메뉴 건너뛰기




Volumn , Issue , 2008, Pages 131-153

Pharmacokinetics and ADME optimization in drug discovery

Author keywords

[No Author keywords available]

Indexed keywords


EID: 84882486368     PISSN: None     EISSN: None     Source Type: Book    
DOI: 10.1016/B978-012369448-5.50009-4     Document Type: Chapter
Times cited : (3)

References (110)
  • 1
    • 0028948839 scopus 로고
    • A theoretical basis for a biopharmaceutic drug classification: the correlation of in vitro drug product dissolution and in vivo bioavailability
    • Amidon G.L., Lennernas H., Shah V.P., Crison J.R. A theoretical basis for a biopharmaceutic drug classification: the correlation of in vitro drug product dissolution and in vivo bioavailability. Pharm. Res. 1995, 12:413-420.
    • (1995) Pharm. Res. , vol.12 , pp. 413-420
    • Amidon, G.L.1    Lennernas, H.2    Shah, V.P.3    Crison, J.R.4
  • 2
    • 0026321138 scopus 로고
    • Cell cultures as models for drug absorption across the intestinal mucosa
    • Artursson P. Cell cultures as models for drug absorption across the intestinal mucosa. Crit. Rev. Ther. Drug Carrier Syst. 1991, 8:305-330.
    • (1991) Crit. Rev. Ther. Drug Carrier Syst. , vol.8 , pp. 305-330
    • Artursson, P.1
  • 3
    • 0031413702 scopus 로고    scopus 로고
    • Intestinal drug absorption and metabolism in cell cultures: Caco-2 and beyond
    • Artursson P., Borchardt R.T. Intestinal drug absorption and metabolism in cell cultures: Caco-2 and beyond. Pharm. Res. 1997, 14:1655-1658.
    • (1997) Pharm. Res. , vol.14 , pp. 1655-1658
    • Artursson, P.1    Borchardt, R.T.2
  • 4
    • 0027730961 scopus 로고
    • Evidence for a polarized efflux system in Caco-2 cells capable of modulating cyclosporin A transport
    • Augustijns P.F., Bradshaw T.P., Gan L.S. Evidence for a polarized efflux system in Caco-2 cells capable of modulating cyclosporin A transport. Biochem. Biophys. Res. Commun. 1993, 197:360-365.
    • (1993) Biochem. Biophys. Res. Commun. , vol.197 , pp. 360-365
    • Augustijns, P.F.1    Bradshaw, T.P.2    Gan, L.S.3
  • 5
    • 0031911963 scopus 로고    scopus 로고
    • PH-metric solubility 1. Solubility-pH profiles from Bjerrum plots
    • Avdeef A. pH-metric solubility 1. Solubility-pH profiles from Bjerrum plots. Pharmacy Pharmacol. Comm. 1998, 4:165-178.
    • (1998) Pharmacy Pharmacol. Comm. , vol.4 , pp. 165-178
    • Avdeef, A.1
  • 6
    • 0036809320 scopus 로고    scopus 로고
    • Physicochemical profiling in drug research: a brief survey of the state-of-the-art of experimental techniques
    • Avdeef A., Testa B. Physicochemical profiling in drug research: a brief survey of the state-of-the-art of experimental techniques. Cell Mol. Life Sci. 2002, 59:1681-1689.
    • (2002) Cell Mol. Life Sci. , vol.59 , pp. 1681-1689
    • Avdeef, A.1    Testa, B.2
  • 7
    • 0035682180 scopus 로고    scopus 로고
    • The role of half-transporters in multidrug resistance
    • Bates S.E., Robey R., Miyake K. The role of half-transporters in multidrug resistance. J. Bioenerg. Biomembr. 2001, 33:503-511.
    • (2001) J. Bioenerg. Biomembr. , vol.33 , pp. 503-511
    • Bates, S.E.1    Robey, R.2    Miyake, K.3
  • 8
    • 0036218554 scopus 로고    scopus 로고
    • Changes in plasma protein binding have little clinical relevance
    • Benet L.Z., Hoener B.A. Changes in plasma protein binding have little clinical relevance. Clin. Pharmacol. Ther. 2002, 71:115-123.
    • (2002) Clin. Pharmacol. Ther. , vol.71 , pp. 115-123
    • Benet, L.Z.1    Hoener, B.A.2
  • 10
    • 0036179239 scopus 로고    scopus 로고
    • Experimental and computational screening models for prediction of aqueous drug solubility
    • Bergstrom C.A., Norinder U., Luthman K., Artursson P. Experimental and computational screening models for prediction of aqueous drug solubility. Pharm. Res. 2002, 19:182-188.
    • (2002) Pharm. Res. , vol.19 , pp. 182-188
    • Bergstrom, C.A.1    Norinder, U.2    Luthman, K.3    Artursson, P.4
  • 11
    • 0034655372 scopus 로고    scopus 로고
    • A high-throughout screening method for the determination of aqueous drug solubility using laser nephelometry in microtiter plates
    • Bevan C.D., Lloyd R.S. A high-throughout screening method for the determination of aqueous drug solubility using laser nephelometry in microtiter plates. Analyt. Chem. 2000, 72:1781-1787.
    • (2000) Analyt. Chem. , vol.72 , pp. 1781-1787
    • Bevan, C.D.1    Lloyd, R.S.2
  • 12
    • 57249085636 scopus 로고    scopus 로고
    • Revisiting the solubility concept of pharmaceutical compounds
    • Blasko A., Leahy-Dios A., Nelson W.O. Revisiting the solubility concept of pharmaceutical compounds. Monatshefte fur Chemie 2001, 132:789-798.
    • (2001) Monatshefte fur Chemie , vol.132 , pp. 789-798
    • Blasko, A.1    Leahy-Dios, A.2    Nelson, W.O.3
  • 13
    • 0029876744 scopus 로고    scopus 로고
    • Hepatobiliary disposition of valproic acid and valproate glucuronide: use of a pharmacokinetic model to examine the rate-limiting steps and potential sites of drug interactions
    • Booth C.L., Pollack G.M., Brouwer K.L. Hepatobiliary disposition of valproic acid and valproate glucuronide: use of a pharmacokinetic model to examine the rate-limiting steps and potential sites of drug interactions. Hepatology 1996, 23:771-780.
    • (1996) Hepatology , vol.23 , pp. 771-780
    • Booth, C.L.1    Pollack, G.M.2    Brouwer, K.L.3
  • 14
    • 0034100505 scopus 로고    scopus 로고
    • High-throughput Caco-2 cell permeability screening by cassette dosing and sample pooling approaches using direct injection/on-line guard cartridge extraction/tandem mass spectrometry
    • Bu H.Z., Poglod M., Micetich R.G., Khan J.K. High-throughput Caco-2 cell permeability screening by cassette dosing and sample pooling approaches using direct injection/on-line guard cartridge extraction/tandem mass spectrometry. Rapid Commun. Mass Spectrom. 2000, 14:523-528.
