-
1
-
-
34447625911
-
Epigenetics and aging: the targets and the marks
-
Fraga M.F., and Esteller M. Epigenetics and aging: the targets and the marks. Trends Genet 23 (2007) 413-418
-
(2007)
Trends Genet
, vol.23
, pp. 413-418
-
-
Fraga, M.F.1
Esteller, M.2
-
2
-
-
34548153747
-
How stem cells age and why this makes us grow old
-
Sharpless N.E., and DePinho R.A. How stem cells age and why this makes us grow old. Nat Rev Mol Cell Biol 8 (2007) 703-713
-
(2007)
Nat Rev Mol Cell Biol
, vol.8
, pp. 703-713
-
-
Sharpless, N.E.1
DePinho, R.A.2
-
3
-
-
24744454199
-
Time of our lives. What controls the length of life?
-
Kirkwood T.B. Time of our lives. What controls the length of life?. EMBO Rep 6 Spec No (2005) S4-S8
-
(2005)
EMBO Rep
, vol.6 Spec No
-
-
Kirkwood, T.B.1
-
4
-
-
13944262937
-
Understanding the odd science of aging
-
Kirkwood T.B. Understanding the odd science of aging. Cell 120 (2005) 437-447
-
(2005)
Cell
, vol.120
, pp. 437-447
-
-
Kirkwood, T.B.1
-
5
-
-
34547617380
-
Genetic determinants of human health span and life span: progress and new opportunities
-
Martin G.M., Bergman A., and Barzilai N. Genetic determinants of human health span and life span: progress and new opportunities. PLoS Genet 3 (2007) e125
-
(2007)
PLoS Genet
, vol.3
-
-
Martin, G.M.1
Bergman, A.2
Barzilai, N.3
-
6
-
-
33644950249
-
Genetic influence on human lifespan and longevity
-
Hjelmborg v.B., Iachine I., Skytthe A., Vaupel J.W., McGue M., Koskenvuo M., Kaprio J., Pedersen N.L., and Christensen K. Genetic influence on human lifespan and longevity. Hum Genet 119 (2006) 312-321
-
(2006)
Hum Genet
, vol.119
, pp. 312-321
-
-
Hjelmborg, v.B.1
Iachine, I.2
Skytthe, A.3
Vaupel, J.W.4
McGue, M.5
Koskenvuo, M.6
Kaprio, J.7
Pedersen, N.L.8
Christensen, K.9
-
7
-
-
33748993124
-
Molecular bases of progeroid syndromes
-
Navarro C.L., Cau P., and Levy N. Molecular bases of progeroid syndromes. Hum Mol Genet 15 Spec No 2 (2006) R151-161
-
(2006)
Hum Mol Genet
, vol.15 Spec No 2
-
-
Navarro, C.L.1
Cau, P.2
Levy, N.3
-
9
-
-
34247390746
-
Werner and Hutchinson-Gilford progeria syndromes: mechanistic basis of human progeroid diseases
-
Kudlow B.A., Kennedy B.K., and Monnat Jr. R.J. Werner and Hutchinson-Gilford progeria syndromes: mechanistic basis of human progeroid diseases. Nat Rev Mol Cell Biol 8 (2007) 394-404
-
(2007)
Nat Rev Mol Cell Biol
, vol.8
, pp. 394-404
-
-
Kudlow, B.A.1
Kennedy, B.K.2
Monnat Jr., R.J.3
-
10
-
-
22544440839
-
Blocking protein farnesyltransferase improves nuclear blebbing in mouse fibroblasts with a targeted Hutchinson-Gilford progeria syndrome mutation
-
Yang S.H., Bergo M.O., Toth J.I., Qiao X., Hu Y., Sandoval S., Meta M., Bendale P., Gelb M.H., Young S.G., et al. Blocking protein farnesyltransferase improves nuclear blebbing in mouse fibroblasts with a targeted Hutchinson-Gilford progeria syndrome mutation. Proc Natl Acad Sci U S A 102 (2005) 10291-10296
-
(2005)
Proc Natl Acad Sci U S A
, vol.102
, pp. 10291-10296
-
-
Yang, S.H.1
Bergo, M.O.2
