-
1
-
-
73649110641
-
DNA methylation signatures identify biologically distinct subtypes in acute myeloid leukemia
-
Figueroa ME, Lugthart S, Li Y, et al. DNA methylation signatures identify biologically distinct subtypes in acute myeloid leukemia. Cancer Cell. 2010;17(1):13-27.
-
(2010)
Cancer Cell
, vol.17
, Issue.1
, pp. 13-27
-
-
Figueroa, M.E.1
Lugthart, S.2
Li, Y.3
-
2
-
-
77449159028
-
Diagnosis and management of acute myeloid leukemia in adults: Recommendations from an international expert panel, on behalf of the European Leukemia- Net
-
Dohner H, Estey EH, Amadori S, et al. Diagnosis and management of acute myeloid leukemia in adults: recommendations from an international expert panel, on behalf of the European Leukemia- Net. Blood. 2010;115(3):453-474.
-
(2010)
Blood
, vol.115
, Issue.3
, pp. 453-474
-
-
Dohner, H.1
Estey, E.H.2
Amadori, S.3
-
4
-
-
0036733675
-
Chromatin modification and epigenetic reprogramming in mammalian development
-
DOI 10.1038/nrg887
-
Li E. Chromatin modification and epigenetic reprogramming in mammalian development. Nat Rev Genet. 2002;3(9):662-673. (Pubitemid 34984255)
-
(2002)
Nature Reviews Genetics
, vol.3
, Issue.9
, pp. 662-673
-
-
Li, E.1
-
5
-
-
0037372003
-
Epigenetic regulation of gene expression: How the genome integrates intrinsic and environmental signals
-
DOI 10.1038/ng1089
-
Jaenisch R, Bird A. Epigenetic regulation of gene expression: how the genome integrates intrinsic and environmental signals. Nat Genet. 2003;33(Suppl):245-254. (Pubitemid 36278835)
-
(2003)
Nature Genetics
, vol.33
, Issue.SUPPL.
, pp. 245-254
-
-
Jaenisch, R.1
Bird, A.2
-
6
-
-
0035962632
-
DNA methylation, chromatin inheritance, and cancer
-
DOI 10.1038/sj.onc.1204339
-
Rountree MR, Bachman KE, Herman JG, Baylin SB. DNA methylation, chromatin inheritance, and cancer. Oncogene. 2001;20(24):3156-3165. (Pubitemid 32553571)
-
(2001)
Oncogene
, vol.20
, Issue.24 REV. ISS. 3
, pp. 3156-3165
-
-
Rountree, M.R.1
Bachman, K.E.2
Herman, J.G.3
Baylin, S.B.4
-
7
-
-
0033753779
-
The DNA methyltransferases of mammals
-
Bestor TH. The DNA methyltransferases of mammals. Hum Mol Genet. 2000;9(16):2395-2402.
-
(2000)
Hum Mol Genet
, vol.9
, Issue.16
, pp. 2395-2402
-
-
Bestor, T.H.1
-
8
-
-
0035933337
-
Enzymatic properties of recombinant Dnmt3a DNA methyltransferase from mouse: The enzyme modifies DNA in a non-processive manner and also methylates non-CpA sites
-
DOI 10.1006/jmbi.2001.4710
-
Gowher H, Jeltsch A. Enzymatic properties of recombinant Dnmt3a DNA methyltransferase from mouse: the enzyme modifies DNA in a nonprogressive manner and also methylates non-CpG [correction of non-CpA] sites. J Mol Biol. 2001;309(5):1201-1208. (Pubitemid 32623318)
-
(2001)
Journal of Molecular Biology
, vol.309
, Issue.5
, pp. 1201-1208
-
-
Gowher, H.1
Jeltsch, A.2
-
9
-
-
0024987810
-
Establishment of de novo DNA methylation patterns. Transcription factor binding and deoxycytidine methylation at CpG and non-CpG sequences in an integrated adenovirus promoter
-
Toth M, Muller U, Doerfler W. Establishment of de novo DNA methylation patterns. Transcription factor binding and deoxycytidine methylation at CpG and non-CpG sequences in an integrated adenovirus promoter. J Mol Biol. 1990;214(3):673-683.
-
(1990)
J Mol Biol
, vol.214
, Issue.3
, pp. 673-683
-
-
Toth, M.1
Muller, U.2
Doerfler, W.3
-
10
-
-
0032937871
-
Evidence that protein binding specifies sites of DNA demethylation
-
Hsieh CL. Evidence that protein binding specifies sites of DNA demethylation. Mol Cell Biol. 1999;19(1):46-56.
