The genetic landscape of the childhood cancer medulloblastoma

Science

Volumn 331, Issue 6016, 2011, Pages 435-439

  Parsons, D Williams ^a,b   Li, Meng ^a   Zhang, Xiaosong ^a   Jones, Siân ^a   Leary, Rebecca J ^a   Lin, Jimmy Cheng Ho ^a   Boca, Simina M ^c   Carter, Hannah ^d   Samayoa, Josue ^d   Bettegowda, Chetan ^a,e   Gallia, Gary L ^e   Jallo, George I ^e   Binder, Zev A ^e   Nikolsky, Yuri ^f   Hartigan, James ^g   Smith, Doug R ^g   Gerhard, Daniela S ^h   Fults, Daniel W ⁱ   VandenBerg, Scott ^j   Berger, Mitchel S ^k   Marie, Suely Kazue Nagahashi ^l   Shinjo, Sueli Mieko Oba ^l   Clara, Carlos ^m   Phillips, Peter C ⁿ   Minturn, Jane E ⁿ   Biegel, Jaclyn A ⁿ   Judkins, Alexander R ^n,r   Resnick, Adam C ⁿ   Storm, Phillip B ⁿ   Curran, Tom ⁿ   He, Yiping ^o   Rasheed, B Ahmed ^o   Friedman, Henry S ^o   Keir, Stephen T ^o   McLendon, Roger ^o   Northcott, Paul A ^p   Taylor, Michael D ^p   Burger, Peter C ^e   Riggins, Gregory J ^a,e   Karchin, Rachel ^d   Parmigiani, Giovanni ^q   Bigner, Darell D ^o   Yan, Hai ^o   Papadopoulos, Nick ^a   Vogelstein, Bert ^a   Kinzler, Kenneth W ^a   Velculescu, Victor E ^a   more..

^a JOHNS HOPKINS UNIVERSITY   (United States)

^b BAYLOR COLLEGE OF MEDICINE   (United States)

^c JOHNS HOPKINS BLOOMBERG SCHOOL OF PUBLIC HEALTH   (United States)

^d DEPARTMENT OF PATHOLOGY   (United States)

^e JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

^f GeneGo bioinformatics software Inc   (United States)

^g Beckman Coulter Genomics   (United States)

^h NATIONAL CANCER INSTITUTE   (United States)

ⁱ UNIVERSITY OF UTAH SCHOOL OF MEDICINE   (United States)

^j UNIVERSITY OF CALIFORNIA   (United States)

^k UNIVERSITY OF CALIFORNIA   (United States)

^l UNIVERSITY OF SÃO PAULO   (Brazil)

^m BARRETOS CANCER HOSPITAL   (Brazil)

ⁿ CHILDREN S HOSPITAL OF PHILADELPHIA   (United States)

^o DUKE UNIVERSITY MEDICAL CENTER   (United States)

^p HOSPITAL FOR SICK CHILDREN   (Canada)

^q HARVARD SCHOOL OF PUBLIC HEALTH   (United States)

^r CHILDREN S HOSPITAL LOS ANGELES   (United States)

more..

Author keywords

[No Author keywords available]

Indexed keywords

HISTONE LYSINE METHYLTRANSFERASE; SONIC HEDGEHOG PROTEIN; WNT PROTEIN;

CANCER; CHILD HEALTH; GENETIC ANALYSIS; GENETICS; LANDSCAPE; NERVOUS SYSTEM DISORDER; PROTEIN; TUMOR;

ARTICLE; CARCINOGENESIS; CHILDHOOD CANCER; COPY NUMBER VARIATION; FRAMESHIFT MUTATION; GENE DELETION; GENE IDENTIFICATION; GENE INSERTION; GENE SEQUENCE; GENETIC VARIABILITY; HISTONE METHYLATION; HUMAN; MEDULLOBLASTOMA; MISSENSE MUTATION; NONSENSE MUTATION; PRIORITY JOURNAL; SOMATIC MUTATION;

ADULT; CEREBELLAR NEOPLASMS; CHILD; DNA COPY NUMBER VARIATIONS; DNA-BINDING PROTEINS; GENES, NEOPLASM; GENES, TUMOR SUPPRESSOR; HISTONE-LYSINE N-METHYLTRANSFERASE; HISTONES; HUMANS; MEDULLOBLASTOMA; METHYLATION; MICRORNAS; MUTATION; NEOPLASM PROTEINS; OLIGONUCLEOTIDE ARRAY SEQUENCE ANALYSIS; POINT MUTATION; SEQUENCE ANALYSIS, DNA; SIGNAL TRANSDUCTION;

ERINACEIDAE;

EID: 79251629946     PISSN: 00368075     EISSN: 10959203     Source Type: Journal    
DOI: 10.1126/science.1198056     Document Type: Article

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45. We thank J. Ptak, N. Silliman, L. Dobbyn, and M. Whalen for technical assistance with sequencing analyses, and M. Ehinger, D. Satterfield, E. Lipp, D. Lister, and M. J. Dougherty for help with sample preparation and data collection. This project has been funded in part by the National Cancer Institute, National Institutes of Health, under contract HHSN261200800001E. The content of this publication does not necessarily reflect the views or policies of the Department of Health and Human Services, nor does mention of trade names, commercial products, or organizations imply endorsement by the U.S. government. This work was supported by the Virginia and D. K. Ludwig Fund for Cancer Research, Alex's Lemonade Stand Foundation, the American Brain Tumor Association, the Brain Tumor Research Fund at Johns Hopkins, the Hoglund Foundation, the Ready or Not Foundation, the Children's Brain Tumor Foundation, the Pediatric Brain Tumor Foundation Institute, the David and Barbara B. Hirschhorn Foundation, American Association for Cancer Research Stand Up To Cancer Dream Team Translational Cancer Research Grant, Johns Hopkins Sommer Scholar Program, NIH grants CA121113, CA096832, CA057345, CA118822, CA135877, and GM074906-01A1/B7BSCW, NSF grant DBI 0845275, and DOD NDSEG Fellowship 32 CFR 168a. D.W.P. is a Graham Cancer Research Scholar at Texas Children's Cancer Center. Under licensing agreements between the Johns Hopkins University and Beckman Coulter, B.V., K.W.K., and V.E.V. are entitled to a share of royalties received by the university on sales of products related to research described in this paper. N.P., B.V., K.W.K., and V.E.V are cofounders of Inostics and Personal Genome Diagnostics and are members of their Scientific Advisory Boards. N.P., B.V., K.W.K., and V.E.V. own Inostics and Personal Genome Diagnostics stock, which is subject to certain restrictions under university policy. The terms of these arrangements are managed by Johns Hopkins University in accordance with its conflict-of-interest policies.