Toth, J.I.3
Qiao, X.4
Hu, Y.5
Sandoval, S.6
Meta, M.7
Bendale, P.8
Gelb, M.H.9
Young, S.G.10
-
11
-
-
0036578920
-
Defective prelamin A processing and muscular and adipocyte alterations in Zmpste24 metalloproteinase-deficient mice
-
Pendas A.M., Zhou Z., Cadinanos J., Freije J.M., Wang J., Hultenby K., Astudillo A., Wernerson A., Rodriguez F., Tryggvason K., et al. Defective prelamin A processing and muscular and adipocyte alterations in Zmpste24 metalloproteinase-deficient mice. Nat Genet 31 (2002) 94-99
-
(2002)
Nat Genet
, vol.31
, pp. 94-99
-
-
Pendas, A.M.1
Zhou, Z.2
Cadinanos, J.3
Freije, J.M.4
Wang, J.5
Hultenby, K.6
Astudillo, A.7
Wernerson, A.8
Rodriguez, F.9
Tryggvason, K.10
-
12
-
-
33645060977
-
A protein farnesyltransferase inhibitor ameliorates disease in a mouse model of progeria
-
Fong L.G., Frost D., Meta M., Qiao X., Yang S.H., Coffinier C., and Young S.G. A protein farnesyltransferase inhibitor ameliorates disease in a mouse model of progeria. Science 311 (2006) 1621-1623
-
(2006)
Science
, vol.311
, pp. 1621-1623
-
-
Fong, L.G.1
Frost, D.2
Meta, M.3
Qiao, X.4
Yang, S.H.5
Coffinier, C.6
Young, S.G.7
-
13
-
-
46849106102
-
Combined treatment with statins and aminobisphosphonates extends longevity in a mouse model of human premature aging
-
Studies in this report demonstrated that a combination of statins and aminobisphosphonates efficiently inhibits both farnesylation and geranylgeranylation of progerin and prelamin A and markedly improves the aging-like phenotypes of mice deficient in the metalloproteinase Zmpste24.
-
Varela I., Pereira S., Ugalde A.P., Navarro C.L., Suarez M.F., Cau P., Cadinanos J., Osorio F.G., Foray N., Cobo J., et al. Combined treatment with statins and aminobisphosphonates extends longevity in a mouse model of human premature aging. Nat Med 14 (2008) 767-772. Studies in this report demonstrated that a combination of statins and aminobisphosphonates efficiently inhibits both farnesylation and geranylgeranylation of progerin and prelamin A and markedly improves the aging-like phenotypes of mice deficient in the metalloproteinase Zmpste24.
-
(2008)
Nat Med
, vol.14
, pp. 767-772
-
-
Varela, I.1
Pereira, S.2
Ugalde, A.P.3
Navarro, C.L.4
Suarez, M.F.5
Cau, P.6
Cadinanos, J.7
Osorio, F.G.8
Foray, N.9
Cobo, J.10
-
14
-
-
47049090142
-
Adiponectin levels and genotype: a potential regulator of life span in humans
-
Atzmon G., Pollin T.I., Crandall J., Tanner K., Schechter C.B., Scherer P.E., Rincon M., Siegel G., Katz M., Lipton R.B., et al. Adiponectin levels and genotype: a potential regulator of life span in humans. J Gerontol A Biol Sci Med Sci 63 (2008) 447-453
-
(2008)
J Gerontol A Biol Sci Med Sci
, vol.63
, pp. 447-453
-
-
Atzmon, G.1
Pollin, T.I.2
Crandall, J.3
Tanner, K.4
Schechter, C.B.5
Scherer, P.E.6
Rincon, M.7
Siegel, G.8
Katz, M.9
Lipton, R.B.10
-
15
-
-
17944375119
-
A genome-wide scan for linkage to human exceptional longevity identifies a locus on chromosome 4
-
