-
1
-
-
1042278765
-
The history of cancer epigenetics
-
Feinberg AP, Tycko B. The history of cancer epigenetics. Nat RevCancer. 2004;4:143-53. (Pubitemid 38198742)
-
(2004)
Nature Reviews Cancer
, vol.4
, Issue.2
, pp. 143-153
-
-
Feinberg, A.P.1
Tycko, B.2
-
2
-
-
0032960181
-
Cancer epigenetics comes of age
-
DOI 10.1038/5947
-
Jones PA, Laird PW. Cancer epigenetics comes of age. Nat Genet. 1999;21:163-7. (Pubitemid 29070360)
-
(1999)
Nature Genetics
, vol.21
, Issue.2
, pp. 163-167
-
-
Jones, P.A.1
Laird, P.W.2
-
3
-
-
0026653420
-
The essentials of DNA methylation
-
Bird A. The essentials of DNA methylation. Cell. 1992;70:5-8.
-
(1992)
Cell
, vol.70
, pp. 5-8
-
-
Bird, A.1
-
4
-
-
0030710153
-
How does DNA methylation repress transcription?
-
DOI 10.1016/S0168-9525(97)01268-7
-
Kass SU, Pruss D, Wolffe AP. How does DNA methylation repress transcription? Trends Genet. 1997;13:444-9. (Pubitemid 27479903)
-
(1997)
Trends in Genetics
, vol.13
, Issue.11
, pp. 444-449
-
-
Kass, S.U.1
Pruss, D.2
Wolffe, A.P.3
-
5
-
-
0031149162
-
DNA methylation: A molecular lock
-
Siegfried Z, Cedar H. DNA methylation: A molecular lock. Curr Biol. 1997;7:R305-7. (Pubitemid 27195597)
-
(1997)
Current Biology
, vol.7
, Issue.5
-
-
Siegfried, Z.1
Cedar, H.2
-
6
-
-
66149123748
-
The nuclear DNA base 5-hydroxymethylcytosine is present in Purkinje neurons and the brain
-
Kriaucionis S, Heintz N. The nuclear DNA base 5-hydroxymethylcytosine is present in Purkinje neurons and the brain. Science. 2009;324:929-30.
-
(2009)
Science
, vol.324
, pp. 929-30
-
-
Kriaucionis, S.1
Heintz, N.2
-
7
-
-
66149146320
-
Conversion of 5-methylcytosine to 5-hydroxymethylcytosine in mammalian DNAby MLL partner TET1
-
Discovery of TET1 catalytic activity by homology with the trypanosome enzymes JBP1 and JBP2. Tahiliani et al. demonstrate for the first time the ability of a mammalian dioxygenase to convert 5-mC into 5-hmC
-
Tahiliani M, Koh KP, Shen Y, et al.: Conversion of 5-methylcytosine to 5-hydroxymethylcytosine in mammalian DNAby MLL partner TET1. Science 2009;324:930-935. Discovery of TET1 catalytic activity by homology with the trypanosome enzymes JBP1 and JBP2. Tahiliani et al. demonstrate for the first time the ability of a mammalian dioxygenase to convert 5-mC into 5-hmC.
-
(2009)
Science
, vol.324
, pp. 930-935
-
-
Tahiliani, M.1
Koh, K.P.2
Shen, Y.3
-
8
-
-
0037350661
-
TET1, a member of a novel protein family, is fused to MLL in acute myeloid leukemia containing the t(10;11)(q22;23) [3]
-
DOI 10.1038/sj.leu.2402834
-
Lorsbach RB, Moore J, Mathew S, et al. Tet1, a member of a novel protein family, is fused to mll in acute myeloid leukemia containing the t(10;11)(q22;q23). Leukemia. 2003;17:637-41. (Pubitemid 36395661)
-
(2003)
Leukemia
, vol.17
, Issue.3
, pp. 637-641
-
-
Lorsback, R.B.1
Moore, J.2
Mathew, S.3
Raimondi, S.C.4
Mukatira, S.T.5
Downing, J.R.6
-
9
-
-
77956189495
-
Role of Tet proteins in 5mC to 5hmC conversion, ES-cell self-renewal and inner cell massspecification
-
Ito et al. show that Tet1, Tet2, and Tet3 share the same catalytic activity and play a role in the transcription control of development genes.
-
Ito S, D'Alessio AC, Taranova OV, et al.: Role of Tet proteins in 5mC to 5hmC conversion, ES-cell self-renewal and inner cell massspecification. Nature 2010;466:1129-1133. Ito et al. show that Tet1, Tet2, and Tet3 share the same catalytic activity and play a role in the transcription control of development genes.
-
(2010)
Nature
, vol.466
, pp. 1129-1133
-
-
Ito, S.1
D'alessio, A.C.2
Taranova, O.V.3
-
10
-
-
66249137734
-
Mutation in TET2 in myeloid cancers
-
First evidence for mutations in TET2 in myeloid malignancies, including MPN. Shows a selective advantage of TET2 mutant cells over TET2 wild-type cells in severe combined immunodeficiency repopulation assays
-
Delhommeau F, Dupont S, Della Valle V, et al.: Mutation in TET2 in myeloid cancers. N Engl J Med 2009;360:2289-2301. First evidence for mutations in TET2 in myeloid malignancies, including MPN. Shows a selective advantage of TET2 mutant cells over TET2 wild-type cells in severe combined immunodeficiency repopulation assays.