-
(1999)
Mol Cell Biol
, vol.19
, Issue.1
, pp. 46-56
-
-
Hsieh, C.L.1
-
11
-
-
0033615717
-
DNA methyltransferases Dnmt3a and Dnmt3b are essential for de novo methylation and mammalian development
-
DOI 10.1016/S0092-8674(00)81656-6
-
Okano M, Bell DW, Haber DA, Li E. DNA methyltransferases Dnmt3a and Dnmt3b are essential for de novo methylation and mammalian development. Cell. 1999;99(3):247-257. (Pubitemid 29519904)
-
(1999)
Cell
, vol.99
, Issue.3
, pp. 247-257
-
-
Okano, M.1
Bell, D.W.2
Haber, D.A.3
Li, E.4
-
12
-
-
27744547290
-
Maintenance and regulation of DNA methylation patterns in mammals
-
DOI 10.1139/o05-138
-
Chen ZX, Riggs AD. Maintenance and regulation of DNA methylation patterns in mammals. Biochem Cell Biol. 2005;83(4):438-448. (Pubitemid 41626762)
-
(2005)
Biochemistry and Cell Biology
, vol.83
, Issue.4
, pp. 438-448
-
-
Chen, Z.-X.1
Riggs, A.D.2
-
13
-
-
77954089584
-
Array-based genomic resequencing of human leukemia
-
Yamashita Y, Yuan J, Suetake I, et al. Array-based genomic resequencing of human leukemia. Oncogene. 2010;29(25):3723-3731.
-
(2010)
Oncogene
, vol.29
, Issue.25
, pp. 3723-3731
-
-
Yamashita, Y.1
Yuan, J.2
Suetake, I.3
-
14
-
-
78649906060
-
DNMT3A mutations in acute myeloid leukemia
-
Ley TJ, Ding L, Walter MJ, et al. DNMT3A mutations in acute myeloid leukemia. N Engl J Med. 2010;16(25):2424-2433.
-
(2010)
N Engl J Med
, vol.16
, Issue.25
, pp. 2424-2433
-
-
Ley, T.J.1
Ding, L.2
Walter, M.J.3
-
15
-
-
79960735923
-
Incidence and prognostic influence of DNMT3A mutations in acute myeloid leukemia
-
Thol F, Damm F, Ludeking A, et al. Incidence and prognostic influence of DNMT3A mutations in acute myeloid leukemia. J Clin Oncol. 2011;29(21):2889-2896.
-
(2011)
J Clin Oncol
, vol.29
, Issue.21
, pp. 2889-2896
-
-
Thol, F.1
Damm, F.2
Ludeking, A.3
-
16
-
-
79953176952
-
Exome sequencing identifies somatic mutations of DNA methyltransferase gene DNMT3A in acute monocytic leukemia
-
Yan XJ, Xu J, Gu ZH, et al. Exome sequencing identifies somatic mutations of DNA methyltransferase gene DNMT3A in acute monocytic leukemia. Nat Genet. 2011;43(4):309-315.
-
(2011)
Nat Genet
, vol.43
, Issue.4
, pp. 309-315
-
-
Yan, X.J.1
Xu, J.2
Gu, Z.H.3
-
17
-
-
0842328518
-
Second hit mutations in the RTK/RAS signaling pathway in acute myeloid leukemia with inv(16)
-
Valk PJ, Bowen DT, Frew ME, Goodeve AC, Lowenberg B, Reilly JT. Second hit mutations in the RTK/RAS signaling pathway in acute myeloid leukemia with inv(16). Haematologica. 2004;89(1):106. (Pubitemid 38165863)
-
(2004)
Haematologica
, vol.89
, Issue.1
, pp. 106
-
-
Valk, P.J.M.1
Bowen, D.T.2
Frew, M.E.3
Goodeve, A.C.4
Lowenberg, B.5
Reilly, J.T.6
-
18
-
-
0037591396
-
Biallelic mutations in the CEBPA gene and low CEBPA expression levels as prognostic markers in intermediate-risk AML
-
Barjesteh van Waalwijk van Doorn-Khosrovani S, Erpelinck C, Meijer J, et al. Biallelic mutations in the CEBPA gene and low CEBPA expression levels as prognostic markers in intermediate-risk AML. Hematol J. 2003;4(1):31-40.
