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Volumn 314, Issue 9, 2008, Pages 1951-1961

Aging of signal transduction pathways, and pathology

Author keywords

Aging; Cancer; Cell signaling; Hedgehog; Notch; RTK; TGF ; Tissue regeneration; WNT

Indexed keywords

NOTCH RECEPTOR; RAS PROTEIN; SONIC HEDGEHOG PROTEIN; TRANSFORMING GROWTH FACTOR BETA; WNT PROTEIN;

EID: 43049168216     PISSN: 00144827     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.yexcr.2008.03.017     Document Type: Review
Times cited : (69)

References (102)
  • 1
    • 34248382155 scopus 로고    scopus 로고
    • Regulating the Notch pathway in embryonic, adult and old stem cells
    • M.E. Carlson I.M. Conboy Regulating the Notch pathway in embryonic, adult and old stem cells Curr. Opin. Pharmacol. 7 2007 303 309
    • (2007) Curr. Opin. Pharmacol. , vol.7 , pp. 303-309
    • Carlson, M.E.1    Conboy, I.M.2
  • 3
    • 0035479835 scopus 로고    scopus 로고
    • New aspects of Wnt signaling pathways in higher vertebrates
    • J. Huelsken W. Birchmeier New aspects of Wnt signaling pathways in higher vertebrates Curr. Opin. Genet. Dev. 11 2001 547 553
    • (2001) Curr. Opin. Genet. Dev. , vol.11 , pp. 547-553
    • Huelsken, J.1    Birchmeier, W.2
  • 4
    • 2942530310 scopus 로고    scopus 로고
    • ERK and p38 MAPK-activated protein kinases: a family of protein kinases with diverse biological functions
    • P.P. Roux J. Blenis ERK and p38 MAPK-activated protein kinases: a family of protein kinases with diverse biological functions Microbiol. Mol. Biol. Rev. 68 2004 320 344
    • (2004) Microbiol. Mol. Biol. Rev. , vol.68 , pp. 320-344
    • Roux, P.P.1    Blenis, J.2
  • 7
    • 0037047068 scopus 로고    scopus 로고
    • The genome-wide expression response to telomerase deletion in Saccharomyces cerevisiae
    • S. Nautiyal J.L. DeRisi E.H. Blackburn The genome-wide expression response to telomerase deletion in Saccharomyces cerevisiae Proc. Natl. Acad. Sci. U. S. A. 99 2002 9316 9321
    • (2002) Proc. Natl. Acad. Sci. U. S. A. , vol.99 , pp. 9316-9321
    • Nautiyal, S.1    DeRisi, J.L.2    Blackburn, E.H.3
  • 10
    • 34748837360 scopus 로고    scopus 로고
    • Networking of WNT, FGF, Notch, BMP, and Hedgehog signaling pathways during carcinogenesis
    • M. Katoh Networking of WNT, FGF, Notch, BMP, and Hedgehog signaling pathways during carcinogenesis Stem Cell Rev. 3 2007 30 38
    • (2007) Stem Cell Rev. , vol.3 , pp. 30-38
    • Katoh, M.1
  • 11
    • 0030748716 scopus 로고    scopus 로고
    • The ins and outs of notch signaling
    • G. Weinmaster The ins and outs of notch signaling Mol. Cell. Neurosci. 9 1997 91 102
    • (1997) Mol. Cell. Neurosci. , vol.9 , pp. 91-102
    • Weinmaster, G.1
  • 12
    • 0344827208 scopus 로고    scopus 로고
    • Notch-mediated restoration of regenerative potential to aged muscle
    • I.M. Conboy M.J. Conboy G.M. Smythe T.A. Rando Notch-mediated restoration of regenerative potential to aged muscle Science 302 2003 1575 1577
    • (2003) Science , vol.302 , pp. 1575-1577
    • Conboy, I.M.1    Conboy, M.J.2    Smythe, G.M.3    Rando, T.A.4
  • 13
    • 31444447881 scopus 로고    scopus 로고
    • Notch signalling in vertebrate neural development
    • A. Louvi S. rtavanis-Tsakonas Notch signalling in vertebrate neural development Nat. Rev., Neurosci. 7 2006 93 102
    • (2006) Nat. Rev., Neurosci. , vol.7 , pp. 93-102
    • Louvi, A.1    rtavanis-Tsakonas, S.2
  • 14
    • 33750566665 scopus 로고    scopus 로고
    • Notch signaling in stem cell systems
    • S. Chiba Notch signaling in stem cell systems Stem Cells 24 2006 2437 2447
    • (2006) Stem Cells , vol.24 , pp. 2437-2447
    • Chiba, S.1
  • 17
    • 0036747296 scopus 로고    scopus 로고
    • Keeping a good pathway down: transcriptional repression of Notch pathway target genes by CSL proteins
    • E.C. Lai Keeping a good pathway down: transcriptional repression of Notch pathway target genes by CSL proteins EMBO Rep. 3 2002 840 845
    • (2002) EMBO Rep. , vol.3 , pp. 840-845
    • Lai, E.C.1
  • 18
    • 0036778127 scopus 로고    scopus 로고
    • CSL-independent Notch signalling: a checkpoint in cell fate decisions during development?
