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Volumn 491, Issue 7424, 2012, Pages 399-405

Pancreatic cancer genomes reveal aberrations in axon guidance pathway genes

(126)  Biankin, Andrew V a,b,c   Waddell, Nicola d   Kassahn, Karin S d   Gingras, Marie Claude e   Muthuswamy, Lakshmi B f   Johns, Amber L a   Miller, David K d   Wilson, Peter J d   Patch, Ann Marie d   Wu, Jianmin a   Chang, David K a,b,c   Cowley, Mark J a   Gardiner, Brooke B d   Song, Sarah d   Harliwong, Ivon d   Idrisoglu, Senel d   Nourse, Craig d   Nourbakhsh, Ehsan d   Manning, Suzanne d   Wani, Shivangi d   more..


Author keywords

[No Author keywords available]

Indexed keywords

ARID1A PROTEIN; ARID2 PROTEIN; ATM PROTEIN; CYCLIN DEPENDENT KINASE INHIBITOR 2A; EPC1 PROTEIN; K RAS PROTEIN; MAGEA6 PROTEIN; MAP2K4 PROTEIN; MLL3 PROTEIN; NALCN PROTEIN; PROTEIN; PROTEIN P53; SF3B1 PROTEIN; SF3BI PROTEIN; SLC1LA4 PROTEIN; SLCI6A4 PROTEIN; SMAD4 PROTEIN; TRANSFORMING GROWTH FACTOR BETA RECEPTOR 2; UNCLASSIFIED DRUG; ZIM2 PROTEIN;

EID: 84869091997     PISSN: 00280836     EISSN: 14764687     Source Type: Journal    
DOI: 10.1038/nature11547     Document Type: Article
Times cited : (1702)

