Liver

Principles of Tissue Engineering, Third Edition

Volumn , Issue , 2007, Pages 707-731

  Underhill, Gregory H ^a   Khetani, Salman R ^a   Chen, Alice A ^a   Bhatia, Sangeeta N ^a  

^a MASSACHUSETTS INSTITUTE OF TECHNOLOGY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

EID: 84885127045     PISSN: None     EISSN: None     Source Type: Book    
DOI: 10.1016/B978-012370615-7/50052-4     Document Type: Chapter

References (170)

1. J.W. Allen and S.N. Bhatia (2002) Engineering liver therapies for the future. Tissue Eng. 8 725-737
2. J.W. Allen and S.N. Bhatia (2003) Formation of steady-state oxygen gradients in vitro: application to liver zonation. Biotechnol. Bioengi. 82 253-262
3. J.W. Allen, T. Hassanein and S.N. Bhatia (2001) Advances in bioartificial liver devices. Hepatology 34 447-455
4. J.W. Allen, S.R. Khetani and S.N. Bhatia (2005) In vitro zonation and toxicity in a hepatocyte bioreactor. Toxicol. Sci. 84 110-119
5. M.J. Alter, D. Kruszon-Moran, O.V. Nainan, G.M. McQuillan, F. Gao, L.A. Moyer, R.A. Kaslow and H.S. Margolis (1999) The prevalence of hepatitis C virus infection in the United States, 1988 through 1994. N. Engl. J. Med. 341 556-562
6. M.K. Auth, R.E. Joplin, M. Okamoto, Y. Ishida, P. McMaster, J.M. Neuberger, R.A. Blaheta, T. Voit and A.J. Strain (2001) Morphogenesis of primary human biliary epithelial cells: induction in high-density culture or by coculture with autologous human hepa-tocytes. Hepatology 33 519-529
7. A. Baquerizo, A. Mhoyan, H. Shirwan, J. Swensson, R.W. Busuttil, A.A. Demetriou and D.V. Cramer (1997) Xenoantibody response of patients with severe acute liver failure exposed to porcine antigens following treatment with a bioartificial liver. Transplant. Proc. 29 964-965
8. D.J. Beebe, J.S. Moore, J.M. Bauer, Q. Yu, R.H. Liu, C. Devadoss and B.H. Jo (2000) Functional hydrogel structures for autonomous flow control inside microfluidic channels. Nature 404 588-590
9. S. Bhatia, M. Toner, B. Foy, A. Rotem, K. O'Neil, R. Tompkins and M. Yarmush (1996) Zonal liver cell heterogeneity: effects of oxygen on metabolic functions of hepatocytes. Cell. Eng. 1 125-135
10. S.N. Bhatia, U.J. Balis, M.L. Yarmush and M. Toner (1999) Effect of cell-cell interactions in preservation of cellular phenotype: cocultivation of hepatocytes and nonparenchymal cells. FASEB J. 13 1883-1900
11. B.M. Bilir, D. Guinette, F. Karrer, D.A. Kumpe, J. Krysl, J. Stephens, L. McGavran, A. Ostrowska and J. Durham (2000) Hepatocyte transplantation in acute liver failure. Liver Transpl. 6 32-40
12. D.M. Bissell, D.M. Arenson, J.J. Maher and F.J. Roll (1987) Support of cultured hepatocytes by a laminin-rich gel. Evidence for a function-ally significant subendothelial matrix in normal rat liver. J. Clin. Invest. 79 801-812
13. P. Blanc, H. Etienne, M. Daujat, I. Fabre, F. Zindy, J. Domergue, C. Astre, A.B. Saint Aubert B., H. Michel and P. Maurel (1992) Mitotic respon-siveness of cultured adult human hepatocytes to epidermal growth factor, transforming growth factor alpha, and human serum. Gastroen-terology 102 1340-1350
14. J.T. Borenstein, H. Terai, K.R. King, E.J. Weinberg, M.R. Kaazempur-Mofrad and J.P. Vacanti (2002) Microfabrication technology for vascularized tissue engineering. Biomed. Microdevices 4 167-175
15. K.A. Brown (2005) Liver transplantation. Curr. Opin. Gastroenterol. 21 331-336
16. R.S. Brown (2005) Hepatitis C and liver transplantation. Nature 436 973-978
17. E.S. Carlisle, M.R. Mariappan, K.D. Nelson, B.E. Thomes, R.B. Timmons, A. Constantinescu, R.C. Eberhart and P.E. Bankey (2000) Enhancing hepatocyte adhesion by pulsed plasma deposition and polyethylene glycol coupling. Tissue Eng. 6 45-52
18. C. Chan, F. Berthiaume, K. Lee and M.L. Yarmush (2003) Metabolic flux analysis of hepatocyte function in hormone-and amino acid-supplemented plasma. Metab. Eng. 5 1-15
19. C. Chesne, C. Guyomard, A. Fautrel, M.G. Poullain, B. Fremond, J.H. De Jong H. and A. Guillouzo (1993) Viability and function in primary culture of adult hepatocytes from various animal species and human beings after cryopreservation. Hepatology 18 406-414
20. S.M. Chia, K.W. Leong, J. Li, X. Xu, K. Zeng, P.N. Er, S. Gao and H. Yu (2000) Hepatocyte encapsulation for enhanced cellular functions. Tissue Eng. 6 481-495
