메뉴 건너뛰기




Volumn 4, Issue 9, 2013, Pages 1507-1526

Selective anticancer agents suppress aging in Drosophila

Author keywords

Aging suppressive substances; Anticancer agents; Drosophila melanogaster; iNOS; Longevity; NF B; PI3K; Quality of life; TOR

Indexed keywords

ANTINEOPLASTIC AGENT; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INDUCIBLE NITRIC OXIDE SYNTHASE; N [3 (AMINOMETHYL)BENZYL]ACETAMIDINE; N4 [2 (4 PHENOXYPHENYL)ETHYL] 4,6 QUINAZOLINEDIAMINE; PHOSPHATIDYLINOSITOL 3 KINASE; PYRROLIDINE DITHIOCARBAMATE; RAPAMYCIN; TARGET OF RAPAMYCIN KINASE; UNCLASSIFIED DRUG; WORTMANNIN;

EID: 84884677201     PISSN: None     EISSN: 19492553     Source Type: Journal    
DOI: 10.18632/oncotarget.1272     Document Type: Article
Times cited : (38)

References (124)
  • 2
    • 10944235398 scopus 로고    scopus 로고
    • Large-scale identification in yeast of conserved ageing genes
    • Kaeberlein M and Kennedy BK. Large-scale identification in yeast of conserved ageing genes. Mech Ageing Dev. 2005; 126(1):17-21.
    • (2005) Mech Ageing Dev. , vol.126 , Issue.1 , pp. 17-21
    • Kaeberlein, M.1    Kennedy, B.K.2
  • 3
    • 16644365353 scopus 로고    scopus 로고
    • TOR pathway: linking nutrient sensing to life span
    • PE34
    • Kapahi P and Zid B. TOR pathway: linking nutrient sensing to life span. Sci Aging Knowledge Environ. 2004; 2004(36):PE34.
    • (2004) Sci Aging Knowledge Environ. , vol.2004 , Issue.36
    • Kapahi, P.1    Zid, B.2
  • 5
    • 0023831256 scopus 로고
    • A mutation in the age-1 gene in Caenorhabditis elegans lengthens life and reduces hermaphrodite fertility
    • Friedman DB and Johnson TE. A mutation in the age-1 gene in Caenorhabditis elegans lengthens life and reduces hermaphrodite fertility. Genetics. 1988; 118(1):75-86.
    • (1988) Genetics. , vol.118 , Issue.1 , pp. 75-86
    • Friedman, D.B.1    Johnson, T.E.2
  • 6
    • 0029834145 scopus 로고    scopus 로고
    • Changes associated with aging and replicative senescence in the regulation of transcription factor nuclear factor-κB
    • Helenius M, Hanninen M, Lehtinen SK and Salminen A. Changes associated with aging and replicative senescence in the regulation of transcription factor nuclear factor-κB. Biochem J. 1996; 318 ( Pt 2):603-608.
    • (1996) Biochem J. , vol.318 , Issue.PART 2 , pp. 603-608
    • Helenius, M.1    Hanninen, M.2    Lehtinen, S.K.3    Salminen, A.4
  • 7
    • 62349092245 scopus 로고    scopus 로고
    • Atypical pathways of NF-κB activation and aging
    • Kriete A and Mayo KL. Atypical pathways of NF-κB activation and aging. Exp Gerontol. 2009; 44(4):250-255.
    • (2009) Exp Gerontol. , vol.44 , Issue.4 , pp. 250-255
    • Kriete, A.1    Mayo, K.L.2
  • 9
    • 0031760291 scopus 로고    scopus 로고
    • Spontaneous expression of inducible nitric oxide synthase in the hypothalamus and other brain regions of aging rats
    • Vernet D, Bonavera JJ, Swerdloff RS, Gonzalez-Cadavid NF and Wang C. Spontaneous expression of inducible nitric oxide synthase in the hypothalamus and other brain regions of aging rats. Endocrinology. 1998; 139(7):3254-3261.
    • (1998) Endocrinology. , vol.139 , Issue.7 , pp. 3254-3261
    • Vernet, D.1    Bonavera, J.J.2    Swerdloff, R.S.3    Gonzalez-Cadavid, N.F.4    Wang, C.5
  • 10
    • 30944458446 scopus 로고    scopus 로고
    • Extension of chronological life span in yeast by decreased TOR pathway signaling
    • Powers RW, 3rd, Kaeberlein M, Caldwell SD, Kennedy BK and Fields S. Extension of chronological life span in yeast by decreased TOR pathway signaling. Genes Dev. 2006; 20(2):174-184.
    • (2006) Genes Dev. , vol.20 , Issue.2 , pp. 174-184
    • Powers 3rd, R.W.1    Kaeberlein, M.2    Caldwell, S.D.3    Kennedy, B.K.4    Fields, S.5
  • 11
  • 12
    • 77952380764 scopus 로고    scopus 로고
    • Pharmacological inhibition of phosphoinositide 3 and TOR kinases improves survival of Drosophila melanogaster
    • Moskalev AA and Shaposhnikov MV. Pharmacological inhibition of phosphoinositide 3 and TOR kinases improves survival of Drosophila melanogaster. Rejuvenation Res. 2010; 13(2-3):246-247.
    • (2010) Rejuvenation Res. , vol.13 , Issue.2-3 , pp. 246-247
    • Moskalev, A.A.1    Shaposhnikov, M.V.2
  • 21
    • 66449099096 scopus 로고    scopus 로고
    • Longevity extension by specific inhibition of pI3K in Drosophila melanogaster
    • Moskalev AA and Shaposhnikov MV. [Longevity extension by specific inhibition of pI3K in Drosophila melanogaster]. Adv Gerontol. 2008; 21(4):602-606.