References (38)
  • 2
    • 38549092718 scopus 로고    scopus 로고
    • Influence of resection margins and treatment on survival in patients with pancreatic cancer: Meta-analysis of randomized controlled trials
    • Butturini, G. et al. Influence of resection margins and treatment on survival in patients with pancreatic cancer: meta-analysis of randomized controlled trials. Arch. Surg. 143, 75-83 (2008).
    • (2008) Arch. Surg. , vol.143 , pp. 75-83
    • Butturini, G.1
  • 3
    • 77956416112 scopus 로고    scopus 로고
    • Adjuvant chemotherapy with fluorouracil plus folinic acid vs gemcitabine following pancreatic cancer resection: A randomized controlled trial
    • Neoptolemos, J. P. et al. Adjuvant chemotherapy with fluorouracil plus folinic acid vs gemcitabine following pancreatic cancer resection: a randomized controlled trial. J. Am. Med. Assoc. 304, 1073-1081 (2010).
    • (2010) J. Am. Med. Assoc. , vol.304 , pp. 1073-1081
    • Neoptolemos, J.P.1
  • 4
    • 52149123619 scopus 로고    scopus 로고
    • Core signaling pathways in human pancreatic cancers revealed by global genomic analyses
    • Jones, S. et al. Core signaling pathways in human pancreatic cancers revealed by global genomic analyses. Science 321, 1801-1806 (2008).
    • (2008) Science , vol.321 , pp. 1801-1806
    • Jones, S.1
  • 5
    • 77951115122 scopus 로고    scopus 로고
    • International network of cancer genome projects
    • International Cancer Genome Consortium
    • International Cancer Genome Consortium. International network of cancer genome projects. Nature 464, 993-998 (2010).
    • (2010) Nature , vol.464 , pp. 993-998
  • 6
    • 67650935823 scopus 로고    scopus 로고
    • Expression of S100A2 calcium-binding protein predicts response to pancreatectomy for pancreatic cancer
    • Biankin, A. V. et al. Expression of S100A2 calcium-binding protein predicts response to pancreatectomy for pancreatic cancer. Gastroenterology 137, 558-568 (2009).
    • (2009) Gastroenterology , vol.137 , pp. 558-568
    • Biankin, A.V.1
  • 7
    • 67649971551 scopus 로고    scopus 로고
    • Margin clearance and outcome in resected pancreatic cancer
    • Chang, D. K. et al. Margin clearance and outcome in resected pancreatic cancer. J. Clin. Oncol. 27, 2855-2862 (2009).
    • (2009) J. Clin. Oncol. , vol.27 , pp. 2855-2862
    • Chang, D.K.1
  • 8
    • 80051551131 scopus 로고    scopus 로고
    • A prospective comparison of the prognostic value of tumorand patient-related factors in patients undergoing potentially curative surgery for pancreatic ductal adenocarcinoma
    • Jamieson, N. B. et al. A prospective comparison of the prognostic value of tumorand patient-related factors in patients undergoing potentially curative surgery for pancreatic ductal adenocarcinoma. Ann. Surg. Oncol. 18, 2318-2328 (2011).
    • (2011) Ann. Surg. Oncol. , vol.18 , pp. 2318-2328
    • Jamieson, N.B.1
  • 9
    • 84863011464 scopus 로고    scopus 로고
    • Whole-exome sequencing of human pancreatic cancers and characterization of genomic instability caused by MLH1 haploinsufficiency and complete deficiency
    • Wang, L. et al. Whole-exome sequencing of human pancreatic cancers and characterization of genomic instability caused by MLH1 haploinsufficiency and complete deficiency. Genome Res. 22, 208-219 (2012).
    • (2012) Genome Res. , vol.22 , pp. 208-219
    • Wang, L.1
  • 10
    • 84866700697 scopus 로고    scopus 로고
    • Qpure: A tool to estimate tumor cellularity fromgenome-wide singlenucleotide polymorphism profiles
    • Song, S. et al. qpure: A tool to estimate tumor cellularity fromgenome-wide singlenucleotide polymorphism profiles. PLoS ONE 7, e45835 (2012).
    • (2012) PLoS ONE , vol.7
    • Song, S.1
  • 11
    • 84856955522 scopus 로고    scopus 로고
    • The molecular and cellular heterogeneity of pancreatic ductal adenocarcinoma
    • Samuel, N. & Hudson, T. J. The molecular and cellular heterogeneity of pancreatic ductal adenocarcinoma. Nature Rev. Gastroenterol. Hepatol. 9, 77-87 (2012).
    • (2012) Nature Rev. Gastroenterol. Hepatol. , vol.9 , pp. 77-87
    • Samuel, N.1    Hudson, T.J.2
  • 12
    • 84864598664 scopus 로고    scopus 로고
    • MuSiC: Identifying mutational significance in cancer genomes
    • Dees, N. D. et al. MuSiC: Identifying mutational significance in cancer genomes. Genome Res. 22, 1589-1598 (2012).
    • (2012) Genome Res. , vol.22 , pp. 1589-1598
    • Dees, N.D.1
  • 13
    • 84863830403 scopus 로고    scopus 로고
    • ATM mutations in patients with hereditary pancreatic cancer
    • Roberts, N. J. et al. ATM mutations in patients with hereditary pancreatic cancer. Cancer Discov. 2, 41-46 (2011).