    • (2000) Rapid Commun. Mass Spectrom. , vol.14 , pp. 523-528
    • Bu, H.Z.1    Poglod, M.2    Micetich, R.G.3    Khan, J.K.4
  • 15
    • 30744466667 scopus 로고    scopus 로고
    • Evaluation of an integrated in vitro-in silico PBPK (physiologically based pharmacokinetic) model to provide estimates of human bioavailability
    • Cai H., Stoner C., Reddy A. Evaluation of an integrated in vitro-in silico PBPK (physiologically based pharmacokinetic) model to provide estimates of human bioavailability. Intl J. Pharm. 2006, 308:133-139.
    • (2006) Intl J. Pharm. , vol.308 , pp. 133-139
    • Cai, H.1    Stoner, C.2    Reddy, A.3
  • 16
    • 0032189375 scopus 로고    scopus 로고
    • Estimation of permeability by passive diffusion through Caco-2 cell monolayers using the drugs' lipophilicity and molecular weight
    • Camenisch G., Alsenz J., van de Waterbeemd H., Folkers G. Estimation of permeability by passive diffusion through Caco-2 cell monolayers using the drugs' lipophilicity and molecular weight. Eur. J. Pharm. Sci. 1998, 6:317-324.
    • (1998) Eur. J. Pharm. Sci. , vol.6 , pp. 317-324
    • Camenisch, G.1    Alsenz, J.2    van de Waterbeemd, H.3    Folkers, G.4
  • 17
    • 0030001630 scopus 로고    scopus 로고
    • Physiologic pharmacokinetic modeling of gastrointestinal blood flow as a rate-limiting step in the oral absorption of digoxin, implications for patients with congestive heart failure receiving epoprostenol
    • Carlton L.D., Pollack G.M., Brouwer K.L. Physiologic pharmacokinetic modeling of gastrointestinal blood flow as a rate-limiting step in the oral absorption of digoxin, implications for patients with congestive heart failure receiving epoprostenol. J. Pharm. Sci. 1996, 85:473-477.
    • (1996) J. Pharm. Sci. , vol.85 , pp. 473-477
    • Carlton, L.D.1    Pollack, G.M.2    Brouwer, K.L.3
  • 18
    • 0033795486 scopus 로고    scopus 로고
    • Commentary: potential role of P-glycoprotein in affecting hepatic metabolism of drugs
    • Chiou W.L., Chung S.M., Wu T.C. Commentary: potential role of P-glycoprotein in affecting hepatic metabolism of drugs. Pharm. Res. 2000, 17:901-903.
    • (2000) Pharm. Res. , vol.17 , pp. 901-903
    • Chiou, W.L.1    Chung, S.M.2    Wu, T.C.3
  • 19
    • 0024505075 scopus 로고
    • The Madin-Darby canine kidney (MDCK) epithelialcell monolayer as a model cellular transport barrier
    • Cho M.J., Thompson D.P., Cramer C.T. The Madin-Darby canine kidney (MDCK) epithelialcell monolayer as a model cellular transport barrier. Pharm. Res. 1989, 6:71-77.
    • (1989) Pharm. Res. , vol.6 , pp. 71-77
    • Cho, M.J.1    Thompson, D.P.2    Cramer, C.T.3
  • 20
    • 0025061744 scopus 로고
    • Transepithelial transport of aliphatic carboxylic acids studied in Madin-Darby canine kidney (MDCK) cell monolayers
    • Cho M.J., Adson A., Kezdy F.J. Transepithelial transport of aliphatic carboxylic acids studied in Madin-Darby canine kidney (MDCK) cell monolayers. Pharm. Res. 1990, 7:325-331.
    • (1990) Pharm. Res. , vol.7 , pp. 325-331
    • Cho, M.J.1    Adson, A.2    Kezdy, F.J.3
  • 22
    • 0027102401 scopus 로고
    • The MDR1 gene product, P-glycoprotein, mediates the transport of the cardiac glycoside, digoxin
    • de Lannoy I.A., Silverman M. The MDR1 gene product, P-glycoprotein, mediates the transport of the cardiac glycoside, digoxin. Biochem. Biophys. Res. Commun. 1992, 189:551-557.
    • (1992) Biochem. Biophys. Res. Commun. , vol.189 , pp. 551-557
    • de Lannoy, I.A.1    Silverman, M.2
  • 23
    • 84962359573 scopus 로고    scopus 로고
    • High-throughput artificial membrane permeability assay for blood-brain barrier
    • Di L., Kerns E.H., Fan K. High-throughput artificial membrane permeability assay for blood-brain barrier. Eur. J. Med. Chem. 2003, 38:223-232.
    • (2003) Eur. J. Med. Chem. , vol.38 , pp. 223-232
    • Di, L.1    Kerns, E.H.2    Fan, K.3
  • 24
    • 0024403640 scopus 로고
    • Specific assay for the quantitation of indocyanine green in rat plasma using high-performance liquid chromatography with fluorescence detection
    • Dorr M.B., Pollack G.M. Specific assay for the quantitation of indocyanine green in rat plasma using high-performance liquid chromatography with fluorescence detection. J. Pharm. Sci. 1989, 78:328-333.
    • (1989) J. Pharm. Sci. , vol.78 , pp. 328-333
    • Dorr, M.B.1    Pollack, G.M.2
  • 25
    • 13044249156 scopus 로고    scopus 로고
    • A multidrug resistance transporter from human MCF-7 breast cancer cells
    • Doyle L.A., Yang W., Abruzzo L.V. A multidrug resistance transporter from human MCF-7 breast cancer cells. Proc. Natl Acad. Sci. USA 1998, 95:15665-15670.
    • (1998) Proc. Natl Acad. Sci. USA , vol.95 , pp. 15665-15670
    • Doyle, L.A.1    Yang, W.2    Abruzzo, L.V.3
  • 26
    • 0029786432 scopus 로고    scopus 로고
    • Differential induction of prehepatic and hepatic metabolism of verapamil by rifampin
    • Fromm M.F., Busse D., Kroemer H.K., Eichelbaum M. Differential induction of prehepatic and hepatic metabolism of verapamil by rifampin. Hepatology 1996, 24:796-801.
    • (1996) Hepatology , vol.24 , pp. 796-801
    • Fromm, M.F.1    Busse, D.2    Kroemer, H.K.3    Eichelbaum, M.4
  • 27
    • 0141537961 scopus 로고    scopus 로고
    • Semi-automatic high-throughput determination of plasma protein binding using a 96-well plate filtrate assembly and fast liquid chromatography-tandem mass spectrometry
    • Fung E.N., Chen Y.H., Lau Y.Y. Semi-automatic high-throughput determination of plasma protein binding using a 96-well plate filtrate assembly and fast liquid chromatography-tandem mass spectrometry. J. Chromatogr. B Analyt. Technol. Biomed. Life Sci. 2003, 795:187-194.