-
(2009)
N Engl J Med
, vol.360
, pp. 2289-2301
-
-
Delhommeau, F.1
Dupont, S.2
Della Valle, V.3
-
11
-
-
67649876132
-
Acquiredmutations in TET2 are common in myelodysplastic syndromes
-
Large study of TET2 mutations in MDS and TET2 expression studies. Evidence for the modulation of TET2 during granulocytic differentiation
-
Langemeijer SM, Kuiper RP, Berends M, et al.: Acquiredmutations in TET2 are common in myelodysplastic syndromes.Nat Genet 2009;41:838-842. Large study of TET2 mutations in MDS and TET2 expression studies. Evidence for the modulation of TET2 during granulocytic differentiation.
-
(2009)
Nat Genet
, vol.41
, pp. 838-842
-
-
Langemeijer, S.M.1
Kuiper, R.P.2
Berends, M.3
-
12
-
-
67349145955
-
Frequent tet2 mutations in systemic mastocytosis: Clinical kitd816v and fip1l1-pdgfra correlates
-
Tefferi A, Levine RL, Lim KH, et al. Frequent TET2 mutations in systemic mastocytosis: clinical, KITD816V and FIP1L1-PDGFRA correlates. Leukemia. 2009;23:900-4.
-
(2009)
Leukemia
, vol.23
, pp. 900-4
-
-
Tefferi, A.1
Levine, R.L.2
Lim, K.H.3
-
13
-
-
67650924270
-
Detection of mutant TET2 in myeloid malignancies other than myeloproliferative neoplasms: CMML, MDS, MDS/MPN and AML
-
Tefferi A, Lim KH, Abdel-Wahab O, et al. Detection of mutant TET2 in myeloid malignancies other than myeloproliferative neoplasms: CMML, MDS, MDS/MPN and AML. Leukemia. 2009;23:1343-5.
-
(2009)
Leukemia
, vol.23
, pp. 1343-5
-
-
Tefferi, A.1
Lim, K.H.2
Abdel-Wahab, O.3
-
14
-
-
67349124376
-
Tet2 mutations and their clinical correlates in polycythemia vera, essential thrombocythemiaand myelofibrosis
-
Tefferi A, Pardanani A, Lim KH, et al. Tet2 mutations and their clinical correlates in polycythemia vera, essential thrombocythemiaand myelofibrosis. Leukemia. 2009;23:905-11.
-
(2009)
Leukemia
, vol.23
, pp. 905-11
-
-
Tefferi, A.1
Pardanani, A.2
Lim, K.H.3
-
15
-
-
78650175023
-
Impaired hydroxylation of 5-methylcytosine in myeloid cancers with mutant tet2
-
Evidence that patients with TET2 mutations have low 5-hmC levels and an abnormal DNA methylation profile
-
Ko M, Huang Y, Jankowska AM, et al.: Impaired hydroxylation of 5-methylcytosine in myeloid cancers with mutant tet2. Nature2010;468:839-843. Evidence that patients with TET2 mutations have low 5-hmC levels and an abnormal DNA methylation profile.
-
(2010)
Nature
, vol.468
, pp. 839-843
-
-
Ko, M.1
Huang, Y.2
Jankowska, A.M.3
-
16
-
-
70349256226
-
The 2008 revision of theWorld Health Organization (WHO) classification of myeloid neoplasms and acute leukemia: Rationale and important changes
-
Vardiman JW, Thiele J, Arber DA, et al. The 2008 revision of theWorld Health Organization (WHO) classification of myeloid neoplasms and acute leukemia: rationale and important changes. Blood. 2009;114:937-51.
-
Blood
, vol.2009
, Issue.114
, pp. 937-51
-
-
Vardiman, J.W.1
Thiele, J.2
Arber, D.A.3
-
17
-
-
68549125412
-
Chronic myelogenous leukemia, bcr-abl1+
-
Vardiman JW. Chronic myelogenous leukemia, bcr-abl1+. Am JClin Pathol. 2009;132:250-60.
-
(2009)
Am JClin Pathol
, vol.132
, pp. 250-60
-
-
Vardiman, J.W.1
-
18
-
-
79952075257
-
Myeloproliferative neoplasms: Molecular pathophysiology, essential clinical understanding, and treatment strategies
-
Tefferi A, Vainchenker W. Myeloproliferative neoplasms: Molecular pathophysiology, essential clinical understanding, and treatment strategies. J Clin Oncol. 2010;29:573-82.
-
(2010)
J Clin Oncol
, vol.29
, pp. 573-82
-
-
Tefferi, A.1
Vainchenker, W.2
-
19
-
-
20144363192
-
Acquired mutation of the tyrosine kinase JAK2 in human myeloproliferative disorders
-
DOI 10.1016/S0140-6736(05)71142-9
-
Baxter EJ, Scott LM, Campbell PJ, et al. Acquired mutation of the tyrosine kinase jak2 in human myeloproliferative disorders. Lancet. 2005;365:1054-61. (Pubitemid 40386783)
-
(2005)
Lancet
, vol.365
, Issue.9464
, pp. 1054-1061
-
-
Baxter, E.J.1
Scott, L.M.2
Campbell, P.J.3
East, C.4
Fourouclas, N.5
Swanton, S.6
Vassiliou, G.S.7
Bench, A.J.8
Boyd, E.M.9
Curtin, N.10
Scott, M.A.11
Erber, W.N.12
Avis, T.13
Barthorpe, A.14
Bignell, G.15
Blow, M.16
Brackenbury, L.17
Buck, G.18
Clegg, S.19
Clements, J.20
Cole, J.21
Davies, H.22
Edkins, S.23
Gray, K.24
Gorton, M.25
O'Meara, S.26
Halliday, K.27
Harrison, R.28
Haynes, W.29
Hills, K.30
Hunter, C.31
Jones, D.32
Kosmidou, V.33
Laman, R.34
Lugg, R.35
Parker, A.36
Perry, J.37
Petty, R.38
Small, A.39
Solomon, H.40
Stephens, P.41
Stephens, Y.42
Stevens, C.43
Smith, R.44
Tarpey, P.45
Tofts, C.46
Varian, J.47
West, S.48
Widaa, S.49
Bamford, S.50
Butler, A.51
Dawson, E.52
Dicks, E.53
Edwards, K.54
Forbes, S.55
Greenman, C.56
Hinton, J.57
Menzies, A.58
Raine, K.59
Shepherd, R.60
Teague, J.61
Yates, A.62
Wooster, R.63
Futreal, A.64
Stratton, M.65
Green, A.R.66
more..
