Novel protein kinase signaling systems regulating lifespan identified by small molecule library screening using drosophila

PLoS ONE

Volumn 7, Issue 2, 2012, Pages

  Spindler, Stephen R ^a   Li, Rui ^a   Dhahbi, Joseph M ^a   Yamakawa, Amy ^a   Sauer, Frank ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

2 (2 AMINO 3 METHOXYPHENYL)CHROMONE; 4 (3 CHLOROANILINO) 6,7 DIMETHOXYQUINAZOLINE; 4 (4 FLUOROPHENYL) 2 (4 METHYLSULFINYLPHENYL) 5 (4 PYRIDYL)IMIDAZOLE; 4 AMINO 7 TERT BUTYL 5 (4 CHLOROPHENYL)PYRAZOLO[3,4 D]PYRIMIDINE; 6,7 DIMETHYL 2 PHENYLQUINOXALINE; ANTHRA[1,9 CD]PYRAZOL 6(2H) ONE; EPIDERMAL GROWTH FACTOR RECEPTOR; ERBSTATIN; EVEROLIMUS; FASUDIL; G PROTEIN COUPLED RECEPTOR; INDIRUBIN; INSULIN RECEPTOR; JANUS KINASE; N (2 GUANIDINOETHYL) 5 ISOQUINOLINESULFONAMIDE; N [2 [[N [3 (4 CHLOROPHENYL) 2 PROPENYL] N METHYLAMINO]METHYL]PHENYL] N (2 HYDROXYETHYL) 4 METHOXYBENZENESULFONAMIDE; N BENZYL 2 CYANO 3 (3,4 DIHYDROXYPHENYL)ACRYLAMIDE; PLATELET DERIVED GROWTH FACTOR RECEPTOR; PROTEIN KINASE; PROTEIN KINASE INHIBITOR; QUERCETIN DERIVATIVE; QUERCETIN DIHYDRATE; SOMATOMEDIN RECEPTOR; STAT PROTEIN; STAUROSPORINE; TYRPHOSTIN; TYRPHOSTIN 1; TYRPHOSTIN 9; UNCLASSIFIED DRUG; VASCULOTROPIN RECEPTOR;

ARTICLE; ASSAY; COMPARATIVE STUDY; CONTROLLED STUDY; DROSOPHILA MELANOGASTER; ENZYME ACTIVITY; IN VITRO STUDY; INTRACELLULAR SIGNALING; LIFE EXTENSION; MOLECULAR LIBRARY; NONHUMAN; PROTEIN ANALYSIS; PROTEIN TARGETING; REGULATORY MECHANISM; SCREENING; ANIMAL; CALORIC RESTRICTION; CELL CULTURE; DRUG EFFECT; ENZYMOLOGY; INTRACELLULAR SPACE; LONGEVITY; METABOLISM; PHOSPHORYLATION; SIGNAL TRANSDUCTION;

ANIMALS; CALORIC RESTRICTION; CELLS, CULTURED; DROSOPHILA MELANOGASTER; INTRACELLULAR SPACE; LONGEVITY; MAP KINASE SIGNALING SYSTEM; PHOSPHORYLATION; PROTEIN KINASE INHIBITORS; PROTEIN KINASES; SIGNAL TRANSDUCTION; SMALL MOLECULE LIBRARIES;

EID: 84857389789     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0029782     Document Type: Article

References (28)