    • (2003) J. Chromatogr. B Analyt. Technol. Biomed. Life Sci. , vol.795 , pp. 187-194
    • Fung, E.N.1    Chen, Y.H.2    Lau, Y.Y.3
  • 28
    • 9044252313 scopus 로고    scopus 로고
    • CYP3A-like cytochrome P450-mediated metabolism and polarized efflux of cyclosporin A in Caco-2 cells
    • Gan L.S., Moseley M.A., Khosla B. CYP3A-like cytochrome P450-mediated metabolism and polarized efflux of cyclosporin A in Caco-2 cells. Drug Metab. Dispos. 1996, 24:344-349.
    • (1996) Drug Metab. Dispos. , vol.24 , pp. 344-349
    • Gan, L.S.1    Moseley, M.A.2    Khosla, B.3
  • 29
    • 0027218689 scopus 로고
    • Biochemistry of multidrug resistance mediated by the multidrug transporter
    • Gottesman M.M., Pastan I. Biochemistry of multidrug resistance mediated by the multidrug transporter. Annu. Rev. Biochem. 1993, 62:385-427.
    • (1993) Annu. Rev. Biochem. , vol.62 , pp. 385-427
    • Gottesman, M.M.1    Pastan, I.2
  • 31
    • 0033660010 scopus 로고    scopus 로고
    • Solvation descriptors for pesticides from the solubility of solids: Diuron as an example
    • Green C.E., Abraham M.H., Acree W.E. Solvation descriptors for pesticides from the solubility of solids: Diuron as an example. Pest Management Sci. 2000, 56:1043-1053.
    • (2000) Pest Management Sci. , vol.56 , pp. 1043-1053
    • Green, C.E.1    Abraham, M.H.2    Acree, W.E.3
  • 33
    • 0032754284 scopus 로고    scopus 로고
    • The role of intestinal P-glycoprotein in the interaction of digoxin and rifampin
    • Greiner B., Eichelbaum M., Fritz P. The role of intestinal P-glycoprotein in the interaction of digoxin and rifampin. J. Clin. Invest. 1999, 104:147-153.
    • (1999) J. Clin. Invest. , vol.104 , pp. 147-153
    • Greiner, B.1    Eichelbaum, M.2    Fritz, P.3
  • 34
    • 0035524138 scopus 로고    scopus 로고
    • Assessing the absorption of new pharmaceuticals
    • Hidalgo I.J. Assessing the absorption of new pharmaceuticals. Curr. Topics Med. Chem. 2001, 1:385-401.
    • (2001) Curr. Topics Med. Chem. , vol.1 , pp. 385-401
    • Hidalgo, I.J.1
  • 35
    • 0024593744 scopus 로고
    • Characterization of the human colon carcinoma cell line (Caco-2) as a model system for intestinal epithelial permeability
    • Hidalgo I.J., Raub T.J., Borchardt R.T. Characterization of the human colon carcinoma cell line (Caco-2) as a model system for intestinal epithelial permeability. Gastroenterology 1989, 96:736-749.
    • (1989) Gastroenterology , vol.96 , pp. 736-749
    • Hidalgo, I.J.1    Raub, T.J.2    Borchardt, R.T.3
  • 36
    • 0026621245 scopus 로고
    • ABC transporters: from microorganisms to man
    • Higgins C.F. ABC transporters: from microorganisms to man. Annu. Rev. Cell Biol. 1992, 8:67-113.
    • (1992) Annu. Rev. Cell Biol. , vol.8 , pp. 67-113
    • Higgins, C.F.1
  • 37
    • 0028914113 scopus 로고
    • P-glycoprotein and cell volumeactivated chloride channels
    • Higgins C.F. P-glycoprotein and cell volumeactivated chloride channels. J. Bioenerg. Biomembr. 1995, 27:63-70.
    • (1995) J. Bioenerg. Biomembr. , vol.27 , pp. 63-70
    • Higgins, C.F.1
  • 39
    • 0025132942 scopus 로고
    • Caco-2 cell monolayers as a model for drug transport across the intestinal mucosa
    • Hilgers A.R., Conradi R.A., Burton P.S. Caco-2 cell monolayers as a model for drug transport across the intestinal mucosa. Pharm. Res. 1990, 7:902-910.
    • (1990) Pharm. Res. , vol.7 , pp. 902-910
    • Hilgers, A.R.1    Conradi, R.A.2    Burton, P.S.3
  • 40
    • 0027818964 scopus 로고
    • Role of P-glycoprotein in renal tubular secretion of digoxin in the isolated perfused rat kidney
    • Hori R., Okamura N., Aiba T., Tanigawara Y. Role of P-glycoprotein in renal tubular secretion of digoxin in the isolated perfused rat kidney. J. Pharmacol. Exper. Ther. 1993, 266:1620-1625.
    • (1993) J. Pharmacol. Exper. Ther. , vol.266 , pp. 1620-1625
    • Hori, R.1    Okamura, N.2    Aiba, T.3    Tanigawara, Y.4
  • 41
    • 0027180795 scopus 로고
    • Drug absorption limited by P-glycoprotein-mediated secretory drug transport in human intestinal epithelial Caco-2 cell layers
    • Hunter J., Hirst B.H., Simmons N.L. Drug absorption limited by P-glycoprotein-mediated secretory drug transport in human intestinal epithelial Caco-2 cell layers. Pharm. Res. 1993, 10:743-749.
    • (1993) Pharm. Res. , vol.10 , pp. 743-749
    • Hunter, J.1    Hirst, B.H.2    Simmons, N.L.3
  • 42
    • 25144450046 scopus 로고    scopus 로고
    • Apical/basolateral surface expression of drug transporters and its role in vectorial drug transport
    • Ito K., Suzuki H., Horie T., Sugiyama Y. Apical/basolateral surface expression of drug transporters and its role in vectorial drug transport. Pharm. Res. 2005, 22:1559-1577.
    • (2005) Pharm. Res. , vol.22 , pp. 1559-1577
    • Ito, K.1    Suzuki, H.2    Horie, T.3    Sugiyama, Y.4
  • 43
    • 33746803672 scopus 로고    scopus 로고
    • Prediction of the clearance of eleven drugs and associated variability in neonates, infants and children
    • Johnson T.N., Rostami-Hodjegan A., Tucker G.T. Prediction of the clearance of eleven drugs and associated variability in neonates, infants and children. Clin. Pharmacokinet. 2006, 45:931-956.
