Hepatocyte transplantation: Emerging insights into mechanisms of liver repopulation and their relevance to potential therapies

Journal of Hepatology

Volumn 30, Issue 1, 1999, Pages 162-170

  Gupta, Sanjeev ^a   Gorla, Giridhar R ^a   Irani, Adil N ^a  

^a ALBERT EINSTEIN COLLEGE OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALLOGRAFT; ARTICLE; CELL GROWTH; CELL ISOLATION; CELL SUBPOPULATION; LIVER CELL; LIVER TRANSPLANTATION; PRIORITY JOURNAL;

EID: 0032953728     PISSN: 01688278     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0168-8278(99)80022-1     Document Type: Article

References (59)

1. Zhao Y, Swenson K, Sergio JJ, Arn JS, Sachs DH, Sykes M. Skin graft tolerance across a dicordant xenogeneic barrier. Nat Med. 2:1996;1211-1216.
2. Bach FH, Ferran C, Hechenleitner P, Mark W, Koyamada N, Miyatake T, et al. Accomodation of vascularized xenografts; expression of"protective genes" by donor endothelial cells in a host Th2 cytokine environment. Nat Med. 3:1997;196-204.
3. Gunsalus JR, Brady DA, Coulter SM, Gray BM, Edge ASB. Reduction of serum cholesterol in Watanabe rabbits by xenogeneic hepatocellular transplantation. Nat Med. 3:1997;48-49.
4. Gupta S. Hepatocyte-directed somatic gene therapy: a molecular approach for treating genetic disorders. Gitnick GL, . Current Hepatology. 11:1991;61-87 Mosby - Year Book, Inc. Chicago.
5. Bosman DK, de Haan JG, Smit J, Jorning GGA, Maas MAW, Chamuleau AFM. Metabolic activity of microcarrier attached liver cells after intraperitoneal transplantation during severe liver insufficiency in the rat. J Hepatol. 9:1989;49-58.
6. Ribiero J, Nordlinger B, Ballet F, Cynober L, Coudray-Lucas C, Baudromont M, et al. Intrasplenic hepatocellular transplantation corrects hepatic encephalopathy in portacaval shunted rats. Hepatology. 15:1992;12-18.
7. Bilir BM, Guenette D, Ostrowska A, Durham J, Kumpe D, Krysl J, et al. Percutaneous hepatocyte transplantation (PHT) in liver failure. [abstract] Hepatology. 26:1997;252A.
8. Mito M, Kusano M, Kauwara Y. Hepatocyte transplantation in man. Transplant Proc. 24:1992;3052-3053.
9. Gupta S, Rajvanshi P, Bhargava KK, Kerr A. Hepatocyte transplantation; progress toward liver repopulation. Prog Liver Dis. 14:1996;199-222.
10. Gupta S. Hepatocyte transplantation: novel applications. Strain AJ, Diehl AM, . Chapman & Hall Ltd. 1998;Liver Growth and Repair, London.
11. Vemuru RP, Davidson A, Aragona E, Burk RD, Chowdhury JR, Gupta S. Immune tolerance to a defined heterologous antigen following intrasplenic hepatocyte transplantation: implications for human gene therapy. FASEB J. 6:1992;2836-2842.
12. Gupta S, Vemuru RP, Lee C-D, Yerneni P, Aragona E, Burk RD. Hepatocytes exhibit superior transgene expression after transplantation into liver and spleen compared with peritoneal cavity or dorsal fat pad: implications for hepatic gene therapy. Hum Gene Ther. 5:1994;959-967.
13. Pollok JM, Vacanti JP. Tissue engineering. Semin Pediatr Surg. 5:1996;191-196.
14. Dixit V, Darvasi R, Arthur M, Brezina M, Lewin K, Gitnick G. Restoration of liver function in Gunn rats without immunosuppression using transplanted microencapsulated hepatocytes. Hepatology. 12:1990;1342-1349.
15. Selden C, Calnan D, Morgan N, Wilcox H, Carr E, Hodgson HJE. Histidinemia in mice: a metabolic defect treated using a novel approach to hepatocellular transplantation. Hepatology. 21:1995;1405-1412.
16. Rugstad HE, Robinson SH, Yamoni C, Tashjian A.A. Jr. Transfer of bilirubin uridine-5-diphosphate-glucuronyltransferase to enzyme deficient rats. Science. 170:1970;553-555.
17. Matas AJ, Sutherland DER, Steffes MW, Mauer SM, Lowe A, Simmons RL, et al. Hepatocellular transplantation for metabolic deficiencies: decrease of plasma bilirubin in Gunn rats. Science. 192:1976;892-894.
18. Groth CG, Arborgh B, Bjorken C, Sundberg B, Lundgren G. Correction of hyperbilirubinemia in the glucuronyltransferase-deficient rats by intraportal hepatocyte transplantation. Transplant Proc. 9:1977;313-316.
19. Sutherland DER, Numate M, Matas AJ, Simmons RL, Najarian JS. Hepatocellular transplantation in acute liver failure. Surgery. 82:1977;124-132.
20. Sommer BG, Sutherland DE, Matas DJ, Simmons RL, Najarian JS. Hepatocellular transplantation for treatment of D-galactosamine induced acute liver failure in rats. Transplant Proc. 11:1979;578-584.