21. R. Chinzei, Y. Tanaka, K. Shimizu-Saito, Y. Hara, S. Kakinuma, M. Watanabe, K. Teramoto, S. Arii, K. Takase, C. Sato, N. Terada and H. Teraoka (2002) Embryoid-body cells derived from a mouse embryonic stem cell line show differentiation into functional hepato-cytes. Hepatology 36 22-29
22. K.N. Chua, W.S. Lim, P. Zhang, H. Lu, J. Wen, S. Ramakrishna, K.W. Leong and H.Q. Mao (2005) Stable immobilization of rat hepa-tocyte spheroids on galactosylated nanofiber scaffold. Biomaterials 26 2537-2547
23. T.W. Chung, J. Yang, T. Akaike, K.Y. Cho, J.W. Nah, S.I. Kim and C.S. Cho (2002) Preparation of alginate/galactosylated chitosan scaf-fold for hepatocyte attachment. Biomaterials 23 2827-2834
24. B.L. De Bartolo L., S.G. Jarosch-Von Schweder G., A. Haverich and A. Bader (2000) A novel full-scale flat-membrane bioreactor utilizing porcine hepatocytes: cell viability and tissue-specific functions. Biotechnol. Prog. 16 102-108
25. L.R. De Loecker R., B.J. Fuller, J. Gruwez and L.W. De Loecker W. (1990) The effects of cryopreservation on membrane integrity, membrane trans-port, and protein synthesis in rat hepatocytes. Cryobiology 27 143-152
26. A.A. Demetriou, J.F. Whiting, D. Feldman, S.M. Levenson, N.R. Chowdhury, A.D. Moscioni, M. Kram and J.R. Chowdhury (1986) Replacement of liver function in rats by transplantation of microcarrier-attached hepatocytes. Science 233 1190-1192
27. V. Dixit and G. Gitnick (1998) The bioartificial liver: state of the art. Eur. J. Surg. Suppl. 5 71-76
28. V. Dixit, R. Darvasi, M. Arthur, M. Brezina, K. Lewin and G. Gitnick (1990) Restoration of liver function in Gunn rats without immuno-suppression using transplanted microencapsulated hepatocytes. Hepatology 12 1342-1349
29. J.L. Drury and D.J. Mooney (2003) Hydrogels for tissue engineering: scaffold design variables and applications. Biomaterials 24 4337-4351
30. J.C. Dunn, M.L. Yarmush, H.G. Koebe and R.G. Tompkins (1989) Hepatocyte function and extracellular matrix geometry: long-term culture in a sandwich configuration [published erratum appears in FASEB J. 3 (7), 1873]. FASEB J. 3 174-177
31. S. Eguchi, H. Lilja, W.R. Hewitt, Y. Middleton, A.A. Demetriou and J. Rozga (1997) Loss and recovery of liver regeneration in rats with fulminant hepatic failure. J. Surg. Res. 72 112-122
32. A.J. Ellis, R.D. Hughes, J.A. Wendon, J. Dunne, P.G. Langley, J.H. Kelly, G.T. Gislason, N.L. Sussman and R. Williams (1996) Pilot-controlled trial of the extracorporeal liver assist device in acute liver failure. Hepatology 24 1446-1451
33. A.J. Ellis, R.D. Hughes, D. Nicholl, P.G. Langley, J.A. Wendon, J.G. O'Grady and R. Williams (1999) Temporary extracorporeal liver support for severe acute alcoholic hepatitis using the BioLogic-DT. Int. J. Artif. Organs 22 27-34
34. H.C. Fiegel, J. Havers, U. Kneser, M.K. Smith, T. Moeller, D. Kluth, D.J. Mooney, X. Rogiers and P.M. Kaufmann (2004) Influence of flow conditions and matrix coatings on growth and differentiation of three-dimensionally cultured rat hepatocytes. Tissue Eng. 10 165-174
35. B. Fisher, P. Szuch, M. Levine and E.R. Fisher (1971) A portal blood factor as the humoral agent in liver regeneration. Science 171 575-577
36. C.J. Flaim, S. Chien and S.N. Bhatia (2005) An extracellular matrix microarray for probing cellular differentiation. Nat. Methods 2 119-125
37. A. Folch and M. Toner (2000) Microengineering of cellular interactions. Annu. Rev. Biomed. Eng. 2 227-256
38. J. Fukuda, Y. Sakai and K. Nakazawa (2006) Novel hepatocyte culture system developed using microfabrication and collagen/polyethylene glycol microcontact printing. Biomaterials 27 1061-1070
39. R. Gebhardt, J.G. Hengstler, D. Muller, R. Glockner, P. Buenning, B. Laube, E. Schmelzer, M. Ullrich, D. Utesch, N. Hewitt, M. Ringel, B.R. Hilz, A. Bader, A. Langsch, T. Koose, H.J. Burger, J. Maas and F. Oesch (2003) New hepatocyte in vitro systems for drug metabolism: metabolic capacity and recommendations for application in basic research and drug development, standard operation procedures. Drug. Metab. Rev. 35 145-213
40. J.C. Gerlach (1996) Development of a hybrid liver support system: a review. Int. J. Artif. Organs 19 645-654
41. J.C. Gerlach, J. Encke, O. Hole, C. Müller, C.J. Ryan and P. Neuhaus (1994) Bioreactor for a larger-scale hepatocyte in vitro perfusion. Transplantation 58 984-988