    • (2008) Adv Gerontol. , vol.21 , Issue.4 , pp. 602-606
    • Moskalev, A.A.1    Shaposhnikov, M.V.2
  • 22
    • 80052102573 scopus 로고    scopus 로고
    • Pharmacological inhibition of NF-κB prolongs lifespan of Drosophila melanogaster
    • Moskalev A and Shaposhnikov M. Pharmacological inhibition of NF-κB prolongs lifespan of Drosophila melanogaster. Aging (Albany NY). 2011; 3(4):391-394.
    • (2011) Aging (Albany NY). , vol.3 , Issue.4 , pp. 391-394
    • Moskalev, A.1    Shaposhnikov, M.2
  • 23
    • 20344407841 scopus 로고    scopus 로고
    • Resveratrol as an anti-inflammatory and anti-aging agent: mechanisms and clinical implications
    • de la Lastra CA and Villegas I. Resveratrol as an anti-inflammatory and anti-aging agent: mechanisms and clinical implications. Mol Nutr Food Res. 2005; 49(5):405-430.
    • (2005) Mol Nutr Food Res. , vol.49 , Issue.5 , pp. 405-430
    • de la Lastra, C.A.1    Villegas, I.2
  • 24
    • 4344683203 scopus 로고    scopus 로고
    • Sex-specific effects of interventions that extend fly life span
    • pe30
    • Burger JM and Promislow DE. Sex-specific effects of interventions that extend fly life span. Sci Aging Knowl Environ. 2004; 2004(28):pe30.
    • (2004) Sci Aging Knowl Environ. , vol.2004 , Issue.28
    • Burger, J.M.1    Promislow, D.E.2
  • 26
    • 33750029285 scopus 로고    scopus 로고
    • Aging and immortality: quasi-programmed senescence and its pharmacologic inhibition
    • Blagosklonny MV. Aging and immortality: quasi-programmed senescence and its pharmacologic inhibition. Cell Cycle. 2006; 5(18):2087-2102.
    • (2006) Cell Cycle. , vol.5 , Issue.18 , pp. 2087-2102
    • Blagosklonny, M.V.1
  • 27
    • 84877734347 scopus 로고    scopus 로고
    • Hypothalamic programming of systemic ageing involving IKK-β, NF-κB and GnRH
    • Zhang G, Li J, Purkayastha S, Tang Y, Zhang H, Yin Y, Li B, Liu G and Cai D. Hypothalamic programming of systemic ageing involving IKK-β, NF-κB and GnRH. Nature. 2013; 497(7448):211-216.
    • (2013) Nature. , vol.497 , Issue.7448 , pp. 211-216
    • Zhang, G.1    Li, J.2    Purkayastha, S.3    Tang, Y.4    Zhang, H.5    Yin, Y.6    Li, B.7    Liu, G.8    Cai, D.9
  • 28
    • 80052493603 scopus 로고    scopus 로고
    • A genetic analysis of nitric oxide-mediated signaling during chronological aging in the yeast
    • Lewinska A, Macierzynska E, Grzelak A and Bartosz G. A genetic analysis of nitric oxide-mediated signaling during chronological aging in the yeast. Biogerontology. 2011; 12(4):309-320.
    • (2011) Biogerontology. , vol.12 , Issue.4 , pp. 309-320
    • Lewinska, A.1    Macierzynska, E.2    Grzelak, A.3    Bartosz, G.4
  • 31
    • 24044551995 scopus 로고    scopus 로고
    • PI3K/Akt/mTOR pathway as a target for cancer therapy
    • Morgensztern D and McLeod HL. PI3K/Akt/mTOR pathway as a target for cancer therapy. Anticancer Drugs. 2005; 16(8):797-803.
    • (2005) Anticancer Drugs. , vol.16 , Issue.8 , pp. 797-803
    • Morgensztern, D.1    McLeod, H.L.2
  • 33
    • 84859876030 scopus 로고    scopus 로고
    • Will PI3K pathway inhibitors be effective as single agents in patients with cancer?
    • Garrett JT, Chakrabarty A and Arteaga CL. Will PI3K pathway inhibitors be effective as single agents in patients with cancer? Oncotarget. 2011; 2(12):1314-1321.
    • (2011) Oncotarget. , vol.2 , Issue.12 , pp. 1314-1321
    • Garrett, J.T.1    Chakrabarty, A.2    Arteaga, C.L.3
  • 34
    • 33645999706 scopus 로고    scopus 로고
    • NF-κB and IKK as therapeutic targets in cancer
    • Kim HJ, Hawke N and Baldwin AS. NF-κB and IKK as therapeutic targets in cancer. Cell Death Differ. 2006; 13(5):738-747.
    • (2006) Cell Death Differ. , vol.13 , Issue.5 , pp. 738-747
    • Kim, H.J.1    Hawke, N.2    Baldwin, A.S.3
  • 35
    • 84870426866 scopus 로고    scopus 로고
    • iNOS-selective inhibitors for cancer prevention: promise and progress
    • Janakiram NB and Rao CV. iNOS-selective inhibitors for cancer prevention: promise and progress. Future medicinal chemistry. 2012; 4(17):2193-2204.
    • (2012) Future medicinal chemistry. , vol.4 , Issue.17 , pp. 2193-2204
    • Janakiram, N.B.1    Rao, C.V.2
  • 36
    • 84873633910 scopus 로고    scopus 로고
    • Genetics of longevity in model organisms: debates and paradigm shifts
    • Gems D and Partridge L. Genetics of longevity in model organisms: debates and paradigm shifts. Annu Rev Physiol. 2013; 75:621-644.
