-
1
-
-
0037374498
-
The price of innovation: New estimates of drug development costs
-
151-185. A good overview for the financial impact of poor decision making
-
DIMASI JA, HANSEN RW, GRABOWSKI HG: The price of innovation: new estimates of drug development costs. J. Health Econ. (2003) 22(2):151-185. A good overview for the financial impact of poor decision making.
-
(2003)
J. Health Econ
, vol.22
, Issue.2
-
-
DIMASI, J.A.1
HANSEN, R.W.2
GRABOWSKI, H.G.3
-
2
-
-
12844283957
-
High-throughput drug discovery: What can we expect from HTS?
-
GRIBBON P, SEWING A: High-throughput drug discovery: what can we expect from HTS? Drug Discov. Today (2005) 10(1):17-22.
-
(2005)
Drug Discov. Today
, vol.10
, Issue.1
, pp. 17-22
-
-
GRIBBON, P.1
SEWING, A.2
-
3
-
-
0035289779
-
-
LIPINSKI CA, LOMBARDO F, DOMINY BW, FEENEY PJ: Experimental and computational approaches to estimate solubility and permeability in drug discovery and development settings. Adv. Drug Deliv. Rev. (2001) 46(1-3):3-26. Thorough overview describing several discovery approaches for assessing solubility and permeability.
-
LIPINSKI CA, LOMBARDO F, DOMINY BW, FEENEY PJ: Experimental and computational approaches to estimate solubility and permeability in drug discovery and development settings. Adv. Drug Deliv. Rev. (2001) 46(1-3):3-26. Thorough overview describing several discovery approaches for assessing solubility and permeability.
-
-
-
-
4
-
-
0035953319
-
Property-based design: Optimization of drug absorption and pharmacokinetics
-
VAN DE WATERBEEMD H, SMITH DA, BEAUMONT K, WALKER DK: Property-based design: optimization of drug absorption and pharmacokinetics. J. Med. Chem. (2001) 44(9):1313-1333.
-
(2001)
J. Med. Chem
, vol.44
, Issue.9
, pp. 1313-1333
-
-
VAN DE WATERBEEMD, H.1
SMITH, D.A.2
BEAUMONT, K.3
WALKER, D.K.4
-
5
-
-
0037523454
-
Profiling drug-like properties in discovery research
-
DI L, KERNS EH: Profiling drug-like properties in discovery research. Curr. Opin. Chem. Biol. (2003) 7(3):402-408.
-
(2003)
Curr. Opin. Chem. Biol
, vol.7
, Issue.3
, pp. 402-408
-
-
DI, L.1
KERNS, E.H.2
-
6
-
-
27744584321
-
Strategy of utilizing in vitro and in vivo ADME tools for lead optimization and drug candidate selection
-
BALANI SK, MIWA GT, GAN L-S, WU J-T, LEE FW: Strategy of utilizing in vitro and in vivo ADME tools for lead optimization and drug candidate selection. Curr. Top. Med. Chem. (2005) 5:1033-1038.
-
(2005)
Curr. Top. Med. Chem
, vol.5
, pp. 1033-1038
-
-
BALANI, S.K.1
MIWA, G.T.2
GAN, L.-S.3
WU, J.-T.4
LEE, F.W.5
-
7
-
-
0035150465
-
High throughput physicochemical profiling for drug discovery
-
KERNS EH: High throughput physicochemical profiling for drug discovery. J. Pharm. Sci. (2001) 90(11):1838-1858.
-
(2001)
J. Pharm. Sci
, vol.90
, Issue.11
, pp. 1838-1858
-
-
KERNS, E.H.1
-
8
-
-
0036809320
-
Physicochemical profiling in drug research: A brief survey of the state-of-the-art of experimental techniques
-
AVDEEF A, TESTA B: Physicochemical profiling in drug research: a brief survey of the state-of-the-art of experimental techniques. Cell. Mol. life Sci. (2002) 59(10):1681-1689.