-
20
-
-
17844383458
-
A unique clonal JAK2 mutation leading to constitutive signalling causes polycythaemia vera
-
DOI 10.1038/nature03546
-
James C, Ugo V, Le Couedic JP, et al. A unique clonal jak2 mutation leading to constitutive signalling causes polycythaemia vera. Nature. 2005;434:1144-8. (Pubitemid 40663494)
-
(2005)
Nature
, vol.434
, Issue.7037
, pp. 1144-1148
-
-
James, C.1
Ugo, V.2
Le Couedic, J.-P.3
Staerk, J.4
Delhommeau, F.5
Lacout, C.6
Garcon, L.7
Raslova, H.8
Berger, R.9
Bennaceur-Griscelli, A.10
Villeval, J.L.11
Constantinescu, S.N.12
Casadevall, N.13
Vainchenker, W.14
-
21
-
-
17644424955
-
A gain-of-function mutation of JAK2 in myeloproliferative disorders
-
DOI 10.1056/NEJMoa051113
-
Kralovics R, Passamonti F, Buser AS, et al. A gain-of-function mutation of jak2 in myeloproliferative disorders. N Engl J Med. 2005;352:1779-90. (Pubitemid 40570926)
-
(2005)
New England Journal of Medicine
, vol.352
, Issue.17
, pp. 1779-1790
-
-
Kralovics, R.1
Passamonti, F.2
Buser, A.S.3
Teo, S.-S.4
Tiedt, R.5
Passweg, J.R.6
Tichelli, A.7
Cazzola, M.8
Skoda, R.C.9
-
22
-
-
20244369569
-
Activating mutation in the tyrosine kinase JAK2 in polycythemia vera, essential thrombocythemia, and myeloid metaplasia with myelofibrosis
-
DOI 10.1016/j.ccr.2005.03.023
-
Levine RL, Wadleigh M, Cools J, et al. Activating mutation in the tyrosine kinase jak2 in polycythemia vera, essential thrombocythemia,and myeloid metaplasia with myelofibrosis. Cancer Cell. 2005;7:387-97. (Pubitemid 40544655)
-
(2005)
Cancer Cell
, vol.7
, Issue.4
, pp. 387-397
-
-
Levine, R.L.1
Wadleigh, M.2
Cools, J.3
Ebert, B.L.4
Wernig, G.5
Huntly, B.J.P.6
Boggon, T.J.7
Wlodarska, I.8
Clark, J.J.9
Moore, S.10
Adelsperger, J.11
Koo, S.12
Lee, J.C.13
Gabriel, S.14
Mercher, T.15
D'Andrea, A.16
Frohling, S.17
Dohner, K.18
Marynen, P.19
Vandenberghe, P.20
Mesa, R.A.21
Tefferi, A.22
Griffin, J.D.23
Eck, M.J.24
Sellers, W.R.25
Meyerson, M.26
Golub, T.R.27
Lee, S.J.28
Gilliland, D.G.29
more..
-
23
-
-
33846660947
-
JAK2 exon 12 mutations in polycythemia vera and idiopathic erythrocytosis
-
DOI 10.1056/NEJMoa065202
-
Scott LM, Tong W, Levine RL, et al. Jak2 exon 12 mutations in polycythemia vera and idiopathic erythrocytosis. N Engl J Med.2007;356:459-68. (Pubitemid 46193073)
-
(2007)
New England Journal of Medicine
, vol.356
, Issue.5
, pp. 459-468
-
-
Scott, L.M.1
Tong, W.2
Levine, R.L.3
Scott, M.A.4
Beer, P.A.5
Stratton, M.R.6
Futreal, P.A.7
Erber, W.N.8
McMullin, M.F.9
Harrison, C.N.10
Warren, A.J.11
Gilliland, D.G.12
Lodish, H.F.13
Green, A.R.14
-
24
-
-
33750534561
-
Mpl515 mutations in myeloproliferative and other myeloid disorders: A study of 1182patients
-
Pardanani AD, Levine RL, Lasho T, et al. Mpl515 mutations in myeloproliferative and other myeloid disorders: a study of 1182patients. Blood. 2006;108:3472-6.
-
(2006)
Blood
, vol.108
, pp. 3472-6
-
-
Pardanani, A.D.1
Levine, R.L.2
Lasho, T.3
-
25
-
-
33746437130
-
Mplw515l is a novel somatic activating mutation in myelofibrosis with myeloid metaplasia
-
Pikman Y, Lee BH, Mercher T, et al. Mplw515l is a novel somatic activating mutation in myelofibrosis with myeloid metaplasia. PLoS Med. 2006;3:e270.
