso A,Altucci L.Sirtuins and disease: the road ahead.Front Pharmacol. 2012;3:4.
11. Kaeberlein M,McVey M,Guarente L.The SIR2/3/4 complex and SIR2 alone promote longevity in Saccharomyces cerevisiae by two different mechanisms.Genes Dev. 1999;13:2570-80.
12. Lin SJ,Defossez PA,Guarente L.Requirement of NAD and SIR2 for life-span extension by calorie restriction in Saccharomyces cerevisiae.Science. 2000;289:2126-8.
13. Wood JG,Rogina B,Lavu S,et al.Sirtuin activators mimic caloric restriction and delay ageing in metazoans.Nature. 2004;430:686-9.
14. Berdichevsky A,Viswanathan M,Horvitz HR,Guarente L. C.elegans SIR-2.1 interacts with 14-3-3 proteins to activate DAF-16 and extend life span.Cell. 2006;125:1165-77.
15. Mostoslavsky R,Chua KF,Lombard DB,et al.Genomic instability and aging-like phenotype in the absence of mammalian SIRT6.Cell. 2006;124:315-29.
16. Pruitt K,Zinn RL,Ohm JE,et al.Inhibition of SIRT1 reactivates silenced cancer genes without loss of promoter DNA hypermethylation.PLoS Genet. 2006;2:e40.
17. Yuan J,Pu M,Zhang Z,Lou Z.Histone H3-K56 acetylation is important for genomic stability in mammals.Cell Cycle. 2009;8:1747-53.
18. Vaquero A,Scher M,Lee D,Erdjument-Bromage H,Tempst P,Reinberg D.Human SirT1 interacts with histone H1 and promotes formation of facultative heterochromatin.Mol Cell. 2004;16:93-105.
19. Vaquero A,Scher M,Erdjument-Bromage H,Tempst P,Serrano L,Reinberg D.SIRT1 regulates the histone methyl-transferase SUV39H1 during heterochromatin formation.Nature. 2007;450:440-4.
20. Brunet A,Sweeney LB,Sturgill JF,et al.Stress-dependent regulation of FOXO transcription factors by the SIRT1 deacetylase.Science. 2004;303:2011-5.
21. Giannakou ME,Partridge L.The interaction between FOXO and SIRT1: tipping the balance towards survival.Trends Cell Biol. 2004;14:408-12.
22. Vaziri H,Dessain SK,Ng Eaton E,et al.hSIR2(SIRT1) functions as an NAD-dependent p53 deacetylase.Cell. 2001;107:149-59.
23. Yeung F,Hoberg JE,Ramsey CS,et al.Modulation of NF-kappaB-dependent transcription and cell survival by the SIRT1 deacetylase.EMBO J. 2004;23:2369-80.
24. Yuan Z,Zhang X,Sengupta N,Lane WS,Seto E.SIRT1 regulates the function of the Nijmegen breakage syndrome protein.Mol Cell. 2007;27:149-62.
25. Dryden SC,Nahhas FA,Nowak JE,Goustin AS,Tainsky MA.Role for human SIRT2 NAD-dependent deacetylase activity in control of mitotic exit in the cell cycle.Mol Cell Biol. 2003;23:3173-85.
26. Nahhas F,Dryden SC,Abrams J,Tainsky MA.Mutations in SIRT2 deacetylase which regulate enzymatic activity but not its interaction with HDAC6 and tubulin.Mol Cell Biochem. 2007;303:221-30.
27. North BJ,Verdin E.Mitotic regulation of SIRT2 by cyclin-dependent kinase 1-dependent phosphorylation.J Biol Chem. 2007;282:19546-55.
28. Inoue T,Hiratsuka M,Osaki M,et al.SIRT2, a tubulin deacetylase, acts to block the entry to chromosome condensation in response to mitotic stress.Oncogene. 2007;26:945-57.
29. Vaquero A,Reinberg DEpigenetics in biology and medicine. Esteller M, ed. Boca Raton, FL: CRC Press; 2009:73-104.
30. Vaquero A,Scher MB,Lee DH,et al.SirT2 is a histone deacetylase with preference for histone H4 Lys 16 during mitosis.Genes Dev. 2006;20:1256-61.
31. Onyango P,Celic I,McCaffery JM,Boeke JD,Feinberg AP.SIRT3, a human SIR2 homologue, is an NAD-dependent deacetylase localized to mitochondria.Proc Natl Acad Sci U S A. 2002;99:13653-8.