42. R. Glicklis, L. Shapiro, R. Agbaria, J.C. Merchuk and S. Cohen (2000) Hepatocyte behavior within three-dimensional porous alginate scaf-folds. Biotechnol. Bioeng. 67 344-353
43. L.G. Griffith, B. Wu, M.J. Cima, M.J. Powers, B. Chaignaud and J.P. Vacanti (1997) In vitro organogenesis of liver tissue. Ann. N. Y. Acad. Sci. 831 382-397
44. C. Guguen-Guillouzo, B. Clement, G. Baffet, C. Beaumont, E. Morel-Chany, D. Glaise and A. Guillouzo (1983) Maintenance and reversibility of active albumin secretion by adult rat hepatocytes co-cultured with another liver epithelial cell type. Exp. Cell. Res. 143 47-54
45. C. Guha, A. Sharma, S. Gupta, A. Alfieri, G.R. Gorla, S. Gagandeep, R. Sokhi, N. Roy-Chowdhury, K.E. Tanaka, B. Vikram and J. Roy-Chowdhury (1999) Amelioration of radiation-induced liver damage in partially hepatectomized rats by hepatocyte transplantation. Cancer Res. 59 5871-5874
46. A. Guillouzo (1998) Liver cell models in in vitro toxicology. Environ. Health Perspect. 106(Suppl. 2), 511-532
47. S. Gupta and J.R. Chowdhury (2002) Therapeutic potential of hepa-tocyte transplantation. Semin. Cell Dev. Biol. 13 439-446
48. S. Gupta, G.R. Gorla and A.N. Irani (1999) Hepatocyte transplanta-tion: emerging insights into mechanisms of liver repopulation and their relevance to potential therapies. J. Hepatol. 30 162-170
49. A.T. Gutsche, H. Lo, J. Zurlo, J. Yager and K.W. Leong (1996) engineering of a sugar-derivatized porous network for hepatocyte culture. Biomaterials 17 387-393
50. M.S. Hahn, L.J. Taite, J.J. Moon, M.C. Rowland, K.A. Ruffino and J.L. West (2006) Photolithographic patterning of polyethylene glycol hydrogels. Biomaterials 27 2519-2524
51. T. Hamazaki, Y. Iiboshi, M. Oka, P.J. Papst, A.M. Meacham, L.I. Zon and N. Terada (2001) Hepatic maturation in differentiating embryonic stem cells in vitro. FEBS Lett. 497 15-19
52. T. Haque, H. Chen, W. Ouyang, C. Martoni, B. Lawuyi, A.M. Urbanska and S. Prakash (2005) In vitro study of alginate-chitosan micro-capsules: an alternative to liver cell transplants for the treatment of liver failure. Biotechnol. Lett. 27 317-322
53. V. Hasirci, F. Berthiaume, S.P. Bondre, J.D. Gresser, D.J. Trantolo, M. Toner and D.L. Wise (2001) Expression of liver-specific functions by rat hepatocytes seeded in treated poly (lactic- co-glycolic) acid bio-degradable foams. Tissue Eng. 7 385-394
54. B.C. Heng, H. Yu, Y. Yin, S.G. Lim and T. Cao (2005) Factors influ-encing stem cell differentiation into the hepatic lineage in vitro. J. Gas-troenterol. Hepatol. 20 975-987
55. G.M. Higgins and R.M. Anderson (1931) Experimental pathology of the liver. I: restoration of the liver of the white rat following partial surgi-cal removal. Arch. Pathol. 12 186-202
56. S. Hirai, S. Kasai and M. Mito (1993) Encapsulated hepatocyte transplantation for the treatment of D-galactosamine-induced acute hepatic failure in rats. Eur. Surg. Res. 25 193-202
57. C. Holzer and P. Maier (1987) Maintenance of periportal and pericentral oxygen tensions in primary rat hepatocyte cultures: influence on cellular DNA and protein content monitored by flow. J. Cell. Physiol. 133 297-304
58. E. Houssaint (1980) Differentiation of the mouse hepatic primordium. I. An analysis of tissue interactions in hepatocyte differentiation. Cell Differ. 9 269-279
59. C.C. Hsiao, J.R. Wu, F.J. Wu, W.J. Ko, R.P. Remmel and W.S. Hu (1999) Receding cytochrome P450activity in disassembling hepatocyte spheroids. Tissue Eng. 5 207-221
60. Y. Ishida, S. Smith, L. Wallace, T. Sadamoto, M. Okamoto, M. Auth, M. Strazzabosco, L. Fabris, J. Medina, J. Prieto, A. Strain, J. Neuberger and R. Joplin (2001) Ductular morphogenesis and functional polar-ization of normal human biliary epithelial cells in three-dimensional culture. J. Hepatol. 35 2-9
61. S. Ishizaka, A. Shiroi, S. Kanda, M. Yoshikawa, H. Tsujinoue, S. Kuriyama, T. Hasuma, K. Nakatani and K. Takahashi (2002) Development of hepatocytes from ES cells after transfection with the HNF-3beta gene. FASEB J. 16 1444-1446
62. H.C. Isom, T. Secott, I. Georgoff, C. Woodworth and J. Mummaw (1985) Maintenance of differentiated rat hepatocytes in primary culture. Proc. Nat. Acad. Sci. U.S.A. 82 3252-3256
63. L.J. Itle, W.G. Koh and M.V. Pishko (2005) Hepatocyte viability and protein expression within hydrogel microstructures. Biotechnol. Prog. 21 926-932