-
(2002)
Cell. Mol. life Sci
, vol.59
, Issue.10
, pp. 1681-1689
-
-
AVDEEF, A.1
TESTA, B.2
-
9
-
-
0346787821
-
Integrated oral bioavailability projection using in vitro screening data as a selection tool in drug discovery
-
STONER CL, CLETON A, JOHNSON K et al.: Integrated oral bioavailability projection using in vitro screening data as a selection tool in drug discovery. Int. J. Pharm. (2004) 269(1):241-249.
-
(2004)
Int. J. Pharm
, vol.269
, Issue.1
, pp. 241-249
-
-
STONER, C.L.1
CLETON, A.2
JOHNSON, K.3
-
10
-
-
0035523085
-
The new pre-preclinical paradigm: Compound optimization in early and late phase drug discovery
-
CALDWELL GW, RITCHIE DM, MASUCCI JA, HAGEMAN W, YAN Z: The new pre-preclinical paradigm: compound optimization in early and late phase drug discovery. Curr. Top. Med. Chem. (2001) 1(5):353-366.
-
(2001)
Curr. Top. Med. Chem
, vol.1
, Issue.5
, pp. 353-366
-
-
CALDWELL, G.W.1
RITCHIE, D.M.2
MASUCCI, J.A.3
HAGEMAN, W.4
YAN, Z.5
-
11
-
-
27944458924
-
An evaluation of the utility of physiologically based models of pharmacokinetics in early drug discovery
-
PARROTT N, PAQUEREAU N, COASSOLO P, LAVE T: An evaluation of the utility of physiologically based models of pharmacokinetics in early drug discovery. J. Pharm. Sci. (2005) 94(10):2327-2343.
-
(2005)
J. Pharm. Sci
, vol.94
, Issue.10
, pp. 2327-2343
-
-
PARROTT, N.1
PAQUEREAU, N.2
COASSOLO, P.3
LAVE, T.4
-
12
-
-
0030444901
-
Interpatient variability in bioavailability is related to the extent of absorption: Implications for bioavailability and bioequivalence studies
-
HELLRIEGEL ET, BJORNSSON TD, HAUCK WW: Interpatient variability in bioavailability is related to the extent of absorption: implications for bioavailability and bioequivalence studies. Clin. Pharmacol. Ther. (1996) 60(6):601-607.
-
(1996)
Clin. Pharmacol. Ther
, vol.60
, Issue.6
, pp. 601-607
-
-
HELLRIEGEL, E.T.1
BJORNSSON, T.D.2
HAUCK, W.W.3
-
13
-
-
0034461768
-
-
LIPINSKI CA: Drug-like properties and the causes of poor solubility and poor permeability. J. Pharmacol. Toxicol. Methods (2000) 44(1):235-249. Provides a prospective to chemical matter output obtained from both HTS and rational drug design approaches.
-
LIPINSKI CA: Drug-like properties and the causes of poor solubility and poor permeability. J. Pharmacol. Toxicol. Methods (2000) 44(1):235-249. Provides a prospective to chemical matter output obtained from both HTS and rational drug design approaches.
-
-
-
-
14
-
-
0037030653
-
Molecular properties that influence the oral bioavailability of drug candidates
-
VEBER DF, JOHNSON SR, CHENG HY et al.: Molecular properties that influence the oral bioavailability of drug candidates. J. Med. Chem. (2002) 45(12):2615-2623.
-
(2002)
J. Med. Chem
, vol.45
, Issue.12
, pp. 2615-2623
-
-
VEBER, D.F.1
JOHNSON, S.R.2
CHENG, H.Y.3
-
15
-
-
0030914681
-
Polar molecular surface properties predict the intestinal absorption of drugs in humans
-
PALM K, STENBERG P, LUTHMAN K, ARTURSSON P: Polar molecular surface properties predict the intestinal absorption of drugs in humans. Pharm. Res. (1997) 14(5):568-571.
