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Volumn 14, Issue 11, 2013, Pages 765-780

Mutations in regulators of the epigenome and their connections to global chromatin patterns in cancer

Author keywords

[No Author keywords available]

Indexed keywords

BIOLOGICAL MARKER; DNA METHYLTRANSFERASE 1; DNA METHYLTRANSFERASE 3A; DNA METHYLTRANSFERASE 3B; HISTONE; HISTONE DEACETYLASE INHIBITOR; HISTONE H3; ISOCITRATE DEHYDROGENASE 1; NEUROTROPHIC TYROSINE KINASE RECEPTOR TYPE 1; PROTEIN TYROSINE KINASE; SCATTER FACTOR; TYROSINE KINASE RECEPTOR; UNCLASSIFIED DRUG; VASCULOTROPIN;

EID: 84886099830     PISSN: 14710056     EISSN: 14710064     Source Type: Journal    
DOI: 10.1038/nrg3554     Document Type: Review
Times cited : (368)

References (156)
  • 2
    • 80053144962 scopus 로고    scopus 로고
    • A decade of exploring the cancer epigenome - Biological and translational implications
    • Baylin, S. B. & Jones, P. A. A decade of exploring the cancer epigenome - biological and translational implications. Nature Rev. Cancer 11, 726-734 (2011).
    • (2011) Nature Rev. Cancer , vol.11 , pp. 726-734
    • Baylin, S.B.1    Jones, P.A.2
  • 3
    • 0037068312 scopus 로고    scopus 로고
    • CpG island hypermethylation and tumor suppressor genes: A booming present, a brighter future
    • DOI 10.1038/sj.onc.1205600
    • Esteller, M. CpG island hypermethylation and tumor suppressor genes: a booming present, a brighter future. Oncogene 21, 5427-5440 (2002). (Pubitemid 34983479)
    • (2002) Oncogene , vol.21 , Issue.35 REV. ISS. 3 , pp. 5427-5440
    • Esteller, M.1
  • 4
    • 84863770814 scopus 로고    scopus 로고
    • Cancer genetics and epigenetics: Two sides of the same coin?
    • You, J. S. & Jones, P. A. Cancer genetics and epigenetics: two sides of the same coin? Cancer Cell 22, 9-20 (2012).
    • (2012) Cancer Cell , vol.22 , pp. 9-20
    • You, J.S.1    Jones, P.A.2
  • 5
    • 84863621527 scopus 로고    scopus 로고
    • Cancer epigenetics: From mechanism to therapy
    • Dawson, M. A. & Kouzarides, T. Cancer epigenetics: from mechanism to therapy. Cell 150, 12-27 (2012).
    • (2012) Cell , vol.150 , pp. 12-27
    • Dawson, M.A.1    Kouzarides, T.2
  • 6
    • 84875745673 scopus 로고    scopus 로고
    • Interplay between the cancer genome and epigenome
    • Shen, H. & Laird, P. W. Interplay between the cancer genome and epigenome. Cell 153, 38-55 (2013).
    • (2013) Cell , vol.153 , pp. 38-55
    • Shen, H.1    Laird, P.W.2
  • 7
    • 0024365892 scopus 로고
    • Epigenetic changes may contribute to the formation and spontaneous regression of retinoblastoma
    • Greger, V., Passarge, E., Hopping, W., Messmer, E. & Horsthemke, B. Epigenetic changes may contribute to the formation and spontaneous regression of retinoblastoma. Hum. Genet. 83, 155-158 (1989). (Pubitemid 19234564)
    • (1989) Human Genetics , vol.83 , Issue.2 , pp. 155-158
    • Greger, V.1    Passarge, E.2    Hopping, W.3    Messmer, E.4    Horsthemke, B.5
  • 8
    • 0022495317 scopus 로고
    • DNA methylation patterns of the calcitonin gene in human lung cancers and lymphomas
    • Baylin, S. B. et al. DNA methylation patterns of the calcitonin gene in human lung cancers and lymphomas. Cancer Res. 46, 2917-2922 (1986). (Pubitemid 16074305)
    • (1986) Cancer Research , vol.46 , Issue.6 , pp. 2917-2922
    • Baylin, S.B.1    Hoppener, J.W.M.2    De Bustros, A.3
  • 10
    • 80052495940 scopus 로고    scopus 로고
    • Tet-mediated formation of 5-carboxylcytosine and its excision by TDG in mammalian DNA
    • He, Y. F. et al. Tet-mediated formation of 5-carboxylcytosine and its excision by TDG in mammalian DNA. Science 333, 1303-1307 (2011).
    • (2011) Science , vol.333 , pp. 1303-1307
    • He, Y.F.1
  • 11
    • 80052461558 scopus 로고    scopus 로고
    • Tet proteins can convert 5-methylcytosine to 5-formylcytosine and 5-carboxylcytosine
    • Ito, S. et al. Tet proteins can convert 5-methylcytosine to 5-formylcytosine and 5-carboxylcytosine. Science 333, 1300-1303 (2011).
    • (2011) Science , vol.333 , pp. 1300-1303
    • Ito, S.1
  • 12
    • 79960927422 scopus 로고    scopus 로고
    • Increased methylation variation in epigenetic domains across cancer types
    • Hansen, K. D. et al. Increased methylation variation in epigenetic domains across cancer types. Nature Genet. 43, 768-775 (2011).
    • (2011) Nature Genet. , vol.43 , pp. 768-775
    • Hansen, K.D.1
  • 14
    • 15744401773 scopus 로고    scopus 로고
    • Eukaryotic cytosine methyltransferases
    • DOI 10.1146/annurev.biochem.74.010904.153721
    • Goll, M. G. & Bestor, T. H. Eukaryotic cytosine methyltransferases. Annu. Rev. Biochem. 74, 481-514 (2005). (Pubitemid 40995515)
    • (2005) Annual Review of Biochemistry , vol.74 , pp. 481-514
    • Goll, M.G.1    Bestor, T.H.2
  • 17
    • 33947629246 scopus 로고    scopus 로고
    • Aberrant DNA methylation of OLIG1, a novel prognostic factor in non-small cell lung cancer
    • Brena, R. M. et al. Aberrant DNA methylation of OLIG1, a novel prognostic factor in non-small cell lung cancer. PLoS Med. 4, e108 (2007).
    • (2007) PLoS Med. , vol.4
    • Brena, R.M.1
  • 18
    • 84867606428 scopus 로고    scopus 로고
    • Hotspot mutations in H3F3A and IDH1 define distinct epigenetic and biological subgroups of glioblastoma
    • Sturm, D. et al. Hotspot mutations in H3F3A and IDH1 define distinct epigenetic and biological subgroups of glioblastoma. Cancer Cell 22, 425-437 (2012).
    • (2012) Cancer Cell , vol.22 , pp. 425-437
    • Sturm, D.1
  • 19
    • 78650019179 scopus 로고    scopus 로고
    • Leukemic IDH1 and IDH2 mutations result in a hypermethylation phenotype, disrupt TET2 function, and impair hematopoietic differentiation
    • Figueroa, M. E. et al. Leukemic IDH1 and IDH2 mutations result in a hypermethylation phenotype, disrupt TET2 function, and impair hematopoietic differentiation. Cancer Cell 18, 553-567 (2010).
    • (2010) Cancer Cell , vol.18 , pp. 553-567
    • Figueroa, M.E.1
  • 21
    • 84860577189 scopus 로고    scopus 로고
    • A DNA hypermethylation module for the stem/progenitor cell signature of cancer
    • Easwaran, H. et al. A DNA hypermethylation module for the stem/progenitor cell signature of cancer. Genome Res. 22, 837-849 (2012).