64. S. Kaihara, J. Borenstein, R. Koka, S. Lalan, E.R. Ochoa, M. Ravens, H. Pien, B. Cunningham and J.P. Vacanti (2000) Silicon micro-machining to tissue engineer branched vascular channels for liver fab-rication. Tissue Eng. 6 105-117
65. P. Kan, H. Miyoshi, K. Yanagi and N. Ohshima (1998) Effects of shear stress on metabolic function of the co-culture system of hepatocyte/nonparenchymal cells for a bioartificial liver. Asaio J. 44 M441-M444
66. E. Karamuk, J. Mayer, E. Wintermantel and T. Akaike (1999) Partially degradable film/fabric composites: textile scaffolds for liver cell culture. Artif. Organs 23 881-884
67. S. Kasai, M. Sawa, Y. Nishida, K. Onodera, S. Hirai, T. Yamamoto and M. Mito (1992) Cellulose microcarrier for high-density culture of hepa-tocytes. Transplant. Proc. 24 2933-2934
68. T. Kawamoto, T. Sueyoshi, I. Zelko, R. Moore, K. Washburn and M. Negishi (1999) Phenobarbital-responsive nuclear translocation of the receptor CAR in induction of the CYP2B gene. Mol. Cell. Biol. 19 6318-6322
69. A. Kedem, A. Perets, I. Gamlieli-Bonshtein, M. Dvir-Ginzberg, S. Mizrahi and S. Cohen (2005) Vascular endothelial growth factor-releasing scaffolds enhance vascularization and engraftment of hepatocytes transplanted on liver lobes. Tissue Eng. 11 715-722
70. J.H. Kelly and G.J. Darlington (1989) Modulation of the liver specific phenotype in the human hepatoblastoma line Hep G2. In Vitro Cell. Dev. Biol. 25 217-222
71. S.S. Kim, H. Utsunomiya, J.A. Koski, B.M. Wu, M.J. Cima, J. Sohn, K. Mukai, L.G. Griffith and J.P. Vacanti (1998) Survival and function of hepatocytes on a novel three-dimensional synthetic biodegradable polymer scaffold with an intrinsic network of channels. Ann. Surg. 228 8-13
72. S.S. Kim, H. Utsunomiya, J.A. Koski, B.M. Wu, M.J. Cima, J. Sohn, K. Mukai, L.G. Griffith and J.P. Vacanti (1998) Survival and function of hepatocytes on a novel three-dimensional synthetic biodegradable polymer scaffold with an intrinsic network of channels [see comments. Ann. Surg. 228 8-13
73. W.R. Kim, R.S. Brown, N.A. Terrault Jr. and H. El-Serag (2002) Burden of liver disease in the United States: summary of a workshop. Hepatology 36 227-242
74. Y. Kino, M. Sawa, S. Kasai and M. Mito (1998) Multiporous cellulose microcarrier for the development of a hybrid artificial liver using isolated hepatocytes. J. Surg. Res. 79 71-76
75. G. Knedlitschek, F. Schneider, E. Gottwald, T. Schaller, E. Eschbach and K.F. Weibezahn (1999) A tissue-like culture system using micro-structures: influence of extracellular matrix material on cell adhesion and aggregation. J. Biomech. Eng. 121 35-39
76. K.D. Kochanek, S.L. Murphy, R.N. Anderson and C. Scott (2004) Deaths: final data for 1802. Natl. Vital Stat. Rep. 53 1-115
77. E. Laconi, R. Oren, D.K. Mukhopadhyay, E. Hurston, S. Laconi, P. Pani, M.D. Dabeva and D.A. Shafritz (1998) Long-term, near-total liver replacement by transplantation of isolated hepatocytes in rats treated with retrorsine. Am. J. Pathol. 153 319-329
78. J. Landry, D. Bernier, C. Ouellet, R. Goyette and N. Marceau (1985) Spheroidal aggregate culture of rat liver cells: histotypic reorganization, biomatrix deposition, and maintenance of functional activities. J. Cell Biol. 101 914-923
79. E.L. LeCluyse (2001) Human hepatocyte culture systems for the in vitro evaluation of cytochrome P450expression and regulation. Eur. J. Pharm. Sci. 13 343-368
80. E.L. LeCluyse, K.L. Audus and J.H. Hochman (1994) Formation of extensive canalicular networks by rat hepatocytes cultured in collagen-sandwich configuration. Am. J. Physiol. 266 C1764-C1774
81. E. LeCluyse, P.L. Bullock and A. Parkinson (1996) Strategies for restoration and maintenance of normal hepatic structure and function in long-term cultures of rat hepatocytes. Adv. Drug Delivery Rev. 22 133-186
82. H. Lee, R.A. Cusick, F. Browne, K.T. Ho Kim T., P.X. Ma, H. Utsunomiya, R. Langer and J.P. Vacanti (2002) Local delivery of basic fibroblast growth factor increases both angiogenesis and engraftment of hepato-cytes in tissue-engineered polymer devices. Transplantation 73 1589-1593
83. J.S. Lee, S.H. Kim, Y.J. Kim, T. Akaike and S.C. Kim (2005) Hepatocyte adhesion on a poly[N-p-vinylbenzyl-4-O-beta-D-galacto-pyranosyl-D-glucoamide]-coated poly (L-lactic acid) surface. Biomacro-molecules 6 1906-1911