-
(1997)
Pharm. Res
, vol.14
, Issue.5
, pp. 568-571
-
-
PALM, K.1
STENBERG, P.2
LUTHMAN, K.3
ARTURSSON, P.4
-
16
-
-
0016053262
-
Mass transport phenomena and models: Theoretical concepts
-
FLYNN GL, YALKOWSKY SH, ROSEMAN TJ: Mass transport phenomena and models: theoretical concepts. J. Pharm. Sci. (1974) 63(4):479-510.
-
(1974)
J. Pharm. Sci
, vol.63
, Issue.4
, pp. 479-510
-
-
FLYNN, G.L.1
YALKOWSKY, S.H.2
ROSEMAN, T.J.3
-
17
-
-
0028948839
-
A theoretical basis for a biopharmaceutic drug classification: The correlation of in vitro drug product dissolution and in vivo bioavailability
-
AMIDON GL, LENNERNAS H, SHAH VP, CRISON JR: A theoretical basis for a biopharmaceutic drug classification: the correlation of in vitro drug product dissolution and in vivo bioavailability. Pharm. Res. (1995) 12(3):413-420.
-
(1995)
Pharm. Res
, vol.12
, Issue.3
, pp. 413-420
-
-
AMIDON, G.L.1
LENNERNAS, H.2
SHAH, V.P.3
CRISON, J.R.4
-
18
-
-
0003882857
-
-
WH Saunders Jr Ed, John Wiley and Sons, New York, USA
-
GRANT DJW, HIGUCHI T: Solubility behavior of organic compounds. WH Saunders Jr (Ed.), John Wiley and Sons, New York, USA (1990):12-88.
-
(1990)
Solubility behavior of organic compounds
, pp. 12-88
-
-
GRANT, D.J.W.1
HIGUCHI, T.2
-
19
-
-
7444226830
-
Automated robotic liquid handling/laser-based nephelometry system for high throughput measurement of kinetic aqueous solubility
-
DEHRING KA, WORKMAN HL, MILLER KD, MANDAGERE A, POOLE SK: Automated robotic liquid handling/laser-based nephelometry system for high throughput measurement of kinetic aqueous solubility. J. Pharm. Biomed. Anal. (2004) 36(3):447-456.
-
(2004)
J. Pharm. Biomed. Anal
, vol.36
, Issue.3
, pp. 447-456
-
-
DEHRING, K.A.1
WORKMAN, H.L.2
MILLER, K.D.3
MANDAGERE, A.4
POOLE, S.K.5
-
20
-
-
30344440543
-
Solubility in water and DMSO: Issues and potential solutions
-
RT Borchardt, EH Kerns, CA Lipinski et al, Eds, AAPS Press, Arlington, VA, USA
-
LIPINSKI CA: Solubility in water and DMSO: Issues and potential solutions. In: Pharmaceutical Profiling in Drug Discovery for Lead Selection. RT Borchardt, EH Kerns, CA Lipinski et al. (Eds), AAPS Press, Arlington, VA, USA (2004):93-126.
-
(2004)
Pharmaceutical Profiling in Drug Discovery for Lead Selection
, pp. 93-126
-
-
LIPINSKI, C.A.1
-
21
-
-
0035138216
-
Estimation of the aqueous solubility I: Application to organic nonelectrolytes
-
JAIN N, YALKOWSKY SH: Estimation of the aqueous solubility I: application to organic nonelectrolytes. J. Pharm. Sci. (2001) 90(2):234-252.
-
(2001)
J. Pharm. Sci
, vol.90
, Issue.2
, pp. 234-252
-
-
JAIN, N.1
YALKOWSKY, S.H.2
-
23
-
-
33846356275
-
Property-based drug design and preformulation
-
Philadelphia UotSi Ed, Lippincott, Williams and Wilkins, Philidelphia, PA, USA
-
ANDO HY, RADEBAUGH GW: Property-based drug design and preformulation. In: Remington: The Science and Practice of Pharmacy. Philadelphia UotSi (Ed.) Lippincott, Williams and Wilkins, Philidelphia, PA, USA (2005):720-744.