    • (2012) Genome Res. , vol.22 , pp. 837-849
    • Easwaran, H.1
  • 23
    • 33646070846 scopus 로고    scopus 로고
    • A bivalent chromatin structure marks key developmental genes in embryonic stem cells
    • Bernstein, B. E. et al. A bivalent chromatin structure marks key developmental genes in embryonic stem cells. Cell 125, 315-326 (2006).
    • (2006) Cell , vol.125 , pp. 315-326
    • Bernstein, B.E.1
  • 24
    • 33644846509 scopus 로고    scopus 로고
    • Epigenetic gene silencing in cancer - A mechanism for early oncogenic pathway addiction?
    • DOI 10.1038/nrc1799, PII N1799
    • Baylin, S. B. & Ohm, J. E. Epigenetic gene silencing in cancer - a mechanism for early oncogenic pathway addiction? Nature Rev. Cancer 6, 107-116 (2006). (Pubitemid 43361543)
    • (2006) Nature Reviews Cancer , vol.6 , Issue.2 , pp. 107-116
    • Baylin, S.B.1    Ohm, J.E.2
  • 25
    • 84878282421 scopus 로고    scopus 로고
    • Epigenomic analysis of multilineage differentiation of human embryonic stem cells
    • Xie, W. et al. Epigenomic analysis of multilineage differentiation of human embryonic stem cells. Cell 153, 1134-1148 (2013).
    • (2013) Cell , vol.153 , pp. 1134-1148
    • Xie, W.1
  • 26
    • 70450217879 scopus 로고    scopus 로고
    • Human DNA methylomes at base resolution show widespread epigenomic differences
    • Lister, R. et al. Human DNA methylomes at base resolution show widespread epigenomic differences. Nature 462, 315-322 (2009).
    • (2009) Nature , vol.462 , pp. 315-322
    • Lister, R.1
  • 27
    • 80053493397 scopus 로고    scopus 로고
    • Large-scale methylation domains mark a functional subset of neuronally expressed genes
    • Schroeder, D. I., Lott, P., Korf, I. & LaSalle, J. M. Large-scale methylation domains mark a functional subset of neuronally expressed genes. Genome Res. 21, 1583-1591 (2011).
    • (2011) Genome Res. , vol.21 , pp. 1583-1591
    • Schroeder, D.I.1    Lott, P.2    Korf, I.3    Lasalle, J.M.4
  • 28
    • 84856528270 scopus 로고    scopus 로고
    • Global DNA hypomethylation coupled to repressive chromatin domain formation and gene silencing in breast cancer
    • Hon, G. C. et al. Global DNA hypomethylation coupled to repressive chromatin domain formation and gene silencing in breast cancer. Genome Res. 22, 246-258 (2012).
    • (2012) Genome Res. , vol.22 , pp. 246-258
    • Hon, G.C.1
  • 29
    • 84655162785 scopus 로고    scopus 로고
    • Regions of focal DNA hypermethylation and long-range hypomethylation in colorectal cancer coincide with nuclear lamina-associated domains
    • Berman, B. P. et al. Regions of focal DNA hypermethylation and long-range hypomethylation in colorectal cancer coincide with nuclear lamina-associated domains. Nature Genet. 44, 40-46 (2012).
    • (2012) Nature Genet. , vol.44 , pp. 40-46
    • Berman, B.P.1
  • 30
    • 79251635938 scopus 로고    scopus 로고
    • Exome sequencing identifies frequent mutation of the SWI/SNF complex gene PBRM1 in renal carcinoma
    • Varela, I. et al. Exome sequencing identifies frequent mutation of the SWI/SNF complex gene PBRM1 in renal carcinoma. Nature 469, 539-542 (2011).
    • (2011) Nature , vol.469 , pp. 539-542
    • Varela, I.1
  • 32
    • 84864425646 scopus 로고    scopus 로고
    • Subgroup-specific structural variation across 1,000 medulloblastoma genomes
    • Northcott, P. A. et al. Subgroup-specific structural variation across 1,000 medulloblastoma genomes. Nature 488, 49-56 (2012).
    • (2012) Nature , vol.488 , pp. 49-56
    • Northcott, P.A.1
  • 33
    • 84862907577 scopus 로고    scopus 로고
    • Genome sequencing of pediatric medulloblastoma links catastrophic DNA rearrangements with TP53 mutations
    • Rausch, T. et al. Genome sequencing of pediatric medulloblastoma links catastrophic DNA rearrangements with TP53 mutations. Cell 148, 59-71 (2012).
    • (2012) Cell , vol.148 , pp. 59-71
    • Rausch, T.1
  • 34
    • 55549101623 scopus 로고    scopus 로고
    • DNA sequencing of a cytogenetically normal acute myeloid leukaemia genome
    • Ley, T. J. et al. DNA sequencing of a cytogenetically normal acute myeloid leukaemia genome. Nature 456, 66-72 (2008).
    • (2008) Nature , vol.456 , pp. 66-72
    • Ley, T.J.1
  • 35
    • 77952108366 scopus 로고    scopus 로고
    • Identification of a CpG island methylator phenotype that defines a distinct subgroup of glioma
    • Noushmehr, H. et al. Identification of a CpG island methylator phenotype that defines a distinct subgroup of glioma. Cancer Cell 17, 510-522 (2010).
    • (2010) Cancer Cell , vol.17 , pp. 510-522
    • Noushmehr, H.1
  • 36
    • 70149093912 scopus 로고    scopus 로고
    • Recurring mutations found by sequencing an acute myeloid leukemia genome
    • Mardis, E. R. et al. Recurring mutations found by sequencing an acute myeloid leukemia genome. N. Engl. J. Med. 361, 1058-1066 (2009).
    • (2009) N. Engl. J. Med. , vol.361 , pp. 1058-1066
    • Mardis, E.R.1
  • 37
    • 78649906060 scopus 로고    scopus 로고
    • DNMT3A mutations in acute myeloid leukemia
    • Ley, T. J. et al. DNMT3A mutations in acute myeloid leukemia. N. Engl. J. Med. 363, 2424-2433 (2010).
    • (2010) N. Engl. J. Med. , vol.363 , pp. 2424-2433
    • Ley, T.J.1
  • 38
    • 84878969599 scopus 로고    scopus 로고
    • SDH mutations establish a hypermethylator phenotype in paraganglioma
    • Letouze, E. et al. SDH mutations establish a hypermethylator phenotype in paraganglioma. Cancer Cell 23, 739-752 (2013).
    • (2013) Cancer Cell , vol.23 , pp. 739-752
    • Letouze, E.1
  • 39
    • 84878152241 scopus 로고    scopus 로고
    • Succinate dehydrogenase mutation underlies global epigenomic divergence in gastrointestinal stromal tumor
    • Killian, J. K. et al. Succinate dehydrogenase mutation underlies global epigenomic divergence in gastrointestinal stromal tumor. Cancer Discov. 3, 648-657 (2013).
    • (2013) Cancer Discov. , vol.3 , pp. 648-657
    • Killian, J.K.1
  • 40
    • 84866410479 scopus 로고    scopus 로고
    • Mapping the hallmarks of lung adenocarcinoma with massively parallel sequencing
    • Imielinski, M. et al. Mapping the hallmarks of lung adenocarcinoma with massively parallel sequencing. Cell 150, 1107-1120 (2012).
    • (2012) Cell , vol.150 , pp. 1107-1120
    • Imielinski, M.1
  • 41
    • 84866851740 scopus 로고    scopus 로고
    • Integrative genome analyses identify key somatic driver mutations of small-cell lung cancer
    • Peifer, M. et al. Integrative genome analyses identify key somatic driver mutations of small-cell lung cancer. Nature Genet. 44, 1104-1110 (2012).