    • (2013) Annu Rev Physiol. , vol.75 , pp. 621-644
    • Gems, D.1    Partridge, L.2
  • 37
    • 84869778322 scopus 로고    scopus 로고
    • Cancer resistance in the blind mole rat is mediated by concerted necrotic cell death mechanism
    • Gorbunova V, Hine C, Tian X, Ablaeva J, Gudkov AV, Nevo E and Seluanov A. Cancer resistance in the blind mole rat is mediated by concerted necrotic cell death mechanism. Proc Natl Acad Sci USA. 2012; 109(47):19392-19396.
    • (2012) Proc Natl Acad Sci USA. , vol.109 , Issue.47 , pp. 19392-19396
    • Gorbunova, V.1    Hine, C.2    Tian, X.3    Ablaeva, J.4    Gudkov, A.V.5    Nevo, E.6    Seluanov, A.7
  • 44
    • 0033602383 scopus 로고    scopus 로고
    • Regulation of dauer larva development in Caenorhabditis elegans by daf-18, a homologue of the tumour suppressor PTEN
    • Rouault JP, Kuwabara PE, Sinilnikova OM, Duret L, Thierry-Mieg D and Billaud M. Regulation of dauer larva development in Caenorhabditis elegans by daf-18, a homologue of the tumour suppressor PTEN. Curr Biol. 1999; 9(6):329-332.
    • (1999) Curr Biol. , vol.9 , Issue.6 , pp. 329-332
    • Rouault, J.P.1    Kuwabara, P.E.2    Sinilnikova, O.M.3    Duret, L.4    Thierry-Mieg, D.5    Billaud, M.6
  • 45
    • 80053007221 scopus 로고    scopus 로고
    • The Regulation of Aging and Longevity: A New and Complex Role of p53
    • Feng Z, Lin M and Wu R. The Regulation of Aging and Longevity: A New and Complex Role of p53. Genes Cancer. 2011; 2(4):443-452.
    • (2011) Genes Cancer. , vol.2 , Issue.4 , pp. 443-452
    • Feng, Z.1    Lin, M.2    Wu, R.3
  • 46
    • 0035793086 scopus 로고    scopus 로고
    • A role of the kinase mTOR in cellular transformation induced by the oncoproteins P3k and Akt
    • Aoki M, Blazek E and Vogt PK. A role of the kinase mTOR in cellular transformation induced by the oncoproteins P3k and Akt. Proc Natl Acad Sci USA. 2001; 98(1):136-141.
    • (2001) Proc Natl Acad Sci USA. , vol.98 , Issue.1 , pp. 136-141
    • Aoki, M.1    Blazek, E.2    Vogt, P.K.3
  • 49
    • 77957743058 scopus 로고    scopus 로고
    • Drosophila melanogaster as a model system for the evaluation of anti-aging compounds
    • Jafari M. Drosophila melanogaster as a model system for the evaluation of anti-aging compounds. Fly (Austin). 2010; 4(3).
    • (2010) Fly (Austin) , vol.4 , Issue.3
    • Jafari, M.1
  • 50
    • 84875910045 scopus 로고    scopus 로고
    • Pharmacological lifespan extension of invertebrates
    • Lucanic M, Lithgow GJ and Alavez S. Pharmacological lifespan extension of invertebrates. Ageing Res Rev. 2013; 12(1):445-458.
    • (2013) Ageing Res Rev. , vol.12 , Issue.1 , pp. 445-458
    • Lucanic, M.1    Lithgow, G.J.2    Alavez, S.3
  • 51
    • 84857389789 scopus 로고    scopus 로고
    • Novel protein kinase signaling systems regulating lifespan identified by small molecule library screening using Drosophila
    • Spindler SR, Li R, Dhahbi JM, Yamakawa A and Sauer F. Novel protein kinase signaling systems regulating lifespan identified by small molecule library screening using Drosophila. PLoS ONE. 2012; 7(2):e29782.
    • (2012) PLoS ONE. , vol.7 , Issue.2
    • Spindler, S.R.1    Li, R.2    Dhahbi, J.M.3    Yamakawa, A.4    Sauer, F.5
  • 52
    • 38349093613 scopus 로고    scopus 로고
    • Remarkable longevity and stress resistance of nematode PI3K-null mutants
    • Ayyadevara S, Alla R, Thaden JJ and Shmookler Reis RJ. Remarkable longevity and stress resistance of nematode PI3K-null mutants. Aging Cell. 2008; 7(1):13-22.
    • (2008) Aging Cell. , vol.7 , Issue.1 , pp. 13-22
    • Ayyadevara, S.1    Alla, R.2    Thaden, J.J.3    Shmookler Reis, R.J.4
  • 53
    • 0034312279 scopus 로고    scopus 로고
    • Genetic and biochemical characterization of dTOR, the Drosophila homolog of the target of rapamycin
    • Oldham S, Montagne J, Radimerski T, Thomas G and Hafen E. Genetic and biochemical characterization of dTOR, the Drosophila homolog of the target of rapamycin. Genes Dev. 2000; 14(21):2689-2694.