-
(2005)
Remington: The Science and Practice of Pharmacy
, pp. 720-744
-
-
ANDO, H.Y.1
RADEBAUGH, G.W.2
-
24
-
-
0036149192
-
Physicochemical characterization and solubility analysis of thalidomide and its N-alkyl analogs
-
GOOSEN C, LAING TJ, DU PJ, GOOSEN TC, FLYNN GL: Physicochemical characterization and solubility analysis of thalidomide and its N-alkyl analogs. Pharm. Res. (2002) 19(1):13-19.
-
(2002)
Pharm. Res
, vol.19
, Issue.1
, pp. 13-19
-
-
GOOSEN, C.1
LAING, T.J.2
DU PJ3
Goosen, T.C.4
Flynn, G.L.5
-
25
-
-
0033577986
-
Design and synthesis of novel quinoxaline-2,3-dione AMPA/GlyN receptor antagonists: Amino acid derivatives
-
NIKAM SS, CORDON JJ, ORTWINE DF et al.: Design and synthesis of novel quinoxaline-2,3-dione AMPA/GlyN receptor antagonists: amino acid derivatives. J. Med. Chem. (1999) 42(12):2266-2271.
-
(1999)
J. Med. Chem
, vol.42
, Issue.12
, pp. 2266-2271
-
-
NIKAM, S.S.1
CORDON, J.J.2
ORTWINE, D.F.3
-
26
-
-
0028222149
-
L-735,524: An orally bioavailable human immunodeficiency virus type 1 protease inhibitor
-
VACCA JP, DORSEY BD, SCHLEIF WA et al.: L-735,524: an orally bioavailable human immunodeficiency virus type 1 protease inhibitor. Proc. Natl. Acad. Sci. USA (1994) 91(9):4096-4100.
-
(1994)
Proc. Natl. Acad. Sci. USA
, vol.91
, Issue.9
, pp. 4096-4100
-
-
VACCA, J.P.1
DORSEY, B.D.2
SCHLEIF, W.A.3
-
27
-
-
0033602220
-
Synthesis of 1-substituted 3-(chloromethyl)-6-aminoindoline (6-amino-seco-CI) DNA minor groove alkylating agents and structure-activity relationships for their cytotoxicity
-
MILBANK JB, TERCEL M, ATWELL GJ et al.: Synthesis of 1-substituted 3-(chloromethyl)-6-aminoindoline (6-amino-seco-CI) DNA minor groove alkylating agents and structure-activity relationships for their cytotoxicity. J. Med. Chem. (1999) 42(4):649-658.
-
(1999)
J. Med. Chem
, vol.42
, Issue.4
, pp. 649-658
-
-
MILBANK, J.B.1
TERCEL, M.2
ATWELL, G.J.3
-
28
-
-
0018145767
-
pH-solubility profiles or organic carboxylic acids and their salts
-
CHOWHAN ZT: pH-solubility profiles or organic carboxylic acids and their salts. J. Pharm. Sci. (1978) 67(9):1257-1260.
-
(1978)
J. Pharm. Sci
, vol.67
, Issue.9
, pp. 1257-1260
-
-
CHOWHAN, Z.T.1
-
29
-
-
0015449031
-
Solubility of organic hydrochlorides
-
KRAMER SF, FLYNN GL: Solubility of organic hydrochlorides. J. Pharm. Sci. (1972) 61(12):1896-1904.
-
(1972)
J. Pharm. Sci
, vol.61
, Issue.12
, pp. 1896-1904
-
-
KRAMER, S.F.1
FLYNN, G.L.2
-
30
-
-
23844499379
-
IV-IVC considerations in the development of immediate-release oral dosage form
-
LI S, HE H, PARTHIBAN LJ, YIN H, SERAJUDDIN AT: IV-IVC considerations in the development of immediate-release oral dosage form. J. Pharm. Sci. (2005) 94(7):1396-1417.
-
(2005)
J. Pharm. Sci
, vol.94
, Issue.7
, pp. 1396-1417
-
-
LI, S.1
HE, H.2
PARTHIBAN, L.J.3
YIN, H.4
SERAJUDDIN, A.T.5
-
31
-
-
0037335193
-
The mean dissolution time depends on the dose/solubility ratio
-
RINAKI E, DOKOUMETZIDIS A, MACHERAS P: The mean dissolution time depends on the dose/solubility ratio. Pharm. Res. (2003) 20(3):406-408.