    • (2012) Nature Genet. , vol.44 , pp. 1104-1110
    • Peifer, M.1
  • 42
    • 84862777348 scopus 로고    scopus 로고
    • Driver mutations in histone H3.3 and chromatin remodelling genes in paediatric glioblastoma
    • Schwartzentruber, J. et al. Driver mutations in histone H3.3 and chromatin remodelling genes in paediatric glioblastoma. Nature 482, 226-231 (2012).
    • (2012) Nature , vol.482 , pp. 226-231
    • Schwartzentruber, J.1
  • 43
    • 79251629946 scopus 로고    scopus 로고
    • The genetic landscape of the childhood cancer medulloblastoma
    • Parsons, D. W. et al. The genetic landscape of the childhood cancer medulloblastoma. Science 331, 435-439 (2011).
    • (2011) Science , vol.331 , pp. 435-439
    • Parsons, D.W.1
  • 44
    • 84864419974 scopus 로고    scopus 로고
    • Dissecting the genomic complexity underlying medulloblastoma
    • Jones, D. T. et al. Dissecting the genomic complexity underlying medulloblastoma. Nature 488, 100-105 (2012).
    • (2012) Nature , vol.488 , pp. 100-105
    • Jones, D.T.1
  • 45
    • 84864492215 scopus 로고    scopus 로고
    • Medulloblastoma exome sequencing uncovers subtype-specific somatic mutations
    • Pugh, T. J. et al. Medulloblastoma exome sequencing uncovers subtype-specific somatic mutations. Nature 488, 106-110 (2012).
    • (2012) Nature , vol.488 , pp. 106-110
    • Pugh, T.J.1
  • 46
    • 84875490185 scopus 로고    scopus 로고
    • Cancer genome landscapes
    • Vogelstein, B. et al. Cancer genome landscapes. Science 339, 1546-1558 (2013).
    • (2013) Science , vol.339 , pp. 1546-1558
    • Vogelstein, B.1
  • 47
    • 84881396090 scopus 로고    scopus 로고
    • Computational approaches to identify functional genetic variants in cancer genomes
    • Gonzalez-Perez, A. et al. Computational approaches to identify functional genetic variants in cancer genomes. Nature Methods 10, 723-729 (2013).
    • (2013) Nature Methods , vol.10 , pp. 723-729
    • Gonzalez-Perez, A.1
  • 48
    • 0033615717 scopus 로고    scopus 로고
    • DNA methyltransferases Dnmt3a and Dnmt3b are essential for de novo methylation and mammalian development
    • DOI 10.1016/S0092-8674(00)81656-6
    • Okano, M., Bell, D. W., Haber, D. A. & Li, E. DNA methyltransferases Dnmt3a and Dnmt3b are essential for de novo methylation and mammalian development. Cell 99, 247-257 (1999). (Pubitemid 29519904)
    • (1999) Cell , vol.99 , Issue.3 , pp. 247-257
    • Okano, M.1    Bell, D.W.2    Haber, D.A.3    Li, E.4
  • 49
    • 0026708177 scopus 로고
    • Targeted mutation of the DNA methyltransferase gene results in embryonic lethality
    • Li, E., Bestor, T. H. & Jaenisch, R. Targeted mutation of the DNA methyltransferase gene results in embryonic lethality. Cell 69, 915-926 (1992).
    • (1992) Cell , vol.69 , pp. 915-926
    • Li, E.1    Bestor, T.H.2    Jaenisch, R.3
  • 50
    • 77956189495 scopus 로고    scopus 로고
    • Role of Tet proteins in 5mC to 5hmC conversion, ES-cell self-renewal and inner cell mass specification
    • Ito, S. et al. Role of Tet proteins in 5mC to 5hmC conversion, ES-cell self-renewal and inner cell mass specification. Nature 466, 1129-1133 (2010).
    • (2010) Nature , vol.466 , pp. 1129-1133
    • Ito, S.1
  • 51
    • 66149146320 scopus 로고    scopus 로고
    • Conversion of 5-methylcytosine to 5-hydroxymethylcytosine in mammalian DNA by MLL partner TET1
    • Tahiliani, M. et al. Conversion of 5-methylcytosine to 5-hydroxymethylcytosine in mammalian DNA by MLL partner TET1. Science 324, 930-935 (2009).
    • (2009) Science , vol.324 , pp. 930-935
    • Tahiliani, M.1
  • 52
    • 57649196594 scopus 로고    scopus 로고
    • DNA demethylation in zebrafish involves the coupling of a deaminase, a glycosylase, and gadd45
    • Rai, K. et al. DNA demethylation in zebrafish involves the coupling of a deaminase, a glycosylase, and gadd45. Cell 135, 1201-1212 (2008).
    • (2008) Cell , vol.135 , pp. 1201-1212
    • Rai, K.1
  • 54
    • 0035839126 scopus 로고    scopus 로고
    • Epigenetic reprogramming in mammalian development
    • DOI 10.1126/science.1063443
    • Reik, W., Dean, W. & Walter, J. Epigenetic reprogramming in mammalian development. Science 293, 1089-1093 (2001). (Pubitemid 32758081)
    • (2001) Science , vol.293 , Issue.5532 , pp. 1089-1093
    • Reik, W.1    Dean, W.2    Walter, J.3
  • 55
    • 79953176952 scopus 로고    scopus 로고
    • Exome sequencing identifies somatic mutations of DNA methyltransferase gene DNMT3A in acute monocytic leukemia
    • Yan, X. J. et al. Exome sequencing identifies somatic mutations of DNA methyltransferase gene DNMT3A in acute monocytic leukemia. Nature Genet. 43, 309-315 (2011).
    • (2011) Nature Genet. , vol.43 , pp. 309-315
    • Yan, X.J.1
  • 56
    • 84862502902 scopus 로고    scopus 로고
    • Mutant DNMT3A: A marker of poor prognosis in acute myeloid leukemia
    • Ribeiro, A. F. et al. Mutant DNMT3A: a marker of poor prognosis in acute myeloid leukemia. Blood 119, 5824-5831 (2012).
    • (2012) Blood , vol.119 , pp. 5824-5831
    • Ribeiro, A.F.1
  • 57
    • 67651065502 scopus 로고    scopus 로고
    • Genetic characterization of TET1, TET2, and TET3 alterations in myeloid malignancies
    • Abdel-Wahab, O. et al. Genetic characterization of TET1, TET2, and TET3 alterations in myeloid malignancies. Blood 114, 144-147 (2009).
    • (2009) Blood , vol.114 , pp. 144-147
    • Abdel-Wahab, O.1
  • 58
    • 84862266735 scopus 로고    scopus 로고
    • TET2 mutations in acute myeloid leukemia (AML): Results from a comprehensive genetic and clinical analysis of the AML study group
    • Gaidzik, V. I. et al. TET2 mutations in acute myeloid leukemia (AML): results from a comprehensive genetic and clinical analysis of the AML study group. J. Clin. Oncol. 30, 1350-1357 (2012).
    • (2012) J. Clin. Oncol. , vol.30 , pp. 1350-1357
    • Gaidzik, V.I.1
  • 59
    • 84859229392 scopus 로고    scopus 로고
    • Role of TET2 mutations in myeloproliferative neoplasms
    • Pronier, E. & Delhommeau, F. Role of TET2 mutations in myeloproliferative neoplasms. Curr. Hematol. Malig. Rep. 7, 57-64 (2012).
    • (2012) Curr. Hematol. Malig. Rep. , vol.7 , pp. 57-64
    • Pronier, E.1    Delhommeau, F.2
  • 60
    • 84858796262 scopus 로고    scopus 로고
    • IDH mutation impairs histone demethylation and results in a block to cell differentiation
    • Lu, C. et al. IDH mutation impairs histone demethylation and results in a block to cell differentiation. Nature 483, 474-478 (2012).