-
(2003)
Hematol J
, vol.4
, Issue.1
, pp. 31-40
-
-
Van Barjesteh Waalwijk Van Doorn-Khosrovani, S.1
Erpelinck, C.2
Meijer, J.3
-
19
-
-
0038170400
-
Incidence and prognosis of c-KIT and FLT3 mutations in core binding factor (CBF) acute myeloid leukaemias
-
DOI 10.1046/j.1365-2141.2003.04362.x
-
Care RS, Valk PJ, Goodeve AC, et al. Incidence and prognosis of c-KIT and FLT3 mutations in core binding factor (CBF) acute myeloid leukaemias. Br J Haematol. 2003;121(5):775-777. (Pubitemid 36718195)
-
(2003)
British Journal of Haematology
, vol.121
, Issue.5
, pp. 775-777
-
-
Care, R.S.1
Valk, P.J.M.2
Goodeve, A.C.3
Abu-Duhier, F.M.4
Geertsma-Kleinekoort, W.M.C.5
Wilson, G.A.6
Gari, M.A.7
Peake, I.R.8
Lowenberg, B.9
Reilly, J.T.10
-
20
-
-
28444446313
-
Mutations in nucleophosmin (NPM1) in acute myeloid leukemia (AML): Association with other gene abnormalities and previously established gene expression signatures and their favorable prognostic significance
-
DOI 10.1182/blood-2005-05-2168
-
Verhaak RG, Goudswaard CS, van Putten W, et al. Mutations in nucleophosmin (NPM1) in acute myeloid leukemia (AML): association with other gene abnormalities and previously established gene expression signatures and their favorable prognostic significance. Blood. 2005;106(12):3747-3754. (Pubitemid 41739008)
-
(2005)
Blood
, vol.106
, Issue.12
, pp. 3747-3754
-
-
Verhaak, R.G.W.1
Goudswaard, C.S.2
Van Putten, W.3
Bijl, M.A.4
Sanders, M.A.5
Hugens, W.6
Uitterlinden, A.G.7
Erpelinck, C.A.J.8
Delwel, R.9
Lowenberg, B.10
Valk, P.J.M.11
-
21
-
-
77957192661
-
Acquired mutations in the genes encoding IDH1 and IDH2 both are recurrent aberrations in acute myeloid leukemia: Prevalence and prognostic value
-
Abbas S, Lugthart S, Kavelaars F, et al. Acquired mutations in the genes encoding IDH1 and IDH2 both are recurrent aberrations in acute myeloid leukemia: prevalence and prognostic value. Blood. 2010;116(12):2122-2126.
-
(2010)
Blood
, vol.116
, Issue.12
, pp. 2122-2126
-
-
Abbas, S.1
Lugthart, S.2
Kavelaars, F.3
-
22
-
-
58149240152
-
Prediction of molecular subtypes in acute myeloid leukemia based on gene expression profiling
-
Valk PJM, Verhaak RGW, Wouters BJ, et al. Prediction of molecular subtypes in acute myeloid leukemia based on gene expression profiling. Haematologica. 2009;94(1):131-134.
-
(2009)
Haematologica
, vol.94
, Issue.1
, pp. 131-134
-
-
Valk, P.J.M.1
Verhaak, R.G.W.2
Wouters, B.J.3
-
23
-
-
79952122978
-
Prognostic impact, concurrent genetic mutations, and gene expression features of AML with CEBPA mutations in a cohort of 1182 cytogenetically normal AML patients: Further evidence for CEBPA double mutant AML as a distinctive disease entity
-
Taskesen E, Bullinger L, Corbacioglu A, et al. Prognostic impact, concurrent genetic mutations, and gene expression features of AML with CEBPA mutations in a cohort of 1182 cytogenetically normal AML patients: further evidence for CEBPA double mutant AML as a distinctive disease entity. Blood. 2011;117(8):2469-2475.
-
(2011)
Blood
, vol.117
, Issue.8
, pp. 2469-2475
-
-
Taskesen, E.1
Bullinger, L.2
Corbacioglu, A.3
-
24
-
-
54349092877
-
Monosomal karyotype in acute myeloid leukemia: A better indicator of poor prognosis than a complex karyotype
-
Breems DA, Van Putten WL, De Greef GE, et al. Monosomal karyotype in acute myeloid leukemia: a better indicator of poor prognosis than a complex karyotype. J Clin Oncol. 2008;26(29):4791-4797.
-
(2008)
J Clin Oncol
, vol.26
, Issue.29
, pp. 4791-4797
-
-
Breems, D.A.1
Van Putten, W.L.2
De Greef, G.E.3
-
25
-
-
78650019179
-
Leukemic IDH1 and IDH2 mutations result in a hypermethylation phenotype, disrupt TET2 function, and impair hematopoietic differentiation
-
Figueroa ME, Abdel-Wahab O, Lu C, et al. Leukemic IDH1 and IDH2 mutations result in a hypermethylation phenotype, disrupt TET2 function, and impair hematopoietic differentiation. Cancer Cell. 2010;18(6):553-567.