    • (2000) Genes Dev. , vol.14 , Issue.21 , pp. 2689-2694
    • Oldham, S.1    Montagne, J.2    Radimerski, T.3    Thomas, G.4    Hafen, E.5
  • 54
    • 0029612196 scopus 로고
    • A family of phosphoinositide 3-kinases in Drosophila identifies a new mediator of signal transduction
    • MacDougall LK, Domin J and Waterfield MD. A family of phosphoinositide 3-kinases in Drosophila identifies a new mediator of signal transduction. Curr Biol. 1995; 5(12):1404-1415.
    • (1995) Curr Biol. , vol.5 , Issue.12 , pp. 1404-1415
    • MacDougall, L.K.1    Domin, J.2    Waterfield, M.D.3
  • 55
    • 0029840669 scopus 로고    scopus 로고
    • Origins of immunity: Relish, a compound Rel-like gene in the antibacterial defense of Drosophila
    • Dushay MS, Asling B and Hultmark D. Origins of immunity: Relish, a compound Rel-like gene in the antibacterial defense of Drosophila. Proc Natl Acad Sci USA. 1996; 93(19):10343-10347.
    • (1996) Proc Natl Acad Sci USA. , vol.93 , Issue.19 , pp. 10343-10347
    • Dushay, M.S.1    Asling, B.2    Hultmark, D.3
  • 56
    • 0026784680 scopus 로고
    • Selective nuclear transport of the Drosophila morphogen dorsal can be established by a signaling pathway involving the transmembrane protein Toll and protein kinase A
    • Norris JL and Manley JL. Selective nuclear transport of the Drosophila morphogen dorsal can be established by a signaling pathway involving the transmembrane protein Toll and protein kinase A. Genes Dev. 1992; 6(9):1654-1667.
    • (1992) Genes Dev. , vol.6 , Issue.9 , pp. 1654-1667
    • Norris, J.L.1    Manley, J.L.2
  • 57
    • 0035834703 scopus 로고    scopus 로고
    • The Drosophila nitric-oxide synthase gene (dNOS) encodes a family of proteins that can modulate NOS activity by acting as dominant negative regulators
    • Stasiv Y, Regulski M, Kuzin B, Tully T and Enikolopov G. The Drosophila nitric-oxide synthase gene (dNOS) encodes a family of proteins that can modulate NOS activity by acting as dominant negative regulators. J Biol Chem. 2001; 276(45):42241-42251.
    • (2001) J Biol Chem. , vol.276 , Issue.45 , pp. 42241-42251
    • Stasiv, Y.1    Regulski, M.2    Kuzin, B.3    Tully, T.4    Enikolopov, G.5
  • 58
    • 69449106873 scopus 로고    scopus 로고
    • Autophagy is required for extension of yeast chronological life span by rapamycin
    • Alvers AL, Wood MS, Hu D, Kaywell AC, Dunn WA, Jr. and Aris JP. Autophagy is required for extension of yeast chronological life span by rapamycin. Autophagy. 2009; 5(6):847-849.
    • (2009) Autophagy. , vol.5 , Issue.6 , pp. 847-849
    • Alvers, A.L.1    Wood, M.S.2    Hu, D.3    Kaywell, A.C.4    Dunn Jr., W.A.5    Aris, J.P.6
  • 61
    • 24144460622 scopus 로고    scopus 로고
    • Insulin-like growth factor signaling pathway involved in regulating longevity of rotifers
    • Yoshinaga T, Kaneko G, Kinoshita S, Furukawa S, Tsukamoto K and Watabe S. (2005). Insulin-like growth factor signaling pathway involved in regulating longevity of rotifers. Rotifera X, pp. 347-352.
    • (2005) Rotifera X , pp. 347-352
    • Yoshinaga, T.1    Kaneko, G.2    Kinoshita, S.3    Furukawa, S.4    Tsukamoto, K.5    Watabe, S.6
  • 63
    • 0033592288 scopus 로고    scopus 로고
    • Inhibition of NF-κB activation by pyrrolidine dithiocarbamate prevents In vivo expression of proinflammatory genes
    • Liu SF, Ye X and Malik AB. Inhibition of NF-κB activation by pyrrolidine dithiocarbamate prevents In vivo expression of proinflammatory genes. Circulation. 1999; 100(12):1330-1337.
    • (1999) Circulation. , vol.100 , Issue.12 , pp. 1330-1337
    • Liu, S.F.1    Ye, X.2    Malik, A.B.3
  • 64
    • 0026590541 scopus 로고
    • Dithiocarbamates as potent inhibitors of nuclear factor kappa B activation in intact cells
    • Schreck R, Meier B, Mannel DN, Droge W and Baeuerle PA. Dithiocarbamates as potent inhibitors of nuclear factor kappa B activation in intact cells. J Exp Med. 1992; 175(5):1181-1194.
    • (1992) J Exp Med. , vol.175 , Issue.5 , pp. 1181-1194
    • Schreck, R.1    Meier, B.2    Mannel, D.N.3    Droge, W.4    Baeuerle, P.A.5
  • 65
    • 0037295377 scopus 로고    scopus 로고
    • Discovery of quinazolines as a novel structural class of potent inhibitors of NF-kappa B activation
    • Tobe M, Isobe Y, Tomizawa H, Nagasaki T, Takahashi H, Fukazawa T and Hayashi H. Discovery of quinazolines as a novel structural class of potent inhibitors of NF-kappa B activation. Bioorg Med Chem. 2003; 11(3):383-391.