    • (2012) Nature , vol.483 , pp. 474-478
    • Lu, C.1
  • 61
    • 84855710482 scopus 로고    scopus 로고
    • Detection of 2-hydroxyglutarate in IDH-mutated glioma patients by in vivo spectral-editing and 2D correlation magnetic resonance spectroscopy
    • Andronesi, O. C. et al. Detection of 2-hydroxyglutarate in IDH-mutated glioma patients by in vivo spectral-editing and 2D correlation magnetic resonance spectroscopy. Sci. Transl Med. 4, 116ra4 (2012).
    • (2012) Sci. Transl Med. , vol.4
    • Andronesi, O.C.1
  • 62
    • 84862907969 scopus 로고    scopus 로고
    • Magnetic resonance of 2-hydroxyglutarate in IDH1-mutated low-grade gliomas
    • Elkhaled, A. et al. Magnetic resonance of 2-hydroxyglutarate in IDH1-mutated low-grade gliomas. Sci. Transl Med. 4, 116ra5 (2012).
    • (2012) Sci. Transl Med. , vol.4
    • Elkhaled, A.1
  • 63
    • 84858796263 scopus 로고    scopus 로고
    • IDH1 mutation is sufficient to establish the glioma hypermethylator phenotype
    • Turcan, S. et al. IDH1 mutation is sufficient to establish the glioma hypermethylator phenotype. Nature 483, 479-483 (2012).
    • (2012) Nature , vol.483 , pp. 479-483
    • Turcan, S.1
  • 64
    • 77952241644 scopus 로고    scopus 로고
    • New functions for an old variant: No substitute for histone H3.3
    • Elsaesser, S. J., Goldberg, A. D. & Allis, C. D. New functions for an old variant: no substitute for histone H3.3. Curr. Opin. Genet. Dev. 20, 110-117 (2010).
    • (2010) Curr. Opin. Genet. Dev. , vol.20 , pp. 110-117
    • Elsaesser, S.J.1    Goldberg, A.D.2    Allis, C.D.3
  • 67
    • 0036682174 scopus 로고    scopus 로고
    • Prognostic significance of partial tandem duplications of the MLL gene in adult patients 16 to 60 years old with acute myeloid leukemia and normal cytogenetics: A study of the Acute Myeloid Leukemia Study Group Ulm
    • DOI 10.1200/JCO.2002.09.088
    • Dohner, K. et al. Prognostic significance of partial tandem duplications of the MLL gene in adult patients 16 to 60 years old with acute myeloid leukemia and normal cytogenetics: a study of the Acute Myeloid Leukemia Study Group Ulm. J. Clin. Oncol. 20, 3254-3261 (2002). (Pubitemid 34831523)
    • (2002) Journal of Clinical Oncology , vol.20 , Issue.15 , pp. 3254-3261
    • Dohner, K.1    Tobis, K.2    Ulrich, R.3    Frohling, S.4    Benner, A.5    Schlenk, R.F.6    Dohner, H.7
  • 68
    • 35548934558 scopus 로고    scopus 로고
    • MLL translocations, histone modifications and leukaemia stem-cell development
    • DOI 10.1038/nrc2253, PII NRC2253
    • Krivtsov, A. V. & Armstrong, S. A. MLL translocations, histone modifications and leukaemia stem-cell development. Nature Rev. Cancer 7, 823-833 (2007). (Pubitemid 350006257)
    • (2007) Nature Reviews Cancer , vol.7 , Issue.11 , pp. 823-833
    • Krivtsov, A.V.1    Armstrong, S.A.2
  • 69
    • 54549083228 scopus 로고    scopus 로고
    • H3K79 methylation profiles define murine and human MLL-AF4 leukemias
    • Krivtsov, A. V. et al. H3K79 methylation profiles define murine and human MLL-AF4 leukemias. Cancer Cell 14, 355-368 (2008).
    • (2008) Cancer Cell , vol.14 , pp. 355-368
    • Krivtsov, A.V.1
  • 71
    • 77955087290 scopus 로고    scopus 로고
    • Somatic mutations of the histone methyltransferase gene EZH2 in myelodysplastic syndromes
    • Nikoloski, G. et al. Somatic mutations of the histone methyltransferase gene EZH2 in myelodysplastic syndromes. Nature Genet. 42, 665-667 (2010).
    • (2010) Nature Genet. , vol.42 , pp. 665-667
    • Nikoloski, G.1
  • 74
    • 58149239686 scopus 로고    scopus 로고
    • Genomic loss of microRNA-101 leads to overexpression of histone methyltransferase EZH2 in cancer
    • Varambally, S. et al. Genomic loss of microRNA-101 leads to overexpression of histone methyltransferase EZH2 in cancer. Science 322, 1695-1699 (2008).
    • (2008) Science , vol.322 , pp. 1695-1699
    • Varambally, S.1
  • 75
    • 84872269688 scopus 로고    scopus 로고
    • Characterization of the EZH2-MMSET histone methyltransferase regulatory axis in cancer
    • Asangani, I. A. et al. Characterization of the EZH2-MMSET histone methyltransferase regulatory axis in cancer. Mol. Cell 49, 80-93 (2013).
    • (2013) Mol. Cell , vol.49 , pp. 80-93
    • Asangani, I.A.1
  • 76
    • 78650454078 scopus 로고    scopus 로고
    • Coordinated activities of wild-type plus mutant EZH2 drive tumor-associated hypertrimethylation of lysine 27 on histone H3 (H3K27) in human B-cell lymphomas
    • Sneeringer, C. J. et al. Coordinated activities of wild-type plus mutant EZH2 drive tumor-associated hypertrimethylation of lysine 27 on histone H3 (H3K27) in human B-cell lymphomas. Proc. Natl Acad. Sci. USA 107, 20980-20985 (2010).
    • (2010) Proc. Natl Acad. Sci. USA , vol.107 , pp. 20980-20985
    • Sneeringer, C.J.1
  • 77
    • 84870215426 scopus 로고    scopus 로고
    • Medulloblastomics: The end of the beginning
    • Northcott, P. A. et al. Medulloblastomics: the end of the beginning. Nature Rev. Cancer 12, 818-834 (2012).
    • (2012) Nature Rev. Cancer , vol.12 , pp. 818-834
    • Northcott, P.A.1
  • 78
    • 84875439460 scopus 로고    scopus 로고
    • Collections of simultaneously altered genes as biomarkers of cancer cell drug response
    • Masica, D. L. & Karchin, R. Collections of simultaneously altered genes as biomarkers of cancer cell drug response. Cancer Res. 73,1699-1708 (2013).
    • (2013) Cancer Res. , vol.73 , pp. 1699-1708
    • Masica, D.L.1    Karchin, R.2
  • 79
    • 79952539053 scopus 로고    scopus 로고
    • ATP-dependent chromatin remodeling: Genetics, genomics and mechanisms
    • Hargreaves, D. C. & Crabtree, G. R. ATP-dependent chromatin remodeling: genetics, genomics and mechanisms. Cell Res. 21, 396-420 (2011).
    • (2011) Cell Res. , vol.21 , pp. 396-420
    • Hargreaves, D.C.1    Crabtree, G.R.2
  • 80
    • 67650725820 scopus 로고    scopus 로고
    • The biology of chromatin remodeling complexes
    • Clapier, C. R. & Cairns, B. R. The biology of chromatin remodeling complexes. Annu. Rev. Biochem. 78, 273-304 (2009).
    • (2009) Annu. Rev. Biochem. , vol.78 , pp. 273-304
    • Clapier, C.R.1    Cairns, B.R.2
  • 81
    • 84872810488 scopus 로고    scopus 로고
    • The spectrum of SWI/SNF mutations, ubiquitous in human cancers
    • Shain, A. H. & Pollack, J. R. The spectrum of SWI/SNF mutations, ubiquitous in human cancers. PLoS ONE 8, e55119 (2013).