Puca A.A., Daly M.J., Brewster S.J., Matise T.C., Barrett J., Shea-Drinkwater M., Kang S., Joyce E., Nicoli J., Benson E., et al. A genome-wide scan for linkage to human exceptional longevity identifies a locus on chromosome 4. Proc Natl Acad Sci U S A 98 (2001) 10505-10508
-
(2001)
Proc Natl Acad Sci U S A
, vol.98
, pp. 10505-10508
-
-
Puca, A.A.1
Daly, M.J.2
Brewster, S.J.3
Matise, T.C.4
Barrett, J.5
Shea-Drinkwater, M.6
Kang, S.7
Joyce, E.8
Nicoli, J.9
Benson, E.10
-
16
-
-
33645992441
-
Chromosome 4q25, microsomal transfer protein gene, and human longevity: novel data and a meta-analysis of association studies
-
Beekman M., Blauw G.J., Houwing-Duistermaat J.J., Brandt B.W., Westendorp R.G., and Slagboom P.E. Chromosome 4q25, microsomal transfer protein gene, and human longevity: novel data and a meta-analysis of association studies. J Gerontol A Biol Sci Med Sci 61 (2006) 355-362
-
(2006)
J Gerontol A Biol Sci Med Sci
, vol.61
, pp. 355-362
-
-
Beekman, M.1
Blauw, G.J.2
Houwing-Duistermaat, J.J.3
Brandt, B.W.4
Westendorp, R.G.5
Slagboom, P.E.6
-
17
-
-
55449120805
-
Genetic mapping in human disease
-
Altshuler D., Daly M.J., and Lander E.S. Genetic mapping in human disease. Science 322 (2008) 881-888
-
(2008)
Science
, vol.322
, pp. 881-888
-
-
Altshuler, D.1
Daly, M.J.2
Lander, E.S.3
-
18
-
-
52949084301
-
Human models of aging and longevity
-
Cevenini E., Invidia L., Lescai F., Salvioli S., Tieri P., Castellani G., and Franceschi C. Human models of aging and longevity. Expert Opin Biol Ther 8 (2008) 1393-1405
-
(2008)
Expert Opin Biol Ther
, vol.8
, pp. 1393-1405
-
-
Cevenini, E.1
Invidia, L.2
Lescai, F.3
Salvioli, S.4
Tieri, P.5
Castellani, G.6
Franceschi, C.7
-
19
-
-
34249683635
-
Cross-talk between aging and cancer: the epigenetic language
-
Fraga M.F., Agrelo R., and Esteller M. Cross-talk between aging and cancer: the epigenetic language. Ann N Y Acad Sci 1100 (2007) 60-74
-
(2007)
Ann N Y Acad Sci
, vol.1100
, pp. 60-74
-
-
Fraga, M.F.1
Agrelo, R.2
Esteller, M.3
-
20
-
-
33748043345
-
Hematopoietic dysfunction in a mouse model for Fanconi anemia group D1
-
Navarro S., Meza N.W., Quintana-Bustamante O., Casado J.A., Jacome A., McAllister K., Puerto S., Surralles J., Segovia J.C., and Bueren J.A. Hematopoietic dysfunction in a mouse model for Fanconi anemia group D1. Mol Ther 14 (2006) 525-535
-
(2006)
Mol Ther
, vol.14
, pp. 525-535
-
-
Navarro, S.1
Meza, N.W.2
Quintana-Bustamante, O.3
Casado, J.A.4
Jacome, A.5
McAllister, K.6
Puerto, S.7
Surralles, J.8
Segovia, J.C.9
Bueren, J.A.10
-
21
-
-
59349086549
-
Mitochondrial DNA mutations and aging: devils in the details?
-
Khrapko K., and Vijg J. Mitochondrial DNA mutations and aging: devils in the details?. Trends Genet 25 (2009) 91-98
-
(2009)
Trends Genet
, vol.25
, pp. 91-98
-
-
Khrapko, K.1
Vijg, J.2
-
22
-
-
0033581704
-
The p66shc adaptor protein controls oxidative stress response and life span in mammals
-
This report showed that targeted mutation of the mouse p66shc gene induces stress resistance and prolongs life span.
