Development and evaluation of an experimental model for investigating the pathogenesis and therapeutic strategies of acute liver failure

Transplantation Proceedings

Volumn 35, Issue 8, 2003, Pages 3142-3146

  Skawran, S ^a   Palmes, D ^a   Budny, T ^a   Bahde, R ^a   Stratmann, U ^a   Spiegel, H U ^a  

^a UNIVERSITY HOSPITAL MÜNSTER   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

AMMONIA; BILIRUBIN; ENDOTHELIN A RECEPTOR ANTAGONIST; ENDOTOXIN;

AMMONIA BLOOD LEVEL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BILIRUBIN BLOOD LEVEL; CONTROLLED STUDY; DISEASE SEVERITY; EXPERIMENTAL MODEL; FEMALE; HISTOPATHOLOGY; LIVER CELL DAMAGE; LIVER FAILURE; LIVER LOBECTOMY; NONHUMAN; PRIORITY JOURNAL; RANDOMIZATION; RAT; SPECIES COMPARISON; SURVIVAL RATE; SURVIVAL TIME; TISSUE SECTION;

EID: 0345870001     PISSN: 00411345     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.transproceed.2003.10.022     Document Type: Article

References (24)

1. O'Grady J. Acute liver failure. J R Coll Physicians Lond. 31:1997;603.
2. Lee WM, Schiodt FV: Fulminant hepatic failure. In Schiff ER et al (eds): Schiff's Diseases of the Liver, 8th Ed. Philadelphia: Lippincott-Raven Publishers; 1999, p 879.
3. Fischer L., Sterneck M., Rogiers X. Liver transplantation for acute liver failure. Eur J Gastroenterol Hepatol. 11:1999;985.
4. Novelli G., Rossi M., Pretagostini R., et al. Use of MARS in the treatment of acute liver failure preliminary monocentric experience . Transplant Proc. 33:2001;1942.
5. Palmes D., Qayumi A.K., Spiegel H.U. Liver bridging techniques in the treatment of acute liver failure. J Invest Surg. 13:2000;299.
6. Secchi A., Ortanderl J.M., Schmidt W., et al. Effect of endotoxemia on hepatic portal and sinusoidal blood flow in rats. J Surg Res. 89:2000;26.
7. Bauer M., Marzi I., Thuma B., et al. Dose-related pattern of sinusoidal leukocyte adhesion in sublobular regions of the liver after systemic endotoxin challenge in the rat. Shock. 1:1994;135.
8. Rahmann T.M., Hodgson H.J. Animal models of acute hepatic failure. Int J Exp Pathol. 81:2000;145.
9. Yachida S., Kokudo Y., Wakabayashi H., et al. Morphological and functional alterations to sinusoidal endothelial cells in the early phase of endotoxin-induced liver failure after partial hepatectomy in rats. Virchows Arch. 433:1998;173.
10. Wang X.D., Soltesz V., Andersson R., et al. Bacterial translocation in acute liver failure induced by 90 percent hepatectomy in the rat. Br J Surg. 80:1993;66.
11. Boermeester M.A., Straatsburg I.H., Houdijk A.P., et al. Endotoxin and interleukin-1 related hepatic inflammatory response promotes liver failure after partial hepatectomy. Hepatology. 22:1995;1499.
12. Court F.G., Wemyss-Holden S.A., Dennison A.R., et al. The mystery of liver regeneration. Br J Surg. 89:2002;1089.
13. Andus T., Bauer J., Gerok W. Effects of cytokines on the liver. Hepatology. 13:1991;364.
14. Peltekian K.M., Levy G.A. Role of cytokines and immune mechanisms in acute liver failure. Lee W.M., Williams R. Acute Liver Failure. 1997;67 Cambridge University Press, Cambridge.
15. Essani N.A., Fisher M.A., Farhood A., et al. Cytokine-induced upregulation of hepatic intercellular adhesion molecule-1 messenger RNA expression and its role in the pathophysiology of murine endotoxin shock and acute liver failure. Hepatology. 21:1995;1632.
16. Schiodt F.V., Ott P., Bondesen S., et al. Reduced serum Gc-globulin concentrations in patients with fulminant hepatic failure association with multiple organ failure . Crit Care Med. 25:1997;1366.
17. Lee W.M., Galbraith R.M. The extracellular actin-scavenger system and actin toxicity. N Engl J Med. 14:1992;1335.
18. Thomas GR, Walder CE, Thiemermann C, et al: Regional vascular resistance and haemodynamics in the spontaneously hypertensive rat: the effects of bradykinin. J Cardiovasc Pharmacol 15:211, 1990.
19. Ishikawa Y., Asuwa N., Ishii T., et al. Collagen alteration in vascular remodeling by hemodynamic factors. Virchows Arch. 437:2000;138.
20. Ricciardi R., Foley D.P., Quarfordt S.H., et al. Hemodynamic and metabolic variables predict porcine ex vivo liver function. J Surg Res. 96:2001;114.
21. Hirata K., Ogata I., Ohta Y., et al. Hepatic sinusoidal cell destruction in the development of intravascular coagulation in acute liver failure of rats. J Pathol. 158:1989;157.
22. Tsukamoto I, Nakata R, Kojo S: Effect of endotoxin on rat liver regeneration after partial hepatectomy. Biochem Int 27: 1047, 1992.
23. Eakes A.T., Howard K.M., Miller J.E., et al. Endothelin-1 production by hepatic endothelial cells characterization and augmentation by endotoxin exposure . Am J Physiol. 272:1997;G605.
24. Chan C.C., Wang S.S., Lee F.Y., et al. Endothelin-1 induces vasoconstriction on portal-systemic collaterals of portal hypertensive rats. Hepatology. 33:2001;816.