    • (2013) PLoS ONE , vol.8
    • Shain, A.H.1    Pollack, J.R.2
  • 82
    • 79959653996 scopus 로고    scopus 로고
    • SWI/SNF nucleosome remodellers and cancer
    • Wilson, B. G. & Roberts, C. W. SWI/SNF nucleosome remodellers and cancer. Nature Rev. Cancer 11, 481-492 (2011).
    • (2011) Nature Rev. Cancer , vol.11 , pp. 481-492
    • Wilson, B.G.1    Roberts, C.W.2
  • 83
    • 84869091997 scopus 로고    scopus 로고
    • Pancreatic cancer genomes reveal aberrations in axon guidance pathway genes
    • Biankin, A. V. et al. Pancreatic cancer genomes reveal aberrations in axon guidance pathway genes. Nature 491, 399-405 (2012).
    • (2012) Nature , vol.491 , pp. 399-405
    • Biankin, A.V.1
  • 84
    • 84866544635 scopus 로고    scopus 로고
    • Mutations and deletions of ARID1A in breast tumors
    • Cornen, S. et al. Mutations and deletions of ARID1A in breast tumors. Oncogene 31, 4255-4256 (2012).
    • (2012) Oncogene , vol.31 , pp. 4255-4256
    • Cornen, S.1
  • 85
    • 84870538715 scopus 로고    scopus 로고
    • The genetic landscape of mutations in Burkitt lymphoma
    • Love, C. et al. The genetic landscape of mutations in Burkitt lymphoma. Nature Genet. 44, 1321-1325 (2012).
    • (2012) Nature Genet. , vol.44 , pp. 1321-1325
    • Love, C.1
  • 86
    • 84871982155 scopus 로고    scopus 로고
    • Integrated genomic analyses identify ARID1A and ARID1B alterations in the childhood cancer neuroblastoma
    • Sausen, M. et al. Integrated genomic analyses identify ARID1A and ARID1B alterations in the childhood cancer neuroblastoma. Nature Genet. 45, 12-17 (2013).
    • (2013) Nature Genet. , vol.45 , pp. 12-17
    • Sausen, M.1
  • 87
    • 84872868948 scopus 로고    scopus 로고
    • ARID1A mutations in cancer: Another epigenetic tumor suppressor?
    • Wu, J. N. & Roberts, C. W. ARID1A mutations in cancer: another epigenetic tumor suppressor? Cancer Discov. 3, 35-43 (2013).
    • (2013) Cancer Discov. , vol.3 , pp. 35-43
    • Wu, J.N.1    Roberts, C.W.2
  • 88
    • 84874495303 scopus 로고    scopus 로고
    • Rhabdoid tumors: An initial clue to the role of chromatin remodeling in cancer
    • Lee, R. S. & Roberts, C. W. Rhabdoid tumors: an initial clue to the role of chromatin remodeling in cancer. Brain Pathol. 23, 200-205 (2013).
    • (2013) Brain Pathol. , vol.23 , pp. 200-205
    • Lee, R.S.1    Roberts, C.W.2
  • 90
    • 84862635654 scopus 로고    scopus 로고
    • Molecular biology. Genetic events that shape the cancer epigenome
    • Ryan, R. J. & Bernstein, B. E. Molecular biology. Genetic events that shape the cancer epigenome. Science 336, 1513-1514 (2012).
    • (2012) Science , vol.336 , pp. 1513-1514
    • Ryan, R.J.1    Bernstein, B.E.2
  • 91
    • 84878723078 scopus 로고    scopus 로고
    • Whole-genome sequencing identifies genetic alterations in pediatric low-grade gliomas
    • Zhang, J. et al. Whole-genome sequencing identifies genetic alterations in pediatric low-grade gliomas. Nature Genet. 45, 602-612 (2013).
    • (2013) Nature Genet. , vol.45 , pp. 602-612
    • Zhang, J.1
  • 92
    • 84862777410 scopus 로고    scopus 로고
    • Somatic histone H3 alterations in pediatric diffuse intrinsic pontine gliomas and non-brainstem glioblastomas
    • Wu, G. et al. Somatic histone H3 alterations in pediatric diffuse intrinsic pontine gliomas and non-brainstem glioblastomas. Nature Genet. 44, 251-253 (2012).
    • (2012) Nature Genet. , vol.44 , pp. 251-253
    • Wu, G.1
  • 93
    • 84882273357 scopus 로고    scopus 로고
    • Evaluation of histone 3 lysine 27 trimethylation (H3K27me3) and enhancer of zest 2 (EZH2) in pediatric glial and glioneuronal tumors shows decreased H3K27me3 in H3F3A K27M mutant glioblastomas
    • Venneti, S. et al. Evaluation of histone 3 lysine 27 trimethylation (H3K27me3) and enhancer of zest 2 (EZH2) in pediatric glial and glioneuronal tumors shows decreased H3K27me3 in H3F3A K27M mutant glioblastomas. Brain Pathol. 23, 558-564 (2013).
    • (2013) Brain Pathol. , vol.23 , pp. 558-564
    • Venneti, S.1
  • 94
    • 84877785024 scopus 로고    scopus 로고
    • Inhibition of PRC2 activity by a gain-of-function H3 mutation found in pediatric glioblastoma
    • Lewis, P. W. et al. Inhibition of PRC2 activity by a gain-of-function H3 mutation found in pediatric glioblastoma. Science 340, 857-861 (2013).
    • (2013) Science , vol.340 , pp. 857-861
    • Lewis, P.W.1
  • 95
    • 84877299145 scopus 로고    scopus 로고
    • The histone H3.3K27M mutation in pediatric glioma reprograms H3K27 methylation and gene expression
    • Chan, K. M. et al. The histone H3.3K27M mutation in pediatric glioma reprograms H3K27 methylation and gene expression. Genes Dev. 27, 985-990 (2013).
    • (2013) Genes Dev. , vol.27 , pp. 985-990
    • Chan, K.M.1
  • 96
    • 79952279828 scopus 로고    scopus 로고
    • DAXX/ATRX, MEN1, and mTOR pathway genes are frequently altered in pancreatic neuroendocrine tumors
    • Jiao, Y. et al. DAXX/ATRX, MEN1, and mTOR pathway genes are frequently altered in pancreatic neuroendocrine tumors. Science 331, 1199-1203 (2011).
    • (2011) Science , vol.331 , pp. 1199-1203
    • Jiao, Y.1
  • 97
    • 84858248558 scopus 로고    scopus 로고
    • Association of age at diagnosis and genetic mutations in patients with neuroblastoma
    • Cheung, N. K. et al. Association of age at diagnosis and genetic mutations in patients with neuroblastoma. JAMA 307, 1062-1071 (2012).
    • (2012) JAMA , vol.307 , pp. 1062-1071
    • Cheung, N.K.1
  • 98
    • 77649262618 scopus 로고    scopus 로고
    • ATRX interacts with H3.3 in maintaining telomere structural integrity in pluripotent embryonic stem cells
    • Wong, L. H. et al. ATRX interacts with H3.3 in maintaining telomere structural integrity in pluripotent embryonic stem cells. Genome Res. 20, 351-360 (2010).
    • (2010) Genome Res. , vol.20 , pp. 351-360
    • Wong, L.H.1
  • 99
    • 77649099092 scopus 로고    scopus 로고
    • Distinct factors control histone variant H3.3 localization at specific genomic regions
    • Goldberg, A. D. et al. Distinct factors control histone variant H3.3 localization at specific genomic regions. Cell 140, 678-691 (2010).