    • A. Martinez Arias V. Zecchini K. Brennan CSL-independent Notch signalling: a checkpoint in cell fate decisions during development? Curr. Opin. Genet. Dev. 12 2002 524 533
    • (2002) Curr. Opin. Genet. Dev. , vol.12 , pp. 524-533
    • Martinez Arias, A.1    Zecchini, V.2    Brennan, K.3
  • 19
    • 0037363922 scopus 로고    scopus 로고
    • HES and HERP families: multiple effectors of the Notch signaling pathway
    • T. Iso L. Kedes Y. Hamamori HES and HERP families: multiple effectors of the Notch signaling pathway J. Cell. Physiol. 194 2003 237 255
    • (2003) J. Cell. Physiol. , vol.194 , pp. 237-255
    • Iso, T.1    Kedes, L.2    Hamamori, Y.3
  • 20
    • 0034654497 scopus 로고    scopus 로고
    • Controlling TGF-beta signaling
    • J. Massague Y.G. Chen Controlling TGF-beta signaling Genes Dev. 14 2000 627 644
    • (2000) Genes Dev. , vol.14 , pp. 627-644
    • Massague, J.1    Chen, Y.G.2
  • 21
    • 0034906821 scopus 로고    scopus 로고
    • TGF-beta-induced apoptosis is mediated by the adapter protein Daxx that facilitates JNK activation
    • R. Perlman W.P. Schiemann M.W. Brooks H.F. Lodish R.A. Weinberg TGF-beta-induced apoptosis is mediated by the adapter protein Daxx that facilitates JNK activation Nat. Cell Biol. 3 2001 708 714
    • (2001) Nat. Cell Biol. , vol.3 , pp. 708-714
    • Perlman, R.1    Schiemann, W.P.2    Brooks, M.W.3    Lodish, H.F.4    Weinberg, R.A.5
  • 22
    • 36448936383 scopus 로고    scopus 로고
    • TGFbeta-SMAD signal transduction: molecular specificity and functional flexibility
    • B. Schmierer C.S. Hill TGFbeta-SMAD signal transduction: molecular specificity and functional flexibility Nat. Rev., Mol. Cell Biol. 8 2007 970 982
    • (2007) Nat. Rev., Mol. Cell Biol. , vol.8 , pp. 970-982
    • Schmierer, B.1    Hill, C.S.2
  • 23
    • 26444515002 scopus 로고    scopus 로고
    • The structure of the follistatin:activin complex reveals antagonism of both type I and type II receptor binding
    • T.B. Thompson T.F. Lerch R.W. Cook T.K. Woodruff T.S. Jardetzky The structure of the follistatin:activin complex reveals antagonism of both type I and type II receptor binding Dev. Cell 9 2005 535 543
    • (2005) Dev. Cell , vol.9 , pp. 535-543
    • Thompson, T.B.1    Lerch, T.F.2    Cook, R.W.3    Woodruff, T.K.4    Jardetzky, T.S.5
  • 24
    • 0036399170 scopus 로고    scopus 로고
    • Extracellular regulation of BMP signaling in vertebrates: a cocktail of modulators
    • W. Balemans H.W. Van Extracellular regulation of BMP signaling in vertebrates: a cocktail of modulators Dev. Biol. 250 2002 231 250
    • (2002) Dev. Biol. , vol.250 , pp. 231-250
    • Balemans, W.1    Van, H.W.2
  • 25
    • 33749538647 scopus 로고    scopus 로고
    • BMP1 controls TGFbeta1 activation via cleavage of latent TGFbeta-binding protein
    • G. Ge D.S. Greenspan BMP1 controls TGFbeta1 activation via cleavage of latent TGFbeta-binding protein J. Cell Biol. 175 2006 111 120
    • (2006) J. Cell Biol. , vol.175 , pp. 111-120
    • Ge, G.1    Greenspan, D.S.2
  • 26
    • 23044466047 scopus 로고    scopus 로고
    • Specificity and versatility in tgf-beta signaling through Smads
    • X.H. Feng R. Derynck Specificity and versatility in tgf-beta signaling through Smads Annu. Rev. Cell Dev. Biol. 21 2005 659 693
    • (2005) Annu. Rev. Cell Dev. Biol. , vol.21 , pp. 659-693
    • Feng, X.H.1    Derynck, R.2
  • 27
    • 33646749327 scopus 로고    scopus 로고
    • Structure of the ternary signaling complex of a TGF-beta superfamily member