-
(2003)
Pharm. Res
, vol.20
, Issue.3
, pp. 406-408
-
-
RINAKI, E.1
DOKOUMETZIDIS, A.2
MACHERAS, P.3
-
32
-
-
20144367317
-
Pyrroloquinolone PDE5 inhibitors with improved pharmaceutical profiles for clinical studies on erectile dysfunction
-
JIANG W, GUAN J, MACIELAG MJ et al.: Pyrroloquinolone PDE5 inhibitors with improved pharmaceutical profiles for clinical studies on erectile dysfunction. J. Med. Chem. (2005) 48(6):2126-2133.
-
(2005)
J. Med. Chem
, vol.48
, Issue.6
, pp. 2126-2133
-
-
JIANG, W.1
GUAN, J.2
MACIELAG, M.J.3
-
33
-
-
0030444550
-
Guidance in the setting of drug particle size specifications to minimize variability in absorption
-
JOHNSON KC, SWINDELL AC: Guidance in the setting of drug particle size specifications to minimize variability in absorption. Pharm. Res. (1996) 13:1795-1798.
-
(1996)
Pharm. Res
, vol.13
, pp. 1795-1798
-
-
JOHNSON, K.C.1
SWINDELL, A.C.2
-
34
-
-
0027473738
-
Estimating the fraction dose absorbed from suspensions of poorly soluble compounds in humans: A mathematical model
-
OH DM, CURL RL, AMIDON GL: Estimating the fraction dose absorbed from suspensions of poorly soluble compounds in humans: a mathematical model. Pharm. Res. (1993) 10(2):264-270.
-
(1993)
Pharm. Res
, vol.10
, Issue.2
, pp. 264-270
-
-
OH, D.M.1
CURL, R.L.2
AMIDON, G.L.3
-
35
-
-
0023013676
-
Particle size distribution affects the human bioavailability of phenytoin
-
YAKOU S, YAMAZAKI S, SONOBE T et al.: Particle size distribution affects the human bioavailability of phenytoin. Chem. Pharm. Bull. (1986) 34(10):4400-4402.
-
(1986)
Chem. Pharm. Bull
, vol.34
, Issue.10
, pp. 4400-4402
-
-
YAKOU, S.1
YAMAZAKI, S.2
SONOBE, T.3
-
36
-
-
0029080002
-
Particle size reduction for improvement of oral bioavailability of hydrophobic drugs: I. Absolute oral bioavailability of nanocrystalline danazol in beagle dogs
-
LIVERSIDGE GG, CUNDY KC: Particle size reduction for improvement of oral bioavailability of hydrophobic drugs: I. Absolute oral bioavailability of nanocrystalline danazol in beagle dogs. Int. J. Pharm. (1995) 125(1):91-97.
-
(1995)
Int. J. Pharm
, vol.125
, Issue.1
, pp. 91-97
-
-
LIVERSIDGE, G.G.1
CUNDY, K.C.2
-
37
-
-
0025163318
-
Intestinal calcium absorption. Interplay of paracellular and cellular pathways
-
NELLANS HN: Intestinal calcium absorption. Interplay of paracellular and cellular pathways. Miner. Electrolyte Metab. (1990) 16(2-3):101-108.
-
(1990)
Miner. Electrolyte Metab
, vol.16
, Issue.2-3
, pp. 101-108
-
-
NELLANS, H.N.1
-
38
-
-
0032872193
-
Paracellular drug transport across intestinal epithelia: Influence of charge and induced water flux
-
KARLSSON J, UNGELL A, GRASJO J, ARTURSSON P: Paracellular drug transport across intestinal epithelia: influence of charge and induced water flux. Eur. J. Pharm. Sci. (1999) 9(1):47-56.