    • (2010) Cell , vol.140 , pp. 678-691
    • Goldberg, A.D.1
  • 100
    • 79955995634 scopus 로고    scopus 로고
    • The ATRX-ADD domain binds to H3 tail peptides and reads the combined methylation state of K4 and K9
    • Dhayalan, A. et al. The ATRX-ADD domain binds to H3 tail peptides and reads the combined methylation state of K4 and K9. Hum. Mol. Genet. 20, 2195-2203 (2011).
    • (2011) Hum. Mol. Genet. , vol.20 , pp. 2195-2203
    • Dhayalan, A.1
  • 101
    • 79960063257 scopus 로고    scopus 로고
    • Combinatorial readout of histone H3 modifications specifies localization of ATRX to heterochromatin
    • Eustermann, S. et al. Combinatorial readout of histone H3 modifications specifies localization of ATRX to heterochromatin. Nature Struct. Mol. Biol. 18, 777-782 (2011).
    • (2011) Nature Struct. Mol. Biol. , vol.18 , pp. 777-782
    • Eustermann, S.1
  • 102
    • 79960050537 scopus 로고    scopus 로고
    • ATRX ADD domain links an atypical histone methylation recognition mechanism to human mental-retardation syndrome
    • Iwase, S. et al. ATRX ADD domain links an atypical histone methylation recognition mechanism to human mental-retardation syndrome. Nature Struct. Mol. Biol. 18, 769-776 (2011).
    • (2011) Nature Struct. Mol. Biol. , vol.18 , pp. 769-776
    • Iwase, S.1
  • 103
    • 79960700556 scopus 로고    scopus 로고
    • Altered telomeres in tumors with ATRX and DAXX mutations
    • Heaphy, C. M. et al. Altered telomeres in tumors with ATRX and DAXX mutations. Science 333, 425 (2011).
    • (2011) Science , vol.333 , pp. 425
    • Heaphy, C.M.1
  • 110
    • 84865790047 scopus 로고    scopus 로고
    • An integrated encyclopedia of DNA elements in the human genome
    • ENCODE Project Consortium et al.
    • ENCODE Project Consortium et al. An integrated encyclopedia of DNA elements in the human genome. Nature 489, 57-74 (2012).
    • (2012) Nature , vol.489 , pp. 57-74
  • 111
    • 84873607610 scopus 로고    scopus 로고
    • Integrative genomic analyses reveal an androgen-driven somatic alteration landscape in early-onset prostate cancer
    • Weischenfeldt, J. et al. Integrative genomic analyses reveal an androgen-driven somatic alteration landscape in early-onset prostate cancer. Cancer Cell 23, 159-170 (2013).
    • (2013) Cancer Cell , vol.23 , pp. 159-170
    • Weischenfeldt, J.1
  • 112
    • 80054681545 scopus 로고    scopus 로고
    • In vivo identification of tumor-suppressive PTEN ceRNAs in an oncogenic BRAF-induced mouse model of melanoma
    • Karreth, F. A. et al. In vivo identification of tumor-suppressive PTEN ceRNAs in an oncogenic BRAF-induced mouse model of melanoma. Cell 147, 382-395 (2011).
    • (2011) Cell , vol.147 , pp. 382-395
    • Karreth, F.A.1
  • 113
    • 79956294708 scopus 로고    scopus 로고
    • Low-dose decitabine versus best supportive care in elderly patients with intermediate-or high-risk myelodysplastic syndrome (MDS) ineligible for intensive chemotherapy: Final results of the randomized phase III study of the European Organisation for Research and Treatment of Cancer Leukemia Group and the German MDS Study Group
    • Lubbert, M. et al. Low-dose decitabine versus best supportive care in elderly patients with intermediate-or high-risk myelodysplastic syndrome (MDS) ineligible for intensive chemotherapy: final results of the randomized phase III study of the European Organisation for Research and Treatment of Cancer Leukemia Group and the German MDS Study Group. J. Clin. Oncol. 29, 1987-1996 (2011).
    • (2011) J. Clin. Oncol. , vol.29 , pp. 1987-1996
    • Lubbert, M.1
  • 114
    • 31344475498 scopus 로고    scopus 로고
    • Inhibitors of DNA methylation: Beyond myelodysplastic syndromes
    • Fenaux, P. Inhibitors of DNA methylation: beyond myelodysplastic syndromes. Nature Clin. Pract. Oncol. 2 (Suppl. 1), 36-44 (2005).
    • (2005) Nature Clin. Pract. Oncol. , vol.2 , Issue.SUPPL. 1 , pp. 36-44
    • Fenaux, P.1
  • 115
    • 84864063679 scopus 로고    scopus 로고
    • Multicenter, randomized, open-label, phase III trial of decitabine versus patient choice, with physician advice, of either supportive care or low-dose cytarabine for the treatment of older patients with newly diagnosed acute myeloid leukemia
    • Kantarjian, H. M. et al. Multicenter, randomized, open-label, phase III trial of decitabine versus patient choice, with physician advice, of either supportive care or low-dose cytarabine for the treatment of older patients with newly diagnosed acute myeloid leukemia. J. Clin. Oncol. 30, 2670-2677 (2012).
    • (2012) J. Clin. Oncol. , vol.30 , pp. 2670-2677
    • Kantarjian, H.M.1
  • 116
    • 84872389658 scopus 로고    scopus 로고
    • Decitabine induces very early in vivo DNA methylation changes in blasts from patients with acute myeloid leukemia
    • Claus, R. et al. Decitabine induces very early in vivo DNA methylation changes in blasts from patients with acute myeloid leukemia. Leuk. Res. 37, 190-196 (2013).
    • (2013) Leuk. Res. , vol.37 , pp. 190-196
    • Claus, R.1
  • 117
    • 84877632013 scopus 로고    scopus 로고
    • An inhibitor of mutant IDH1 delays growth and promotes differentiation of glioma cells
    • Rohle, D. et al. An inhibitor of mutant IDH1 delays growth and promotes differentiation of glioma cells. Science 340, 626-630 (2013).
    • (2013) Science , vol.340 , pp. 626-630
    • Rohle, D.1
  • 118
    • 51649126841 scopus 로고    scopus 로고
    • Histone deacetylase inhibitor panobinostat induces clinical responses with associated alterations in gene expression profiles in cutaneous T-cell lymphoma
    • Ellis, L. et al. Histone deacetylase inhibitor panobinostat induces clinical responses with associated alterations in gene expression profiles in cutaneous T-cell lymphoma. Clin. Cancer Res. 14, 4500-4510 (2008).
    • (2008) Clin. Cancer Res. , vol.14 , pp. 4500-4510
    • Ellis, L.1
  • 119
    • 70349194470 scopus 로고    scopus 로고
    • Preliminary evidence of disease response to the pan deacetylase inhibitor panobinostat (LBH589) in refractory Hodgkin lymphoma
    • Dickinson, M. et al. Preliminary evidence of disease response to the pan deacetylase inhibitor panobinostat (LBH589) in refractory Hodgkin lymphoma. Br. J. Haematol. 147, 97-101 (2009).
    • (2009) Br. J. Haematol. , vol.147 , pp. 97-101
    • Dickinson, M.1
  • 120
    • 77951884767 scopus 로고    scopus 로고
    • A phase i study of oral panobinostat alone and in combination with docetaxel in patients with castration-resistant prostate cancer
    • Rathkopf, D. et al. A phase I study of oral panobinostat alone and in combination with docetaxel in patients with castration-resistant prostate cancer. Cancer Chemother. Pharmacol. 66, 181-189 (2010).