21. Makowka L, Rotstein LE, Falk RE, Falk JA, Langer B, Nossal NA, et al. Reversal of toxic and anoxic induced hepatic failure by syngeneic, allogeneic and xenogeneic hepatocyte transplantation. Surgery. 88:1980;2243-2253.
22. Makowka L, Rotstein LE, Falk RE, Falk JA, Zuk R, Langer B, et al. Studies into the mechanism of reversal of experimental acute hepatic failure by hepatocyte transplantation. Canad J Surg. 24:1981;39-43.
23. Miyazaki M, Makowka L, Falk RE, Falk JA, Falk W, Ventura D. Reversal of lethal, chemotherapeutically induced acute hepatic necrosis in rats by regenerating liver cytosol. Surgery. 94:1983;142-150.
24. Baumgartner D, LaPlante-O'Neill P, Sutherland D, Najarian J. Effects of intrasplenic injection of hepatocytes, hepatocyte fragments and hepatocyte culture supernatants on D-galactosamineinduced liver failure in rats. Eur Surg Res. 5:1983;129-135.
25. Soriano HE, Lewis D, Legner M, Brandt M, Baley P, Darlington G, et al. Use of DiI marked hepatocytes to demonstrate orthotopic, intrahepatic engraftment following hepatocellular transplantation. Transplantation. 54:1992;717-723.
26. Fujioka H, Hunt PJ, Rozga J, Wu GD, Cramer DV, Demetriou AA, et al. Carboxyfluorescein (CFSE) labelling of hepatocytes for short-term localization following intraportal transplantation. Cell Transplantation. 3:1994;397-408.
27. Gupta S, Lee C-D, Vemuru RP, Bhargava KK. 111Indium-labeling of hepatocytes for analyzing biodistribution of transplanted cells. Hepatology. 19:1994;750-757.
28. Gupta S, Vasa SRG, Rajvanshi P, Zuckier L, Palestro CJ, Bhargava KK. Analysis of hepatocyte distribution and survival in vascular beds with cells marked by 99m-Tc or endogenous dipeptidyl peptidase IV activity. Cell Transplantation. 6:1997;377-386.
29. Gupta S, Roy Chowdhury R, Jagtiani R, Gustin K, Shafritz DA, et al. A novel system for transplantation of isolated hepatocytes utilizing HBsAg producing transgenic donor cells. Transplantation. 50:1990;472-475.
30. Ponder KP, Gupta S, Leland F, Darlington G, Finegold M, DeMayo J, et al. Mouse hepatocytes migrate to liver parenchyma and function indefinitely after intrasplenic transplantation. Proc Natl Acad Sci (USA). 88:1991;1217-1221.
31. Rhim JA, Sandgren EP, Degen JL, Palmiter RD, Brinster RL. Replacement of diseased mouse liver by hepatic cell transplantation. Science. 263:1994;1149-1152.
32. Rajvanshi P, Kerr A, Bhargava KK, Burk RD, Gupta S. Studies of liver repopulation using the dipeptidyl peptidase IV deficient rat and other rodent recipients: cell size and structure relationships regulate capacity for increased transplanted hepatocyte mass in the liver lobule. Hepatology. 23:1996;482-496.
33. Overturf K, Al-Dhalimy M, Ou C-N, Finegold M, Grompe M. Serial transplantation reveals the stem-cell-like regenerative potential of adult mouse hepatocytes. Am J Pathol. 151:1997;1273-1280.
34. Petersen J, Dandri M, Gupta S, Rogler CE. Liver repopulation with xenogenic hepatocytes in B and T cell-deficient mice leads to chronic hepadnavirus infection and clonal growth of hepatocellular carcinoma. Proc Natl Acad Sci (USA). 95:1998;310-315.
35. Sigal S, Rajvanshi P, Reid LM, Gupta S. Demonstration of differentiation in hepatocyte progenitor cells using dipeptidyl peptidase IV deficient mutant rats. Cell Mol Biol Res. 41:1995;39-47.
36. Dabeva MD, Hwang SG, Vasa SRG, Hurston E, Novikoff PM, Hixson DC, et al. Differentiation of pancreatic epithelial progenitor cells into hepatocytes following transplantation into rat liver. Proc Natl Acad Sci (USA). 94:1997;7356-7361.
37. Coleman WB, McCullough KD, Esch GL, Faris RA, Hixson DC, Smith JG, et al. Evaluation of the differentiation potential of WB-F344 rat liver epithelial stem-like cells in vivo. Differentiation to hepatocytes after transplantation into dipeptidyl peptidase-IV-deficient rat liver. Am J Pathol. 151:1997;353-359.
38. Mito M, Kusano M, Ohnishi T, Saito T, Ebata H. Hepatocellular transplantation. Gastroenterol Jpn. 13:1978;480-490.
39. Gupta S, Aragona E, Vemuru RP, Bhargava K, Burk RD, Roy Chowdhury J. Permanent engraftment and function of hepatocytes delivered to the liver: implications for gene therapy and liver repopulation. Hepatology. 14:1991;144-149.