    • (2003) Bioorg Med Chem. , vol.11 , Issue.3 , pp. 383-391
    • Tobe, M.1    Isobe, Y.2    Tomizawa, H.3    Nagasaki, T.4    Takahashi, H.5    Fukazawa, T.6    Hayashi, H.7
  • 66
    • 56849125235 scopus 로고    scopus 로고
    • Aging is associated with greater nuclear NFκB, reduced IκBα, and increased expression of proinflammatory cytokines in vascular endothelial cells of healthy humans
    • Donato AJ, Black AD, Jablonski KL, Gano LB and Seals DR. Aging is associated with greater nuclear NFκB, reduced IκBα, and increased expression of proinflammatory cytokines in vascular endothelial cells of healthy humans. Aging Cell. 2008; 7(6):805-812.
    • (2008) Aging Cell. , vol.7 , Issue.6 , pp. 805-812
    • Donato, A.J.1    Black, A.D.2    Jablonski, K.L.3    Gano, L.B.4    Seals, D.R.5
  • 70
    • 37249009271 scopus 로고    scopus 로고
    • Motif module map reveals enforcement of aging by continual NF-κB activity
    • Adler AS, Sinha S, Kawahara TL, Zhang JY, Segal E and Chang HY. Motif module map reveals enforcement of aging by continual NF-κB activity. Genes Dev. 2007; 21(24):3244-3257.
    • (2007) Genes Dev. , vol.21 , Issue.24 , pp. 3244-3257
    • Adler, A.S.1    Sinha, S.2    Kawahara, T.L.3    Zhang, J.Y.4    Segal, E.5    Chang, H.Y.6
  • 71
    • 67949099105 scopus 로고    scopus 로고
    • Insights into physiology of aging and novel ways to increase lifespan
    • Libert S. Insights into physiology of aging and novel ways to increase lifespan. Fly. 2007; 1(2):113-115.
    • (2007) Fly. , vol.1 , Issue.2 , pp. 113-115
    • Libert, S.1
  • 74
    • 84877348381 scopus 로고    scopus 로고
    • Dnr1 mutations cause neurodegeneration in Drosophila by activating the innate immune response in the brain
    • Cao Y, Chtarbanova S, Petersen AJ and Ganetzky B. Dnr1 mutations cause neurodegeneration in Drosophila by activating the innate immune response in the brain. Proc Natl Acad Sci USA. 2013; 110(19):E1752-1760.
    • (2013) Proc Natl Acad Sci USA. , vol.110 , Issue.19
    • Cao, Y.1    Chtarbanova, S.2    Petersen, A.J.3    Ganetzky, B.4
  • 78
    • 70049083635 scopus 로고    scopus 로고
    • Protein S-nitrosylation in health and disease: a current perspective
    • Foster MW, Hess DT and Stamler JS. Protein S-nitrosylation in health and disease: a current perspective. Trends Mol Med. 2009; 15(9):391-404.
    • (2009) Trends Mol Med. , vol.15 , Issue.9 , pp. 391-404
    • Foster, M.W.1    Hess, D.T.2    Stamler, J.S.3
  • 80
    • 84860441601 scopus 로고    scopus 로고
    • Regulation of DNA repair by S-nitrosylation
    • Tang CH, Wei W and Liu L. Regulation of DNA repair by S-nitrosylation. Biochim Biophys Acta. 2012; 1820(6):730-735.
    • (2012) Biochim Biophys Acta. , vol.1820 , Issue.6 , pp. 730-735
    • Tang, C.H.1    Wei, W.2    Liu, L.3
  • 83
    • 43949092458 scopus 로고    scopus 로고
    • Sexual selection, sexual conflict and the evolution of ageing and life span
    • Bonduriansky R, Maklakov A, Zajitschek F and Brooks R. Sexual selection, sexual conflict and the evolution of ageing and life span. Funct Ecol. 2008; 22(3):443-453.
    • (2008) Funct Ecol. , vol.22 , Issue.3 , pp. 443-453
    • Bonduriansky, R.1    Maklakov, A.2    Zajitschek, F.3    Brooks, R.4
  • 84
    • 79954571967 scopus 로고    scopus 로고
    • Amyloid-binding compounds maintain protein homeostasis during ageing and extend lifespan
    • Alavez S, Vantipalli MC, Zucker DJ, Klang IM and Lithgow GJ. Amyloid-binding compounds maintain protein homeostasis during ageing and extend lifespan. Nature. 2011; 472(7342):226-229.
    • (2011) Nature. , vol.472 , Issue.7342 , pp. 226-229
    • Alavez, S.1    Vantipalli, M.C.2    Zucker, D.J.3    Klang, I.M.4    Lithgow, G.J.5
  • 85
    • 77956919284 scopus 로고    scopus 로고
    • The ERK-MAPK pathway regulates longevity through SKN-1 and insulin-like signaling in Caenorhabditis elegans
    • Okuyama T, Inoue H, Ookuma S, Satoh T, Kano K, Honjoh S, Hisamoto N, Matsumoto K and Nishida E. The ERK-MAPK pathway regulates longevity through SKN-1 and insulin-like signaling in Caenorhabditis elegans. J Biol Chem. 2010; 285(39):30274-30281.
    • (2010) J Biol Chem. , vol.285 , Issue.39 , pp. 30274-30281
    • Okuyama, T.1    Inoue, H.2    Ookuma, S.3    Satoh, T.4    Kano, K.5    Honjoh, S.6    Hisamoto, N.7    Matsumoto, K.8    Nishida, E.9
  • 87
    • 34248583886 scopus 로고    scopus 로고
    • MAP kinase signalling pathways in cancer
    • Dhillon AS, Hagan S, Rath O and Kolch W. MAP kinase signalling pathways in cancer. Oncogene. 2007; 26(22):3279-3290.