-
(2006)
PLoS Med
, vol.3
-
-
Pikman, Y.1
Lee, B.H.2
Mercher, T.3
-
26
-
-
77954661062
-
Deletions of the transcriptionfactor ikaros in myeloproliferative neoplasms
-
Jager R, Gisslinger H, Passamonti F, et al. Deletions of the transcriptionfactor ikaros in myeloproliferative neoplasms. Leukemia. 2010;24:1290-8.
-
(2010)
Leukemia.
, vol.24
, pp. 1290-8
-
-
Jager, R.1
Gisslinger, H.2
Passamonti, F.3
-
27
-
-
77953485892
-
Novel mutations in the inhibitory adaptor protein lnk drive JAK-STAT signaling in patients with myeloproliferative neoplasms
-
Oh ST, Simonds EF, Jones C, et al. Novel mutations in the inhibitory adaptor protein lnk drive JAK-STAT signaling in patients with myeloproliferative neoplasms. Blood. 2010;116:988-92.
-
(2010)
Blood
, vol.116
, pp. 988-92
-
-
Oh, S.T.1
Simonds, E.F.2
Jones, C.3
-
28
-
-
67650401377
-
Frequent CBL mutations associated with 11q acquired uniparental disomy inmyeloproliferative neoplasms
-
Grand FH, Hidalgo-Curtis CE, Ernst T, et al. Frequent CBL mutations associated with 11q acquired uniparental disomy inmyeloproliferative neoplasms. Blood. 2009;113:6182-92.
-
(2009)
Blood
, vol.113
, pp. 6182-92
-
-
Grand, F.H.1
Hidalgo-Curtis, C.E.2
Ernst, T.3
-
29
-
-
75449119103
-
Somatic mutations of IDH1 and IDH2 in the leukemic transformation of myeloproliferative neoplasms
-
Green A, Beer P. Somatic mutations of IDH1 and IDH2 in the leukemic transformation of myeloproliferative neoplasms. N Engl J Med. 2010;362:369-70.
-
(2010)
N Engl J Med
, vol.362
, pp. 369-70
-
-
Green, A.1
Beer, P.2
-
30
-
-
77955085750
-
Inactivating mutations of the histone methyltransferase gene EZH2 in myeloid disorders
-
Ernst T, Chase AJ, Score J, et al. Inactivating mutations of the histone methyltransferase gene EZH2 in myeloid disorders. Nat Genet. 2010;42:722-6.
-
(2010)
Nat Genet
, vol.42
, pp. 722-6
-
-
Ernst, T.1
Chase, A.J.2
Score, J.3
-
31
-
-
70450239681
-
Mutations of ASXL1 gene in myeloproliferative neoplasms
-
Carbuccia N, Murati A, Trouplin V, et al. Mutations of ASXL1 gene in myeloproliferative neoplasms. Leukemia. 2009;23:2183-6.
-
(2009)
Leukemia
, vol.23
, pp. 2183-6
-
-
Carbuccia, N.1
Murati, A.2
Trouplin, V.3
-
32
-
-
67651065502
-
Genetic characterization of TET1, TET2, and TET3 alterations in myeloid malignancies
-
Abdel-Wahab O, Mullally A, Hedvat C, et al. Genetic characterization of TET1, TET2, and TET3 alterations in myeloid malignancies.Blood. 2009;114:144-7.
-
(2009)
Blood
, vol.114
, pp. 144-7
-
-
Abdel-Wahab, O.1
Mullally, A.2
Hedvat, C.3
-
33
-
-
23744440061
-
Common 4q24 deletion in four cases of hematopoietic malignancy: Early stem cell involvement?
-
DOI 10.1038/sj.leu.2403818
-
Viguie F, Aboura A, Bouscary D, et al. Common 4q24 deletion in four cases of hematopoietic malignancy: Early stem cell involvement? Leukemia. 2005;19:1411-5. (Pubitemid 41136336)
-
(2005)
Leukemia
, vol.19
, Issue.8
, pp. 1411-1415
-
-
Viguie, F.1
Aboura, A.2
Bouscary, D.3
Ramond, S.4
Delmer, A.5
Tachdjian, G.6
Marie, J.P.7
Casadevall, N.8
-
34
-
-
79957593717
-
CBL, CBLB, TET2, ASXL1, and IDH1/2 mutations and additional chromosomal aberrations constitute molecular events in chronic myelogenous leukemia
-
Makishima H, Jankowska AM, McDevitt MA, et al. CBL, CBLB, TET2, ASXL1, and IDH1/2 mutations and additional chromosomal aberrations constitute molecular events in chronic myelogenous leukemia. Blood. 2011;117:e198-206.
-
(2011)
Blood
, vol.117
-
-
Makishima, H.1
Jankowska, A.M.2
McDevitt, M.A.3
-
35
-
-
80054051299
-
Mutation analysis of TET2, IDH1, IDH2 and ASXL1 in chronic myeloid leukemia
-
Roche-Lestienne C, Marceau A, Labis E, et al. Mutation analysis of TET2, IDH1, IDH2 and ASXL1 in chronic myeloid leukemia. Leukemia. 2011;25(10):1661-4.
-
(2011)
Leukemia
, vol.25
, Issue.10
, pp. 1661-4
-
-
Roche-Lestienne, C.1
Marceau, A.2
Labis, E.3
-
36
-
-
79952322394
-
The role of the JAK2 GGCC haplotype and the TET2 gene in familial myeloproliferative neoplasms
-
Olcaydu D, Rumi E, Harutyunyan A, et al. The role of the JAK2 GGCC haplotype and the TET2 gene in familial myeloproliferative neoplasms. Haematologica. 2010;96:367-74.