    • (2006) Clin. Pharmacokinet. , vol.45 , pp. 931-956
    • Johnson, T.N.1    Rostami-Hodjegan, A.2    Tucker, G.T.3
  • 44
    • 33645830172 scopus 로고
    • A surface glycoprotein modulating drug permeability in Chinese hamster ovary cell mutants
    • Juliano R.L., Ling V. A surface glycoprotein modulating drug permeability in Chinese hamster ovary cell mutants. Biochim. Biophys. Acta 1976, 455:152-162.
    • (1976) Biochim. Biophys. Acta , vol.455 , pp. 152-162
    • Juliano, R.L.1    Ling, V.2
  • 45
    • 0034851313 scopus 로고    scopus 로고
    • N-in-one determination of retention factors for drugs by immobilized artificial membrane chromatography coupled to atmospheric pressure chemical ionization mass spectrometry
    • Kangas H., Kotiaho T., Salminen T., Kostiainen R. N-in-one determination of retention factors for drugs by immobilized artificial membrane chromatography coupled to atmospheric pressure chemical ionization mass spectrometry. Rapid Commun. Mass Spectrom. 2001, 15:1501-1505.
    • (2001) Rapid Commun. Mass Spectrom. , vol.15 , pp. 1501-1505
    • Kangas, H.1    Kotiaho, T.2    Salminen, T.3    Kostiainen, R.4
  • 46
    • 0032568397 scopus 로고    scopus 로고
    • Physicochemical high throughput screening: parallel artificial membrane permeation assay in the description of passive absorption processes
    • Kansy M., Senner F., Gubernator K. Physicochemical high throughput screening: parallel artificial membrane permeation assay in the description of passive absorption processes. J. Med. Chem. 1998, 41:1007-1010.
    • (1998) J. Med. Chem. , vol.41 , pp. 1007-1010
    • Kansy, M.1    Senner, F.2    Gubernator, K.3
  • 47
    • 0032518290 scopus 로고    scopus 로고
    • The drug transporter P-glycoprotein limits oral absorption and brain entry of HIV-1 protease inhibitors
    • Kim R.B., Fromm M.F., Wandel C. The drug transporter P-glycoprotein limits oral absorption and brain entry of HIV-1 protease inhibitors. J. Clin. Invest. 1998, 101:289-294.
    • (1998) J. Clin. Invest. , vol.101 , pp. 289-294
    • Kim, R.B.1    Fromm, M.F.2    Wandel, C.3
  • 48
    • 33748417554 scopus 로고    scopus 로고
    • Deconvoluting the effects of P-glycoprotein on intestinal CYP3A, a major challenge
    • Knight B., Troutman M., Thakker D.R. Deconvoluting the effects of P-glycoprotein on intestinal CYP3A, a major challenge. Curr. Opin. Pharmacol. 2006, 6:528-532.
    • (2006) Curr. Opin. Pharmacol. , vol.6 , pp. 528-532
    • Knight, B.1    Troutman, M.2    Thakker, D.R.3
  • 49
    • 0032428485 scopus 로고    scopus 로고
    • Applications and limitations of interspecies scaling and in vitro extrapolation in pharmacokinetics
    • Lin J.H. Applications and limitations of interspecies scaling and in vitro extrapolation in pharmacokinetics. Drug Metab. Dispos. 1998, 26:1202-1212.
    • (1998) Drug Metab. Dispos. , vol.26 , pp. 1202-1212
    • Lin, J.H.1
  • 50
    • 0034461768 scopus 로고    scopus 로고
    • Drug-like properties and the causes of poor solubility and poor permeability
    • Lipinski C.A. Drug-like properties and the causes of poor solubility and poor permeability. J. Pharmacol. Toxicol. Methods 2000, 44:235-249.
    • (2000) J. Pharmacol. Toxicol. Methods , vol.44 , pp. 235-249
    • Lipinski, C.A.1
  • 51
    • 0030743356 scopus 로고    scopus 로고
    • Competitive, non-competitive and cooperative interactions between substrates of P-glycoprotein as measured by its ATPase activity
    • Litman T., Zeuthen T., Skovsgaard T., Stein W.D. Competitive, non-competitive and cooperative interactions between substrates of P-glycoprotein as measured by its ATPase activity. Biochim. Biophys. Acta 1997, 1361:169-176.
    • (1997) Biochim. Biophys. Acta , vol.1361 , pp. 169-176
    • Litman, T.1    Zeuthen, T.2    Skovsgaard, T.3    Stein, W.D.4
  • 52
    • 0030791978 scopus 로고    scopus 로고
    • Structure-activity relationships of P-glycoprotein interacting drugs, kinetic characterization of their effects on ATPase activity
    • Litman T., Zeuthen T., Skovsgaard T., Stein W.D. Structure-activity relationships of P-glycoprotein interacting drugs, kinetic characterization of their effects on ATPase activity. Biochim. Biophys. Acta 1997, 1361:159-168.
    • (1997) Biochim. Biophys. Acta , vol.1361 , pp. 159-168
    • Litman, T.1    Zeuthen, T.2    Skovsgaard, T.3    Stein, W.D.4
  • 53
    • 0025325289 scopus 로고
    • Pharmacokinetics and pharmacodynamics of valproate analogues in rats I. Spiro{4.6}undecane-2carboxylic acid
    • Liu M.J., Scott K.R., Pollack G.M. Pharmacokinetics and pharmacodynamics of valproate analogues in rats I. Spiro{4.6}undecane-2carboxylic acid. Epilepsia 1990, 31:465-473.
    • (1990) Epilepsia , vol.31 , pp. 465-473
    • Liu, M.J.1    Scott, K.R.2    Pollack, G.M.3
  • 54
    • 0034720879 scopus 로고    scopus 로고
    • ElogDoct: a tool for lipophilicity determination in drug discovery
    • Lombardo F., Shalaeva M.Y., Tupper K.A. ElogDoct: a tool for lipophilicity determination in drug discovery. J. Med. Chem. 2000, 43:2922-2928.
    • (2000) J. Med. Chem. , vol.43 , pp. 2922-2928
    • Lombardo, F.1    Shalaeva, M.Y.2    Tupper, K.A.3
  • 55
    • 0035913059 scopus 로고    scopus 로고
    • ElogD(oct): a tool for lipophilicity determination in drug discovery 2. Basic and neutral compounds
    • Lombardo F., Shalaeva M.Y., Tupper K.A., Gao F. ElogD(oct): a tool for lipophilicity determination in drug discovery 2. Basic and neutral compounds. J. Med. Chem. 2001, 44:2490-2497.
    • (2001) J. Med. Chem. , vol.44 , pp. 2490-2497
    • Lombardo, F.1    Shalaeva, M.Y.2    Tupper, K.A.3    Gao, F.4
  • 56
    • 0037142338 scopus 로고    scopus 로고
    • Prediction of volume of distribution values in humans for neutral and basic drugs using physicochemical measurements and plasma protein binding data
    • Lombardo F., Obach R.S., Shalaeva M.Y., Gao F. Prediction of volume of distribution values in humans for neutral and basic drugs using physicochemical measurements and plasma protein binding data. J. Med. Chem. 2002, 45:2867-2876.