    • (2007) Oncogene. , vol.26 , Issue.22 , pp. 3279-3290
    • Dhillon, A.S.1    Hagan, S.2    Rath, O.3    Kolch, W.4
  • 88
    • 67749122122 scopus 로고    scopus 로고
    • Targeting PI3K signalling in cancer: opportunities, challenges and limitations
    • Engelman JA. Targeting PI3K signalling in cancer: opportunities, challenges and limitations. Nat Rev Cancer. 2009; 9(8):550-562.
    • (2009) Nat Rev Cancer. , vol.9 , Issue.8 , pp. 550-562
    • Engelman, J.A.1
  • 89
    • 77953642042 scopus 로고    scopus 로고
    • Circadian disruption induced by light-at-night accelerates aging and promotes tumorigenesis in rats
    • Vinogradova IA, Anisimov VN, Bukalev AV, Semenchenko AV and Zabezhinski MA. Circadian disruption induced by light-at-night accelerates aging and promotes tumorigenesis in rats. AGING. 2009; 1(10):855-865.
    • (2009) AGING. , vol.1 , Issue.10 , pp. 855-865
    • Vinogradova, I.A.1    Anisimov, V.N.2    Bukalev, A.V.3    Semenchenko, A.V.4    Zabezhinski, M.A.5
  • 90
    • 78049451932 scopus 로고    scopus 로고
    • The Hippo signaling pathway restricts the oncogenic potential of an intestinal regeneration program
    • Cai J, Zhang N, Zheng Y, de Wilde RF, Maitra A and Pan D. The Hippo signaling pathway restricts the oncogenic potential of an intestinal regeneration program. Genes Dev. 2010; 24(21):2383-2388.
    • (2010) Genes Dev. , vol.24 , Issue.21 , pp. 2383-2388
    • Cai, J.1    Zhang, N.2    Zheng, Y.3    de Wilde, R.F.4    Maitra, A.5    Pan, D.6
  • 91
    • 43049168216 scopus 로고    scopus 로고
    • Aging of signal transduction pathways, and pathology
    • Carlson ME, Silva HS and Conboy IM. Aging of signal transduction pathways, and pathology. Exp Cell Res. 2008; 314(9):1951-1961.
    • (2008) Exp Cell Res. , vol.314 , Issue.9 , pp. 1951-1961
    • Carlson, M.E.1    Silva, H.S.2    Conboy, I.M.3
  • 92
    • 0031812234 scopus 로고    scopus 로고
    • Ornithine decarboxylase in human brain: influence of aging, regional distribution, and Alzheimer's disease
    • Morrison LD, Cao XC and Kish SJ. Ornithine decarboxylase in human brain: influence of aging, regional distribution, and Alzheimer's disease. J Neurochem. 1998; 71(1):288-294.
    • (1998) J Neurochem. , vol.71 , Issue.1 , pp. 288-294
    • Morrison, L.D.1    Cao, X.C.2    Kish, S.J.3
  • 95
    • 33646482549 scopus 로고    scopus 로고
    • Diapause-associated metabolic traits reiterated in long-lived daf-2 mutants in the nematode Caenorhabditis elegans
    • McElwee JJ, Schuster E, Blanc E, Thornton J and Gems D. Diapause-associated metabolic traits reiterated in long-lived daf-2 mutants in the nematode Caenorhabditis elegans. Mech Ageing Dev. 2006; 127(5):458-472.
    • (2006) Mech Ageing Dev. , vol.127 , Issue.5 , pp. 458-472
    • McElwee, J.J.1    Schuster, E.2    Blanc, E.3    Thornton, J.4    Gems, D.5
  • 96
    • 0028803718 scopus 로고
    • The gerontogenes age-1 and daf-2 determine metabolic rate potential in aging Caenorhabditis elegans
    • Vanfleteren JR and De Vreese A. The gerontogenes age-1 and daf-2 determine metabolic rate potential in aging Caenorhabditis elegans. FASEB J. 1995; 9(13):1355-1361.
    • (1995) FASEB J. , vol.9 , Issue.13 , pp. 1355-1361
    • Vanfleteren, J.R.1    De Vreese, A.2
  • 97
    • 0142155089 scopus 로고    scopus 로고
    • Aging-related changes in myocardial purine metabolism and ischemic tolerance
    • Willems L, Garnham B and Headrick JP. Aging-related changes in myocardial purine metabolism and ischemic tolerance. Exp Gerontol. 2003; 38(10):1169-1177.
    • (2003) Exp Gerontol. , vol.38 , Issue.10 , pp. 1169-1177
    • Willems, L.1    Garnham, B.2    Headrick, J.P.3
  • 99
    • 79952269372 scopus 로고    scopus 로고
    • DNA damaging agents and p53 do not cause senescence in quiescent cells, while consecutive re-activation of mTOR is associated with conversion to senescence
    • Leontieva OV and Blagosklonny MV. DNA damaging agents and p53 do not cause senescence in quiescent cells, while consecutive re-activation of mTOR is associated with conversion to senescence. Aging (Albany NY). 2010; 2(12):924-935.
    • (2010) Aging (Albany NY). , vol.2 , Issue.12 , pp. 924-935
    • Leontieva, O.V.1    Blagosklonny, M.V.2
  • 101
    • 79958084497 scopus 로고    scopus 로고
    • Increase of Drosophila melanogaster lifespan due to D-GADD45 overexpression in the nervous system
    • Plyusnina EN, Shaposhnikov MV and Moskalev AA. Increase of Drosophila melanogaster lifespan due to D-GADD45 overexpression in the nervous system. Biogerontology. 2011; 12(3):211-226.