-
(2010)
Haematologica
, vol.96
, pp. 367-74
-
-
Olcaydu, D.1
Rumi, E.2
Harutyunyan, A.3
-
37
-
-
70149101696
-
Analysis of the ten-eleven translocation 2 (TET2) gene in familial myeloproliferativeneoplasms
-
Saint-Martin C, Leroy G, Delhommeau F, et al. Analysis of the ten-eleven translocation 2 (TET2) gene in familial myeloproliferativeneoplasms. Blood. 2009;114:1628-32.
-
(2009)
Blood
, vol.114
, pp. 1628-32
-
-
Saint-Martin, C.1
Leroy, G.2
Delhommeau, F.3
-
38
-
-
77950388949
-
Clonal analysis of TET2 and JAK2 mutations suggests that TET2 can be a late event in the progression ofmyeloproliferative neoplasms
-
Schaub FX, Looser R, Li S, et al. Clonal analysis of TET2 and JAK2 mutations suggests that TET2 can be a late event in the progression ofmyeloproliferative neoplasms. Blood. 2010;115:2003-7.
-
(2010)
Blood
, vol.115
, pp. 2003-7
-
-
Schaub, F.X.1
Looser, R.2
Li, S.3
-
39
-
-
79551587102
-
Tet1 and Tet2 regulate 5-hydroxymethylcytosine production and cell lineage specification in mouse embryonic stem cells
-
Koh KP, Yabuuchi A, Rao S, et al. Tet1 and Tet2 regulate 5-hydroxymethylcytosine production and cell lineage specification in mouse embryonic stem cells. Cell Stem Cell. 2011;8:200-13.
-
(2011)
Cell Stem Cell
, vol.8
, pp. 200-13
-
-
Koh, K.P.1
Yabuuchi, A.2
Rao, S.3
-
40
-
-
77955838329
-
Recruitment of MBD1 to target genes requires sequence-specific interaction of theMBD domain with methylated DNA
-
Clouaire T, de Las Heras JI, Merusi C, Stancheva I. Recruitment of MBD1 to target genes requires sequence-specific interaction of theMBD domain with methylated DNA. Nucleic Acids Res.2010;38:4620-34.
-
(2010)
Nucleic Acids Res
, vol.38
, pp. 4620-34
-
-
Clouaire, T.1
De Las Heras, J.I.2
Merusi, C.3
Stancheva, I.4
-
41
-
-
0035197407
-
Regulation of transcription and chromatin by methyl-CPG binding protein MBD1
-
Nakao M, Matsui S, Yamamoto S, et al. Regulation of transcription and chromatin by methyl-CPG binding protein MBD1. Brain Dev. 2001;23 Suppl 1:S174-6.
-
(2001)
Brain Dev
, vol.23 SUPPL. 1
-
-
Nakao, M.1
Matsui, S.2
Yamamoto, S.3
-
42
-
-
33847611155
-
CXXC finger protein 1 is required for normal proliferation and differentiation of the PLB-985 myeloid cell line
-
DOI 10.1089/dna.2006.0535
-
Young SR, Skalnik DG. CXXC finger protein 1 is required for normal proliferation and differentiation of the PLB-985 myeloidcell line. DNA Cell Biol. 2007;26:80-90. (Pubitemid 46363873)
-
(2007)
DNA and Cell Biology
, vol.26
, Issue.2
, pp. 80-90
-
-
Young, S.R.L.1
Skalnik, D.G.2
-
43
-
-
72049125350
-
Cancer-associated IDH1 mutations produce 2-hydroxyglutarate
-
Dang L, White DW, Gross S, et al. Cancer-associated IDH1 mutations produce 2-hydroxyglutarate. Nature. 2009;462:739-44.
-
(2009)
Nature
, vol.462
, pp. 739-44
-
-
Dang, L.1
White, D.W.2
Gross, S.3
-
44
-
-
77649305610
-
The common feature of leukemiaassociatedidh1 and idh2 mutations is a neomorphic enzyme activity converting alpha-ketoglutarate to 2-hydroxyglutarate
-
Ward PS, Patel J, Wise DR, et al. The common feature of leukemiaassociatedidh1 and idh2 mutations is a neomorphic enzyme activity converting alpha-ketoglutarate to 2-hydroxyglutarate. Cancer Cell.2010;17:225-34.
-
(2010)
Cancer Cell
, vol.17
, pp. 225-34
-
-
Ward, P.S.1
Patel, J.2
Wise, D.R.3
-
45
-
-
78650019179
-
Leukemic IDH1 and IDH2 mutations result in a hypermethylation phenotype, disrupt TET2 function, and impair hematopoietic differentiation
-
Evidence that IDH1/2 and TET2 mutations impair hematopoietic differentiation in a similar way
-
Figueroa ME, Abdel-Wahab O, Lu C, et al.: Leukemic IDH1 and IDH2 mutations result in a hypermethylation phenotype, disrupt TET2 function, and impair hematopoietic differentiation. Cancer Cell 2010;18:553-567. Evidence that IDH1/2 and TET2 mutations impair hematopoietic differentiation in a similar way.
-
(2010)
Cancer Cell
, vol.18
, pp. 553-567
-
-
Figueroa, M.E.1
Abdel-Wahab, O.2
Lu, C.3
-
46
-
-
80052461558
-
TET proteins can convert 5-methylcytosine to 5-formylcytosine and 5-carboxylcytosine
-
Ito S, Shen L, Dai Q, et al. TET proteins can convert 5-methylcytosine to 5-formylcytosine and 5-carboxylcytosine. Science. 2011;333:1300-3.