-
(1999)
Eur. J. Pharm. Sci
, vol.9
, Issue.1
, pp. 47-56
-
-
KARLSSON, J.1
UNGELL, A.2
GRASJO, J.3
ARTURSSON, P.4
-
39
-
-
0031946994
-
Membrane transport of drugs in different regions of the intestinal tract of the rate
-
UNGELL A-L, NYLANDER S, BERGSTRAND S, SJOBERG A, LENNERNAS H: Membrane transport of drugs in different regions of the intestinal tract of the rate. J. Pharm. Sci. (1998) 87:360-366.
-
(1998)
J. Pharm. Sci
, vol.87
, pp. 360-366
-
-
UNGELL, A.-L.1
NYLANDER, S.2
BERGSTRAND, S.3
SJOBERG, A.4
LENNERNAS, H.5
-
40
-
-
0029557644
-
Does fluid flow across the intestinal mucosa affect quantitative oral drug absorption? Is it time for a reevaluation?
-
LENNERNAS H: Does fluid flow across the intestinal mucosa affect quantitative oral drug absorption? Is it time for a reevaluation? Pharm. Res. (1995) 12(11):1573-1582.
-
(1995)
Pharm. Res
, vol.12
, Issue.11
, pp. 1573-1582
-
-
LENNERNAS, H.1
-
41
-
-
0033980917
-
Cimetidine absorption and elimination in rat small intestine
-
PIYAPOLRUNGROJ N, ZHOU YS, LI C et al.: Cimetidine absorption and elimination in rat small intestine. Drug Metab. Dispos. (2000) 28(1):65-72.
-
(2000)
Drug Metab. Dispos
, vol.28
, Issue.1
, pp. 65-72
-
-
PIYAPOLRUNGROJ, N.1
ZHOU, Y.S.2
LI, C.3
-
42
-
-
8344242021
-
Drug delivery to the small intestine
-
FRIEND DR: Drug delivery to the small intestine. Curr. Gastroenterol. Rep. (2004) 6(5):371-376.
-
(2004)
Curr. Gastroenterol. Rep
, vol.6
, Issue.5
, pp. 371-376
-
-
FRIEND, D.R.1
-
43
-
-
85009583484
-
Intestinal absorption of drugs mediated by drug transporters: Mechanisms and regulation
-
1-15. Good overview of intestinal transporters
-
KATSURA T, INUI K: Intestinal absorption of drugs mediated by drug transporters: mechanisms and regulation. Drug Metab. Pharmacokinet. (2003) 18(1):1-15. Good overview of intestinal transporters.
-
(2003)
Drug Metab. Pharmacokinet
, vol.18
, Issue.1
-
-
KATSURA, T.1
INUI, K.2
-
44
-
-
0036891925
-
Improved intestinal transport of PD-158473, an N-methyl-D-aspartate (NMDA) antagonist, by involvement of multiple transporters
-
OH DM, HAN HK, WILLIAMSON RM et al.: Improved intestinal transport of PD-158473, an N-methyl-D-aspartate (NMDA) antagonist, by involvement of multiple transporters. J. Pharm. Sci. (2002) 91(12):2579-2587.
-
(2002)
J. Pharm. Sci
, vol.91
, Issue.12
, pp. 2579-2587
-
-
OH, D.M.1
HAN, H.K.2
WILLIAMSON, R.M.3
-
45
-
-
0036093847
-
The mucosa of the small intestine: How clinically relevant as an organ of drug metabolism?
-
DOHERTY MM, CHARMAN WN: The mucosa of the small intestine: how clinically relevant as an organ of drug metabolism? Clin. Pharmacokinet. (2002) 41(4):235-253.
-
(2002)
Clin. Pharmacokinet
, vol.41
, Issue.4
, pp. 235-253
-
-
DOHERTY, M.M.1
CHARMAN, W.N.2
-
46
-
-
0033958156
-
Involvement of an organic anion transporter (canalicular multispecific organic anion transporter/multidrug resistance-associated protein 2) in gastrointestinal secretion of glutathione conjugates in rats
-
GOTOH Y, SUZUKI H, KINOSHITA S et al.: Involvement of an organic anion transporter (canalicular multispecific organic anion transporter/multidrug resistance-associated protein 2) in gastrointestinal secretion of glutathione conjugates in rats. J. Pharmacol. Exp. Ther. (2000) 292(1):433-439.