40. Gupta S, Yerneni P, Vemuru RP, Lee CD, Yellin EL, Bhargava KK. Studies on the safety of intrasplenic hepatocyte transplantation: relevance to ex-vivo gene therapy and liver repopulation in acute hepatic failure. Human Gene Ther. 4:1993;249-257.
41. M Grossman, Raper SE, Wilson JM. Transplantation of genetically modified autologous hepatocytes into nonhuman primates: feasibility and short-term toxicity. Hum Gene Ther. 3:1992;501-510.
42. Grossman M, Raper SE, Kozarsky K, Stein EA, Engelhardt JF, Muller D, et al. Successful ex-vivo gene therapy directed to liver in a patient with familial hypercholesterolemia. Nat Genet. 6:1994;335-341.
43. Rajvanshi P, Bhargava KK, Afriye M, Camaya M, Gagandeep S, Vasa SRG, et al. Human serum albumin microspheres approximate initial organ-specific biodistributions of transplanted hepatocytes and are effective cell surrogates for safety studies. Cell Transplantation. 7:1998;275-283.
44. Kerr A, Rajvanshi P, Gupta S. Transcatheter hepatocyte transplantation: preclinical studies of anatomic consequences in the portal venous system. Acad Radiol. 1:1994;229-236.
45. Rajvanshi P, Kerr A, Bhargava KK, Burk RD, Gupta S. Efficacy and safety of repeated hepatocyte transplantation for significant liver repopulation in rodents. Gastroenterology. 111:1996;1092-1102.
46. Gupta S, Rajvanshi P, Lee C-D. Integration of transplanted hepatocytes in host liver plates demonstrated with dipeptidyl peptidase IV deficient rats. Proc Natl Acad Sci (USA). 92:1995;5860-5864.
47. Slehria S, Gupta S. Vascular endothelial growth factor is released before sinusoidal endothelial disruption during liver repopulation with hepatocyte transplantation. [abstract] J Invest Med. 46:1998;211A.
48. Rajvanshi P, Kerr A, Gupta S. Transplanted hepatocytes require several days to fully integrate into liver plates: implications for liver repopulation and ex vivo gene therapy. [abstract] J Invest Med. 43:1995;400A.
49. Vroemen JP, Buurman WA, Schutte B, Maessen JG, van der Linden CJ, Kootstra G. The cytokinetic behavior of donor hepatocytes after syngeneic hepatocyte transplantation into the spleen. Transplantation. 45:1988;600-607.
50. Gupta S, Rajvanshi P, Vasa SRG, Dabeva M, Shafritz DA, Sokhi RP, et al. Hepatocyte transplantation induces changes in the host liver suggestive of microcirculatory deficits. [abstract] Hepatology. 26:1997;251A.
51. Gupta S, Rajvanshi P, Sokhi RP, Burk R. Mechanisms determining augmentation of the transplanted hepatocyte mass with growth stimulating signals. [abstract] Hepatology. 26:1997;167A.
52. Rajvanshi P, Gupta S. Rapid integration and proliferation of transplanted hepatocytes in D-galactosamine-injured rat liver indicates potential of cell transplantation in acute liver failure. [abstract] Hepatology. 22:1995;213A.
53. Laconi E, Oren R, Mukhopadhyay DK, Hurston H, Laconi S, Pani P, et al. Long-term, near-total liver replacement by transplantation of isolated hepatocytes in rats treated with retrorsine. Am J Pathol. 153:1998;319-329.
54. Guha C, Vikram B, Gupta S, Sharma A, Alfieri A, Gagandeep S, et al. Hepatocyte transplantation increases survival after partial hepatectomy and whole liver irradiation in F344 rats. [abstract] Gastroenterology. 114:1998;A1250.
55. Fox IJ, Chowdhury JR, Kaufman SS, Goertzen TC, Chowdhury NR, Warkentin PI, et al. Treatment of the Crigler-Najjar syndrome type I with hepatocyte transplantation. N Engl J Med. 338:1998;1422.
56. Grossman M, Rader DJ, Muller DWM, Kolansky DM, Kozarsky K, Clark III BJ, et al. A pilot study of ex vivo gene therapy for homozygous familiar hypercholesterolaemia. Nat Med. 1:1995;1148-1154.
57. Slehria S, Gagandeep S, Rajvanshi P, Sokhi R, Furgiuele J, Bhargava K, et al. Long-term liver repopulation with transplanted hepatocytes in cirrhotic F344 rats. Hepatology. 1998;. in press.
58. Yoshida Y, Tokusashi Y, Lee G-H, Ogawa K. Intrahepatic transplantation of normal hepatocytes prevents Wilson's disease in Long-Evans cinnamon rats. Gastroenterology. 111:1996;1654-1660.
59. Hamaguchi H, Yamaguchi Y, Goto M, Misumi M, Hisama N, Miyanari N, et al. Hepatic biliary transport after hepatocyte transplantation in Eizai hyperbilirubinemic rats. Hepatology. 20:1994;220-224.