-
Migliaccio E., Giorgio M., Mele S., Pelicci G., Reboldi P., Pandolfi P.P., Lanfrancone L., and Pelicci P.G. The p66shc adaptor protein controls oxidative stress response and life span in mammals. Nature 402 (1999) 309-313. This report showed that targeted mutation of the mouse p66shc gene induces stress resistance and prolongs life span.
-
(1999)
Nature
, vol.402
, pp. 309-313
-
-
Migliaccio, E.1
Giorgio, M.2
Mele, S.3
Pelicci, G.4
Reboldi, P.5
Pandolfi, P.P.6
Lanfrancone, L.7
Pelicci, P.G.8
-
23
-
-
34447543913
-
Cellular senescence in cancer and aging
-
Collado M., Blasco M.A., and Serrano M. Cellular senescence in cancer and aging. Cell 130 (2007) 223-233
-
(2007)
Cell
, vol.130
, pp. 223-233
-
-
Collado, M.1
Blasco, M.A.2
Serrano, M.3
-
24
-
-
34248370975
-
High-throughput telomere length quantification by FISH and its application to human population studies
-
Canela A., Vera E., Klatt P., and Blasco M.A. High-throughput telomere length quantification by FISH and its application to human population studies. Proc Natl Acad Sci U S A 104 (2007) 5300-5305
-
(2007)
Proc Natl Acad Sci U S A
, vol.104
, pp. 5300-5305
-
-
Canela, A.1
Vera, E.2
Klatt, P.3
Blasco, M.A.4
-
25
-
-
23844540299
-
Effects of telomerase and telomere length on epidermal stem cell behavior
-
Flores I., Cayuela M.L., and Blasco M.A. Effects of telomerase and telomere length on epidermal stem cell behavior. Science 309 (2005) 1253-1256
-
(2005)
Science
, vol.309
, pp. 1253-1256
-
-
Flores, I.1
Cayuela, M.L.2
Blasco, M.A.3
-
26
-
-
55449122193
-
Telomerase reverse transcriptase delays aging in cancer-resistant mice
-
This report demonstrated that constitutive expression of Tert provides antiaging activity in cancer-resistant mice.
-
Tomas-Loba A., Flores I., Fernandez-Marcos P.J., Cayuela M.L., Maraver A., Tejera A., Borras C., Matheu A., Klatt P., Flores J.M., et al. Telomerase reverse transcriptase delays aging in cancer-resistant mice. Cell 135 (2008) 609-622. This report demonstrated that constitutive expression of Tert provides antiaging activity in cancer-resistant mice.
-
(2008)
Cell
, vol.135
, pp. 609-622
-
-
Tomas-Loba, A.1
Flores, I.2
Fernandez-Marcos, P.J.3
Cayuela, M.L.4
Maraver, A.5
Tejera, A.6
Borras, C.7
Matheu, A.8
Klatt, P.9
Flores, J.M.10
-
27
-
-
0002947085
-
The epigenotype
-
In this report, Conrad H. Waddington coined the term epigenetics.
-
Waddington C. The epigenotype. Endeavour 1 (1942) 18-20. In this report, Conrad H. Waddington coined the term epigenetics.