    • (2010) Cancer Chemother. Pharmacol. , vol.66 , pp. 181-189
    • Rathkopf, D.1
  • 121
    • 70349311616 scopus 로고    scopus 로고
    • Histone acetyl transferases as emerging drug targets
    • Dekker, F. J. & Haisma, H. J. Histone acetyl transferases as emerging drug targets. Drug Discov. Today 14, 942-948 (2009).
    • (2009) Drug Discov. Today , vol.14 , pp. 942-948
    • Dekker, F.J.1    Haisma, H.J.2
  • 122
    • 34547896549 scopus 로고    scopus 로고
    • The MYST family of histone acetyltransferases and their intimate links to cancer
    • DOI 10.1038/sj.onc.1210608, PII 1210608
    • Avvakumov, N. & Cote, J. The MYST family of histone acetyltransferases and their intimate links to cancer. Oncogene 26, 5395-5407 (2007). (Pubitemid 47255922)
    • (2007) Oncogene , vol.26 , Issue.37 , pp. 5395-5407
    • Avvakumov, N.1    Cote, J.2
  • 123
    • 84855698571 scopus 로고    scopus 로고
    • Small molecule inhibitors of histone acetyltransferases as epigenetic tools and drug candidates
    • Furdas, S. D., Kannan, S., Sippl, W. & Jung, M. Small molecule inhibitors of histone acetyltransferases as epigenetic tools and drug candidates. Arch. Pharm. (Weinheim) 345, 7-21 (2012).
    • (2012) Arch. Pharm. (Weinheim) , vol.345 , pp. 7-21
    • Furdas, S.D.1    Kannan, S.2    Sippl, W.3    Jung, M.4
  • 124
    • 39149109887 scopus 로고    scopus 로고
    • The structural basis of protein acetylation by the p300/CBP transcriptional coactivator
    • DOI 10.1038/nature06546, PII NATURE06546
    • Liu, X. et al. The structural basis of protein acetylation by the p300/CBP transcriptional coactivator. Nature 451, 846-850 (2008). (Pubitemid 351253165)
    • (2008) Nature , vol.451 , Issue.7180 , pp. 846-850
    • Liu, X.1    Wang, L.2    Zhao, K.3    Thompson, P.R.4    Hwang, Y.5    Marmorstein, R.6    Cole, P.A.7
  • 125
    • 84870573126 scopus 로고    scopus 로고
    • EZH2 inhibition as a therapeutic strategy for lymphoma with EZH2-activating mutations
    • McCabe, M. T. et al. EZH2 inhibition as a therapeutic strategy for lymphoma with EZH2-activating mutations. Nature 492, 108-112 (2012).
    • (2012) Nature , vol.492 , pp. 108-112
    • McCabe, M.T.1
  • 126
    • 84862777766 scopus 로고    scopus 로고
    • Inhibition of the LSD1 (KDM1A) demethylase reactivates the all-trans-retinoic acid differentiation pathway in acute myeloid leukemia
    • Schenk, T. et al. Inhibition of the LSD1 (KDM1A) demethylase reactivates the all-trans-retinoic acid differentiation pathway in acute myeloid leukemia. Nature Med. 18, 605-611 (2012).
    • (2012) Nature Med. , vol.18 , pp. 605-611
    • Schenk, T.1
  • 127
    • 83455202613 scopus 로고    scopus 로고
    • Progress in the discovery of small-molecule inhibitors of bromodomain-histone interactions
    • Chung, C. W. & Witherington, J. Progress in the discovery of small-molecule inhibitors of bromodomain-histone interactions. J. Biomol. Screen 16, 1170-1185 (2011).
    • (2011) J. Biomol. Screen , vol.16 , pp. 1170-1185
    • Chung, C.W.1    Witherington, J.2
  • 128
    • 78650847770 scopus 로고    scopus 로고
    • Selective inhibition of BET bromodomains
    • Filippakopoulos, P. et al. Selective inhibition of BET bromodomains. Nature 468, 1067-1073 (2010).
    • (2010) Nature , vol.468 , pp. 1067-1073
    • Filippakopoulos, P.1
  • 129
    • 80054984945 scopus 로고    scopus 로고
    • Inhibition of BET recruitment to chromatin as an effective treatment for MLL-fusion leukaemia
    • Dawson, M. A. et al. Inhibition of BET recruitment to chromatin as an effective treatment for MLL-fusion leukaemia. Nature 478, 529-533 (2011).
    • (2011) Nature , vol.478 , pp. 529-533
    • Dawson, M.A.1
  • 130
    • 80052955256 scopus 로고    scopus 로고
    • BET bromodomain inhibition as a therapeutic strategy to target c-Myc
    • Delmore, J. E. et al. BET bromodomain inhibition as a therapeutic strategy to target c-Myc. Cell 146, 904-917 (2011).
    • (2011) Cell , vol.146 , pp. 904-917
    • Delmore, J.E.1
  • 131
    • 80053651202 scopus 로고    scopus 로고
    • Targeting MYC dependence in cancer by inhibiting BET bromodomains
    • Mertz, J. A. et al. Targeting MYC dependence in cancer by inhibiting BET bromodomains. Proc. Natl Acad. Sci. USA 108, 16669-16674 (2011).
    • (2011) Proc. Natl Acad. Sci. USA , vol.108 , pp. 16669-16674
    • Mertz, J.A.1
  • 132
    • 84876907152 scopus 로고    scopus 로고
    • Genome-wide profiling of 5-formylcytosine reveals its roles in epigenetic priming
    • Song, C. X. et al. Genome-wide profiling of 5-formylcytosine reveals its roles in epigenetic priming. Cell 153, 678-691 (2013).
    • (2013) Cell , vol.153 , pp. 678-691
    • Song, C.X.1
  • 133
    • 84860747716 scopus 로고    scopus 로고
    • FLASH assembly of TALENs for high-throughput genome editing
    • Reyon, D. et al. FLASH assembly of TALENs for high-throughput genome editing. Nature Biotech. 30, 460-465 (2012).
    • (2012) Nature Biotech. , vol.30 , pp. 460-465
    • Reyon, D.1
  • 134
    • 84861364920 scopus 로고    scopus 로고
    • SnapShot: Glioblastoma multiforme
    • Kotliarova, S. & Fine, H. A. SnapShot: glioblastoma multiforme. Cancer Cell 21, 710-710.e1 (2012).
    • (2012) Cancer Cell , vol.21
    • Kotliarova, S.1    Fine, H.A.2
  • 135
    • 84877621282 scopus 로고    scopus 로고
    • Histone H3.3 mutations drive pediatric glioblastoma through upregulation of MYCN
    • Bjerke, L. et al. Histone H3.3 mutations drive pediatric glioblastoma through upregulation of MYCN. Cancer Discov. 3, 512-519 (2013).
    • (2013) Cancer Discov. , vol.3 , pp. 512-519
    • Bjerke, L.1
  • 136
    • 79955494277 scopus 로고    scopus 로고
    • Histone methylation by PRC2 is inhibited by active chromatin marks
    • Schmitges, F. W. et al. Histone methylation by PRC2 is inhibited by active chromatin marks. Mol. Cell 42, 330-341 (2011).
    • (2011) Mol. Cell , vol.42 , pp. 330-341
    • Schmitges, F.W.1
  • 137
    • 79953143753 scopus 로고    scopus 로고
    • H3K36 methylation antagonizes PRC2-mediated H3K27 methylation
    • Yuan, W. et al. H3K36 methylation antagonizes PRC2-mediated H3K27 methylation. J. Biol. Chem. 286, 7983-7989 (2011).
    • (2011) J. Biol. Chem. , vol.286 , pp. 7983-7989
    • Yuan, W.1
  • 138
    • 78651463452 scopus 로고    scopus 로고
    • Oncometabolite 2-hydroxyglutarate is a competitive inhibitor of alpha-ketoglutarate-dependent dioxygenases
    • Xu, W. et al. Oncometabolite 2-hydroxyglutarate is a competitive inhibitor of alpha-ketoglutarate-dependent dioxygenases. Cancer Cell 19, 17-30 (2011).