    • G.P. Allendorph W.W. Vale S. Choe Structure of the ternary signaling complex of a TGF-beta superfamily member Proc. Natl. Acad. Sci. U. S. A. 103 2006 7643 7648
    • (2006) Proc. Natl. Acad. Sci. U. S. A. , vol.103 , pp. 7643-7648
    • Allendorph, G.P.1    Vale, W.W.2    Choe, S.3
  • 29
    • 0142104985 scopus 로고    scopus 로고
    • Smad-dependent and Smad-independent pathways in TGF-beta family signalling
    • R. Derynck Y.E. Zhang Smad-dependent and Smad-independent pathways in TGF-beta family signalling Nature 425 2003 577 584
    • (2003) Nature , vol.425 , pp. 577-584
    • Derynck, R.1    Zhang, Y.E.2
  • 30
    • 1242351972 scopus 로고    scopus 로고
    • Planar polarity from flies to vertebrates
    • M. Fanto H. McNeill Planar polarity from flies to vertebrates J. Cell Sci. 117 2004 527 533
    • (2004) J. Cell Sci. , vol.117 , pp. 527-533
    • Fanto, M.1    McNeill, H.2
  • 31
    • 33644928412 scopus 로고    scopus 로고
    • Asymmetric localization of numb in the chick somite and the influence of myogenic signals
    • T. Holowacz L. Zeng A.B. Lassar Asymmetric localization of numb in the chick somite and the influence of myogenic signals Dev. Dyn. 235 2006 633 645
    • (2006) Dev. Dyn. , vol.235 , pp. 633-645
    • Holowacz, T.1    Zeng, L.2    Lassar, A.B.3
  • 32
    • 0041695485 scopus 로고    scopus 로고
    • A second canon. Functions and mechanisms of beta-catenin-independent Wnt signaling
    • M.T. Veeman J.D. Axelrod R.T. Moon A second canon. Functions and mechanisms of beta-catenin-independent Wnt signaling Dev. Cell 5 2003 367 377
    • (2003) Dev. Cell , vol.5 , pp. 367-377
    • Veeman, M.T.1    Axelrod, J.D.2    Moon, R.T.3
  • 34
    • 1542347695 scopus 로고    scopus 로고
    • Convergence of Wnt, beta-catenin, and cadherin pathways
    • W.J. Nelson R. Nusse Convergence of Wnt, beta-catenin, and cadherin pathways Science 303 2004 1483 1487
    • (2004) Science , vol.303 , pp. 1483-1487
    • Nelson, W.J.1    Nusse, R.2
  • 35
    • 2342430345 scopus 로고    scopus 로고
    • LDL receptor-related proteins 5 and 6 in Wnt/beta-catenin signaling: arrows point the way
    • X. He M. Semenov K. Tamai X. Zeng LDL receptor-related proteins 5 and 6 in Wnt/beta-catenin signaling: arrows point the way Development 131 2004 1663 1677
    • (2004) Development , vol.131 , pp. 1663-1677
    • He, X.1    Semenov, M.2    Tamai, K.3    Zeng, X.4
  • 36
    • 28644448036 scopus 로고    scopus 로고
    • Cell biology: relays at the membrane
    • R. Nusse Cell biology: relays at the membrane Nature 438 2005 747 749
    • (2005) Nature , vol.438 , pp. 747-749
    • Nusse, R.1
  • 37
    • 27844516613 scopus 로고    scopus 로고
    • Rapid, Wnt-induced changes in GSK3beta associations that regulate beta-catenin stabilization are mediated by Galpha proteins
    • X. Liu J.S. Rubin A.R. Kimmel Rapid, Wnt-induced changes in GSK3beta associations that regulate beta-catenin stabilization are mediated by Galpha proteins Curr. Biol. 15 2005 1989 1997
    • (2005) Curr. Biol. , vol.15 , pp. 1989-1997
    • Liu, X.1    Rubin, J.S.2    Kimmel, A.R.3
  • 38
    • 27644575157 scopus 로고    scopus 로고
    • Coordinating ERK/MAPK signalling through scaffolds and inhibitors
    • W. Kolch Coordinating ERK/MAPK signalling through scaffolds and inhibitors Nat. Rev., Mol. Cell Biol. 6 2005 827 837
    • (2005) Nat. Rev., Mol. Cell Biol. , vol.6 , pp. 827-837
    • Kolch, W.1
  • 39
    • 0033607633 scopus 로고    scopus 로고
    • Phosphorylation and regulation of Raf by Akt (protein kinase B)
    • S. Zimmermann K. Moelling Phosphorylation and regulation of Raf by Akt (protein kinase B) Science (New York, N.Y.) 286 1999 1741 1744
