Excessive CpG island hypermethylation in cancer cell lines versus primary human malignancies

Human Molecular Genetics

Volumn 10, Issue 13, 2001, Pages 1413-1419

  Smiraglia, Dominic J ^a   Rush, Laura J ^a,b   Frühwald, Michael C ^a,c   Dai, Zunyan ^a,b   Held, William A ^d   Costello, Joseph F ^e   Lang, James C ^b   Eng, Charis ^a,b   Li, Bin ^a   Wright, Fred A ^a   Caligiuri, Michael A ^a,b   Plass, Christoph ^a  

^a THE OHIO STATE UNIVERSITY COLLEGE OF MEDICINE   (United States)

^b OHIO STATE UNIVERSITY   (United States)

^c UNIVERSITY OF MÜNSTER   (Germany)

^d ROSWELL PARK CANCER INSTITUTE   (United States)

^e UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

DNA;

ARTICLE; CANCER CELL CULTURE; CANCER GROWTH; CANCER RESEARCH; CLINICAL OBSERVATION; COLON CANCER; COLON TUMOR; CONTROLLED STUDY; CPG ISLAND; DNA METHYLATION; GENE EXPRESSION; GENE REPRESSION; GENETIC ANALYSIS; HEAD AND NECK CARCINOMA; HUMAN; HUMAN CELL; MALIGNANT NEOPLASTIC DISEASE; PHENOTYPE; PRIORITY JOURNAL; PROMOTER REGION; SQUAMOUS CELL CARCINOMA; TUMOR SUPPRESSOR GENE;

EID: 0035875049     PISSN: 09646906     EISSN: None     Source Type: Journal    
DOI: 10.1093/hmg/10.13.1413     Document Type: Article

References (19)

1. Alterations in DNA methylation: A fundamental aspect of neoplasia
2. Aberrant CpG-island methylation has non-random and tumour-type-specific patterns
3. Altered DNA methylation and genome instability: A new pathway to cancer?
4. DNA methylation and chromatin modification
5. DNA methylation: Past, present and future directions
6. Inhibition of DNA methyltransferase stimulates the expression of signal transducer and activator of transcription 1, 2, and 3 genes in colon tumor cells
7. Inhibition of DNA methylation by 5-azacytidine
8. Stabilization of DNA methyltransferase levels and CpG island hypermethylation precede SV40-induced immortalization of human fibroblasts
9. DNA methylation decreases in aging but not in immortal cells
10. Variable 5-methylcytosine levels in human tumor cell lines and fresh pediatric tumor explants
11. De novo methylation of CpG island sequences in human fibroblasts overexpressing DNA (cytosine-5-)-methyltransferase
12. High levels of de novo methylation and altered chromatin structure at CpG islands in cell lines
13. Comparison of DNA methylation patterns among mouse cell lines by restriction landmark genomic scanning
14. An expanded system of restriction landmark genomic scanning (RLGS Ver. 1.8)
15. Restriction landmark genome scanning for aberrant methylation in primary refractory and relapsed acute myeloid leukemia; involvement of the WIT-1 gene
16. A new tool for the rapid cloning of amplified and hypermethylated human DNA sequences from restriction landmark genome scanning gels
17. Global methylation profiling of lung cancer specimens reveals novel methylated genes
18. Systematic variation in gene expression patterns in human cancer cell lines
19. Variable and nonrandom CpG island hypermethylation in de novo acute myeloid leukemia with prevalence of chromosome 11 loci