    • (2011) Cancer Cell , vol.19 , pp. 17-30
    • Xu, W.1
  • 139
    • 0026708211 scopus 로고
    • New approach for detection of amplification in cancer DNA using restriction landmark genomic scanning
    • Hirotsune, S. et al. New approach for detection of amplification in cancer DNA using restriction landmark genomic scanning. Cancer Res. 52, 3642-3647 (1992).
    • (1992) Cancer Res. , vol.52 , pp. 3642-3647
    • Hirotsune, S.1
  • 140
    • 0033047813 scopus 로고    scopus 로고
    • Methylation profiling of CpG islands in human breast cancer cells
    • Huang, T. H., Perry, M. R. & Laux, D. E. Methylation profiling of CpG islands in human breast cancer cells. Hum. Mol. Genet. 8, 459-470 (1999). (Pubitemid 29097334)
    • (1999) Human Molecular Genetics , vol.8 , Issue.3 , pp. 459-470
    • Huang, T.H.-M.1    Perry, M.R.2    Laux, D.E.3
  • 141
    • 79958754527 scopus 로고    scopus 로고
    • Validation of a DNA methylation microarray for 450,000 CpG sites in the human genome
    • Sandoval, J. et al. Validation of a DNA methylation microarray for 450,000 CpG sites in the human genome. Epigenetics 6, 692-702 (2011).
    • (2011) Epigenetics , vol.6 , pp. 692-702
    • Sandoval, J.1
  • 142
    • 33745700202 scopus 로고    scopus 로고
    • Genome-wide profiling of CpG methylation identifies novel targets of aberrant hypermethylation in myeloid leukemia
    • Gebhard, C. et al. Genome-wide profiling of CpG methylation identifies novel targets of aberrant hypermethylation in myeloid leukemia. Cancer Res. 66, 6118-6128 (2006).
    • (2006) Cancer Res. , vol.66 , pp. 6118-6128
    • Gebhard, C.1
  • 143
    • 23044514626 scopus 로고    scopus 로고
    • Chromosome-wide and promoter-specific analyses identify sites of differential DNA methylation in normal and transformed human cells
    • DOI 10.1038/ng1598
    • Weber, M. et al. Chromosome-wide and promoter-specific analyses identify sites of differential DNA methylation in normal and transformed human cells. Nature Genet. 37, 853-862 (2005). (Pubitemid 41077111)
    • (2005) Nature Genetics , vol.37 , Issue.8 , pp. 853-862
    • Weber, M.1    Davies, J.J.2    Wittig, D.3    Oakeley, E.J.4    Haase, M.5    Lam, W.L.6    Schubeler, D.7
  • 144
    • 27144500218 scopus 로고    scopus 로고
    • Reduced representation bisulfite sequencing for comparative high-resolution DNA methylation analysis
    • DOI 10.1093/nar/gki901
    • Meissner, A. et al. Reduced representation bisulfite sequencing for comparative high-resolution DNA methylation analysis. Nucleic Acids Res. 33, 5868-5877 (2005). (Pubitemid 41742606)
    • (2005) Nucleic Acids Research , vol.33 , Issue.18 , pp. 5868-5877
    • Meissner, A.1    Gnirke, A.2    Bell, G.W.3    Ramsahoye, B.4    Lander, E.S.5    Jaenisch, R.6
  • 146
    • 84861904633 scopus 로고    scopus 로고
    • Ultra-low-input, tagmentation-based whole-genome bisulfite sequencing
    • Adey, A. & Shendure, J. Ultra-low-input, tagmentation-based whole-genome bisulfite sequencing. Genome Res. 22, 1139-1143 (2012).
    • (2012) Genome Res. , vol.22 , pp. 1139-1143
    • Adey, A.1    Shendure, J.2
  • 147
    • 84869055271 scopus 로고    scopus 로고
    • The GLIB technique for genome-wide mapping of 5-hydroxymethylcytosine
    • Pastor, W. A., Huang, Y., Henderson, H. R., Agarwal, S. & Rao, A. The GLIB technique for genome-wide mapping of 5-hydroxymethylcytosine. Nature Protoc. 7, 1909-1917 (2012).
    • (2012) Nature Protoc. , vol.7 , pp. 1909-1917
    • Pastor, W.A.1    Huang, Y.2    Henderson, H.R.3    Agarwal, S.4    Rao, A.5
  • 148
    • 84861990517 scopus 로고    scopus 로고
    • Base-resolution analysis of 5-hydroxymethylcytosine in the mammalian genome
    • Yu, M. et al. Base-resolution analysis of 5-hydroxymethylcytosine in the mammalian genome. Cell 149, 1368-1380 (2012).
    • (2012) Cell , vol.149 , pp. 1368-1380
    • Yu, M.1
  • 149
    • 70349267600 scopus 로고    scopus 로고
    • Mapping accessible chromatin regions using Sono-Seq
    • Auerbach, R. K. et al. Mapping accessible chromatin regions using Sono-Seq. Proc. Natl Acad. Sci. USA 106, 14926-14931 (2009).
    • (2009) Proc. Natl Acad. Sci. USA , vol.106 , pp. 14926-14931
    • Auerbach, R.K.1
  • 150
    • 84872446709 scopus 로고    scopus 로고
    • Methods for identifying higher-order chromatin structure
    • Sajan, S. A. & Hawkins, R. D. Methods for identifying higher-order chromatin structure. Annu. Rev. Genom. Hum. Genet. 13, 59-82 (2012).
    • (2012) Annu. Rev. Genom. Hum. Genet. , vol.13 , pp. 59-82
    • Sajan, S.A.1    Hawkins, R.D.2
  • 151
    • 3543008920 scopus 로고    scopus 로고
    • High-resolution genome-wide mapping of histone modifications
    • DOI 10.1038/nbt990
    • Roh, T. Y., Ngau, W. C., Cui, K., Landsman, D. & Zhao, K. High-resolution genome-wide mapping of histone modifications. Nature Biotech. 22, 1013-1016 (2004). (Pubitemid 39014479)
    • (2004) Nature Biotechnology , vol.22 , Issue.8 , pp. 1013-1016
    • Roh, T.-Y.1    Ngau, W.C.2    Cui, K.3    Landsman, D.4    Zhao, K.5
  • 154
    • 77249137168 scopus 로고    scopus 로고
    • Principles and challenges of genomewide DNA methylation analysis
    • Laird, P. W. Principles and challenges of genomewide DNA methylation analysis. Nature Rev. Genet. 11, 191-203 (2010).
    • (2010) Nature Rev. Genet. , vol.11 , pp. 191-203
    • Laird, P.W.1
  • 155
    • 84870412337 scopus 로고    scopus 로고
    • Linking DNA methyltransferases to epigenetic marks and nucleosome structure genome-wide in human tumor cells
    • Jin, B. et al. Linking DNA methyltransferases to epigenetic marks and nucleosome structure genome-wide in human tumor cells. Cell Rep. 2, 1411-1424 (2012).
    • (2012) Cell Rep. , vol.2 , pp. 1411-1424
    • Jin, B.1
  • 156
    • 80053388216 scopus 로고    scopus 로고
    • Whole-genome chromatin profiling from limited numbers of cells using nano-ChIP-seq
    • Adli, M. & Bernstein, B. E. Whole-genome chromatin profiling from limited numbers of cells using nano-ChIP-seq. Nature Protoc. 6, 1656-1668 (2011).
    • (2011) Nature Protoc. , vol.6 , pp. 1656-1668
    • Adli, M.1    Bernstein, B.E.2


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