    • (1999) Science (New York, N.Y.) , vol.286 , pp. 1741-1744
    • Zimmermann, S.1    Moelling, K.2
  • 40
    • 0030839766 scopus 로고    scopus 로고
    • Phosphatidylinositol 3-kinase is required for integrin-stimulated AKT and Raf-1/mitogen-activated protein kinase pathway activation
    • W.G. King M.D. Mattaliano T.O. Chan P.N. Tsichlis J.S. Brugge Phosphatidylinositol 3-kinase is required for integrin-stimulated AKT and Raf-1/mitogen-activated protein kinase pathway activation Mol. Cell. Biol. 17 1997 4406 4418
    • (1997) Mol. Cell. Biol. , vol.17 , pp. 4406-4418
    • King, W.G.1    Mattaliano, M.D.2    Chan, T.O.3    Tsichlis, P.N.4    Brugge, J.S.5
  • 41
    • 4043102610 scopus 로고    scopus 로고
    • Involvement of 3-phosphoinositide-dependent protein kinase-1 in the MEK/MAPK signal transduction pathway
    • S. Sato N. Fujita T. Tsuruo Involvement of 3-phosphoinositide-dependent protein kinase-1 in the MEK/MAPK signal transduction pathway J. Biol. Chem. 279 2004 33759 33767
    • (2004) J. Biol. Chem. , vol.279 , pp. 33759-33767
    • Sato, S.1    Fujita, N.2    Tsuruo, T.3
  • 43
    • 0033013866 scopus 로고    scopus 로고
    • Role of phosphoinositide 3-kinase in activation of ras and mitogen-activated protein kinase by epidermal growth factor
    • S. Wennstrom J. Downward Role of phosphoinositide 3-kinase in activation of ras and mitogen-activated protein kinase by epidermal growth factor Mol. Cell. Biol. 19 1999 4279 4288
    • (1999) Mol. Cell. Biol. , vol.19 , pp. 4279-4288
    • Wennstrom, S.1    Downward, J.2
  • 44
    • 33750200389 scopus 로고    scopus 로고
    • Orchestrating ontogenesis: variations on a theme by sonic hedgehog
    • P.W. Ingham M. Placzek Orchestrating ontogenesis: variations on a theme by sonic hedgehog Nat. Rev., Genet. 7 2006 841 850
    • (2006) Nat. Rev., Genet. , vol.7 , pp. 841-850
    • Ingham, P.W.1    Placzek, M.2
  • 45
    • 0037218819 scopus 로고    scopus 로고
    • Sonic hedgehog regulates adult neural progenitor proliferation in vitro and in vivo
    • K. Lai B.K. Kaspar F.H. Gage D.V. Schaffer Sonic hedgehog regulates adult neural progenitor proliferation in vitro and in vivo Nat. Neurosci. 6 2003 21 27
    • (2003) Nat. Neurosci. , vol.6 , pp. 21-27
    • Lai, K.1    Kaspar, B.K.2    Gage, F.H.3    Schaffer, D.V.4
  • 47
    • 33744783432 scopus 로고    scopus 로고
    • Attenuation of LDH-A expression uncovers a link between glycolysis, mitochondrial physiology, and tumor maintenance
    • V.R. Fantin J. St-Pierre P. Leder Attenuation of LDH-A expression uncovers a link between glycolysis, mitochondrial physiology, and tumor maintenance Cancer Cell 9 2006 425 434
    • (2006) Cancer Cell , vol.9 , pp. 425-434
    • Fantin, V.R.1    St-Pierre, J.2    Leder, P.3
  • 48
    • 23944506654 scopus 로고    scopus 로고
    • The love–hate relationship between Ras and Notch
    • M.V. Sundaram The love–hate relationship between Ras and Notch Genes Dev. 19 2005 1825 1839
    • (2005) Genes Dev. , vol.19 , pp. 1825-1839
    • Sundaram, M.V.1
  • 52
    • 8644219672 scopus 로고    scopus 로고
    • LEF1-mediated regulation of Delta-like1 links Wnt and Notch signaling in somitogenesis
    • J. Galceran C. Sustmann S.C. Hsu S. Folberth R. Grosschedl LEF1-mediated regulation of Delta-like1 links Wnt and Notch signaling in somitogenesis Genes Dev. 18 2004 2718 2723
    • (2004) Genes Dev. , vol.18 , pp. 2718-2723
    • Galceran, J.1    Sustmann, C.2    Hsu, S.C.3    Folberth, S.4    Grosschedl, R.5
  • 54
    • 37549039009 scopus 로고    scopus 로고