-
(2011)
Science
, vol.333
, pp. 1300-3
-
-
Ito, S.1
Shen, L.2
Dai, Q.3
-
47
-
-
79960768558
-
Inhibition of TET2-mediated conversion of 5-methylcytosine to 5-hydroxymethylcytosine disturbserythroid and granulomonocytic differentiation of human hematopoietic progenitors
-
Demonstration that MPN patients with TET2 mutations have low DNA contents of 5-hmC, and that TET2 depletion in human progenitors leads to abnormal myeloid differentiation
-
Pronier E, Almire C,Mokrani H, et al.: Inhibition of TET2-mediated conversion of 5-methylcytosine to 5-hydroxymethylcytosine disturbserythroid and granulomonocytic differentiation of human hematopoietic progenitors. Blood 2011;118:2551-2555. Demonstration that MPN patients with TET2 mutations have low DNA contents of 5-hmC, and that TET2 depletion in human progenitors leads to abnormal myeloid differentiation.
-
(2011)
Blood
, vol.118
, pp. 2551-2555
-
-
Pronier, E.1
Almire Cmokrani, H.2
-
48
-
-
32344450824
-
Genomic DNA methylation: The mark and its mediators
-
DOI 10.1016/j.tibs.2005.12.008, PII S096800040500352X
-
Klose RJ, Bird AP. Genomic DNA methylation: the mark and itsmediators. Trends Biochem Sci. 2006;31:89-97. (Pubitemid 43221841)
-
(2006)
Trends in Biochemical Sciences
, vol.31
, Issue.2
, pp. 89-97
-
-
Klose, R.J.1
Bird, A.P.2
-
49
-
-
0015298215
-
The presence of 5-hydroxymethylcytosine in animal deoxyribonucleic acid
-
Penn NW, Suwalski R, O'Riley C, et al. The presence of 5-hydroxymethylcytosine in animal deoxyribonucleic acid. Biochem J. 1972;126:781-90.
-
(1972)
Biochem J
, vol.126
, pp. 781-90
-
-
Penn, N.W.1
Suwalski, R.2
O'riley, C.3
-
50
-
-
84864129535
-
Distribution of 5-hydroxymethylcytosine in different human tissues
-
Li W, Liu M. Distribution of 5-hydroxymethylcytosine in different human tissues. J Nucleic Acids. 2011;2011:870726.
-
(2011)
J Nucleic Acids
, vol.2011
, pp. 870726
-
-
Li, W.1
Liu, M.2
-
51
-
-
79956323623
-
Dynamic regulation of 5-hydroxymethylcytosine in mouse ES cells and during differentiation
-
Ficz G, Branco MR, Seisenberger S, et al. Dynamic regulation of 5-hydroxymethylcytosine in mouse ES cells and during differentiation. Nature. 2011;473:398-402.
-
(2011)
Nature
, vol.473
, pp. 398-402
-
-
Ficz, G.1
Branco, M.R.2
Seisenberger, S.3
-
52
-
-
79956308473
-
Genome-wide mapping of 5-hydroxymethylcytosine in embryonic stem cells
-
Pastor WA, Pape UJ, Huang Y, et al. Genome-wide mapping of 5-hydroxymethylcytosine in embryonic stem cells. Nature.2011;473:394-7.
-
(2011)
Nature
, vol.473
, pp. 394-7
-
-
Pastor, W.A.1
Pape, U.J.2
Huang, Y.3
-
53
-
-
79960560477
-
The presence of 5-hydroxymethylcytosine at the gene promoter and not in the genebody negatively regulates gene expression
-
Robertson J, Robertson AB, Klungland A. The presence of 5-hydroxymethylcytosine at the gene promoter and not in the genebody negatively regulates gene expression. Biochem Biophys Res Commun. 2011;411:40-3.
-
(2011)
Biochem Biophys Res Commun
, vol.411
, pp. 40-3
-
-
Robertson, J.1
Robertson, A.B.2
Klungland, A.3
-
54
-
-
79959209733
-
5-hydroxymethylcytosine is associated with enhancers and gene bodies in human embryonicstem cells
-
Stroud H, Feng S, Morey Kinney S, et al. 5-hydroxymethylcytosine is associated with enhancers and gene bodies in human embryonicstem cells. Genome Biol. 2011;12:R54.
-
(2011)
Genome Biol
, vol.12
-
-
Stroud, H.1
Feng, S.2
Morey Kinney, S.3
-
55
-
-
79959859654
-
Integrating 5-hydroxymethylcytosine into the epigenomic landscape of human embryonic stem cells
-
Szulwach KE, Li X, Li Y, et al. Integrating 5-hydroxymethylcytosine into the epigenomic landscape of human embryonic stem cells. PLoS Genet. 2011;7:e1002154.
-
(2011)
PLoS Genet
, vol.7
-
-
Szulwach, K.E.1
Li, X.2
Li, Y.3
-
56
-
-
79956302047
-
TET1 and hydroxymethylcytosine in transcription and DNA methylation fidelity
-
Mapping of 5-hmC and TET1 localization: consequences for transcription and methylation
-
Williams K, Christensen J, Pedersen MT, et al.: TET1 and hydroxymethylcytosine in transcription and DNA methylation fidelity. Nature 2011;473:343-348. Mapping of 5-hmC and TET1 localization: consequences for transcription and methylation.