    • (2002) J. Med. Chem. , vol.45 , pp. 2867-2876
    • Lombardo, F.1    Obach, R.S.2    Shalaeva, M.Y.3    Gao, F.4
  • 57
    • 1242273811 scopus 로고    scopus 로고
    • Prediction of human volume of distribution values for neutral and basic drugs 2. Extended data set and leave-class-out statistics
    • Lombardo F., Obach R.S., Shalaeva M.Y., Gao F. Prediction of human volume of distribution values for neutral and basic drugs 2. Extended data set and leave-class-out statistics. J. Med. Chem. 2004, 47:1242-1250.
    • (2004) J. Med. Chem. , vol.47 , pp. 1242-1250
    • Lombardo, F.1    Obach, R.S.2    Shalaeva, M.Y.3    Gao, F.4
  • 58
    • 0032955949 scopus 로고    scopus 로고
    • The pharmacokinetic principles behind scaling from preclinical results to Phase I protocols
    • Mahmood I., Balian J.D. The pharmacokinetic principles behind scaling from preclinical results to Phase I protocols. Clin. Pharmacokinet. 1999, 36:1-11.
    • (1999) Clin. Pharmacokinet. , vol.36 , pp. 1-11
    • Mahmood, I.1    Balian, J.D.2
  • 59
    • 0023872441 scopus 로고
    • Distribution coefficient, a convenient term for the relation of predictable physico-chemical properties to metabolic processes
    • Manners C.N., Payling D.W., Smith D.A. Distribution coefficient, a convenient term for the relation of predictable physico-chemical properties to metabolic processes. Xenobiotica 1988, 18:331-350.
    • (1988) Xenobiotica , vol.18 , pp. 331-350
    • Manners, C.N.1    Payling, D.W.2    Smith, D.A.3
  • 60
    • 0035031472 scopus 로고    scopus 로고
    • In vitro high throughput screening of compounds for favorable metabolic properties in drug discovery
    • Masimirembwa C.M., Thompson R., Andersson T.B. In vitro high throughput screening of compounds for favorable metabolic properties in drug discovery. Comb. Chem. High Throughput Screen 2001, 4:245-263.
    • (2001) Comb. Chem. High Throughput Screen , vol.4 , pp. 245-263
    • Masimirembwa, C.M.1    Thompson, R.2    Andersson, T.B.3
  • 61
    • 0030588645 scopus 로고    scopus 로고
    • The use of adult human hepatocytes in primary culture and other in vitro systems to investigate drug metabolism in man
    • Maurel P. The use of adult human hepatocytes in primary culture and other in vitro systems to investigate drug metabolism in man. Adv. Drug Deliv. Rev. 1996, 22:105-132.
    • (1996) Adv. Drug Deliv. Rev. , vol.22 , pp. 105-132
    • Maurel, P.1
  • 62
    • 0032733974 scopus 로고    scopus 로고
    • Prediction of human clearance of twenty-nine drugs from hepatic microsomal intrinsic clearance data: an examination of in vitro half-life approach and nonspecific binding to microsomes
    • Obach R.S. Prediction of human clearance of twenty-nine drugs from hepatic microsomal intrinsic clearance data: an examination of in vitro half-life approach and nonspecific binding to microsomes. Drug Metab. Dispos. 1999, 27:1350-1359.
    • (1999) Drug Metab. Dispos. , vol.27 , pp. 1350-1359
    • Obach, R.S.1
  • 63
    • 0031445547 scopus 로고    scopus 로고
    • Characterization of interintestinal and intraintestinal variations in human CYP3A-dependent metabolism
    • Paine M.F., Khalighi M., Fisher J.M. Characterization of interintestinal and intraintestinal variations in human CYP3A-dependent metabolism. J. Pharmacol. Exper. Ther. 1997, 283:1552-1562.
    • (1997) J. Pharmacol. Exper. Ther. , vol.283 , pp. 1552-1562
    • Paine, M.F.1    Khalighi, M.2    Fisher, J.M.3
  • 64
    • 0035069173 scopus 로고    scopus 로고
    • Comparison of chromatographic and spectroscopic methods used to rank compounds for aqueous solubility
    • Pan L., Ho Q., Tsutsui K., Takahashi L. Comparison of chromatographic and spectroscopic methods used to rank compounds for aqueous solubility. J. Pharm. Sci. 2001, 90:521-529.
    • (2001) J. Pharm. Sci. , vol.90 , pp. 521-529
    • Pan, L.1    Ho, Q.2    Tsutsui, K.3    Takahashi, L.4
  • 65
    • 0013508682 scopus 로고
    • A retrovirus carrying an MDR1 cDNA confers multidrug resistance and polarized expression of P-glycoprotein in MDCK cells
    • Pastan I., Gottesman M.M., Ueda K. A retrovirus carrying an MDR1 cDNA confers multidrug resistance and polarized expression of P-glycoprotein in MDCK cells. Proc. Natl Acad. Sci. USA 1988, 85:4486-4490.
    • (1988) Proc. Natl Acad. Sci. USA , vol.85 , pp. 4486-4490
    • Pastan, I.1    Gottesman, M.M.2    Ueda, K.3
  • 66
    • 0034604758 scopus 로고    scopus 로고
    • Rapid method for estimating the octanol-water partition coefficient (log P ow) by microemulsion electrokinetic chromatography
    • Poole S.K., Durham D., Kibbey C. Rapid method for estimating the octanol-water partition coefficient (log P ow) by microemulsion electrokinetic chromatography. J. Chromatogr. B Biomed. Sci. Appl. 2000, 745:117-126.
    • (2000) J. Chromatogr. B Biomed. Sci. Appl. , vol.745 , pp. 117-126
    • Poole, S.K.1    Durham, D.2    Kibbey, C.3
  • 67
    • 33748905486 scopus 로고    scopus 로고
    • Use of immortalized human hepatocytes to predict the magnitude of clinical drug-drug interactions caused by CYP3A4 induction
    • Ripp S.L., Mills J.B., Fahmi O.A. Use of immortalized human hepatocytes to predict the magnitude of clinical drug-drug interactions caused by CYP3A4 induction. Drug Metab. Dispos. 2006, 34:1742-1748.
    • (2006) Drug Metab. Dispos. , vol.34 , pp. 1742-1748
    • Ripp, S.L.1    Mills, J.B.2    Fahmi, O.A.3
  • 69
    • 22344448841 scopus 로고    scopus 로고
    • Expression and induction potential of cytochromes P450 in human cryopreserved hepatocytes
    • Roymans D., Annaert P., van Houdt J. Expression and induction potential of cytochromes P450 in human cryopreserved hepatocytes. Drug Metab. Dispos. 2005, 33:1004-1016.