    • A temporal switch from Notch to Wnt signaling in muscle stem cells is necessary for normal adult myogenesis
    • A.S. Brack I.M. Conboy M.J. Conboy J. Shen T.A. Rando A temporal switch from Notch to Wnt signaling in muscle stem cells is necessary for normal adult myogenesis Cell. Stem. Cell. 2 2008 50 59
    • (2008) Cell. Stem. Cell. , vol.2 , pp. 50-59
    • Brack, A.S.1    Conboy, I.M.2    Conboy, M.J.3    Shen, J.4    Rando, T.A.5
  • 55
    • 34547924424 scopus 로고    scopus 로고
    • Increased Wnt signaling during aging alters muscle stem cell fate and increases fibrosis
    • A.S. Brack M.J. Conboy S. Roy M. Lee C.J. Kuo C. Keller T.A. Rando Increased Wnt signaling during aging alters muscle stem cell fate and increases fibrosis Science 317 2007 807 810
    • (2007) Science , vol.317 , pp. 807-810
    • Brack, A.S.1    Conboy, M.J.2    Roy, S.3    Lee, M.4    Kuo, C.J.5    Keller, C.6    Rando, T.A.7
  • 59
    • 24144489118 scopus 로고    scopus 로고
    • Cellular and molecular signatures of muscle regeneration: current concepts and controversies in adult myogenesis
    • A.J. Wagers I.M. Conboy Cellular and molecular signatures of muscle regeneration: current concepts and controversies in adult myogenesis Cell 122 2005 659 667
    • (2005) Cell , vol.122 , pp. 659-667
    • Wagers, A.J.1    Conboy, I.M.2
  • 60
    • 22744438723 scopus 로고    scopus 로고
    • Stem cell function, self-renewal, and behavioral heterogeneity of cells from the adult muscle satellite cell niche
    • C.A. Collins I. Olsen P.S. Zammit L. Heslop A. Petrie T.A. Partridge J.E. Morgan Stem cell function, self-renewal, and behavioral heterogeneity of cells from the adult muscle satellite cell niche Cell 122 2005 289 301
    • (2005) Cell , vol.122 , pp. 289-301
    • Collins, C.A.1    Olsen, I.2    Zammit, P.S.3    Heslop, L.4    Petrie, A.5    Partridge, T.A.6    Morgan, J.E.7
  • 61
    • 34248354983 scopus 로고    scopus 로고
    • Loss of stem cell regenerative capacity within aged niches
    • M.E. Carlson I.M. Conboy Loss of stem cell regenerative capacity within aged niches Aging Cell 2007
    • (2007) Aging Cell
    • Carlson, M.E.1    Conboy, I.M.2
  • 62
    • 0345166971 scopus 로고    scopus 로고
    • Cross-talk between the Notch and TGF-beta signaling pathways mediated by interaction of the Notch intracellular domain with Smad3
    • A. Blokzijl C. Dahlqvist E. Reissmann A. Falk A. Moliner U. Lendahl C.F. Ibanez Cross-talk between the Notch and TGF-beta signaling pathways mediated by interaction of the Notch intracellular domain with Smad3 J. Cell Biol. 163 2003 723 728
    • (2003) J. Cell Biol. , vol.163 , pp. 723-728
    • Blokzijl, A.1    Dahlqvist, C.2    Reissmann, E.3    Falk, A.4    Moliner, A.5    Lendahl, U.6    Ibanez, C.F.7
  • 64
    • 25144490620 scopus 로고    scopus 로고
    • Presenilins in the developing, adult, and aging cerebral cortex
    • M. Wines-Samuelson J. Shen Presenilins in the developing, adult, and aging cerebral cortex Neuroscientist. 11 2005 441 451
    • (2005) Neuroscientist. , vol.11 , pp. 441-451
    • Wines-Samuelson, M.1    Shen, J.2
  • 67
    • 30944436222 scopus 로고    scopus 로고
    • Smad3 phosphorylation by cyclin-dependent kinases
    • F. Liu Smad3 phosphorylation by cyclin-dependent kinases Cytokine Growth Factor Rev. 17 2006 9 17
    • (2006) Cytokine Growth Factor Rev. , vol.17 , pp. 9-17
    • Liu, F.1
  • 70
    • 33744732501 scopus 로고    scopus 로고
    • A keratinocyte hypermotility/growth-arrest response involving laminin 5 and p16INK4A activated in wound healing and senescence