    • (2011) Cancer Discov. , vol.2 , pp. 41-46
    • Roberts, N.J.1
  • 14
    • 79955166265 scopus 로고    scopus 로고
    • GISTIC2.0 facilitates sensitive and confident localization of the targets of focal somatic copy-number alteration in human cancers
    • Mermel, C. H. et al. GISTIC2.0 facilitates sensitive and confident localization of the targets of focal somatic copy-number alteration in human cancers. Genome Biol. 12, R41 (2011).
    • (2011) Genome Biol. , vol.12
    • Mermel, C.H.1
  • 15
    • 70449418416 scopus 로고    scopus 로고
    • Integrated study of copy number states and genotype calls using high-density SNP arrays
    • Sun, W. et al. Integrated study of copy number states and genotype calls using high-density SNP arrays. Nucleic Acids Res. 37, 5365-5377 (2009).
    • (2009) Nucleic Acids Res. , vol.37 , pp. 5365-5377
    • Sun, W.1
  • 16
    • 78049380554 scopus 로고    scopus 로고
    • The patterns and dynamics of genomic instability in metastatic pancreatic cancer
    • Campbell, P. J. et al. The patterns and dynamics of genomic instability in metastatic pancreatic cancer. Nature 467, 1109-1113 (2010).
    • (2010) Nature , vol.467 , pp. 1109-1113
    • Campbell, P.J.1
  • 17
    • 84859947197 scopus 로고    scopus 로고
    • Sleeping Beautymutagenesis reveals cooperating mutations and pathways in pancreatic adenocarcinoma
    • Mann, K. M. et al. SleepingBeautymutagenesis reveals cooperatingmutations and pathways in pancreatic adenocarcinoma. Proc. Natl Acad. Sci. USA 109, 5934-5941 (2012).
    • (2012) Proc. Natl Acad. Sci. USA , vol.109 , pp. 5934-5941
    • Mann, K.M.1
  • 18
    • 84861990162 scopus 로고    scopus 로고
    • The deubiquitinase USP9X suppresses pancreatic ductal adenocarcinoma
    • Pérez-Mancera, P. A. et al. The deubiquitinase USP9X suppresses pancreatic ductal adenocarcinoma. Nature 486, 266-270 (2012).
    • (2012) Nature , vol.486 , pp. 266-270
    • Pérez-Mancera, P.A.1
  • 19
    • 79961062492 scopus 로고    scopus 로고
    • Systematic investigation of genetic vulnerabilities across cancer cell lines reveals lineage-specific dependencies in ovariancancer
    • Cheung, H. W. et al. Systematic investigation of genetic vulnerabilities across cancer cell lines reveals lineage-specific dependencies in ovariancancer. Proc.Natl Acad. Sci. USA 108, 12372-12377 (2011).
    • (2011) Proc.Natl Acad. Sci. USA , vol.108 , pp. 12372-12377
    • Cheung, H.W.1
  • 20
    • 79952027445 scopus 로고    scopus 로고
    • Novel roles for Slits and netrins: Axonguidance cues as anticancer targets?
    • Mehlen, P., Delloye-Bourgeois, C. & Chedotal, A. Novel roles for Slits and netrins: axonguidance cues as anticancer targets? Nature Rev. Cancer 11, 188-197 (2011).
    • (2011) Nature Rev. Cancer , vol.11 , pp. 188-197
    • Mehlen, P.1    Delloye-Bourgeois, C.2    Chedotal, A.3
  • 21
    • 1942421724 scopus 로고    scopus 로고
    • The divergent Robo family protein rig-1/Robo3 is a negative regulator of slit responsiveness required for midline crossing by commissural axons
    • Sabatier, C. et al. The divergent Robo family protein rig-1/Robo3 is a negative regulator of slit responsiveness required for midline crossing by commissural axons. Cell 117, 157-169 (2004).
    • (2004) Cell , vol.117 , pp. 157-169
    • Sabatier, C.1
  • 22
    • 0036551486 scopus 로고    scopus 로고
    • Scatter-factor and semaphorin receptors: Cell signalling for invasive growth
    • Trusolino, L. & Comoglio, P. M. Scatter-factor and semaphorin receptors: cell signalling for invasive growth. Nature Rev. Cancer 2, 289-300 (2002).
    • (2002) Nature Rev. Cancer , vol.2 , pp. 289-300
    • Trusolino, L.1    Comoglio, P.M.2
  • 23
    • 79954425673 scopus 로고    scopus 로고
    • Genome profiling of pancreatic adenocarcinoma
    • Birnbaum, D. J. et al. Genome profiling of pancreatic adenocarcinoma. Genes Chromosom. Cancer 50, 456-465 (2011).
    • (2011) Genes Chromosom. Cancer , vol.50 , pp. 456-465
    • Birnbaum, D.J.1
  • 24
    • 3843084078 scopus 로고    scopus 로고
    • The COSMIC (catalogue of somatic mutations in cancer) database and website
    • Bamford, S. et al. The COSMIC (Catalogue of Somatic Mutations in Cancer) database and website. Br. J. Cancer 91, 355-358 (2004).
    • (2004) Br. J. Cancer , vol.91 , pp. 355-358
    • Bamford, S.1
  • 25
    • 84857467474 scopus 로고    scopus 로고
    • Somaticmutations in the chromatin remodeling geneARID1A occur in several tumor types
    • Jones, S. et al.Somaticmutations in the chromatin remodeling geneARID1A occur in several tumor types. Hum. Mutat. 33, 100-103 (2012).
    • (2012) Hum. Mutat. , vol.33 , pp. 100-103