84. W.M. Lee (2003) Acute liver failure in the United States. Semin. Liver Dis. 23 217-226
85. F. Lemaigre and K.S. Zaret (2004) Liver development update: new embryo models, cell lineage control, and morphogenesis. Curr. Opin. Genet. Dev. 14 582-590
86. K. Li, Y. Wang, Z. Miao, D. Xu, Y. Tang and M. Feng (2004) Chitosan/gelatin composite microcarrier for hepatocyte culture. Biotechnol. Lett. 26 879-883
87. P. Lin, W.C. Chan, S.F. Badylak and S.N. Bhatia (2004) Assessing porcine liver-derived biomatrix for hepatic tissue engineering. Tissue Eng. 10 1046-1053
88. K.O. Lindros (1997) Zonation of cytochrome P450expression, drug metabolism and toxicity in liver. Gen. Pharmacol. 28 191-196
89. J. Liu, J. Pan, S. Naik, H. Santangini, D. Trenkler, N. Thompson, A. Rifai, J.R. Chowdhury and H.O. Jauregui (1999) Characterization and evaluation of detoxification functions of a nontumorigenic immor-talized porcine hepatocyte cell line (HepLiu). Cell Transpl. 8 219-232
90. V.A. Liu and S.N. Bhatia (2002) Three-dimensional photopatterning of hydrogels containing living cells. Biomed. Microdevices 4 257-266
91. M.P. Lutolf, J.L. Lauer-Fields, H.G. Schmoekel, A.T. Metters, F.E. Weber, G.B. Fields and J.A. Hubbell (2003) Synthetic matrix metallo-proteinase-sensitive hydrogels for the conduction of tissue regenera-tion: engineering cell-invasion characteristics. Proc. Natl. Acad. Sci. U.S.A. 100 5413-5418
92. T. Maguire, E. Novik, R. Schloss and M. Yarmush (2006) Alginate-PLL microencapsulation: effect on the differentiation of embryonic stem cells into hepatocytes. Biotechnol. Bioeng. 93 581-591
93. L. Makowka, R.E. Falk, L.E. Rotstein, J.A. Falk, N. Nossal, B. Langer, L.M. Blendis and M.J. Phillips (1980) Reversal of experimental acute hepatic failure in the rat. J. Surg. Res. 29 479-487
94. B.K. Mann, A.S. Gobin, A.T. Tsai, R.H. Schmedlen and J.L. West (2001) Smooth muscle cell growth in photopolymerized hydrogels with cell adhesive and proteolytically degradable domains: synthetic ECM analogs for tissue engineerin. Biomaterials 22 3045-3051
95. M.S. Margulis, E.A. Erukhimov, L.A. Andreiman and L.M. Viksna (1989) Temporary organ substitution by hemoperfusion through sus-pension of active donor hepatocytes in a total complex of intensive therapy in patients with acute hepatic insufficiency. Resuscitation 18 85-94
96. K. Matsumoto, H. Yoshitomi, J. Rossant and K.S. Zaret (2001) Liver organogenesis promoted by endothelial cells prior to vascular function. Science 294 559-563
97. J. Mayer, E. Karamuk, T. Akaike and E. Wintermantel (2000) Matrices for tissue engineering —scaffold structure for a bioartificial liver support system. J. Controlled Release 64 81-90
98. G.K. Michalopoulos and M.C. DeFrances (1997) Liver regeneration. Science 276 60-66
99. A. Mignon, J.E. Guidotti, C. Mitchell, M. Fabre, A. Wernet, L.C.A. De La Coste A., O. Soubrane, H. Gilgenkrantz and A. Kahn (1998) Selective repopulation of normal mouse liver by Fas/CD95-resistant hepato-cytes. Nat. Med. 4 1185-1188
100. J.M. Millis, D.C. Cronin, R. Johnson, H. Conjeevaram, C. Conlin, S. Trevino and P. Maguire (2002) Initial experience with the modified extracorporeal liver-assist device for patients with fulminant hepatic failure: system modifications and clinical impact. Transplantation 74 1735-1746
101. T. Mitaka (1998) The current status of primary hepatocyte culture. Int. J. Exp. Pathol. 79 393-409
102. T. Mitaka, C.A. Sattler, G.L. Sattler, L.M. Sargent and H.C. Pitot (1991) Multiple cell cycles occur in rat hepatocytes cultured in the presence of nicotinamide and epidermal growth factor. Hepatology 13 21-30
103. Y. Miura, T. Akimoto, H. Kanazawa and K. Yagi (1986) Synthesis and secretion of protein by hepatocytes entrapped within calcium alginate. Artif. Organs 10 460-465
104. M. Miyazaki, Y. Handa, M. Oda, T. Yabe, K. Miyano and J. Sato (1985) Long-term survival of functional hepatocytes from adult rat in the presence of phenobarbital in primary culture. Exp. Cell Res. 159 176-190
105. M. Miyazawa, T. Torii, Y. Toshimitsu, K. Okada, I. Koyama and Y. Ikada (2005) A tissue-engineered artificial bile duct grown to resemble the native bile duct. Am. J. Transplant. 5 1541-1547
106. F.L. Moolten and N.L. Bucher (1967) Regeneration of rat liver: transfer of humoral agent by cross circulation. Science 158 272-274