-
(2011)
Nature
, vol.473
, pp. 343-348
-
-
Williams, K.1
Christensen, J.2
Pedersen, M.T.3
-
57
-
-
33847055935
-
Endogenous cytosine damage products alter the site selectivity of human DNA maintenance methyltransferaseDNMT1
-
Valinluck V, Sowers LC. Endogenous cytosine damage products alter the site selectivity of human DNA maintenance methyltransferaseDNMT1. Cancer Res. 2007;67:946-50.
-
(2007)
Cancer Res
, vol.67
, pp. 946-50
-
-
Valinluck, V.1
Sowers, L.C.2
-
58
-
-
77954362183
-
Examination of the specificity of DNA methylation profiling techniques towards 5-methylcytosineand 5-hydroxymethylcytosine
-
Jin SG, Kadam S, Pfeifer GP. Examination of the specificity of DNA methylation profiling techniques towards 5-methylcytosineand 5-hydroxymethylcytosine. Nucleic Acids Res. 2010;38:e125.
-
(2010)
Nucleic Acids Res
, vol.38
-
-
Jin, S.G.1
Kadam, S.2
Pfeifer, G.P.3
-
59
-
-
79955538247
-
Hydroxylation of 5-methylcytosine by TET1 promotes active DNA demethylation in the adult brain
-
Guo JU, Su Y, Zhong C, et al. Hydroxylation of 5-methylcytosine by TET1 promotes active DNA demethylation in the adult brain.Cell. 2011;145:423-34.
-
(2011)
Cell
, vol.145
, pp. 423-34
-
-
Guo, J.U.1
Su, Y.2
Zhong, C.3
-
60
-
-
79959937861
-
Thymine DNA glycosylase is essential for active DNA demethylation by linked deaminationbase excision repair
-
Cortellino S, Xu J, Sannai M, et al. Thymine DNA glycosylase is essential for active DNA demethylation by linked deaminationbase excision repair. Cell. 2011;146:67-79.
-
(2011)
Cell
, vol.146
, pp. 67-79
-
-
Cortellino, S.1
Xu, J.2
Sannai, M.3
-
61
-
-
79960062301
-
Tet2 inactivation results in pleiotropic hematopoietic abnormalities in mouse and is a recurrent event during human lymphomagenesis
-
Description of two Tet2 gene-disrupted mouse models with dramatic consequences on HSCs and both myeloidand lymphoid differentiations. First description of TET2 mutations in human B and T lymphomas
-
Quivoron C, Couronne L, Della Valle V, et al.: Tet2 inactivation results in pleiotropic hematopoietic abnormalities in mouse and is a recurrent event during human lymphomagenesis. Cancer Cell 2011;20:25-38. Description of two Tet2 gene-disrupted mouse models with dramatic consequences on HSCs and both myeloidand lymphoid differentiations. First description of TET2 mutations in human B and T lymphomas.
-
(2011)
Cancer Cell
, vol.20
, pp. 25-38
-
-
Quivoron, C.1
Couronne, L.2
Della Valle, V.3
-
62
-
-
79960064353
-
Tet2 loss leads to increased hematopoietic stem cell self-renewal and myeloid transformation
-
Moran-Crusio K, Reavie L, Shih A, et al. Tet2 loss leads to increased hematopoietic stem cell self-renewal and myeloid transformation. Cancer Cell. 2011;20:11-24.
-
(2011)
Cancer Cell
, vol.20
, pp. 11-24
-
-
Moran-Crusio, K.1
Reavie, L.2
Shih, A.3
-
63
-
-
80052285127
-
Deletion of Tet2 in mice leads to dysregulated hematopoietic stem cells and subsequent development of myeloid malignancies
-
Li Z, Cai X, Cai CL, et al. Deletion of Tet2 in mice leads to dysregulated hematopoietic stem cells and subsequent development of myeloid malignancies. Blood. 2011;118(17):4509-18.
-
(2011)
Blood
, vol.118
, Issue.17
, pp. 4509-18
-
-
Li, Z.1
Cai, X.2
Cai, C.L.3
-
64
-
-
80052284526
-
Ten-eleven-translocation 2 (tet2) negatively regulates homeostasis and differentiation of hematopoieticstem cells in mice
-
Ko M, Bandukwala HS, An J, et al. Ten-eleven-translocation 2 (tet2) negatively regulates homeostasis and differentiation of hematopoieticstem cells in mice. Proc Natl Acad Sci U S A. 2011;108:14566-71.
-
(2011)
Proc Natl Acad Sci U S A.
, vol.108
, pp. 14566-71
-
-
Ko, M.1
Bandukwala, H.S.2
An, J.3
-
65
-
-
80053620171
-
TET2 mutation is an unfavorable prognostic factor in acute myeloid leukemia patients with intermediate-risk cytogenetics
-
Chou WC, Chou SC, Liu CY, et al. TET2 mutation is an unfavorable prognostic factor in acute myeloid leukemia patients with intermediate-risk cytogenetics. Blood. 2011;118(14):3803-10.
-
(2011)
Blood
, vol.118
, Issue.14
, pp. 3803-10
-
-
Chou, W.C.1
Chou, S.C.2
Liu, C.Y.3
-
66
-
-
79955810336
-
Molecular profiling of chronic myelomonocytic leukemia reveals diverse mutations in >80% of patients with TET2 and EZH2 being of high prognostic relevance
-
Grossmann V, Kohlmann A, Eder C, et al. Molecular profiling of chronic myelomonocytic leukemia reveals diverse mutations in >80% of patients with TET2 and EZH2 being of high prognostic relevance. Leukemia. 2011;25:877-9.