    • Jones, S.1
  • 26
    • 79251635938 scopus 로고    scopus 로고
    • Exome sequencing identifies frequent mutation of the SWI/SNF complex gene PBRM1 in renal carcinoma
    • Varela, I. et al. Exome sequencing identifies frequent mutation of the SWI/SNF complex gene PBRM1 in renal carcinoma. Nature 469, 539-542 (2011).
    • (2011) Nature , vol.469 , pp. 539-542
    • Varela, I.1
  • 27
    • 0036217866 scopus 로고    scopus 로고
    • Invasive growth: From development to metastasis
    • Comoglio, P. M. & Trusolino, L. Invasive growth: from development to metastasis. J. Clin. Invest. 109, 857-862 (2002).
    • (2002) J. Clin. Invest. , vol.109 , pp. 857-862
    • Comoglio, P.M.1    Trusolino, L.2
  • 28
    • 23044512910 scopus 로고    scopus 로고
    • The brain with in the tumor: New roles for axon guidance molecules in cancers
    • Chédotal, A., Kerjan, G. & Moreau-Fauvarque, C.Thebrainwithin the tumor:newroles for axon guidance molecules in cancers. Cell Death Differ. 12, 1044-1056 (2005).
    • (2005) Cell Death Differ. , vol.12 , pp. 1044-1056
    • Chédotal, A.1    Kerjan, G.2    Moreau-Fauvarque, C.3
  • 29
    • 84861581233 scopus 로고    scopus 로고
    • Exome sequencing of liver fluke-associated cholangiocarcinoma
    • Ong, C. K. et al. Exome sequencing of liver fluke-associated cholangiocarcinoma. Nature Genet. 44, 690-693 (2012).
    • (2012) Nature Genet. , vol.44 , pp. 690-693
    • Ong, C.K.1
  • 30
    • 69449097679 scopus 로고    scopus 로고
    • Semaphorin signaling in cancer cells and in cells of the tumor microenvironment-two sides of a coin
    • Capparuccia, L. & Tamagnone, L. Semaphorin signaling in cancer cells and in cells of the tumor microenvironment-two sides of a coin. J. Cell Sci. 122, 1723-1736 (2009).
    • (2009) J. Cell Sci. , vol.122 , pp. 1723-1736
    • Capparuccia, L.1    Tamagnone, L.2
  • 31
    • 35649009802 scopus 로고    scopus 로고
    • Association of axon guidance factor semaphorin 3A with poor outcome in pancreatic cancer
    • Müller, M. W. et al. Association of axon guidance factor semaphorin 3A with poor outcome in pancreatic cancer. Int. J. Cancer 121, 2421-2433 (2007).
    • (2007) Int. J. Cancer , vol.121 , pp. 2421-2433
    • Müller, M.W.1
  • 32
    • 33745063095 scopus 로고    scopus 로고
    • The role of neuropilins in cancer
    • Ellis, L. M.The role of neuropilins in cancer.Mol. Cancer Ther. 5, 1099-1107 (2006).
    • (2006) Mol. Cancer Ther. , vol.5 , pp. 1099-1107
    • Ellis, L.M.1
  • 33
    • 0242290356 scopus 로고    scopus 로고
    • Vitro and in vivo characterization of a novel semaphorin 3A inhibitor, SM-216289 or xanthofulvin
    • Kikuchi, K. et al. In vitro and in vivo characterization of a novel semaphorin 3A inhibitor, SM-216289 or xanthofulvin. J. Biol. Chem. 278, 42985-42991 (2003).
    • (2003) J. Biol. Chem. , vol.278 , pp. 42985-42991
    • Kikuchi, K.1
  • 35
    • 79959929490 scopus 로고    scopus 로고
    • Preclinical strategies to define predictive biomarkers for therapeutically relevant cancer subtypes
    • Pajic, M., Scarlett, C. J., Chang, D. K., Sutherland, R. L. & Biankin, A. V. Preclinical strategies to define predictive biomarkers for therapeutically relevant cancer subtypes. Hum. Genet. 130, 93-101 (2011).
    • (2011) Hum. Genet. , vol.130 , pp. 93-101
    • Pajic, M.1    Scarlett, C.J.2    Chang, D.K.3    Sutherland, R.L.4    Biankin, A.V.5
  • 36
    • 79959952060 scopus 로고    scopus 로고
    • Somatic variation and cancer: Therapies lost in the mix
    • Biankin, A. V. & Hudson, T. J. Somatic variation and cancer: therapies lost in the mix. Hum. Genet. 130, 79-91 (2011).
    • (2011) Hum. Genet. , vol.130 , pp. 79-91
    • Biankin, A.V.1    Hudson, T.J.2
  • 37
    • 84869095746 scopus 로고    scopus 로고
    • Accelerating progress against cancer: ASCO's blueprint for transforming clinical and translational cancer research
    • Kris, M. G., Meropol, N. J. & Winer, E. P. (eds) . Accelerating Progress Against Cancer: ASCO's Blueprint for Transforming Clinical and Translational Cancer Research (Am. Soc. Clin. Oncol., 2011).
    • (2011) Am. Soc. Clin. Oncol.
    • Kris, M.G.1    Meropol, N.J.2    Winer, E.P.3
  • 38
    • 27344435774 scopus 로고    scopus 로고
    • Gene set enrichment analysis: A knowledge-based approach for interpreting genome-wide expression profiles
    • Subramanian, A. et al. Gene set enrichment analysis: a knowledge-based approach for interpreting genome-wide expression profiles. Proc. Natl Acad. Sci. USA 102, 15545-15550 (2005).
    • (2005) Proc. Natl Acad. Sci. USA , vol.102 , pp. 15545-15550
    • Subramanian, A.1


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