-
(1942)
Endeavour
, vol.1
, pp. 18-20
-
-
Waddington, C.1
-
28
-
-
0035839136
-
Translating the histone code
-
Jenuwein T., and Allis C.D. Translating the histone code. Science 293 (2001) 1074-1080
-
(2001)
Science
, vol.293
, pp. 1074-1080
-
-
Jenuwein, T.1
Allis, C.D.2
-
29
-
-
64949114140
-
Epigenetics and aging: status, challenges, and needs for the future
-
Kahn A., and Fraga M.F. Epigenetics and aging: status, challenges, and needs for the future. J Gerontol A Biol Sci Med Sci 64 (2009) 195-198
-
(2009)
J Gerontol A Biol Sci Med Sci
, vol.64
, pp. 195-198
-
-
Kahn, A.1
Fraga, M.F.2
-
30
-
-
40849139208
-
Epigenetics in cancer
-
Esteller M. Epigenetics in cancer. N Engl J Med 358 (2008) 1148-1159
-
(2008)
N Engl J Med
, vol.358
, pp. 1148-1159
-
-
Esteller, M.1
-
31
-
-
17944397700
-
Nucleotide composition of DNA and RNA from somatic tissues of humpback salmon and its changes during spawning
-
Berdyshev G.D., Korotaev G.K., Boyarskikh G.V., and Vanyushin B.F. Nucleotide composition of DNA and RNA from somatic tissues of humpback salmon and its changes during spawning. Biokhimia 32 (1967) 988-993
-
(1967)
Biokhimia
, vol.32
, pp. 988-993
-
-
Berdyshev, G.D.1
Korotaev, G.K.2
Boyarskikh, G.V.3
Vanyushin, B.F.4
-
32
-
-
4444375474
-
Age related changes in 5-methylcytosine content in human peripheral leukocytes and placentas: an HPLC-based study
-
Fuke C., Shimabukuro M., Petronis A., Sugimoto J., Oda T., Miura K., Miyazaki T., Ogura C., Okazaki Y., and Jinno Y. Age related changes in 5-methylcytosine content in human peripheral leukocytes and placentas: an HPLC-based study. Ann Hum Genet 68 (2004) 196-204
-
(2004)
Ann Hum Genet
, vol.68
, pp. 196-204
-
-
Fuke, C.1
Shimabukuro, M.2
Petronis, A.3
Sugimoto, J.4
Oda, T.5
Miura, K.6
Miyazaki, T.7
Ogura, C.8
Okazaki, Y.9
Jinno, Y.10
-
33
-
-
0037452665
-
Aging results in hypermethylation of ribosomal DNA in sperm and liver of male rats
-
Oakes C.C., Smiraglia D.J., Plass C., Trasler J.M., and Robaire B. Aging results in hypermethylation of ribosomal DNA in sperm and liver of male rats. Proc Natl Acad Sci U S A 100 (2003) 1775-1780
-
(2003)
Proc Natl Acad Sci U S A
, vol.100
, pp. 1775-1780
-
-
Oakes, C.C.1
Smiraglia, D.J.2
Plass, C.3
Trasler, J.M.4
Robaire, B.5
-
34
-
-
33748867063
-
Quantitative assessment of RUNX3 methylation in neoplastic and non-neoplastic gastric epithelia using a DNA microarray
-
So K., Tamura G., Honda T., Homma N., Endoh M., Togawa N., Nishizuka S., and Motoyama T. Quantitative assessment of RUNX3 methylation in neoplastic and non-neoplastic gastric epithelia using a DNA microarray. Pathol Int 56 (2006) 571-575
-
(2006)
Pathol Int
, vol.56
, pp. 571-575
-
-
So, K.1
Tamura, G.2
Honda, T.3
Homma, N.4
Endoh, M.5
Togawa, N.6
Nishizuka, S.7
Motoyama, T.8
-
35
-
-
68149100569
-
The role of epigenetics in aging and age related diseases
-
10.1016/j.arr.2009.03.004
-
Calvanese V., Lara E., Kahn A., and Fraga M. The role of epigenetics in aging and age related diseases. Ageing Res Rev (2009) 10.1016/j.arr.2009.03.004
-
(2009)
Ageing Res Rev
-
-
Calvanese, V.1
Lara, E.2
Kahn, A.3
Fraga, M.4
-
36
-
-
34247473478
-
The epigenetic basis of twin discordance in age-related diseases
-
Poulsen P., Esteller M., Vaag A., and Fraga M.F. The epigenetic basis of twin discordance in age-related diseases. Pediatr Res 61 (2007) 38R-42R
-
(2007)
Pediatr Res
, vol.61
-
-
Poulsen, P.1
Esteller, M.2
Vaag, A.3
Fraga, M.F.4
-
37
-
-
23044514669
-
Epigenetic differences arise during the lifetime of monozygotic twins
-
This report provided evidence of age-related global epigenetic differences between monozygotic twin pairs.