    • (2011) Biogerontology. , vol.12 , Issue.3 , pp. 211-226
    • Plyusnina, E.N.1    Shaposhnikov, M.V.2    Moskalev, A.A.3
  • 102
    • 0037484558 scopus 로고    scopus 로고
    • Isolation and characterization of fourteen novel putative and nine known target genes of the p53 family
    • Chen X, Liu G, Zhu J, Jiang J, Nozell S and Willis A. Isolation and characterization of fourteen novel putative and nine known target genes of the p53 family. Cancer Biol Ther. 2003; 2(1):55-62.
    • (2003) Cancer Biol Ther. , vol.2 , Issue.1 , pp. 55-62
    • Chen, X.1    Liu, G.2    Zhu, J.3    Jiang, J.4    Nozell, S.5    Willis, A.6
  • 103
    • 34247103512 scopus 로고    scopus 로고
    • Hormetic modulation of aging and longevity by mild heat stress
    • Rattan SI. Hormetic modulation of aging and longevity by mild heat stress. Dose Response. 2005; 3(4):533-546.
    • (2005) Dose Response. , vol.3 , Issue.4 , pp. 533-546
    • Rattan, S.I.1
  • 104
    • 34548458640 scopus 로고    scopus 로고
    • Radiation-induced life span alteration of Drosophila lines with genotype differences
    • Moskalev A. Radiation-induced life span alteration of Drosophila lines with genotype differences. Biogerontology. 2007; 8(5):499-504.
    • (2007) Biogerontology. , vol.8 , Issue.5 , pp. 499-504
    • Moskalev, A.1
  • 105
    • 79958152231 scopus 로고    scopus 로고
    • Radiation hormesis and radioadaptive response in Drosophila melanogaster flies with different genetic backgrounds: the role of cellular stress-resistance mechanisms
    • Moskalev AA, Plyusnina EN and Shaposhnikov MV. Radiation hormesis and radioadaptive response in Drosophila melanogaster flies with different genetic backgrounds: the role of cellular stress-resistance mechanisms. Biogerontology. 2011; 12(3):253-263.
    • (2011) Biogerontology. , vol.12 , Issue.3 , pp. 253-263
    • Moskalev, A.A.1    Plyusnina, E.N.2    Shaposhnikov, M.V.3
  • 106
    • 58149295809 scopus 로고    scopus 로고
    • Life span alteration after irradiation in Drosophila melanogaster strains with mutations of Hsf and Hsps
    • Moskalev A, Shaposhnikov M and Turysheva E. Life span alteration after irradiation in Drosophila melanogaster strains with mutations of Hsf and Hsps. Biogerontology. 2009; 10(1):3-11.
    • (2009) Biogerontology. , vol.10 , Issue.1 , pp. 3-11
    • Moskalev, A.1    Shaposhnikov, M.2    Turysheva, E.3
  • 107
    • 83755206847 scopus 로고    scopus 로고
    • Hormesis does not make sense except in the light of TOR-driven aging
    • Blagosklonny MV. Hormesis does not make sense except in the light of TOR-driven aging. Aging (Albany NY). 2011; 3(11):1051-1062.
    • (2011) Aging (Albany NY). , vol.3 , Issue.11 , pp. 1051-1062
    • Blagosklonny, M.V.1
  • 108
    • 77953091045 scopus 로고    scopus 로고
    • Structure of the Human mTOR Complex I and Its Implications for Rapamycin Inhibition
    • Yip CK, Murata K, Walz T, Sabatini DM and Kang SA. Structure of the Human mTOR Complex I and Its Implications for Rapamycin Inhibition. Mol Cell. 2010; 38(5):768-774.
    • (2010) Mol Cell. , vol.38 , Issue.5 , pp. 768-774
    • Yip, C.K.1    Murata, K.2    Walz, T.3    Sabatini, D.M.4    Kang, S.A.5
  • 110
    • 0031040613 scopus 로고    scopus 로고
    • 1400W is a slow, tight binding, and highly selective inhibitor of inducible nitric-oxide synthase in vitro and in vivo
    • Garvey EP, Oplinger JA, Furfine ES, Kiff RJ, Laszlo F, Whittle BJ and Knowles RG. 1400W is a slow, tight binding, and highly selective inhibitor of inducible nitric-oxide synthase in vitro and in vivo. J Biol Chem. 1997; 272(8):4959-4963.
    • (1997) J Biol Chem. , vol.272 , Issue.8 , pp. 4959-4963
    • Garvey, E.P.1    Oplinger, J.A.2    Furfine, E.S.3    Kiff, R.J.4    Laszlo, F.5    Whittle, B.J.6    Knowles, R.G.7
  • 111
    • 84884690601 scopus 로고
    • Nonparametric Estimation from Incomplete Observations
    • Kotz S and Johnson N, eds. Springer New York
    • Kaplan EL and Meier P. (1992). Nonparametric Estimation from Incomplete Observations. In: Kotz S and Johnson N, eds. Breakthroughs in Statistics: Springer New York), pp. 319-337.
    • (1992) Breakthroughs in Statistics , pp. 319-337
    • Kaplan, E.L.1    Meier, P.2
  • 112
    • 0000656617 scopus 로고
    • Modified Kolmogorov-Smirnov test procedures with application to arbitrarily right-censored data
    • Fleming TR, O'Fallon JR, O'Brien PC and Harrington DP. Modified Kolmogorov-Smirnov test procedures with application to arbitrarily right-censored data. Biometrics. 1980; 36(4):607-625.