-
(2010)
Cancer Cell
, vol.18
, Issue.6
, pp. 553-567
-
-
Figueroa, M.E.1
Abdel-Wahab, O.2
Lu, C.3
-
26
-
-
23044459136
-
+ AML) shows a distinct gene expression profile characterized by up-regulation of genes involved in stem-cell maintenance
-
DOI 10.1182/blood-2005-02-0560
-
Alcalay M, Tiacci E, Bergomas R, et al. Acute myeloid leukemia bearing cytoplasmic nucleophosmin (NPMc+ AML) shows a distinct gene expression profile characterized by up-regulation of genes involved in stem-cell maintenance. Blood. 2005;106(3):899-902. (Pubitemid 41076430)
-
(2005)
Blood
, vol.106
, Issue.3
, pp. 899-902
-
-
Alcalay, M.1
Tiacci, E.2
Bergomas, R.3
Bigerna, B.4
Venturini, E.5
Minardi, S.P.6
Meani, N.7
Diverio, D.8
Bernard, L.9
Tizzoni, L.10
Volorio, S.11
Luzi, L.12
Colombo, E.13
Lo, C.F.14
Mecucci, C.15
Falini, B.16
Pelicci, P.G.17
-
27
-
-
77449140390
-
Favorable prognostic impact of NPM1 mutations in older patients with cytogenetically normal de novo acute myeloid leukemia and associated gene- And microRNA-expression signatures: A Cancer and Leukemia Group B study
-
Becker H, Marcucci G, Maharry K, et al. Favorable prognostic impact of NPM1 mutations in older patients with cytogenetically normal de novo acute myeloid leukemia and associated gene- and microRNA-expression signatures: a Cancer and Leukemia Group B study. J Clin Oncol. 2010;28(4):596-604.
-
(2010)
J Clin Oncol
, vol.28
, Issue.4
, pp. 596-604
-
-
Becker, H.1
Marcucci, G.2
Maharry, K.3
-
28
-
-
79955469651
-
Mutant nucleophosmin and cooperating pathways drive leukemia initiation and progression in mice
-
Vassiliou GS, Cooper JL, Rad R, et al. Mutant nucleophosmin and cooperating pathways drive leukemia initiation and progression in mice. Nat Genet. 2011;43(5):470-475.
-
(2011)
Nat Genet
, vol.43
, Issue.5
, pp. 470-475
-
-
Vassiliou, G.S.1
Cooper, J.L.2
Rad, R.3
-
29
-
-
79952086942
-
Therapeutic advances in acute myeloid leukemia
-
Burnett A, Wetzler M, Lowenberg B. Therapeutic advances in acute myeloid leukemia. J Clin Oncol. 2011;29(5):487-494.
-
(2011)
J Clin Oncol
, vol.29
, Issue.5
, pp. 487-494
-
-
Burnett, A.1
Wetzler, M.2
Lowenberg, B.3
-
30
-
-
79952092487
-
Molecular genetics of adult acute myeloid leukemia: Prognostic and therapeutic implications
-
Marcucci G, Haferlach T, Dohner H. Molecular genetics of adult acute myeloid leukemia: prognostic and therapeutic implications. J Clin Oncol. 2011;29(5):475-486.
-
(2011)
J Clin Oncol
, vol.29
, Issue.5
, pp. 475-486
-
-
Marcucci, G.1
Haferlach, T.2
Dohner, H.3
-
31
-
-
0032188805
-
The importance of diagnostic cytogenetics on outcome in AML: Analysis of 1,612 patients entered into the MRC AML 10 trial
-
Grimwade D, Walker H, Oliver F, et al. The importance of diagnostic cytogenetics on outcome in AML: analysis of 1,612 patients entered into the MRC AML 10 trial. The Medical Research Council Adult and Children's Leukaemia Working Parties. Blood. 1998;92(7):2322-2333. (Pubitemid 28452973)
-
(1998)
Blood
, vol.92
, Issue.7
, pp. 2322-2333
-
-
Grimwade, D.1
Walker, H.2
Oliver, F.3
Wheatley, K.4
Harrison, C.5
Harrison, G.6
Rees, J.7
Hann, I.8
Stevens, R.9
Burnett, A.10
Goldstone, A.11
|