-
Fraga M.F., Ballestar E., Paz M.F., Ropero S., Setien F., Ballestar M.L., Heine-Suner D., Cigudosa J.C., Urioste M., Benitez J., et al. Epigenetic differences arise during the lifetime of monozygotic twins. Proc Natl Acad Sci U S A 102 (2005) 10604-10609. This report provided evidence of age-related global epigenetic differences between monozygotic twin pairs.
-
(2005)
Proc Natl Acad Sci U S A
, vol.102
, pp. 10604-10609
-
-
Fraga, M.F.1
Ballestar, E.2
Paz, M.F.3
Ropero, S.4
Setien, F.5
Ballestar, M.L.6
Heine-Suner, D.7
Cigudosa, J.C.8
Urioste, M.9
Benitez, J.10
-
38
-
-
0037370311
-
Natural variation in human gene expression assessed in lymphoblastoid cells
-
Cheung V.G., Conlin L.K., Weber T.M., Arcaro M., Jen K.Y., Morley M., and Spielman R.S. Natural variation in human gene expression assessed in lymphoblastoid cells. Nat Genet 33 (2003) 422-425
-
(2003)
Nat Genet
, vol.33
, pp. 422-425
-
-
Cheung, V.G.1
Conlin, L.K.2
Weber, T.M.3
Arcaro, M.4
Jen, K.Y.5
Morley, M.6
Spielman, R.S.7
-
39
-
-
34249035861
-
Environmental effects on gene expression phenotype have regional biases in the human genome
-
Choi J.K., and Kim S.C. Environmental effects on gene expression phenotype have regional biases in the human genome. Genetics 175 (2007) 1607-1613
-
(2007)
Genetics
, vol.175
, pp. 1607-1613
-
-
Choi, J.K.1
Kim, S.C.2
-
40
-
-
21244465079
-
Assessing natural variations in gene expression in humans by comparing with monozygotic twins using microarrays
-
Sharma A., Sharma V.K., Horn-Saban S., Lancet D., Ramachandran S., and Brahmachari S.K. Assessing natural variations in gene expression in humans by comparing with monozygotic twins using microarrays. Physiol Genomics 21 (2005) 117-123
-
(2005)
Physiol Genomics
, vol.21
, pp. 117-123
-
-
Sharma, A.1
Sharma, V.K.2
Horn-Saban, S.3
Lancet, D.4
Ramachandran, S.5
Brahmachari, S.K.6
-
41
-
-
3242663659
-
An integrated epigenetic and genetic approach to common human disease
-
Bjornsson H.T., Fallin M.D., and Feinberg A.P. An integrated epigenetic and genetic approach to common human disease. Trends Genet 20 (2004) 350-358
-
(2004)
Trends Genet
, vol.20
, pp. 350-358
-
-
Bjornsson, H.T.1
Fallin, M.D.2
Feinberg, A.P.3
-
42
-
-
45849127657
-
Intra-individual change over time in DNA methylation with familial clustering
-
Data provided in this study indicate that, in humans, DNA methylation changes over time.
-
Bjornsson H.T., Sigurdsson M.I., Fallin M.D., Irizarry R.A., Aspelund T., Cui H., Yu W., Rongione M.A., Ekstrom T.J., Harris T.B., et al. Intra-individual change over time in DNA methylation with familial clustering. JAMA 299 (2008) 2877-2883. Data provided in this study indicate that, in humans, DNA methylation changes over time.
-
(2008)
JAMA
, vol.299
, pp. 2877-2883
-
-
Bjornsson, H.T.1
Sigurdsson, M.I.2
Fallin, M.D.3
Irizarry, R.A.4
Aspelund, T.5
Cui, H.6
Yu, W.7
Rongione, M.A.8
Ekstrom, T.J.9
Harris, T.B.10
-
43
-
-
59249107052
-
DNA methylation profiles in monozygotic and dizygotic twins
-
Studies in this report suggest that higher epigenetic discordance in dizygotic twins than in monozygotic twins is due to epigenomic differences in the zygotes, which favors the hypothesis that some epigenetic marks can be transmitted across generations.
