Survival and function of hepatocytes on a novel three-dimensional synthetic biodegradable polymer scaffold with an intrinsic network of channels

Annals of Surgery

Volumn 228, Issue 1, 1998, Pages 8-13

  Kim, Stephen S ^a,b   Utsunomiya, Hirofumi ^a   Koski, John A ^a   Wu, Benjamin M ^c   Cima, Michael J ^c   Sohn, Jane ^c   Mukai, Kanae ^c   Griffith, Linda G ^c   Vacanti, Joseph P ^a  

^a BOSTON CHILDREN S HOSPITAL   (United States)

^b UNIVERSITY OF CHICAGO MEDICAL CENTER   (United States)

^c USA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

COPOLYMER; POLYGLACTIN; POLYMER;

ANIMAL CELL; ARTICLE; BIODEGRADATION; BIOREACTOR; CELL SURVIVAL; CELL TRANSPLANTATION; CHRONIC LIVER DISEASE; ENZYME LINKED IMMUNOSORBENT ASSAY; FEMALE; HISTOLOGY; LIVER CELL; LIVER DISEASE; NONHUMAN; PRIORITY JOURNAL; RAT; SCANNING ELECTRON MICROSCOPY;

ANIMALS; BIODEGRADATION, ENVIRONMENTAL; CELL CULTURE TECHNIQUES; CELL SURVIVAL; CELL TRANSPLANTATION; EQUIPMENT DESIGN; IMPLANTS, EXPERIMENTAL; LIVER; LIVER, ARTIFICIAL; MALE; POLYMERS; RATS; RATS, INBRED LEW;

EID: 0032471714     PISSN: 00034932     EISSN: None     Source Type: Journal    
DOI: 10.1097/00000658-199807000-00002     Document Type: Article

References (23)

1. American Liver Foundation. Fact sheet: hepatitis, liver and gallbladder diseases in the United States. Cedar Grove, NJ: American Liver Foundation; 1996.
2. Russell PS. Selective transplantation. Ann Surg 1985; 201:255-262.
3. Vacanti JP. Beyond transplantation. Arch Surg 1988; 123:545-549.
4. Vacanti JP, Morse MA, Saltzman WM, et al. Selective cell transplantation using bioabsorbable artificial polymers as matrices. J Pediatr Surg 1988; 23:3-9.
5. Langer R, Vacanti JP. Tissue engineering. Science 1993; 260:920-926.
6. Mooney DJ, Kaufmann PM, McNamara KM, et al. Transplantation of hepatocytes using porous, biodegradable sponges. Transplant Proc 1994; 26:3425-3426.
7. Mooney DJ, Park S, Kaufmann PM, et al. Biodegradable sponges for hepatocyte transplantation. J Biomed Mater Res 1995; 29:959-965.
8. Sano K, Cusick RA, Lee H, et al. Regenerative signals for heterotopic hepatocyte transplantation. Transplant Proc 1996; 28:1859-1860.
9. Kaufmann PM, Sano K, Uyama S, et al. Heterotopic hepatocyte transplantation: assessing the impact of hepatotrophic stimulation. Transplant Proc 1994; 26:2240-2241.
10. Takeda T, Kim TH, Lee SK, et al. Hepatocyte transplantation in biodegradable polymer scaffolds using the Dalmatian dog model of hyperuricosuria. Transplant Proc 1995; 27:635-636.
11. Lee H, Cusick RA, Pollok JM, et al. Formation of hepatocyte spheroids on biodegradable polymers under continuous flow conditions. Tissue Eng (in press).
12. Wu BM, Borland SW, Giordano RA, et al. Solid free-form fabrication of drug delivery devices. J Controlled Release 1996; 40:77-87.
13. Sachs EM, Cima MJ, Bredt J, et al. CAD casting: direct fabrication of ceramic shells and cores by three-dimensional printing. Manuf Rev 1992; 5:117-126.
14. Sachs EM, Cima MJ, Williams P, et al. Three-dimensional printing: rapid tooling and prototypes directly from a CAD model. J Eng Ind 1992; 114:481-488.
15. Seglen PO. Preparation of isolated rat liver cells. Methods Cell Biol 1976; 13:29-83.
16. Aiken J. Cima L, Schloo B, et al. Studies in rat liver perfusion for optimal harvest of hepatocytes. J Pediatr Surg 1990; 25:140-145.
17. Yamamoto N, Imazato K, Masumoto A. Growth stimulation of adult rat hepatocytes in a primary culture by soluble factor(s) secreted from nonparenchymal liver cell. Cell Struct Funct 1989; 14:217-229.
18. Shimaoka S, Nakamura T, Ichihara A. Stimulation of growth of primary cultured adult rat hepatocytes without growth factors by coculture with nonparenchymal liver cells. Exp Cell Res 1987; 172: 228-242.
19. Cima LG, Wilke CR, Blanch HW. A theoretical and experimental evaluation of a novel radial-flow hollow fiber reactor for mammalian cell culture. Bioprocess Eng 1990; 5:19-30.
20. Landry J, Bernier D, Ouellet C, et al. Spheroidal aggregate of rat liver cells: histotypic reorganization, biomatrix deposition, and maintenance of functional activities. J Cell Biol 1985; 101:914-923.
21. Koide N, Shinji T, Tanabe T, et al. Continued high albumin production by multicellular spheroids of adult rat hepatocytes formed in the presence of liver-derived proteoglycans. Biochem Biophys Res Commun 1989; 161:385-391.
22. Tong JZ, De LP, Furlan BD, et al. Long-term culture of adult rat hepatocyte spheroids. Exp Cell Res 1992; 200:326-332.
23. Folkman J, Hochberg MM. Self-regulation of growth in three dimensions. J Exp Med 1973; 138:745-753.