107. D.J. Mooney, S. Park, P.M. Kaufmann, K. Sano, K. McNamara, J.P. Vacanti and R. Langer (1995) Biodegradable sponges for hepato-cyte transplantation. J. Biomed. Mater. Res. 29 959-965
108. D.J. Mooney, K. Sano, P.M. Kaufmann, K. Majahod, B. Schloo, J.P. Vacanti and R. Langer (1997) Long-term engraftment of hepato-cytes transplanted on biodegradable polymer sponges. J. Biomed. Mater. Res. 37 413-420
109. Y.S. Nam, J.J. Yoon, J.G. Lee and T.G. Park (1999) Adhesion behaviors of hepatocytes cultured onto biodegradable polymer surface modified by alkali hydrolysis process. J. Biomater. Sci. Polym. Ed. 10 1145-1158
110. M. Nauck, D. Wolfle, N. Katz and K. Jungermann (1981) Modulation of the glucagon-dependent induction of phosphoenolpyruvate car-boxykinase and tyrosine aminotransferase by arterial and venous oxygen concentration hepatocyte cultures. Eur. J. Biochem. 119 657-661
111. S.L. Nyberg, J.A. Hardin, L.E. Matos, D.J. Rivera, S.P. Misra and G.J. Gores (2000) Cytoprotective influence of ZVAD-fmk and glycine on gel-entrapped rat hepatocytes in a bioartificial liver. Surgery 127 447-455
112. K. Ogawa, E.R. Ochoa, J. Borenstein, K. Tanaka and J.P. Vacanti (2004) The generation of functionally differentiated, three-dimensional hepatic tissue from two-dimensional sheets of progenitor small hepatocytes and nonparenchymal. Transplantation 77 1783-1789
113. M. Olson, M. Mancini, M. Venkatachalam and A. Roy (1990) Hepatocyte cytodifferentiation and cell-to-cell communication. W. De Mello (Ed.) Cell Intercommunication Boca Raton, FL: CRC Press 71-92
114. G. Ostapowicz, R.J. Fontana, F.V. Schiodt, A. Larson, T.J. Davern, S.H. Han, T.M. McCashland, A.O. Shakil, J.E. Hay, L. Hynan, J.S. Crippin, A.T. Blei, G. Samuel, J. Reisch and W.M. Lee (2002) Results of a prospective study of acute liver failure at 17 tertiary care centers in the United States. Ann. Intern. Med. 137 947-954
115. K. Overturf, M. al-Dhalimy, C.N. Ou, M. Finegold and M. Grompe (1997) Serial transplantation reveals the stem-cell-like regenera-tive potential of adult mouse hepatocytes. Am. J. Pathol. 151 1273-1280
116. D. Palmes and H.U. Spiegel (2004) Animal models of liver regenera-tion. Biomaterials 25 1601-1611
117. J.K. Park and D.H. Lee (2005) Bioartificial liver systems: current status and future perspective. J. Biosci. Bioeng. 99 311-319
118. J. Park, F. Berthiaume, M. Toner, M.L. Yarmush and A.W. Tilles (2005) Microfabricated grooved substrates as platforms for bioartificial liver reactors. Biotechnol. Bioeng. 90 632-644
119. T.G. Park (2002) Perfusion culture of hepatocytes within galactose-derivatized biodegradable poly (lactide- co-glycolide) scaffolds prepared by gas foaming of effervescent. J. Biomed. Mater. Res. 59 127-135
120. C. Patience, Y. Takeuchi and R.A. Weiss (1997) Infection of human cells by an endogenous retrovirus of pigs. Nat. Med. 3 282-286
121. N.A. Peppas, P. Bures, W. Leobandung and H. Ichikawa (2000) Hydrogels in pharmaceutical formulations. Eur. J. Pharm. Biopharm. 50 27-46
122. S. Petronis, K.L. Eckert, J. Gold and E. Wintermantel (2001) Micro-structuring ceramic scaffolds for hepatocyte cell culture. J. Mater. Sci. Mater. Med. 12 523-528
123. Z. Pitkin and C. Mullon (1999) Evidence of absence of porcine endogenous retrovirus (PERV) infection in patients treated with a bioartificial liver support system. Artif. Organs 23 829-833
124. M.J. Powers, K. Domansky, M.R. Kaazempur-Mofrad, A. Kalezi, A. Capitano, A. Upadhyaya, P. Kurzawski, K.E. Wack, D.B. Stolz, R. Kamm and L.G. Griffith (2002) A microfabricated-array bioreactor for perfused 3D liver culture. Biotechnol. Bioeng. 78 257-269
125. V. Racanelli and B. Rehermann (2006) The liver as an immunological organ. Hepatology 43 S54-S62
126. T.M. Rahman and H.J. Hodgson (2000) Animal models of acute hepatic failure. Int. J. Exp. Pathol. 81 145-157
127. C.S. Ranucci, A. Kumar, S.P. Batra and P.V. Moghe (2000) Control of hepatocyte function on collagen foams: sizing matrix pores toward selective induction of 2D and 3D cellular morphogenesis. Biomaterials 21 783-793
128. L.M. Reid, A.S. Fiorino, S.H. Sigal, S. Brill and P.A. Holst (1992) Extracellular matrix gradients in the space of Disse: relevance to liver biology [editorial]. Hepatology 15 1198-1203