-
(2011)
Leukemia
, vol.25
, pp. 877-9
-
-
Grossmann, V.1
Kohlmann, A.2
Eder, C.3
-
67
-
-
79954428737
-
TET2 mutations improve the new European LeukemiaNet risk classification ofacute myeloid leukemia: A Cancer and Leukemia Group B study
-
Metzeler KH, Maharry K, Radmacher MD, et al. TET2 mutations improve the new European LeukemiaNet risk classification ofacute myeloid leukemia: a Cancer And Leukemia Group B study. J Clin Oncol. 2011;29:1373-81.
-
(2011)
J Clin Oncol
, vol.29
, pp. 1373-81
-
-
Metzeler, K.H.1
Maharry, K.2
Radmacher, M.D.3
-
68
-
-
77956513784
-
Incidence and prognostic value of TET2 alterations in de novo acute myeloid leukemiaachieving complete remission
-
Nibourel O, Kosmider O, Cheok M, et al. Incidence and prognostic value of TET2 alterations in de novo acute myeloid leukemiaachieving complete remission. Blood. 2010;116:1132-5.
-
(2010)
Blood
, vol.116
, pp. 1132-5
-
-
Nibourel, O.1
Kosmider, O.2
Cheok, M.3
-
69
-
-
81555228423
-
Gene mutation patterns and their prognostic impact in a cohort of 1185 patients with acute myeloidleukemia
-
Shen Y, Zhu YM, Fan X, et al. Gene mutation patterns and their prognostic impact in a cohort of 1185 patients with acute myeloidleukemia. Blood. 2011;118(20):5593-603.
-
(2011)
Blood
, vol.118
, Issue.20
, pp. 5593-603
-
-
Shen, Y.1
Zhu, Y.M.2
Fan, X.3
-
70
-
-
78149454504
-
Nextgeneration sequencing of the TET2 gene in 355 MDS and CMML patients reveals low-abundance mutant clones with early origins, but indicates no definite prognostic value
-
Smith AE, Mohamedali AM, Kulasekararaj A, et al. Nextgeneration sequencing of the TET2 gene in 355 MDS and CMML patients reveals low-abundance mutant clones with early origins, but indicates no definite prognostic value. Blood. 2010;116:3923-32.
-
(2010)
Blood
, vol.116
, pp. 3923-32
-
-
Smith, A.E.1
Mohamedali, A.M.2
Kulasekararaj, A.3
-
71
-
-
77953183772
-
Mutational analysis in bcr-abl-negative classic myeloproliferative neoplasms: Impact on prognosis and therapeuticchoices
-
Tefferi A. Mutational analysis in bcr-abl-negative classic myeloproliferative neoplasms: impact on prognosis and therapeuticchoices. Leuk Lymphoma. 2010;51:576-82.
-
(2010)
Leuk Lymphoma
, vol.51
, pp. 576-82
-
-
Tefferi, A.1
-
72
-
-
76549109434
-
Genetic analysis of transforming events that convert chronic myeloproliferative neoplasms to leukemias
-
Abdel-Wahab O, Manshouri T, Patel J, et al. Genetic analysis of transforming events that convert chronic myeloproliferative neoplasms to leukemias. Cancer Res. 2010;70:447-52.
-
(2010)
Cancer Res
, vol.70
, pp. 447-52
-
-
Abdel-Wahab, O.1
Manshouri, T.2
Patel, J.3
-
73
-
-
77950977381
-
Two routes to leukemic transformation after a jak2 mutation-positive myeloproliferativeneoplasm
-
Beer PA, Delhommeau F, LeCouedic JP, et al. Two routes to leukemic transformation after a jak2 mutation-positive myeloproliferativeneoplasm. Blood. 2010;115:2891-900.
-
(2010)
Blood
, vol.115
, pp. 2891-900
-
-
Beer, P.A.1
Delhommeau, F.2
Lecouedic, J.P.3
-
74
-
-
77957868375
-
Chromosomal abnormalities in transformed ph-negative myeloproliferative neoplasms are associated to the transformation subtype and independent of JAK2 and the TET2 mutations
-
Nguyen-Khac F, Lesty C, Eclache V, et al. Chromosomal abnormalities in transformed ph-negative myeloproliferative neoplasms are associated to the transformation subtype and independent of JAK2 and the TET2 mutations. Genes Chromosomes Cancer. 2010;49:919-27.
-
(2010)
Genes Chromosomes Cancer
, vol.49
, pp. 919-27
-
-
Nguyen-Khac, F.1
Lesty, C.2
Eclache, V.3
-
76
-
-
77955716180
-
Clonal analysis of erythroid progenitors suggests that pegylated interferon alpha-2a treatmenttargets JAK2V617F clones without affecting TET2 mutant cells
-
Kiladjian JJ, Masse A, Cassinat B, et al. Clonal analysis of erythroid progenitors suggests that pegylated interferon alpha-2a treatmenttargets JAK2V617F clones without affecting TET2 mutant cells. Leukemia. 2010;24:1519-23.
-
(2010)
Leukemia
, vol.24
, pp. 1519-23
-
-
Kiladjian, J.J.1
Masse, A.2
Cassinat, B.3
-
77
-
-
74249096163
-
Analyses of TET2 mutations in post-myeloproliferative neoplasm acute myeloid leukemias
-
Couronne L, Lippert E, Andrieux J, et al. Analyses of TET2 mutations in post-myeloproliferative neoplasm acute myeloid leukemias. Leukemia. 2010;24:201-3.
-
(2010)
Leukemia
, vol.24
, pp. 201-3
-
-
Couronne, L.1
Lippert, E.2
Andrieux, J.3
|