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Volumn 23, Issue 4, 1996, Pages 771-780

Hepatobiliary disposition of valproic acid and valproate glucuronide: Use of a pharmacokinetic model to examine the rate-limiting steps and potential sites of drug interactions

Author keywords

[No Author keywords available]

Indexed keywords

ANTICONVULSIVE AGENT; DRUG METABOLITE; MORPHINE; PARACETAMOL; PHENOBARBITAL; TRITIUM; VALPROIC ACID;

EID: 0029876744     PISSN: 02709139     EISSN: None     Source Type: Journal    
DOI: 10.1053/jhep.1996.v23.pm0008666331     Document Type: Article
Times cited : (25)

References (9)
  • 1
    • 0027450681 scopus 로고
    • Canalicular transport: Discovery of ATP-dependent mechanisms
    • Vore M. Canalicular transport: discovery of ATP-dependent mechanisms. Toxicol Appl Pharmacol 1993;118:2-7.
    • (1993) Toxicol Appl Pharmacol , vol.118 , pp. 2-7
    • Vore, M.1
  • 2
    • 0023807112 scopus 로고
    • Intestinal and hepatobiliary disposition of drugs
    • Klaassen CD. Intestinal and hepatobiliary disposition of drugs. Toxicol Pathol 1988;16:130-137.
    • (1988) Toxicol Pathol , vol.16 , pp. 130-137
    • Klaassen, C.D.1
  • 3
    • 0025267309 scopus 로고
    • Altered hepatobiliary disposition of acetaminophen metabolites after phenobarbital pretreatment and renal ligation: Evidence for impaired biliary excretion and a diffusional barrier
    • Brouwer KLR, Jones JA. Altered hepatobiliary disposition of acetaminophen metabolites after phenobarbital pretreatment and renal ligation: evidence for impaired biliary excretion and a diffusional barrier. J Pharmacol Exp Ther 1990;252:657-664.
    • (1990) J Pharmacol Exp Ther , vol.252 , pp. 657-664
    • Brouwer, K.L.R.1    Jones, J.A.2
  • 4
    • 0021934181 scopus 로고
    • Effects of phenobarbital, phorone and carbon tetrachloride pretreatment on the biliary excretion of acetaminophen in rats
    • Loeser W, Siegers CP. Effects of phenobarbital, phorone and carbon tetrachloride pretreatment on the biliary excretion of acetaminophen in rats. Arch Int Pharmacodyn Ther 1985;275:180-188.
    • (1985) Arch Int Pharmacodyn Ther , vol.275 , pp. 180-188
    • Loeser, W.1    Siegers, C.P.2
  • 5
    • 0025261947 scopus 로고
    • Effect of microsomal enzyme inducers on biliary and urinary excretion of acetaminophen metabolites in rats. Decreased hepatobiliary and increased hepatovascular transport of acetaminophen-glucuronide after microsomal enzyme induction
    • Gregus Z, Madhu C, Klaassen CD. Effect of microsomal enzyme inducers on biliary and urinary excretion of acetaminophen metabolites in rats. Decreased hepatobiliary and increased hepatovascular transport of acetaminophen-glucuronide after microsomal enzyme induction. Drug Metab Dispos 1990; 18:10-19.
    • (1990) Drug Metab Dispos , vol.18 , pp. 10-19
    • Gregus, Z.1    Madhu, C.2    Klaassen, C.D.3
  • 6
    • 0015972127 scopus 로고
    • Effect of chloroquine and phenobarbital on morphine glucuronidation and biliary excretion in the rat
    • Roerig DL, Hasegawa AT, Peterson RE, Wang RIH. Effect of chloroquine and phenobarbital on morphine glucuronidation and biliary excretion in the rat. Biochem Pharmacol 1974;23:1331-1339.
    • (1974) Biochem Pharmacol , vol.23 , pp. 1331-1339
    • Roerig, D.L.1    Hasegawa, A.T.2    Peterson, R.E.3    Wang, R.I.H.4
  • 7
    • 0020044727 scopus 로고
    • Effect of inducers and inhibitors of glucuronidation on the biliary excretion and choleretic action of valproic acid in the rat
    • Watkins JB, Klaassen CD. Effect of inducers and inhibitors of glucuronidation on the biliary excretion and choleretic action of valproic acid in the rat. J Pharmacol Exp Ther 1982;220:305-310.
    • (1982) J Pharmacol Exp Ther , vol.220 , pp. 305-310
    • Watkins, J.B.1    Klaassen, C.D.2
  • 8
    • 0019212040 scopus 로고
    • Clinical pharmacokinetics of valproic acid
    • Gugler R, von Unruh GE. Clinical pharmacokinetics of valproic acid. Clin Pharmacokinet 1980;5:67-83.
    • (1980) Clin Pharmacokinet , vol.5 , pp. 67-83
    • Gugler, R.1    Von Unruh, G.E.2
  • 9
    • 0001797602 scopus 로고
    • Valproate: Biotransformation
    • Woodbury DM, Penry JK, Pippenger CE, eds. New York: Raven Press
    • Schobben F, van der Kleijn E. Valproate: Biotransformation. In: Woodbury DM, Penry JK, Pippenger CE, eds. Antiepileptic drugs. New York: Raven Press, 1982:567-578.
    • (1982) Antiepileptic Drugs , pp. 567-578
    • Schobben, F.1    Van Der Kleijn, E.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.