-
Kaminsky Z.A., Tang T., Wang S.C., Ptak C., Oh G.H., Wong A.H., Feldcamp L.A., Virtanen C., Halfvarson J., Tysk C., et al. DNA methylation profiles in monozygotic and dizygotic twins. Nat Genet 41 (2009) 240-245. Studies in this report suggest that higher epigenetic discordance in dizygotic twins than in monozygotic twins is due to epigenomic differences in the zygotes, which favors the hypothesis that some epigenetic marks can be transmitted across generations.
-
(2009)
Nat Genet
, vol.41
, pp. 240-245
-
-
Kaminsky, Z.A.1
Tang, T.2
Wang, S.C.3
Ptak, C.4
Oh, G.H.5
Wong, A.H.6
Feldcamp, L.A.7
Virtanen, C.8
Halfvarson, J.9
Tysk, C.10
-
44
-
-
34047142805
-
Heritable rather than age-related environmental and stochastic factors dominate variation in DNA methylation of the human IGF2/H19 locus
-
Heijmans B.T., Kremer D., Tobi E.W., Boomsma D.I., and Slagboom P.E. Heritable rather than age-related environmental and stochastic factors dominate variation in DNA methylation of the human IGF2/H19 locus. Hum Mol Genet 16 (2007) 547-554
-
(2007)
Hum Mol Genet
, vol.16
, pp. 547-554
-
-
Heijmans, B.T.1
Kremer, D.2
Tobi, E.W.3
Boomsma, D.I.4
Slagboom, P.E.5
-
45
-
-
34249275353
-
Phenotypic plasticity and the epigenetics of human disease
-
Feinberg A.P. Phenotypic plasticity and the epigenetics of human disease. Nature 447 (2007) 433-440
-
(2007)
Nature
, vol.447
, pp. 433-440
-
-
Feinberg, A.P.1
-
46
-
-
41149176108
-
Production of different phenotypes from the same genotype in the same environment by developmental variation
-
Vogt G., Huber M., Thiemann M., van den Boogaart G., Schmitz O.J., and Schubart C.D. Production of different phenotypes from the same genotype in the same environment by developmental variation. J Exp Biol 211 (2008) 510-523
-
(2008)
J Exp Biol
, vol.211
, pp. 510-523
-
-
Vogt, G.1
Huber, M.2
Thiemann, M.3
van den Boogaart, G.4
Schmitz, O.J.5
Schubart, C.D.6
-
47
-
-
0025173860
-
A third component causing random variability beside environment and genotype. A reason for the limited success of a 30 year long effort to standardize laboratory animals?
-
Gartner K. A third component causing random variability beside environment and genotype. A reason for the limited success of a 30 year long effort to standardize laboratory animals?. Lab Anim 24 (1990) 71-77
-
(1990)
Lab Anim
, vol.24
, pp. 71-77
-
-
Gartner, K.1
-
48
-
-
0025004091
-
Increased life-span of age-1 mutants in Caenorhabditis elegans and lower Gompertz rate of aging
-
Johnson T.E. Increased life-span of age-1 mutants in Caenorhabditis elegans and lower Gompertz rate of aging. Science 249 (1990) 908-912
-
(1990)
Science
, vol.249
, pp. 908-912
-
-
Johnson, T.E.1
-
49
-
-
0025034494
-
Sources of human psychological differences: the Minnesota Study of Twins Reared Apart
-
Bouchard Jr. T.J., Lykken D.T., McGue M., Segal N.L., and Tellegen A. Sources of human psychological differences: the Minnesota Study of Twins Reared Apart. Science 250 (1990) 223-228
-
(1990)
Science
, vol.250
, pp. 223-228
-
-
Bouchard Jr., T.J.1
Lykken, D.T.2
McGue, M.3
Segal, N.L.4
Tellegen, A.5
-
50
-
-
0026753048
-
Age differences in genetic and environmental influences for health from the Swedish Adoption/Twin Study of Aging
-
Harris J., Pedersen N., McClearn G., Plomin R., and Nesselroade J. Age differences in genetic and environmental influences for health from the Swedish Adoption/Twin Study of Aging. J Gerontol 47 (1992) 213-220
-
(1992)
J Gerontol
, vol.47
, pp. 213-220
-
-
Harris, J.1
Pedersen, N.2
McClearn, G.3
Plomin, R.4
Nesselroade, J.5
-
51
-
-
0027938319
-
Genetic and environmental influences on pulmonary function in aging Swedish twins
-
McClearn G.E., Svartengren M., Pedersen N.L., Heller D.A., and Plomin R. Genetic and environmental influences on pulmonary function in aging Swedish twins. J Gerontol 49 (1994) 264-268
-
(1994)
J Gerontol
, vol.49
, pp. 264-268
-
-
McClearn, G.E.1
Svartengren, M.2
Pedersen, N.L.3
Heller, D.A.4
Plomin, R.5
-
52
-
-
0034644185
-
Environmental and heritable factors in the causation of cancer - analyses of cohorts of twins from Sweden, Denmark, and Finland
-
This study utilized monozygotic twins to show that the environment has the principal role in causing sporadic cancer, a well-known age-related disease.