    • (2005) Drug Metab. Dispos. , vol.33 , pp. 1004-1016
    • Roymans, D.1    Annaert, P.2    van Houdt, J.3
  • 70
    • 0028840847 scopus 로고
    • Possible involvement of multiple P-glycoprotein-mediated efflux systems in the transport of verapamil and other organic cations across rat intestine
    • Saitoh H., Aungst B.J. Possible involvement of multiple P-glycoprotein-mediated efflux systems in the transport of verapamil and other organic cations across rat intestine. Pharm. Res. 1995, 12:1304-1310.
    • (1995) Pharm. Res. , vol.12 , pp. 1304-1310
    • Saitoh, H.1    Aungst, B.J.2
  • 71
    • 0031982725 scopus 로고    scopus 로고
    • Pharmacological insights from P-glycoprotein knockout mice
    • Schinkel A.H. Pharmacological insights from P-glycoprotein knockout mice. Intl J. Clin. Pharmacol. Ther. 1998, 36:9-13.
    • (1998) Intl J. Clin. Pharmacol. Ther. , vol.36 , pp. 9-13
    • Schinkel, A.H.1
  • 72
    • 0027408359 scopus 로고
    • N-glycosylation and deletion mutants of the human MDR1 P-glycoprotein
    • Schinkel A.H., Kemp S., Dolle M. N-glycosylation and deletion mutants of the human MDR1 P-glycoprotein. J. Biol. Chem. 1993, 268:7474-7481.
    • (1993) J. Biol. Chem. , vol.268 , pp. 7474-7481
    • Schinkel, A.H.1    Kemp, S.2    Dolle, M.3
  • 73
    • 0028229150 scopus 로고
    • Disruption of the mouse mdr1a P-glycoprotein gene leads to a deficiency in the blood-brain barrier and to increased sensitivity to drugs
    • Schinkel A.H., Smit J.J., van Tellingen O. Disruption of the mouse mdr1a P-glycoprotein gene leads to a deficiency in the blood-brain barrier and to increased sensitivity to drugs. Cell 1994, 77:491-502.
    • (1994) Cell , vol.77 , pp. 491-502
    • Schinkel, A.H.1    Smit, J.J.2    van Tellingen, O.3
  • 74
    • 0029098340 scopus 로고
    • Multidrug resistance and the role of P-glycoprotein knockout mice
    • Schinkel A.H., Mol C.A., Wagenaar E. Multidrug resistance and the role of P-glycoprotein knockout mice. Eur. J. Cancer 1995, 31A:1295-1298.
    • (1995) Eur. J. Cancer , vol.31 A , pp. 1295-1298
    • Schinkel, A.H.1    Mol, C.A.2    Wagenaar, E.3
  • 75
    • 0028825399 scopus 로고
    • Absence of the mdr1a P-glycoprotein in mice affects tissue distribution and pharmacokinetics of dexamethasone, digoxin, and cyclosporin A
    • Schinkel A.H., Wagenaar E., van Deemter L. Absence of the mdr1a P-glycoprotein in mice affects tissue distribution and pharmacokinetics of dexamethasone, digoxin, and cyclosporin A. J. Clin. Invest. 1995, 96:1698-1705.
    • (1995) J. Clin. Invest. , vol.96 , pp. 1698-1705
    • Schinkel, A.H.1    Wagenaar, E.2    van Deemter, L.3
  • 76
    • 0032518454 scopus 로고    scopus 로고
    • A general pattern for substrate recognition by P-glycoprotein
    • Seelig A. A general pattern for substrate recognition by P-glycoprotein. Eur. J. Biochem. 1998, 251:252-261.
    • (1998) Eur. J. Biochem. , vol.251 , pp. 252-261
    • Seelig, A.1
  • 77
    • 0028914111 scopus 로고
    • Characterization and functional reconstitution of the multidrug transporter
    • Sharom F.J. Characterization and functional reconstitution of the multidrug transporter. J. Bioenerg. Biomembr. 1995, 27:15-22.
    • (1995) J. Bioenerg. Biomembr. , vol.27 , pp. 15-22
    • Sharom, F.J.1
  • 78
    • 0031455482 scopus 로고    scopus 로고
    • The P-glycoprotein efflux pump: how does it transport drugs? J
    • Sharom F.J. The P-glycoprotein efflux pump: how does it transport drugs? J. Membr. Biol. 1997, 160:161-175.
    • (1997) Membr. Biol. , vol.160 , pp. 161-175
    • Sharom, F.J.1
  • 79
    • 0030869122 scopus 로고    scopus 로고
    • The P-glycoprotein multidrug transporter: interactions with membrane lipids, and their modulation of activity
    • Sharom F.J. The P-glycoprotein multidrug transporter: interactions with membrane lipids, and their modulation of activity. Biochem. Soc. Trans. 1997, 25:1088-1096.
    • (1997) Biochem. Soc. Trans. , vol.25 , pp. 1088-1096
    • Sharom, F.J.1
  • 80
    • 0027482461 scopus 로고
    • Functional reconstitution of drug transport and ATPase activity in proteoliposomes containing partially purified P-glycoprotein
    • Sharom F.J., Yu X., Doige C.A. Functional reconstitution of drug transport and ATPase activity in proteoliposomes containing partially purified P-glycoprotein. J. Biol. Chem. 1993, 268:24197-24202.
    • (1993) J. Biol. Chem. , vol.268 , pp. 24197-24202
    • Sharom, F.J.1    Yu, X.2    Doige, C.A.3
  • 81
    • 0029027674 scopus 로고
    • Characterization of the ATPase activity of P-glycoprotein from multidrug-resistant Chinese hamster ovary cells
    • Sharom F.J., Yu X., Chu J.W., Doige C.A. Characterization of the ATPase activity of P-glycoprotein from multidrug-resistant Chinese hamster ovary cells. Biochem. J. 1995, 308:381-390.
    • (1995) Biochem. J. , vol.308 , pp. 381-390
    • Sharom, F.J.1    Yu, X.2    Chu, J.W.3    Doige, C.A.4
  • 82
    • 33644896517 scopus 로고    scopus 로고
    • Preclinical pharmacokinetics: an approach towards safer and effi cacious drugs
    • Singh S.S. Preclinical pharmacokinetics: an approach towards safer and effi cacious drugs. Curr. Drug Metab. 2006, 7:165-182.
    • (2006) Curr. Drug Metab. , vol.7 , pp. 165-182
    • Singh, S.S.1
  • 83
    • 0027363563 scopus 로고
    • Homozygous disruption of the murine mdr2 P-glycoprotein gene leads to a complete absence of phospholipid from bile and to liver disease
    • Smit J.J., Schinkel A.H., Oude Elferink R.P. Homozygous disruption of the murine mdr2 P-glycoprotein gene leads to a complete absence of phospholipid from bile and to liver disease. Cell 1993, 75:451-462.