129. A. Revzin, R.J. Russell, V.K. Yadavalli, W.G. Koh, C. Deister, D.D. Hile, M.B. Mellott and M.V. Pishko (2001) Fabricationofpoly (ethylene glycol) hydrogel microstructures using photolithography. Langmuir 17 5440-5447
130. J.A. Rhim, E.P. Sandgren, J.L. Degen, R.D. Palmiter and R.L. Brinster (1994) Replacement of diseased mouse liver by hepatic cell transplantation. Science 263 1149-1152
131. T.P. Richardson, M.C. Peters, A.B. Ennett and D.J. Mooney (2001) Polymeric system for dual growth factor delivery. Nat. Biotechnol. 19 1029-1034
132. L. Richert, D. Binda, G. Hamilton, C. Viollon-Abadie, E. Alexandre, D. Bigot-Lasserre, R. Bars, P. Coassolo and E. LeCluyse (2002) Evalu-ation of the effect of culture configuration on morphology, survival time, antioxidant status and metabolic capacities of cultured rat hepa-tocytes. Toxicol. In Vitro 16 89-99
133. P. Roy, H. Baskaran, A.W. Tilles, M.L. Yarmush and M. Toner (2001) Analysis of oxygen transport to hepatocytes in a flat-plate microchan-nel bioreactor. Ann. Biomed. Eng. 29 947-955
134. J. Rozga, M.D. Holzman, M.S. Ro, D.W. Griffin, D.F. Neuzil, T. Giorgio, A.D. Moscioni and A.A. Demetriou (1993) Development of a hybrid bioartificial liver. Ann. Surg. 217 502-509. discussion 509-511
135. Y. Sakai, K. Naruse, I. Nagashima, T. Muto and M. Suzuki (1996) In vitro function of porcine hepatocyte spheroids in 100% human plasma. Cell Transplant. 5 S41-S43
136. I.M. Sauer, K. Zeilinger, N. Obermayer, G. Pless, A. Grunwald, A. Pascher, T. Mieder, S. Roth, M. Goetz, D. Kardassis, A. Mas, P. Neuhaus and J.C. Gerlach (2002) Primary human liver cells as source for modular extracorporeal liver support —a preliminary report. Int. J. Artif. Organs 25 1001-1005
137. R.E. Schwartz, M. Reyes, L. Koodie, Y. Jiang, M. Blackstad, T. Lund, T. Lenvik, S. Johnson, W.S. Hu and C.M. Verfaillie (2002) Multipotent adult progenitor cells from bone marrow differentiate into functional hepatocyte-like cells. J. Clin. Invest. 109 1291-1302
138. D. Seliktar, A.H. Zisch, M.P. Lutolf, J.L. Wrana and J.A. Hubbell (2004) MMP-2 sensitive, VEGF-bearing bioactive hydrogels for promotion of vascular healing. J. Biomed. Mater. Res. 68A 704-716
139. S. Sell (2001) The role of progenitor cells in repair of liver injury and in liver transplantation. Wound Repair Regen. 9 467-482
140. C.E. Semino, J.R. Merok, G.G. Crane, G. Panagiotakos and S. Zhang (2003) Functional differentiation of hepatocyte-like spheroid structures from putative liver progenitor cells in three-dimensional peptide scaffolds. Differentiation 71 262-270
141. S. Sen and R. Williams (2003) New liver support devices in acute liver failure: a critical evaluation. Semin. Liver Dis. 23 283-294
142. S.J. Seo, Y.J. Choi, T. Akaike, A. Higuchi and C.S. Cho (2006) Alginate/galactosylated chitosan/heparin scaffold as a new synthetic extracellular matrix for hepatocytes. Tissue Eng. 12 33-44
143. A. Sivaraman, J.K. Leach, S. Townsend, T. Iida, B.J. Hogan, D.B. Stolz, R. Fry, L.D. Samson, S.R. Tannenbaum and L.G. Griffith (2005) A microscale in vitro physiological model of the liver: predictive screens for drug metabolism and enzyme induction. Curr. Drug Metab. 6 569-591
144. S. Skawran, D. Palmes, T. Budny, R. Bahde, U. Stratmann and H.U. Spiegel (2003) Development and evaluation of an experimental model for investigating the pathogenesis and therapeutic strategies of acute liver failure. Transplant. Proc. 35 3142-3146
145. M.K. Smith, M.C. Peters, T.P. Richardson, J.C. Garbern and D.J. Mooney (2004) Locally enhanced angiogenesis promotes transplanted cell survival. Tissue Eng. 10 63-71
146. R.P. Sokhi, P. Rajvanshi and S. Gupta (2000) Transplanted reporter cells help in defining onset of hepatocyte proliferation during the life of F344 rats. Am. J. Physiol. Gastrointest. Liver Physiol. 279 G631-G640
147. M.N. Sosef, J.M. Baust, K. Sugimachi, A. Fowler, R.G. Tompkins and M. Toner (2005) Cryopreservation of isolated primary rat hepatocytes: enhanced survival and long-term hepatospecific function. Ann. Surg. 241 125-133
148. J. Stange, W. Ramlow, S. Mitzner, R. Schmidt and H. Klinkmann (1993) Dialysis against a recycled albumin solution enables the removal of albumin-bound toxins. Artif. Organs 17 809-813