32. Schwer B,North BJ,Frye RA,Ott M,Verdin E.The human silent information regulator (Sir)2 homologue hSIRT3 is a mitochondrial nicotinamide adenine dinucleotide-dependent deacetylase.J Cell Biol. 2002;158:647-57.
33. Lombard DB,Alt FW,Cheng HL,et al.Mammalian Sir2 homolog SIRT3 regulates global mitochondrial lysine acetylation.Mol Cell Biol. 2007;27:8807-14.
34. Scher MB,Vaquero A,Reinberg D.SirT3 is a nuclear NAD+-dependent histone deacetylase that translocates to the mitochondria upon cellular stress.Genes Dev. 2007;21:920-8.
35. Schwer B,Bunkenborg J,Verdin RO,Andersen JS,Verdin E.Reversible lysine acetylation controls the activity of the mitochondrial enzyme acetyl-CoA synthetase 2.Proc Natl Acad Sci U S A. 2006;103:10224-9.
36. Hallows WC,Lee S,Denu JM.Sirtuins deacetylate and activate mammalian acetyl-CoA synthetases.Proc Natl Acad Sci U S A. 2006;103:10230-5.
37. Shi T,Wang F,Stieren E,Tong Q.SIRT3, a mitochondrial sirtuin deacetylase, regulates mitochondrial function and thermogenesis in brown adipocytes.J Biol Chem. 2005;280:13560-7.
38. Yang H,Yang T,Baur JA,et al.Nutrient-sensitive mitochondrial NAD+ levels dictate cell survival.Cell. 2007;130:1095-107.
39. Sundaresan NR,Samant SA,Pillai VB,Rajamohan SB,Gupta MP.SIRT3 is a stress-responsive deacetylase in cardiomyocytes that protects cells from stress-mediated cell death by deacetylation of Ku70.Mol Cell Biol. 2008;28:6384-401.
40. Yang B,Zwaans BM,Eckersdorff M,Lombard DB.The sirtuin SIRT6 deacetylates H3 K56Ac in vivo to promote genomic stability.Cell Cycle. 2009;8:2662-3.
41. Michishita E,McCord RA,Berber E,et al.SIRT6 is a histone H3 lysine 9 deacetylase that modulates telomeric chromatin.Nature. 2008;452:492-6.
42. Kawahara TL,Michishita E,Adler AS,et al.SIRT6 links histone H3 lysine 9 deacetylation to NF-kappaB-dependent gene expression and organismal life span.Cell. 2009;136:62-74.
43. Haigis MC,Mostoslavsky R,Haigis KM,et al.SIRT4 inhibits glutamate dehydrogenase and opposes the effects of calorie restriction in pancreatic beta cells.Cell. 2006;126:941-54.
44. Schlicker C,Gertz M,Papatheodorou P,Kachholz B,Becker CF,Steegborn C.Substrates and regulation mechanisms for the human mitochondrial sirtuins Sirt3 and Sirt5.J Mol Biol. 2008;382:790-801.
45. Nakagawa T,Lomb DJ,Haigis MC,Guarente L.SIRT5 deacetylates carbamoyl phosphate synthetase 1 and regulates the urea cycle.Cell. 2009;137:560-70.
46. Du J,Zhou Y,Su X,et al.Sirt5 is a NAD-dependent protein lysine demalonylase and desuccinylase.Science. 2011;334:806-9.
47. Ford E,Voit R,Liszt G,Magin C,Grummt I,Guarente L.Mammalian Sir2 homolog SIRT7 is an activator of RNA polymerase I transcription.Genes Dev. 2006;20:1075-80.
48. Adenot PG,Mercier Y,Renard JP,Thompson EM.Differential H4 acetylation of paternal and maternal chromatin precedes DNA replication and differential transcriptional activity in pronuclei of 1-cell mouse embryos.Development. 1997;124:4615-25.
49. Lepikhov K,Walter J.Differential dynamics of histone H3 methylation at positions K4 and K9 in the mouse zygote.BMC Dev Biol. 2004;4:12.
50. Worrad DM,Turner BM,Schultz RM.Temporally restricted spatial localization of acetylated isoforms of histone H4 and RNA polymerase II in the 2-cell mouse embryo.Development. 1995;121:2949-59.
51. Ma P,Schultz RM.Histone deacetylase 1 (HDAC1) regulates histone acetylation, development, and gene expression in preimplantation mouse embryos.Dev Biol. 2008;319:110-20.
