Discovery of quinazolines as a novel structural class of potent inhibitors of NF-κB activation

Bioorganic and Medicinal Chemistry

Volumn 11, Issue 3, 2003, Pages 383-391

  Tobe, Masanori ^a   Isobe, Yoshiaki ^a   Tomizawa, Hideyuki ^a   Nagasaki, Takahiro ^a   Takahashi, Hirotada ^a   Fukazawa, Tominaga ^a   Hayashi, Hideya ^a  

^a JAPAN ENERGY CORPORATION   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

1 (4 CHLOROPHENETHYLAMINO)ISOQUINOLINE; 1 (4 CHLOROPHENETHYLAMINO)PHTHALAZINE; 4 (4 CHLOROBENZYLAMINO)QUINAZOLINE; 4 (4 CHLOROPHENETHYLAMINO) 6 HYDROXYQUINAZOLINE; 4 (4 CHLOROPHENETHYLAMINO) 6 METHYLQUINAZOLINE; 4 (4 CHLOROPHENETHYLAMINO) 6 NITROQUINAZOLINE; 4 (4 CHLOROPHENETHYLAMINO) 7 NITROQUINAZOLINE; 4 (4 CHLOROPHENETHYLAMINO)QUINAZOLINE; 4 (4 CHLOROPHENETHYLAMINO)QUINOLINE; 4 (4 CHLOROPHENYLAMINO)QUINAZOLINE; 4 [3 (4 CHLOROPHENYL)PROPYLAMINO]QUINAZOLINE; 4 [3 (PHENYL)PROPYLAMINO]QUINAZOLINE; 6 ACETAMIDO 4 (4 CHLOROPHENETHYLAMINO)QUINAZOLINE; 6 AMINO 4 (4 CHLOROPHENETHYLAMINO)QUINAZOLINE; 6 AMINO 4 (4 HYDROXYPHENETHYLAMINO)QUINAZOLINE; 6 AMINO 4 (4 METHOXYPHENETHYLAMINO)QUINAZOLINE; 6 AMINO 4 (4 METHYLPHENETHYLAMINO)QUINAZOLINE; 6 AMINO 4 (4 PHENOXYPHENETHYLAMINO)QUINAZOLINE; 6 AMINO 4 (PHENETHYLAMINO)QUINAZOLINE; 6 AMINO 7 CHLORO 4 (4 CHLOROPHENETHYLAMINO)QUINAZOLINE; 6 BENZYLOXY 4 (4 CHLOROPHENETHYLAMINO)QUINAZOLINE; 6 BROMO 4 (4 CHLOROPHENETHYLAMINO)QUINAZOLINE; 6 CHLORO 4 (4 CHLOROPHENETHYLAMINO)QUINAZOLINE; 7 AMINO 4 (4 CHLOROPHENETHYLAMINO)QUINAZOLINE; 7 CHLORO 4 (4 CHLOROPHENETHYLAMINO) 6 NITROQUINAZOLINE; BENZYLOXYCARBONYLLEUCYLLEUCYLLEUCINAL; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; QUINAZOLINE DERIVATIVE; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG; UNINDEXED DRUG;

ANIMAL CELL; ANIMAL MODEL; ANTIINFLAMMATORY ACTIVITY; ARTICLE; CONTROLLED STUDY; CYTOKINE PRODUCTION; DRUG DESIGN; DRUG EFFECT; DRUG POTENCY; DRUG SYNTHESIS; ENZYME ACTIVATION; HUMAN; HUMAN CELL; MALE; MOUSE; NONHUMAN; PAW EDEMA; RAT; STRUCTURE ACTIVITY RELATION; TRANSCRIPTION INITIATION;

ANIMALS; ANTI-INFLAMMATORY AGENTS, NON-STEROIDAL; CARRAGEENAN; EDEMA; HINDLIMB; HUMANS; INHIBITORY CONCENTRATION 50; JURKAT CELLS; MALE; MICE; MICE, INBRED BALB C; NF-KAPPA B; QUINAZOLINES; RATS; SPLEEN; STRUCTURE-ACTIVITY RELATIONSHIP; TRANS-ACTIVATION (GENETICS); TUMOR NECROSIS FACTOR-ALPHA;

EID: 0037295377     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0968-0896(02)00440-6     Document Type: Article

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