    • (1980) Biometrics. , vol.36 , Issue.4 , pp. 607-625
    • Fleming, T.R.1    O'Fallon, J.R.2    O'Brien, P.C.3    Harrington, D.P.4
  • 113
    • 77956891394 scopus 로고
    • A generalized Kruskal-Wallis test for comparing K samples subject to unequal patterns of censorship
    • Breslow N. A generalized Kruskal-Wallis test for comparing K samples subject to unequal patterns of censorship. Biometrika. 1970; 57(3):579-594.
    • (1970) Biometrika. , vol.57 , Issue.3 , pp. 579-594
    • Breslow, N.1
  • 114
    • 0013886333 scopus 로고
    • Evaluation of survival data and two new rank order statistics arising in its consideration
    • Mantel N. Evaluation of survival data and two new rank order statistics arising in its consideration. Cancer Chemother Rep. 1966; 50(3):163-170.
    • (1966) Cancer Chemother Rep. , vol.50 , Issue.3 , pp. 163-170
    • Mantel, N.1
  • 115
    • 5644262798 scopus 로고    scopus 로고
    • Statistical methods for testing effects on "maximum lifespan"
    • Wang C, Li Q, Redden DT, Weindruch R and Allison DB. Statistical methods for testing effects on "maximum lifespan". Mech Ageing Dev. 2004; 125(9):629-632.
    • (2004) Mech Ageing Dev. , vol.125 , Issue.9 , pp. 629-632
    • Wang, C.1    Li, Q.2    Redden, D.T.3    Weindruch, R.4    Allison, D.B.5
  • 116
    • 84870339889 scopus 로고    scopus 로고
    • Low doses of paraquat and polyphenols prolong life span and locomotor activity in knock-down parkin Drosophila melanogaster exposed to oxidative stress stimuli: implication in autosomal recessive juvenile Parkinsonism
    • Bonilla-Ramirez L, Jimenez-Del-Rio M and Velez-Pardo C. Low doses of paraquat and polyphenols prolong life span and locomotor activity in knock-down parkin Drosophila melanogaster exposed to oxidative stress stimuli: implication in autosomal recessive juvenile Parkinsonism. Gene. 2013; 512(2):355-363.
    • (2013) Gene. , vol.512 , Issue.2 , pp. 355-363
    • Bonilla-Ramirez, L.1    Jimenez-Del-Rio, M.2    Velez-Pardo, C.3
  • 118
    • 0033982936 scopus 로고    scopus 로고
    • KEGG: kyoto encyclopedia of genes and genomes
    • Kanehisa M and Goto S. KEGG: kyoto encyclopedia of genes and genomes. Nucleic Acids Res. 2000; 28(1):27-30.
    • (2000) Nucleic Acids Res. , vol.28 , Issue.1 , pp. 27-30
    • Kanehisa, M.1    Goto, S.2
  • 120
    • 66349132579 scopus 로고    scopus 로고
    • From disease ontology to disease-ontology lite: statistical methods to adapt a general-purpose ontology for the test of gene-ontology associations
    • Du P, Feng G, Flatow J, Song J, Holko M, Kibbe WA and Lin SM. From disease ontology to disease-ontology lite: statistical methods to adapt a general-purpose ontology for the test of gene-ontology associations. Bioinformatics. 2009; 25(12):i63-68.
    • (2009) Bioinformatics. , vol.25 , Issue.12
    • Du, P.1    Feng, G.2    Flatow, J.3    Song, J.4    Holko, M.5    Kibbe, W.A.6    Lin, S.M.7
  • 121
    • 84874253819 scopus 로고    scopus 로고
    • Gene Ontology annotations and resources
    • Gene Ontology Consortium.
    • Gene Ontology Consortium. Gene Ontology annotations and resources. Nucleic Acids Res. 2013; 41(Database issue):D530-535.
    • (2013) Nucleic Acids Res. , vol.41 , Issue.DATABASE ISSUE
  • 122
    • 24044522270 scopus 로고    scopus 로고
    • BioMart and Bioconductor: a powerful link between biological databases and microarray data analysis
    • Durinck S, Moreau Y, Kasprzyk A, Davis S, De Moor B, Brazma A and Huber W. BioMart and Bioconductor: a powerful link between biological databases and microarray data analysis. Bioinformatics. 2005; 21(16):3439-3440.
    • (2005) Bioinformatics. , vol.21 , Issue.16 , pp. 3439-3440
    • Durinck, S.1    Moreau, Y.2    Kasprzyk, A.3    Davis, S.4    De Moor, B.5    Brazma, A.6    Huber, W.7
  • 123
    • 68449101067 scopus 로고    scopus 로고
    • Mapping identifiers for the integration of genomic datasets with the R/Bioconductor package biomaRt
    • Durinck S, Spellman PT, Birney E and Huber W. Mapping identifiers for the integration of genomic datasets with the R/Bioconductor package biomaRt. Nature protocols. 2009; 4(8):1184-1191.
    • (2009) Nature protocols. , vol.4 , Issue.8 , pp. 1184-1191
    • Durinck, S.1    Spellman, P.T.2    Birney, E.3    Huber, W.4
  • 124
    • 84555188294 scopus 로고    scopus 로고
    • Using the bioconductor GeneAnswers package to interpret gene lists
    • Feng G, Shaw P, Rosen ST, Lin SM and Kibbe WA. Using the bioconductor GeneAnswers package to interpret gene lists. Methods Mol Biol. 2012; 802:101-112.
    • (2012) Methods Mol Biol. , vol.802 , pp. 101-112
    • Feng, G.1    Shaw, P.2    Rosen, S.T.3    Lin, S.M.4    Kibbe, W.A.5


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.