    • E. Natarajan J.D. Omobono Z. Guo S. Hopkinson A.J. Lazar T. Brenn J.C. Jones J.G. Rheinwald A keratinocyte hypermotility/growth-arrest response involving laminin 5 and p16INK4A activated in wound healing and senescence Am. J. Pathol. 168 2006 1821 1837
    • (2006) Am. J. Pathol. , vol.168 , pp. 1821-1837
    • Natarajan, E.1    Omobono, J.D.2    Guo, Z.3    Hopkinson, S.4    Lazar, A.J.5    Brenn, T.6    Jones, J.C.7    Rheinwald, J.G.8
  • 71
    • 34249661093 scopus 로고    scopus 로고
    • FGF-2 suppresses cellular senescence of human mesenchymal stem cells by down-regulation of TGF-beta2
    • T. Ito R. Sawada Y. Fujiwara Y. Seyama T. Tsuchiya FGF-2 suppresses cellular senescence of human mesenchymal stem cells by down-regulation of TGF-beta2 Biochem. Biophys. Res. Commun. 359 2007 108 114
    • (2007) Biochem. Biophys. Res. Commun. , vol.359 , pp. 108-114
    • Ito, T.1    Sawada, R.2    Fujiwara, Y.3    Seyama, Y.4    Tsuchiya, T.5
  • 72
    • 85119777249 scopus 로고    scopus 로고
    • Age-specific balance between TGF-β/pSmad3 and Notch controls levels of cyclin dependent kinase inhibitors in muscle stem cells and their regenerative potential
    • M.H.M.a.I.M.C. Carlson Age-specific balance between TGF-β/pSmad3 and Notch controls levels of cyclin dependent kinase inhibitors in muscle stem cells and their regenerative potential Nature 2008
    • (2008) Nature
    • Carlson, M.H.M.a.I.M.C.1
  • 76
    • 10944232632 scopus 로고    scopus 로고
    • Profiling molecular targets of TGF-beta1 in prostate fibroblast-to-myofibroblast transdifferentiation
    • G. Untergasser R. Gander C. Lilg G. Lepperdinger E. Plas P. Berger Profiling molecular targets of TGF-beta1 in prostate fibroblast-to-myofibroblast transdifferentiation Mech. Ageing Dev. 126 2005 59 69
    • (2005) Mech. Ageing Dev. , vol.126 , pp. 59-69
    • Untergasser, G.1    Gander, R.2    Lilg, C.3    Lepperdinger, G.4    Plas, E.5    Berger, P.6
  • 78
    • 0043192681 scopus 로고    scopus 로고
    • The intracellular form of notch blocks transforming growth factor beta-mediated growth arrest in Mv1Lu epithelial cells
    • P. Rao T. Kadesch The intracellular form of notch blocks transforming growth factor beta-mediated growth arrest in Mv1Lu epithelial cells Mol. Cell. Biol. 23 2003 6694 6701
    • (2003) Mol. Cell. Biol. , vol.23 , pp. 6694-6701
    • Rao, P.1    Kadesch, T.2
  • 79
    • 33645325642 scopus 로고    scopus 로고
    • Crosstalk between the EGFR and other signalling pathways at the level of the global transcriptional corepressor Groucho/TLE
    • P. Hasson Z. Paroush Crosstalk between the EGFR and other signalling pathways at the level of the global transcriptional corepressor Groucho/TLE Br. J. Cancer 94 2006 771 775
    • (2006) Br. J. Cancer , vol.94 , pp. 771-775
    • Hasson, P.1    Paroush, Z.2
  • 80
    • 0033168915 scopus 로고    scopus 로고
    • Regulation of Smad signalling by protein associations and signalling crosstalk
    • Y. Zhang R. Derynck Regulation of Smad signalling by protein associations and signalling crosstalk Trends Cell. Biol. 9 1999 274 279
    • (1999) Trends Cell. Biol. , vol.9 , pp. 274-279
    • Zhang, Y.1    Derynck, R.2
  • 81
    • 18844408581 scopus 로고    scopus 로고
    • Age-related alteration in hepatic acyl-CoA: cholesterol acyltransferase and its relation to LDL receptor and MAPK
    • C. Bose C. Bhuvaneswaran K.B. Udupa Age-related alteration in hepatic acyl-CoA: cholesterol acyltransferase and its relation to LDL receptor and MAPK Mech. Ageing Dev. 126 2005 740 751