-
(2000)
J. Pharmacol. Exp. Ther
, vol.292
, Issue.1
, pp. 433-439
-
-
GOTOH, Y.1
SUZUKI, H.2
KINOSHITA, S.3
-
47
-
-
17944379428
-
Potential role for P-glycoprotein in the non-proportional pharmacokinetics of UK-343,664 in man
-
ABEL S, BEAUMONT KC, CRESPI CL et al.: Potential role for P-glycoprotein in the non-proportional pharmacokinetics of UK-343,664 in man. Xenobiotica (2001) 31(8-9):665-676.
-
(2001)
Xenobiotica
, vol.31
, Issue.8-9
, pp. 665-676
-
-
ABEL, S.1
BEAUMONT, K.C.2
CRESPI, C.L.3
-
48
-
-
4344701123
-
Identification of P-glycoprotein substrates and inhibitors among psychoactive compounds- implications for pharmacokinetics of selected substrates
-
EL ELA AA, HARTTER S, SCHMITT U et al.: Identification of P-glycoprotein substrates and inhibitors among psychoactive compounds- implications for pharmacokinetics of selected substrates. J. Pharm. Pharmacol. (2004) 56(8):967-975.
-
(2004)
J. Pharm. Pharmacol
, vol.56
, Issue.8
, pp. 967-975
-
-
EL ELA, A.A.1
HARTTER, S.2
SCHMITT, U.3
-
49
-
-
0031861258
-
Effects of ketoconazole on digoxin absorption and disposition in rat
-
SALPHATI L, BENET LZ: Effects of ketoconazole on digoxin absorption and disposition in rat. Pharmacology (1998) 56(6):308-313.
-
(1998)
Pharmacology
, vol.56
, Issue.6
, pp. 308-313
-
-
SALPHATI, L.1
BENET, L.Z.2
-
50
-
-
0037309349
-
Optimal structure requirements for pluronic block copolymers in modifying P-glycoprotein drug efflux transporter activity in bovine brain microvessel endothelial cells
-
BATRAKOVA EV, LI S, ALAKHOV VY, MILLER DW, KABANOV AV: Optimal structure requirements for pluronic block copolymers in modifying P-glycoprotein drug efflux transporter activity in bovine brain microvessel endothelial cells. J. Pharmacol. Exp. Ther. (2003) 304(2):845-854.
-
(2003)
J. Pharmacol. Exp. Ther
, vol.304
, Issue.2
, pp. 845-854
-
-
BATRAKOVA, E.V.1
LI, S.2
ALAKHOV, V.Y.3
MILLER, D.W.4
KABANOV, A.V.5
-
51
-
-
1842535990
-
-
DIDZIAPETRIS R, JAPERTAS P, AVDEEF A, PETRAUSKAS A: Classification analysis of P-glycoprotein substrate specificity. J. Drug Target. (2003) 11(7):391-406. Detailed analysis into P-gp substrate recognition.
-
DIDZIAPETRIS R, JAPERTAS P, AVDEEF A, PETRAUSKAS A: Classification analysis of P-glycoprotein substrate specificity. J. Drug Target. (2003) 11(7):391-406. Detailed analysis into P-gp substrate recognition.
-
-
-
-
52
-
-
1842586876
-
Predicting P-glycoprotein substrates by a quantitative structure-activity relationship model
-
GOMBAR VK, POLLI JW, HUMPHREYS JE, WRING SA, SERABJIT-SINGH CS: Predicting P-glycoprotein substrates by a quantitative structure-activity relationship model. J. Pharm. Sci. (2004) 93(4):957-968.