52. McBurney MW,Yang X,Jardine K,et al.The mammalian SIR2alpha protein has a role in embryogenesis and gametogenesis.Mol Cell Biol. 2003;23:38-54.
53. Cheng HL,Mostoslavsky R,Saito S,et al.Developmental defects and p53 hyperacetylation in Sir2 homolog (SIRT1)-deficient mice.Proc Natl Acad Sci U S A. 2003;100:10794-9.
54. Wang RH,Sengupta K,Li C,et al.Impaired DNA damage response, genome instability, and tumorigenesis in SIRT1 mutant mice.Cancer Cell. 2008;14:312-23.
55. Kim HS,Vassilopoulos A,Wang RH,et al.SIRT2 maintains genome integrity and suppresses tumorigenesis through regulating APC/C activity.Cancer Cell. 2011;20:487-99.
56. Vakhrusheva O,Smolka C,Gajawada P,et al.Sirt7 increases stress resistance of cardiomyocytes and prevents apoptosis and inflammatory cardiomyopathy in mice.Circ Res. 2008;102:703-10.
57. Efroni S,Duttagupta R,Cheng J,et al.Global transcription in pluripotent embryonic stem cells.Cell Stem Cell. 2008;2:437-47.
58. Calvanese V,Lara E,Suarez-Alvarez B,et al.Sirtuin 1 regulation of developmental genes during differentiation of stem cells.Proc Natl Acad Sci U S A. 2010;107:13736-41.
59. Saunders LR,Sharma AD,Tawney J,et al.miRNAs regulate SIRT1 expression during mouse embryonic stem cell differentiation and in adult mouse tissues.Aging (Albany NY). 2010;2:415-31.
60. Tarantino C,Paolella G,Cozzuto L,et al.miRNA 34a, 100, and 137 modulate differentiation of mouse embryonic stem cells.FASEB J. 2010;24:3255-63.
61. Han MK,Song EK,Guo Y,Ou X,Mantel C,Broxmeyer HE.SIRT1 regulates apoptosis and Nanog expression in mouse embryonic stem cells by controlling p53 subcellular localization.Cell Stem Cell. 2008;2:241-51.
62. Kuzmichev A,Margueron R,Vaquero A,et al.Composition and histone substrates of polycomb repressive group complexes change during cellular differentiation.Proc Natl Acad Sci U S A. 2005;102:1859-64.
63. Hisahara S,Chiba S,Matsumoto H,et al.Histone deacetylase SIRT1 modulates neuronal differentiation by its nuclear translocation.Proc Natl Acad Sci U S A. 2008;105:15599-604.
64. Prozorovski T,Schulze-Topphoff U,Glumm R,et al.Sirt1 contributes critically to the redox-dependent fate of neural progenitors.Nat Cell Biol. 2008;10:385-94.
65. Fulco M,Schiltz RL,Iezzi S,et al.Sir2 regulates skeletal muscle differentiation as a potential sensor of the redox state.Mol Cell. 2003;12:51-62.
66. Picard F,Kurtev M,Chung N,et al.Sirt1 promotes fat mobilization in white adipocytes by repressing PPAR-gamma.Nature. 2004;429:771-6.
67. Ou X,Chae HD,Wang RH,et al.SIRT1 deficiency compromises mouse embryonic stem cell hematopoietic differentiation, and embryonic and adult hematopoiesis in the mouse.Blood. 2011;117:440-50.
68. Matsui K,Ezoe S,Oritani K,et al.NAD-dependent histone deacetylase, SIRT1, plays essential roles in the maintenance of hematopoietic stem cells.Biochem Biophys Res Commun. 2012;418:811-7.
69. Leko V,Varnum-Finney B,Li H,et al.SIRT1 is dispensable for function of hematopoietic stem cells in adult mice.Blood. 2012;119:1856-60.
70. Southwood CM,Peppi M,Dryden S,Tainsky MA,Gow A.Microtubule deacetylases, SirT2 and HDAC6, in the nervous system.Neurochem Res. 2007;32:187-95.
71. Li W,Zhang B,Tang J,et al.Sirtuin 2, a mammalian homolog of yeast silent information regulator-2 longevity regulator, is an oligodendroglial protein that decelerates cell differentiation through deacetylating alpha-tubulin.J Neurosci. 2007;27:2606-16.
72. Jing E,Gesta S,Kahn CR.SIRT2 regulates adipocyte differentiation through FoxO1 acetylation/deacetylation.Cell Metab. 2007;6:105-14.