    • (2005) Mech. Ageing Dev. , vol.126 , pp. 740-751
    • Bose, C.1    Bhuvaneswaran, C.2    Udupa, K.B.3
  • 82
    • 34548011435 scopus 로고    scopus 로고
    • Uniaxial stretch-induced regulation of mitogen-activated protein kinase, Akt and p70 S6 kinase in the ageing Fischer 344 x Brown Norway rat aorta
    • K.M. Rice D.H. Desai D.L. Preston P.S. Wehner E.R. Blough Uniaxial stretch-induced regulation of mitogen-activated protein kinase, Akt and p70 S6 kinase in the ageing Fischer 344 x Brown Norway rat aorta Exp. Physiol. 92 2007 963 970
    • (2007) Exp. Physiol. , vol.92 , pp. 963-970
    • Rice, K.M.1    Desai, D.H.2    Preston, D.L.3    Wehner, P.S.4    Blough, E.R.5
  • 83
    • 0037444470 scopus 로고    scopus 로고
    • Mitogen-activated protein kinase (MAPK) pathway activation: effects of age and acute exercise on human skeletal muscle
    • D. Williamson P. Gallagher M. Harber C. Hollon S. Trappe Mitogen-activated protein kinase (MAPK) pathway activation: effects of age and acute exercise on human skeletal muscle J. Physiol. 547 2003 977 987
    • (2003) J. Physiol. , vol.547 , pp. 977-987
    • Williamson, D.1    Gallagher, P.2    Harber, M.3    Hollon, C.4    Trappe, S.5
  • 86
    • 33846574233 scopus 로고    scopus 로고
    • Age-dependent loss of NGF signaling in the rat basal forebrain is due to disrupted MAPK activation
    • B. Williams A.C. Granholm K. Sambamurti Age-dependent loss of NGF signaling in the rat basal forebrain is due to disrupted MAPK activation Neurosci. Lett. 413 2007 110 114
    • (2007) Neurosci. Lett. , vol.413 , pp. 110-114
    • Williams, B.1    Granholm, A.C.2    Sambamurti, K.3
  • 87
    • 22044454171 scopus 로고    scopus 로고
    • Bridging the BMP and Wnt pathways by PI3 kinase/Akt and 14-3-3zeta
    • Q. Tian X.C. He L. Hood L. Li Bridging the BMP and Wnt pathways by PI3 kinase/Akt and 14-3-3zeta Cell Cycle 4 2005 215 216
    • (2005) Cell Cycle , vol.4 , pp. 215-216
    • Tian, Q.1    He, X.C.2    Hood, L.3    Li, L.4
  • 88
    • 31544461492 scopus 로고    scopus 로고
    • Protein kinase C-delta and mitogen-activated protein/extracellular signal-regulated kinase-1 control GLI activation in hedgehog signaling
    • N.A. Riobo G.M. Haines C.P. Emerson Jr. Protein kinase C-delta and mitogen-activated protein/extracellular signal-regulated kinase-1 control GLI activation in hedgehog signaling Cancer Res. 66 2006 839 845
    • (2006) Cancer Res. , vol.66 , pp. 839-845
    • Riobo, N.A.1    Haines, G.M.2    Emerson, C.P.3
  • 89
    • 33747827890 scopus 로고    scopus 로고
    • Hedgehog signal transduction: signal integration and cross talk in development and cancer
    • N.A. Riobo K. Lu C.P. Emerson Jr. Hedgehog signal transduction: signal integration and cross talk in development and cancer Cell Cycle 5 2006 1612 1615
    • (2006) Cell Cycle , vol.5 , pp. 1612-1615
    • Riobo, N.A.1    Lu, K.2    Emerson, C.P.3
  • 90
  • 91
    • 38049059990 scopus 로고    scopus 로고
    • The activation of NF-kappaB through Akt-induced FOXO1 phosphorylation during aging and its modulation by calorie restriction
    • D.H. Kim J.Y. Kim B.P. Yu H.Y. Chung The activation of NF-kappaB through Akt-induced FOXO1 phosphorylation during aging and its modulation by calorie restriction Biogerontology 9 2008 33 47
    • (2008) Biogerontology , vol.9 , pp. 33-47
    • Kim, D.H.1    Kim, J.Y.2    Yu, B.P.3    Chung, H.Y.4
  • 92
    • 0033789065 scopus 로고    scopus 로고
    • Direct action of the nodal-related signal cyclops in induction of sonic hedgehog in the ventral midline of the CNS