-
Lichtenstein P., Holm N.V., Verkasalo P.K., Iliadou A., Kaprio J., Koskenvuo M., Pukkala E., Skytthe A., and Hemminki K. Environmental and heritable factors in the causation of cancer - analyses of cohorts of twins from Sweden, Denmark, and Finland. N Engl J Med 343 (2000) 78-85. This study utilized monozygotic twins to show that the environment has the principal role in causing sporadic cancer, a well-known age-related disease.
-
(2000)
N Engl J Med
, vol.343
, pp. 78-85
-
-
Lichtenstein, P.1
Holm, N.V.2
Verkasalo, P.K.3
Iliadou, A.4
Kaprio, J.5
Koskenvuo, M.6
Pukkala, E.7
Skytthe, A.8
Hemminki, K.9
-
53
-
-
0034644187
-
Cancer - nature, nurture, or both
-
Hoover R.N. Cancer - nature, nurture, or both. N Engl J Med 343 (2000) 135-136
-
(2000)
N Engl J Med
, vol.343
, pp. 135-136
-
-
Hoover, R.N.1
-
54
-
-
0032751471
-
Epigenetic inheritance at the agouti locus in the mouse
-
This study showed that the DNA methylation patterns at the agouti locus in mice can be inherited.
-
Morgan H.D., Sutherland H.G., Martin D.I., and Whitelaw E. Epigenetic inheritance at the agouti locus in the mouse. Nat Genet 23 (1999) 314-318. This study showed that the DNA methylation patterns at the agouti locus in mice can be inherited.
-
(1999)
Nat Genet
, vol.23
, pp. 314-318
-
-
Morgan, H.D.1
Sutherland, H.G.2
Martin, D.I.3
Whitelaw, E.4
-
55
-
-
0034598784
-
Demethylation of the zygotic paternal genome
-
Mayer W., Niveleau A., Walter J., Fundele R., and Haaf T. Demethylation of the zygotic paternal genome. Nature 403 (2000) 501-502
-
(2000)
Nature
, vol.403
, pp. 501-502
-
-
Mayer, W.1
Niveleau, A.2
Walter, J.3
Fundele, R.4
Haaf, T.5
-
56
-
-
62549160981
-
A role for RNAi in the selective correction of DNA methylation defects
-
Teixeira F.K., Heredia F., Sarazin A., Roudier F., Boccara M., Ciaudo C., Cruaud C., Poulain J., Berdasco M., Fraga M.F., et al. A role for RNAi in the selective correction of DNA methylation defects. Science 323 (2009) 1600-1604
-
(2009)
Science
, vol.323
, pp. 1600-1604
-
-
Teixeira, F.K.1
Heredia, F.2
Sarazin, A.3
Roudier, F.4
Boccara, M.5
Ciaudo, C.6
Cruaud, C.7
Poulain, J.8
Berdasco, M.9
Fraga, M.F.10
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