    • (1993) Cell , vol.75 , pp. 451-462
    • Smit, J.J.1    Schinkel, A.H.2    Oude Elferink, R.P.3
  • 84
    • 0031962002 scopus 로고    scopus 로고
    • P-glycoprotein transporters and the gastrointestinal tract: evaluation of the potential in vivo relevance of in vitro data employing talinolol as model compound
    • Spahn-Langguth H., Baktir G., Radschuweit A. P-glycoprotein transporters and the gastrointestinal tract: evaluation of the potential in vivo relevance of in vitro data employing talinolol as model compound. Intl J. Clin. Pharmacol. Ther. 1998, 36:16-24.
    • (1998) Intl J. Clin. Pharmacol. Ther. , vol.36 , pp. 16-24
    • Spahn-Langguth, H.1    Baktir, G.2    Radschuweit, A.3
  • 85
    • 12644278301 scopus 로고    scopus 로고
    • Limited oral bioavailability and active epithelial excretion of paclitaxel (Taxol) caused by P-glycoprotein in the intestine
    • Sparreboom A., van Asperen J., Mayer U. Limited oral bioavailability and active epithelial excretion of paclitaxel (Taxol) caused by P-glycoprotein in the intestine. Proc. Natl Acad. Sci. USA 1997, 94:2031-2035.
    • (1997) Proc. Natl Acad. Sci. USA , vol.94 , pp. 2031-2035
    • Sparreboom, A.1    van Asperen, J.2    Mayer, U.3
  • 86
    • 33746706762 scopus 로고    scopus 로고
    • PXR and CAR: nuclear receptors which play a pivotal role in drug disposition and chemical toxicity
    • Stanley L.A., Horsburgh B.C., Ross J. PXR and CAR: nuclear receptors which play a pivotal role in drug disposition and chemical toxicity. Drug Metab. Rev. 2006, 38:515-597.
    • (2006) Drug Metab. Rev. , vol.38 , pp. 515-597
    • Stanley, L.A.1    Horsburgh, B.C.2    Ross, J.3
  • 87
    • 0031893374 scopus 로고    scopus 로고
    • Kinetics of the P-glycoprotein, the multidrug transporter
    • Stein W.D. Kinetics of the P-glycoprotein, the multidrug transporter. Exper. Physiol. 1998, 83:221-232.
    • (1998) Exper. Physiol. , vol.83 , pp. 221-232
    • Stein, W.D.1
  • 88
    • 0028285002 scopus 로고
    • Kinetic evidence suggesting that the multidrug transporter differentially handles influx and efflux of its substrates
    • Stein W.D., Cardarelli C., Pastan I., Gottesman M.M. Kinetic evidence suggesting that the multidrug transporter differentially handles influx and efflux of its substrates. Mol. Pharmacol. 1994, 45:763-772.
    • (1994) Mol. Pharmacol. , vol.45 , pp. 763-772
    • Stein, W.D.1    Cardarelli, C.2    Pastan, I.3    Gottesman, M.M.4
  • 89
    • 0346787821 scopus 로고    scopus 로고
    • Integrated oral bioavailability projection using in vitro screening data as a selection tool in drug discovery
    • Stoner C.L., Cleton A., Johnson K. Integrated oral bioavailability projection using in vitro screening data as a selection tool in drug discovery. Intl J. Pharm. 2004, 269:241-249.
    • (2004) Intl J. Pharm. , vol.269 , pp. 241-249
    • Stoner, C.L.1    Cleton, A.2    Johnson, K.3
  • 90
    • 33749596971 scopus 로고    scopus 로고
    • Moving in silico screening into practice: a minimalist approach to guide permeability screening
    • Stoner C.L., Troutman M., Gao H. Moving in silico screening into practice: a minimalist approach to guide permeability screening. Lett. Drug Design Discov. 2006, 3:575-581.
    • (2006) Lett. Drug Design Discov. , vol.3 , pp. 575-581
    • Stoner, C.L.1    Troutman, M.2    Gao, H.3
  • 91
    • 33645045860 scopus 로고    scopus 로고
    • Modification of the ultrafiltration technique to overcome solubility and non-specific binding challenges associated with the measurement of plasma protein binding of corticosteroids
    • Taylor S., Harker A. Modification of the ultrafiltration technique to overcome solubility and non-specific binding challenges associated with the measurement of plasma protein binding of corticosteroids. J. Pharm. Biomed. Anal. 2006, 41:299-303.
    • (2006) J. Pharm. Biomed. Anal. , vol.41 , pp. 299-303
    • Taylor, S.1    Harker, A.2
  • 92
    • 0029800447 scopus 로고    scopus 로고
    • Active secretion of drugs from the small intestinal epithelium in rats by P-glycoprotein functioning as an absorption barrier
    • Terao T., Hisanaga E., Sai Y. Active secretion of drugs from the small intestinal epithelium in rats by P-glycoprotein functioning as an absorption barrier. J. Pharm. Pharmacol. 1996, 48:1083-1089.
    • (1996) J. Pharm. Pharmacol. , vol.48 , pp. 1083-1089
    • Terao, T.1    Hisanaga, E.2    Sai, Y.3
  • 95
    • 0037452445 scopus 로고    scopus 로고
    • Utility of physiologically based pharmacokinetic models to drug development and rational drug discovery candidate selection
    • Theil F.P., Guentert T.W., Haddad S., Poulin P. Utility of physiologically based pharmacokinetic models to drug development and rational drug discovery candidate selection. Toxicol. Lett. 2003, 138:29-49.
    • (2003) Toxicol. Lett. , vol.138 , pp. 29-49
    • Theil, F.P.1    Guentert, T.W.2    Haddad, S.3    Poulin, P.4
  • 96
    • 0023447098 scopus 로고
    • Cellular localization of the multidrug-resistance gene product P-glycoprotein in normal human tissues
    • Thiebaut F., Tsuruo T., Hamada H. Cellular localization of the multidrug-resistance gene product P-glycoprotein in normal human tissues. Proc. Natl Acad. Sci. USA 1987, 84:7735-7738.
    • (1987) Proc. Natl Acad. Sci. USA , vol.84 , pp. 7735-7738
    • Thiebaut, F.1    Tsuruo, T.2    Hamada, H.3
  • 97
    • 0024576304 scopus 로고
    • Immunohistochemical localization in normal tissues of different epitopes in the multidrug transport protein P170: evidence for localization in brain capillaries and crossreactivity of one antibody with a muscle protein
    • Thiebaut F., Tsuruo T., Hamada H. Immunohistochemical localization in normal tissues of different epitopes in the multidrug transport protein P170: evidence for localization in brain capillaries and crossreactivity of one antibody with a muscle protein. J. Histochem. Cytochem. 1989, 37:159-164.