    • F. Muller S. Albert P. Blader N. Fischer M. Hallonet U. Strahle Direct action of the nodal-related signal cyclops in induction of sonic hedgehog in the ventral midline of the CNS Development (Cambridge, England) 127 2000 3889 3897
    • (2000) Development (Cambridge, England) , vol.127 , pp. 3889-3897
    • Muller, F.1    Albert, S.2    Blader, P.3    Fischer, N.4    Hallonet, M.5    Strahle, U.6
  • 95
    • 0043125614 scopus 로고    scopus 로고
    • The amount of sonic hedgehog in multiple sclerosis white matter is decreased and cleavage to the signaling peptide is deficient
    • F.G. Mastronardi L.A. daCruz H. Wang J. Boggs M.A. Moscarello The amount of sonic hedgehog in multiple sclerosis white matter is decreased and cleavage to the signaling peptide is deficient Mult. Scler. 9 2003 362 371
    • (2003) Mult. Scler. , vol.9 , pp. 362-371
    • Mastronardi, F.G.1    daCruz, L.A.2    Wang, H.3    Boggs, J.4    Moscarello, M.A.5
  • 96
    • 4444235437 scopus 로고    scopus 로고
    • Differentiation and transcription factor gene therapy in experimental parkinson's disease: sonic hedgehog and Gli-1, but not Nurr-1, protect nigrostriatal cell bodies from 6-OHDA-induced neurodegeneration
    • A. Hurtado-Lorenzo E. Millan V. Gonzalez-Nicolini D. Suwelack M.G. Castro P.R. Lowenstein Differentiation and transcription factor gene therapy in experimental parkinson's disease: sonic hedgehog and Gli-1, but not Nurr-1, protect nigrostriatal cell bodies from 6-OHDA-induced neurodegeneration Mol. Ther. 10 2004 507 524
    • (2004) Mol. Ther. , vol.10 , pp. 507-524
    • Hurtado-Lorenzo, A.1    Millan, E.2    Gonzalez-Nicolini, V.3    Suwelack, D.4    Castro, M.G.5    Lowenstein, P.R.6
  • 97
    • 0036144970 scopus 로고    scopus 로고
    • Intrastriatal injection of sonic hedgehog reduces behavioral impairment in a rat model of Parkinson's disease
    • K. Tsuboi C.W. Shults Intrastriatal injection of sonic hedgehog reduces behavioral impairment in a rat model of Parkinson's disease Exp. Neurol. 173 2002 95 104
    • (2002) Exp. Neurol. , vol.173 , pp. 95-104
    • Tsuboi, K.1    Shults, C.W.2
  • 99
    • 0037424249 scopus 로고    scopus 로고
    • Sonic hedgehog induces capillary morphogenesis by endothelial cells through phosphoinositide 3-kinase
    • S. Kanda Y. Mochizuki T. Suematsu Y. Miyata K. Nomata H. Kanetake Sonic hedgehog induces capillary morphogenesis by endothelial cells through phosphoinositide 3-kinase J. Biol. Chem. 278 2003 8244 8249
    • (2003) J. Biol. Chem. , vol.278 , pp. 8244-8249
    • Kanda, S.1    Mochizuki, Y.2    Suematsu, T.3    Miyata, Y.4    Nomata, K.5    Kanetake, H.6
  • 101
    • 0033523005 scopus 로고    scopus 로고
    • Interaction of frizzled related protein (FRP) with Wnt ligands and the frizzled receptor suggests alternative mechanisms for FRP inhibition of Wnt signaling
    • A. Bafico A. Gazit T. Pramila P.W. Finch A. Yaniv S.A. Aaronson Interaction of frizzled related protein (FRP) with Wnt ligands and the frizzled receptor suggests alternative mechanisms for FRP inhibition of Wnt signaling J. Biol. Chem. 274 1999 16180 16187
    • (1999) J. Biol. Chem. , vol.274 , pp. 16180-16187
    • Bafico, A.1    Gazit, A.2    Pramila, T.3    Finch, P.W.4    Yaniv, A.5    Aaronson, S.A.6
  • 102
    • 0035902140 scopus 로고    scopus 로고
    • The Hedgehog and Wnt signalling pathways in cancer
    • J. Taipale P.A. Beachy The Hedgehog and Wnt signalling pathways in cancer Nature 411 2001 349 354
    • (2001) Nature , vol.411 , pp. 349-354
    • Taipale, J.1    Beachy, P.A.2


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