Cancer resistance in the blind mole rat is mediated by concerted necrotic cell death mechanism

Proceedings of the National Academy of Sciences of the United States of America

Volumn 109, Issue 47, 2012, Pages 19392-19396

  Gorbunova, Vera ^a   Hine, Christopher ^a,d   Tian, Xiao ^a   Ablaeva, Julia ^a   Gudkov, Andrei V ^b   Nevo, Eviatar ^c   Seluanov, Andrei ^a  

^a UNIVERSITY OF ROCHESTER   (United States)

^b ROSWELL PARK CANCER INSTITUTE   (United States)

^c UNIVERSITY OF HAIFA   (Israel)

^d HARVARD SCHOOL OF PUBLIC HEALTH   (United States)

Author keywords

Aging; Necrosis

Indexed keywords

BETA INTERFERON; PROTEIN P53; RETINOBLASTOMA PROTEIN;

ANIMAL CELL; ARTICLE; CELL DEATH; CELL FUNCTION; CONTROLLED STUDY; CYTOKINE RELEASE; DISEASE RESISTANCE; HUMAN; HUMAN CELL; MOLE RAT; MOUSE; NEOPLASM; NONHUMAN; PRIORITY JOURNAL; PROTEIN FUNCTION; RAT; SPALAX GOLANI; SPALAX JUDAEI;

ANIMALS; ANTIGENS, POLYOMAVIRUS TRANSFORMING; CONTACT INHIBITION; DISEASE RESISTANCE; FIBROBLASTS; HUMANS; INTERFERON-BETA; MALE; MICE; NECROSIS; NEOPLASMS; PHENOTYPE; RETINOBLASTOMA PROTEIN; SIGNAL TRANSDUCTION; SPALAX; TELOMERE SHORTENING; TUMOR SUPPRESSOR PROTEIN P53;

CRYPTOMYS HOTTENTOTUS; HETEROCEPHALUS GLABER; MAMMALIA; RODENTIA; SPALACIDAE; SPALACINAE; SPALAX; SPALAX GOLANI; SPALAX JUDAEI;

EID: 84869778322     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1217211109     Document Type: Article

References (21)

1. Nevo E (1999) Mosaic Evolution of Subterranean Mammals: Regression, Progression, and Global Convergence (Oxford Univ Press, London).
2. Nevo E, Ivanitskaya I, Beiles A (2001) Adaptive Radiation of Blind Subterranian Mole Rats (Backhuys, Leiden, The Netherlands).
3. Edrey YH, et al. (2012) Sustained high levels of neuregulin-1 in the longest-lived rodents; A key determinant of rodent longevity. Aging Cell 11(2):213-222.
4. Turturro A, et al. (1999) Growth curves and survival characteristics of the animals used in the Biomarkers of Aging Program. J Gerontol A Biol Sci Med Sci 54(11):B492-B501.
5. de Magalhães JP, Costa J, Toussaint O (2005) HAGR: The Human Ageing Genomic Resources. Nucleic Acids Res 33(Database issue):D537-D543.
6. Heron M (2012) Deaths: Leading Causes for 2008, National Vital Statistics Reports 60(6):9-11.
7. Lipman R, Galecki A, Burke DT, Miller RA (2004) Genetic loci that influence cause of death in a heterogeneous mouse stock. J Gerontol A Biol Sci Med Sci 59(10):977-983.
8. Burek JD, Hollander CF (1977) Incidence patterns of spontaneous tumors in BN/Bi rats. J Natl Cancer Inst 58(1):99-105.
9. Wright WE, Shay JW (2000) Telomere dynamics in cancer progression and prevention: Fundamental differences in human and mouse telomere biology. Nat Med 6(8):849-851.
10. Seluanov A, et al. (2007) Telomerase activity coevolves with body mass not lifespan. Aging Cell 6(1):45-52.
11. Seluanov A, et al. (2008) Distinct tumor suppressor mechanisms evolve in rodent species that differ in size and lifespan. Aging Cell 7(6):813-823.
12. Ashur-Fabian O, et al. (2004) Evolution of p53 in hypoxia-stressed Spalax mimics human tumor mutation. Proc Natl Acad Sci USA 101(33):12236-12241.
13. Liu G, et al. (2004) Chromosome stability, in the absence of apoptosis, is critical for suppression of tumorigenesis in Trp53 mutant mice. Nat Genet 36(1):63-68.
14. Seluanov A, et al. (2009) Hypersensitivity to contact inhibition provides a clue to cancer resistance of naked mole-rat. Proc Natl Acad Sci USA 106(46):19207-19208.
15. Hahn WC, et al. (2002) Enumeration of the simian virus 40 early region elements necessary for human cell transformation. Mol Cell Biol 22(7):2111-2123.
16. Di Micco R, Fumagalli M, d'Adda di Fagagna F (2007) Breaking news: High-speed race ends in arrest - How oncogenes induce senescence. Trends Cell Biol 17(11):529-536.
17. Serrano M, Lin AW, McCurrach ME, Beach D, Lowe SW (1997) Oncogenic ras provokes premature cell senescence associated with accumulation of p53 and p16INK4a. Cell 88(5):593-602.
18. Mueller MM, Fusenig NE (2004) Friends or foes - Bipolar effects of the tumour stroma in cancer. Nat Rev Cancer 4(11):839-849.
19. Kim EB, et al. (2011) Genome sequencing reveals insights into physiology and longevity of the naked mole rat. Nature 479(7372):223-227.
20. Seluanov A, Vaidya A, Gorbunova V (2010) Establishing primary adult fibroblast cultures from rodents. J Vis Exp (44)pii:2033.
21. Diaz RM (2007) Oncolytic immunovirotherapy for melanoma using vesicular stomatitis virus. Cancer Res 67(6):2840-2848.