73. Wang F,Tong Q.SIRT2 suppresses adipocyte differentiation by deacetylating FOXO1 and enhancing FOXO1's repressive interaction with PPARgamma.Mol Biol Cell. 2009;20:801-8.
74. Rothgiesser KM,Erener S,Waibel S,Luscher B,Hottiger MO.SIRT2 regulates NF-kappaB dependent gene expression through deacetylation of p65 Lys310.J Cell Sci. 2010;123:4251-8.
75. Hayden MS,Ghosh S.NF-kappaB in immunobiology.Cell Res. 2011;21:223-44.
76. Giralt A,Hondares E,Villena JA,et al.Peroxisome proliferator-activated receptor-gamma coactivator-1alpha controls transcription of the Sirt3 gene, an essential component of the thermogenic brown adipocyte phenotype.J Biol Chem. 2011;286:16958-66.
77. Krishnamurthy J,Sharpless NE.Stem cells and the rate of living.Cell Stem Cell. 2007;1:9-11.
78. Sharpless NE,DePinho RA.How stem cells age and why this makes us grow old.Nat Rev Mol Cell Biol. 2007;8:703-13.
79. Chambers SM,Shaw CA,Gatza C,Fisk CJ,Donehower LA,Goodell MA.Aging hematopoietic stem cells decline in function and exhibit epigenetic dysregulation.PLoS Biol. 2007;5:e201.
80. Gonzalo S,Jaco I,Fraga MF,et al.DNA methyltransferases control telomere length and telomere recombination in mammalian cells.Nat Cell Biol. 2006;8:416-24.
81. Pollina EA,Brunet A.Epigenetic regulation of aging stem cells.Oncogene. 2011;30:3105-26.
82. Fraga MF.Genetic and epigenetic regulation of aging.Curr Opin Immunol. 2009;21:446-53.
83. Tissenbaum HA,Guarente L.Increased dosage of a sir-2 gene extends lifespan in Caenorhabditis elegans.Nature. 2001;410:227-30.
84. Rogina B,Helfand SL.Sir2 mediates longevity in the fly through a pathway related to calorie restriction.Proc Natl Acad Sci U S A. 2004;101:15998-6003.
85. Boily G,Seifert EL,Bevilacqua L,et al.SirT1 regulates energy metabolism and response to caloric restriction in mice.PLoS One. 2008;3:e1759.
86. Li Y,Xu W,McBurney MW,Longo VD.SirT1 inhibition reduces IGF-I/IRS-2/Ras/ERK1/2 signaling and protects neurons.Cell Metab. 2008;8:38-48.
87. Bordone L,Cohen D,Robinson A,et al.SIRT1 transgenic mice show phenotypes resembling calorie restriction.Aging Cell. 2007;6:759-67.
88. Cohen HY,Miller C,Bitterman KJ,et al.Calorie restriction promotes mammalian cell survival by inducing the SIRT1 deacetylase.Science. 2004;305:390-2.
89. Mair W,Dillin A.Aging and survival: the genetics of life span extension by dietary restriction.Annu Rev Biochem. 2008;77:727-54.
90. Frankel S,Rogina B.Sir2, caloric restriction and aging.Pathol Biol (Paris). 2006;54:55-7.
91. Guarente L,Picard F.Calorie restriction: the SIR2 connection.Cell. 2005;120:473-82.
92. Wang Y,Tissenbaum HA.Overlapping and distinct functions for a Caenorhabditis elegans SIR2 and DAF-16/FOXO.Mech Ageing Dev. 2006;127:48-56.
93. Chen D,Guarente L.SIR2: a potential target for calorie restriction mimetics.Trends Mol Med. 2007;13:64-71.
94. Burnett C,Valentini S,Cabreiro F,et al.Absence of effects of Sir2 overexpression on lifespan in C. elegans and Drosophila.Nature. 2011;477:482-5.
95. Viswanathan M,Guarente L.Regulation of Caenorhabditis elegans lifespan by sir-2.1 transgenes.Nature. 2011;477:E1-2.
96. Baur JA,Chen D,Chini EN,et al.Dietary restriction: standing up for sirtuins.Science. 2010;329:1012 3-3 4.
97. Kanfi Y,Naiman S,Amir G,et al.The sirtuin SIRT6 regulates lifespan in male mice.Nature. 2012;483:218-21.
98. Mantel C,Broxmeyer HE.Sirtuin 1, stem cells, aging, and stem cell aging.Curr Opin Hematol. 2008;15:326-31.