149. P. Stefanovich, H.W. Matthew, M. Toner, R.G. Tompkins and M.L. Yarmush (1996) Extracorporeal plasma perfusion of cultured hepatocytes: effect of intermittent perfusion on hepatocyte function and morphol-ogy. J. Surg. Res. 66 57-63
150. H. Strick-Marchand and M.C. Weiss (2002) Inducible differentiation and morphogenesis of bipotential liver cell lines from wild-type mouse embryos. Hepatology 36 794-804
151. H. Strick-Marchand, S. Morosan, P. Charneau, D. Kremsdorf and M.C. Weiss (2004) Bipotential mouse embryonic liver stem cell lines contribute to liver regeneration and differentiate as bile ducts and hepatocytes. Proc. Natl. Acad. Sci. U.S.A. 101 8360-8365
152. S.C. Strom, J.R. Chowdhury and I.J. Fox (1999) Hepatocyte transplantation for the treatment of human disease. Semin. Liver Dis. 19 39-48
153. R. Sudo, T. Mitaka, M. Ikeda and K. Tanishita (2005) Reconstruction of 3D stacked-up structures by rat small hepatocytes on microporous membranes. FASEBJ. 19 1695-1697
154. K. Taguchi, M. Matsushita, M. Takahashi and J. Uchino (1996) development of a bioartificial liver with sandwiched-cultured hepatocytes between two collagen gel layers. Artif. Organs 20 178-185
155. W. Tan and T.A. Desai (2003) Microfluidic patterning of cells in extra-cellular matrix biopolymers: effects of channel size, cell type, and matrix composition on pattern integrity. Tissue Eng. 9 255-267
156. X. Tao, L. Shaolin and Y. Yaoting (2003) Preparation and culture of hepatocyte on gelatin microcarriers. J. Biomed. Mater. Res. A 65 306-310
157. S.S. Thorgeirsson and J.W. Grisham (2006) Hematopoietic cells as hepatocyte stem cells: a critical review of the evidence. Hepatology 43 2-8
158. A.W. Tilles, H. Baskaran, P. Roy, M.L. Yarmush and M. Toner (2001) Effects of oxygenation and flow on the viability and function of rat hepatocytes cocultured in a microchannel flat-plate bioreactor. Bio-technol. Bioeng. 73 379-389
159. V.L. Tsang and S.N. Bhatia (2004) Three-dimensional tissue fabrica-tion. Adv. Drug Deliv. Rev. 56 1635-1647
160. M.P. van de Kerkhove, F.E. Di Florio E., V. Scuderi, A. Mancini, A. Belli, A. Bracco, M. Dauri, G. Tisone, N.G. Di Nicuolo G., P. Amoroso, A. Spadari, G. Lombardi, R. Hoekstra, F. Calise and R.A. Chamuleau (2002) Phase I clinical trial with the AMC-bioartificial liver. Int. J. Artif. Organs 25 950-959
161. M.P. van de Kerkhove, R. Hoekstra, R.A. Chamuleau and T.M. van Gulik (2004) Clinical application of bioartificial liver support systems. Ann. Surg. 240 216-230
162. G. Vozzi, C. Flaim, A. Ahluwalia and S.N. Bhatia (2003) Fabrication of PLGA scaffolds using soft lithography and microsyringe deposition. Biomaterials 24 2533-2540
163. S. Vukicevic, H.K. Kleinman, F.P. Luyten, A.B. Roberts, N.S. Roche and A.H. Reddi (1992) Identification of multiple active growth factors in basement membrane Matrigel suggests caution in interpretation of cellular activity related to extracellula matrix components. Exp. Cell Res. 202 1-8
164. X. Wang, Y. Yan, Y. Pan, Z. Xiong, H. Liu, J. Cheng, F. Liu, F. Lin, R. Wu, R. Zhang and Q. Lu (2006) Generation of three-dimensional hepa-tocyte/gelatin structures with rapid prototyping system. Tissue Eng. 12 83-90
165. J. Washizu, F. Berthiaume, C. Chan, R.G. Tompkins, M. Toner and M.L. Yarmush (2000) Optimization of rat hepatocyte culture in citrated human plasma. J. Surg. Res. 93 237-246
166. S.P. Wolfe, E. Hsu, L.M. Reid and J.M. Macdonald (2002) A novel multi-coaxial hollow-fiber bioreactor for adherent cell types. Part 1: hydrodynamic studies. Biotechnol. Bioeng. 77 83-90
167. T. Yamada, M. Yoshikawa, S. Kanda, Y. Kato, Y. Nakajima, S. Ishizaka and Y. Tsunoda (2002) In vitro differentiation of embryonic stem cells into hepatocyte-like cells identified by cellular uptake of indocyanine green. Stem Cells 20 146-154
168. K. Yanagi, K. Ookawa, S. Mizuno and N. Ohshima (1989) Performance of a new hybrid artificial liver support system using hepatocytes entrapped within a hydrogel. ASAIO Trans. 35 570-572
169. M.L. Yarmush, J.C. Dunn and R.G. Tompkins (1992) Assessment of artificial liver support technology. Cell. Transplant. 1 323-341
170. J.H. Yoon, H.V. Lee, J.S. Lee, J.B. Park and C.Y. Kim (1999) Development of a nontransformed human liver cell line with differentiated-hepatocyte and urea-synthetic functions: applicable for bioartificial liver. Int. J. Artif. Organs 22