    • (1989) J. Histochem. Cytochem. , vol.37 , pp. 159-164
    • Thiebaut, F.1    Tsuruo, T.2    Hamada, H.3
  • 99
    • 3843082996 scopus 로고    scopus 로고
    • Exact kinetic analysis of passive transport across a polarized confluent MDCK cell monolayer modeled as a single barrier
    • Tran T.T., Mittal A., Gales T. Exact kinetic analysis of passive transport across a polarized confluent MDCK cell monolayer modeled as a single barrier. J. Pharm. Sci. 2004, 93:2108-2123.
    • (2004) J. Pharm. Sci. , vol.93 , pp. 2108-2123
    • Tran, T.T.1    Mittal, A.2    Gales, T.3
  • 100
    • 0041402720 scopus 로고    scopus 로고
    • Efflux ratio cannot assess P-glycoprotein-mediated attenuation of absorptive transport: asymmetric effect of P-glycoprotein on absorptive and secretory transport across Caco-2 cell monolayers
    • Troutman M.D., Thakker D.R. Efflux ratio cannot assess P-glycoprotein-mediated attenuation of absorptive transport: asymmetric effect of P-glycoprotein on absorptive and secretory transport across Caco-2 cell monolayers. Pharm. Res. 2003, 20:1200-1209.
    • (2003) Pharm. Res. , vol.20 , pp. 1200-1209
    • Troutman, M.D.1    Thakker, D.R.2
  • 101
    • 0042905800 scopus 로고    scopus 로고
    • Novel experimental parameters to quantify the modulation of absorptive and secretory transport of compounds by P-glycoprotein in cell culture models of intestinal epithelium
    • Troutman M.D., Thakker D.R. Novel experimental parameters to quantify the modulation of absorptive and secretory transport of compounds by P-glycoprotein in cell culture models of intestinal epithelium. Pharm. Res. 2003, 20:1210-1224.
    • (2003) Pharm. Res. , vol.20 , pp. 1210-1224
    • Troutman, M.D.1    Thakker, D.R.2
  • 102
    • 0029782485 scopus 로고    scopus 로고
    • Carrier-mediated intestinal transport of drugs
    • Tsuji A., Tamai I. Carrier-mediated intestinal transport of drugs. Pharm. Res. 1996, 13:963-977.
    • (1996) Pharm. Res. , vol.13 , pp. 963-977
    • Tsuji, A.1    Tamai, I.2
  • 103
    • 0033818097 scopus 로고    scopus 로고
    • Rapidgradient HPLC method for measuring drug interactions with immobilized artificial membrane: comparison with other lipophilicity measures
    • Valko K., Du C.M., Bevan C.D. Rapidgradient HPLC method for measuring drug interactions with immobilized artificial membrane: comparison with other lipophilicity measures. J. Pharm. Sci. 2000, 89:1085-1096.
    • (2000) J. Pharm. Sci. , vol.89 , pp. 1085-1096
    • Valko, K.1    Du, C.M.2    Bevan, C.D.3
  • 104
    • 0034105897 scopus 로고    scopus 로고
    • The role of mdr1a P-glycoprotein in the biliary and intestinal secretion of doxorubicin and vinblastine in mice
    • van Asperen J., van Tellingen O., Beijnen J.H. The role of mdr1a P-glycoprotein in the biliary and intestinal secretion of doxorubicin and vinblastine in mice. Drug Metab. Dispos. 2000, 28:264-267.
    • (2000) Drug Metab. Dispos. , vol.28 , pp. 264-267
    • van Asperen, J.1    van Tellingen, O.2    Beijnen, J.H.3
  • 105
    • 0035953319 scopus 로고    scopus 로고
    • Property-based design: optimization of drug absorption and pharmacokinetics
    • van de Waterbeemd H., Smith D.A., Beaumont K., Walker D.K. Property-based design: optimization of drug absorption and pharmacokinetics. J. Med. Chem. 2001, 44:1313-1333.
    • (2001) J. Med. Chem. , vol.44 , pp. 1313-1333
    • van de Waterbeemd, H.1    Smith, D.A.2    Beaumont, K.3    Walker, D.K.4
  • 106
    • 0035866672 scopus 로고    scopus 로고
    • High-throughput permeability pH profile and high-throughput alkane/water log P with artifi cial membranes
    • Wohnsland F., Faller B. High-throughput permeability pH profile and high-throughput alkane/water log P with artifi cial membranes. J. Med. Chem. 2001, 44:923-930.
    • (2001) J. Med. Chem. , vol.44 , pp. 923-930
    • Wohnsland, F.1    Faller, B.2
  • 107
    • 0034721159 scopus 로고    scopus 로고
    • Humanized xenobiotic response in mice expressing nuclear receptor SXR
    • Xie W., Barwick J.L., Downes M. Humanized xenobiotic response in mice expressing nuclear receptor SXR. Nature 2000, 406:435-439.
    • (2000) Nature , vol.406 , pp. 435-439
    • Xie, W.1    Barwick, J.L.2    Downes, M.3
  • 108
    • 0027172915 scopus 로고
    • Analysis of the expression of MRP, the gene for a new putative transmembrane drug transporter, in human multidrug resistant lung cancer cell lines
    • Zaman G.J., Versantvoort C.H., Smit J.J. Analysis of the expression of MRP, the gene for a new putative transmembrane drug transporter, in human multidrug resistant lung cancer cell lines. Cancer Res. 1993, 53:1747-1750.
    • (1993) Cancer Res. , vol.53 , pp. 1747-1750
    • Zaman, G.J.1    Versantvoort, C.H.2    Smit, J.J.3
  • 109
    • 0031687181 scopus 로고    scopus 로고
    • Characterization of P-glycoprotein mediated transport of K02, a novel vinylsulfone peptidomimetic cysteine protease inhibitor, across MDR1 MDCK and Caco-2 cell monolayers
    • Zhang Y., Benet L.Z. Characterization of P-glycoprotein mediated transport of K02, a novel vinylsulfone peptidomimetic cysteine protease inhibitor, across MDR1 MDCK and Caco-2 cell monolayers. Pharm. Res. 1998, 15:1520-1524.
    • (1998) Pharm. Res. , vol.15 , pp. 1520-1524
    • Zhang, Y.1    Benet, L.Z.2
  • 110
    • 0036238280 scopus 로고    scopus 로고
    • A comparative study of artificial membrane permeability assay for high throughput profiling of drug absorption potential
    • Zhu C., Jiang L., Chen T.M., Hwang K.K. A comparative study of artificial membrane permeability assay for high throughput profiling of drug absorption potential. Eur. J. Med. Chem. 2002, 37:399-407.
    • (2002) Eur. J. Med. Chem. , vol.37 , pp. 399-407
    • Zhu, C.1    Jiang, L.2    Chen, T.M.3    Hwang, K.K.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.