1. Fontana L, Partridge L, Longo VD, (2010) Extending healthy life span-from yeast to humans. Science 328: 321-326.
2. Spindler SR, (2010) Caloric restriction: From soup to nuts. Ageing Res Rev 9: 324-353.
3. Kalaany NY, Sabatini DM, (2009) Tumours with PI3K activation are resistant to dietary restriction. Nature 458: 725-731.
4. Aritakula A, Ramasamy A, (2008) Drosophila-based in vivo assay for the validation of inhibitors of the epidermal growth factor receptor/Ras pathway. J Biosci 33: 731-742.
5. Bain J, McLauchlan H, Elliott M, Cohen P, (2003) The specificities of protein kinase inhibitors: an update. Biochem J 371: 199-204.
6. Miller RS, Thomas JL, (1958) The Effects of Larval Crowding and Body Size on the Longevity of Adult Drosophila Melanogaster. Ecology 39: 118-125.
7. Baldal EA, van der LK, van Alphen JJ, Brakefield PM, Zwaan BJ, (2005) The effects of larval density on adult life-history traits in three species of Drosophila. Mech Ageing Dev 126: 407-416.
8. Mair W, Piper MD, Partridge L, (2005) Calories do not explain extension of life span by dietary restriction in Drosophila. PLoS Biol 3: e223.
9. Lamb MJ, (1968) Temperature and lifespan in Drosophila. Nature 220: 808-809.
10. Min KJ, Flatt T, Kulaots I, Tatar M, (2007) Counting calories in Drosophila diet restriction. Exp Gerontol 42: 247-251.
11. Driver CJ, Wallis R, Cosopodiotis G, Ettershank G, (1986) Is a fat metabolite the major diet dependent accelerator of aging? Exp Gerontol 21: 497-507.
12. Min KJ, Tatar M, (2006) Drosophila diet restriction in practice: do flies consume fewer nutrients? Mech Ageing Dev 127: 93-96.
13. Ja WW, Carvalho GB, Mak EM, de la Rosa NN, Fang AY, et al. (2007) Prandiology of Drosophila and the CAFE assay. Proc Natl Acad Sci U S A 104: 8253-8256.
14. Spindler SR, Li R, Dhahbi JM, Yamakawa A, Mote PL, et al. (2011) Statin treatment increases lifespan and improves cardiac health in Drosophila. PLoS ONE In revision.
15. Biteau B, Karpac J, Hwangbo D, Jasper H, (2011) Regulation of Drosophila lifespan by JNK signaling. Exp Gerontol 46: 349-354.
16. Libert S, Chao Y, Zwiener J, Pletcher SD, (2008) Realized immune response is enhanced in long-lived puc and chico mutants but is unaffected by dietary restriction. Mol Immunol 45: 810-817.
17. Wang MC, Bohmann D, Jasper H, (2005) JNK extends life span and limits growth by antagonizing cellular and organism-wide responses to insulin signaling. Cell 121: 115-125.
18. Wang MC, Bohmann D, Jasper H, (2003) JNK signaling confers tolerance to oxidative stress and extends lifespan in Drosophila. Dev Cell 5: 811-816.
19. Karpac J, Jasper H, (2009) Insulin and JNK: optimizing metabolic homeostasis and lifespan. Trends Endocrinol Metab 20: 100-106.
20. Chen J, Xie C, Tian L, Hong L, Wu X, et al. (2010) Participation of the p38 pathway in Drosophila host defense against pathogenic bacteria and fungi. Proc Natl Acad Sci U S A 107: 20774-20779.
21. Goto M, (2008) Inflammaging (inflammation+aging): A driving force for human aging based on an evolutionarily antagonistic pleiotropy theory? Biosci Trends 2: 218-230.
22. Oliva JL, Griner EM, Kazanietz MG, (2005) PKC isozymes and diacylglycerol-regulated proteins as effectors of growth factor receptors. Growth Factors 23: 245-252.
23. Spindler SR, (2010) Biological Effects of Calorie Restriction: Implications for modification of Human Aging. In: Fahy GM, West MD, Coles S, Harris SB, editors. pp. 367-438 The Future of Aging, Science and Business Media B.V. Dordrech, New York.
24. Tschape JA, Hammerschmied C, Muhlig-Versen M, Athenstaedt K, Daum G, et al. (2002) The neurodegeneration mutant lochrig interferes with cholesterol homeostasis and Appl processing. EMBO J 21: 6367-6376.
25. Apfeld J, O'Connor G, McDonagh T, Distefano PS, Curtis R, (2004) The AMP-activated protein kinase AAK-2 links energy levels and insulin-like signals to lifespan in C. elegans. Genes Dev 18: 3004-3009.
26. Johnson EC, Kazgan N, Bretz CA, Forsberg LJ, Hector CE, et al. (2010) Altered metabolism and persistent starvation behaviors caused by reduced AMPK function in Drosophila. PLoS ONE 5: e12799.
27. Tohyama D, Yamaguchi A, (2010) A critical role of SNF1A/dAMPKalpha (Drosophila AMP-activated protein kinase alpha) in muscle on longevity and stress resistance in Drosophila melanogaster. Biochem Biophys Res Commun 394: 112-118.
28. Clancy DJ, Kennington WJ, (2001) A simple method to achieve consistent larval density in bottle cultures. Dros Inf Serv 84: 168.