New hepatocyte in vitro systems for drug metabolism: Metabolic capacity and recommendations for application in basic research and drug development, standard operation procedures

Drug Metabolism Reviews

Volumn 35, Issue 2-3, 2003, Pages 145-213

  Gebhardt, Rolf ^a   Hengstler, Jan G ^b   Müller, Dieter ^c   Glöckner, Reinhild ^c   Buenning, Peter ^d   Laube, Britta ^a   Schmelzer, Eva ^e   Ullrich, Martina ^a   Utesch, Dietmar ^f   Hewitt, Nicola ^f,h   Ringel, Michael ^g   Hilz, Beate Reder ^a   Bader, Augustinus ^e   Langsch, Angelika ^e   Koose, Thomas ^d   Burger, Hans Jörg ^d   Maas, Jochen ^d   Oesch, Franz ^g  

^a UNIVERSITY OF LEIPZIG   (Germany)

^b Institute of Legal Medicine   (Germany)

^c FRIEDRICH SCHILLER UNIVERSITY JENA   (Germany)

^d SANOFI AVENTIS DEUTSCHLAND GMBH   (Germany)

^e Institut für Bioanalytische Chemie   (Germany)

^f MERCK KGAA   (Germany)

^g JOHANNES GUTENBERG UNIVERSITY   (Germany)

^h In Vitro Technologies Inc   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

3 METHYLCHOLANTHRENE; 4 HYDROXYBIPHENYL; 4 NITROPHENOL; 5 [1 (3,4 DIMETHOXYBENZOYL) 1,2,3,4 TETRAHYDRO 6 QUINOLYL] 3,6 DIHYDRO 6 METHYL 2H 1,3,4 THIADIAZIN 2 ONE; 7 ETHOXYCOUMARIN; 7 ETHOXYCOUMARIN DEETHYLASE; AZO REDUCTASE; BETA GLUCOSIDASE; BETA GLUCURONIDASE; CIPROFIBRATE; DEXAMETHASONE; ETHOXYRESORUFIN DEETHYLASE; GLUCAGON; GLUTAMINE; HYMECROMONE; HYPERFORIN; HYPERICIN; HYPERICUM EXTRACT; INSULIN; MIDAZOLAM; NITROREDUCTASE; PANTOPRAZOLE; PENICILLIN DERIVATIVE; PHENOBARBITAL; PREDNISOLONE; PROPAFENONE; STREPTOMYCIN; SULFATASE; TOLBUTAMIDE; UNINDEXED DRUG;

AEROBIC METABOLISM; ANALYTIC METHOD; BIOREACTOR; CELL REGENERATION; CELL SUSPENSION; CELL TRANSPLANTATION; COCULTURE; CRYOPRESERVATION; CULTURE MEDIUM; DRUG METABOLISM; DRUG RESEARCH; ENZYME ACTIVITY; ENZYME INDUCTION; HUMAN; IN VITRO STUDY; INTESTINE FLORA; LIVER CELL; LIVER CELL CULTURE; LIVER METABOLISM; LIVER SLICE; LIVER TOXICITY; NONHUMAN; OXYGEN SUPPLY; REVIEW; THAWING; VALIDATION PROCESS; VIRUS HEPATITIS;

EID: 10744231826     PISSN: 03602532     EISSN: None     Source Type: Journal    
DOI: 10.1081/DMR-120023684     Document Type: Review

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