Rapid-gradient HPLC method for measuring drug interactions with immobilized artificial membrane: Comparison with other lipophilicity measures

Journal of Pharmaceutical Sciences

Volumn 89, Issue 8, 2000, Pages 1085-1096

  Valko, Klara ^a   Du, Chau My ^b   Bevan, Christopher D ^a   Reynolds, Derek P ^a   Abraham, Michael H ^b  

^a GLAXOSMITHKLINE   (United Kingdom)

^b UNIVERSITY COLLEGE LONDON   (United Kingdom)

Author keywords

CHI solvation equation; High throughput screening; IAM chromatographic hydrophobicity index; Immobilized artificial membrane

Indexed keywords

4 METHYLANILINE; ACETANILIDE; ACETOPHENONE; ALDOSTERONE; ANILINE DERIVATIVE; ANISOLE; BENZAMIDE DERIVATIVE; BENZENE DERIVATIVE; BENZOIC ACID DERIVATIVE; BENZONITRILE; CAFFEINE; CHLOROBENZENE; HYDROCORTISONE; INDAZOLE DERIVATIVE; NAPHTHALENE; NICOTINE; OCTANOL; PHENOL DERIVATIVE; PHENYLACETIC ACID; PROCAINE; PROGESTERONE; PROPRANOLOL; PYRENE; PYRIDAZINE DERIVATIVE; RESORCINOL; SALICYLIC ACID; TESTOSTERONE; THEOPHYLLINE; UNINDEXED DRUG; WATER;

ARTICLE; HYDROPHOBICITY; LIPOPHILICITY; MODEL; PARTITION COEFFICIENT; PH; REVERSED PHASE HIGH PERFORMANCE LIQUID CHROMATOGRAPHY;

EID: 0033818097     PISSN: 00223549     EISSN: None     Source Type: Journal    
DOI: 10.1002/1520-6017(200008)89:8<1085::AID-JPS13>3.0.CO;2-N     Document Type: Article

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