-
(2004)
J. Pharm. Sci
, vol.93
, Issue.4
, pp. 957-968
-
-
GOMBAR, V.K.1
POLLI, J.W.2
HUMPHREYS, J.E.3
WRING, S.A.4
SERABJIT-SINGH, C.S.5
-
53
-
-
0033739115
-
Structure-activity relationship of P-glycoprotein substrates and modifiers
-
SEELIG A, LANDWOJTOWICZ E: Structure-activity relationship of P-glycoprotein substrates and modifiers. Eur. J. Pharm. Sci. (2000) 12(1):31-40.
-
(2000)
Eur. J. Pharm. Sci
, vol.12
, Issue.1
, pp. 31-40
-
-
SEELIG, A.1
LANDWOJTOWICZ, E.2
-
54
-
-
0037052062
-
The medicinal chemistry of multidrug resistance (MDR) reversing drugs
-
TEODORI E, DEI S, SCAPECCHI S, GUALTIERI F: The medicinal chemistry of multidrug resistance (MDR) reversing drugs. Farmaco (2002) 57(5):385-415.
-
(2002)
Farmaco
, vol.57
, Issue.5
, pp. 385-415
-
-
TEODORI, E.1
DEI, S.2
SCAPECCHI, S.3
GUALTIERI, F.4
-
55
-
-
0038282311
-
The role of absorption, distribution, metabolism, excretion and toxicity in drug discovery
-
LIN J, SAHAKIAN DC, DE MORAIS SM et al.: The role of absorption, distribution, metabolism, excretion and toxicity in drug discovery. Curr. Top. Med. Chem. (2003) 3(10):1125-1154.
-
(2003)
Curr. Top. Med. Chem
, vol.3
, Issue.10
, pp. 1125-1154
-
-
LIN, J.1
SAHAKIAN, D.C.2
DE MORAIS, S.M.3
-
56
-
-
0347512122
-
Increasing the throughput and productivity of Caco-2 cell permeability assays using liquid chromatography-massspectrometry: Application to resveratrol absorption and metabolism
-
LI Y, SHIN YG, YU C et al.: Increasing the throughput and productivity of Caco-2 cell permeability assays using liquid chromatography-massspectrometry: application to resveratrol absorption and metabolism. Comb. Chem. High Throughput Screen. (2003) 6(8):757-767.
-
(2003)
Comb. Chem. High Throughput Screen
, vol.6
, Issue.8
, pp. 757-767
-
-
LI, Y.1
SHIN, Y.G.2
YU, C.3
-
57
-
-
0031925268
-
Human intestinal permeability
-
LENNERNAS H: Human intestinal permeability. J. Pharm. Sci. (1998) 87(4):403-410.
-
(1998)
J. Pharm. Sci
, vol.87
, Issue.4
, pp. 403-410
-
-
LENNERNAS, H.1
-
58
-
-
0031938959
-
Human drug absorption kinetics and comparison to Caco-2 monolayer permeabilities
-
POLLI JE, GINSKI MJ: Human drug absorption kinetics and comparison to Caco-2 monolayer permeabilities. Pharm. Res. (1998) 15(1):47-52.
-
(1998)
Pharm. Res
, vol.15
, Issue.1
, pp. 47-52
-
-
POLLI, J.E.1
GINSKI, M.J.2
-
59
-
-
23044469809
-
Estimating human drug oral absorption kinetics from Caco-2 permeability using an absorption-disposition model: Model development and evaluation and derivation of analytical solutions for k(a) and F(a)
-
USANSKY HH, SINKO PJ: Estimating human drug oral absorption kinetics from Caco-2 permeability using an absorption-disposition model: model development and evaluation and derivation of analytical solutions for k(a) and F(a). J. Pharmacol. Exp. Ther. (2005) 314(0:391-399.
-
(2005)
J. Pharmacol. Exp. Ther
, vol.314
, Issue.0
, pp. 391-399
-
-
USANSKY, H.H.1
SINKO, P.J.2
-
60
-
-
0030990079
-
In vitro permeability across Caco-2 cells (colonic) can predict in vivo (small intestinal) absorption in man - fact or myth
-
YEE S: In vitro permeability across Caco-2 cells (colonic) can predict in vivo (small intestinal) absorption in man - fact or myth. Pharm. Res. (1997) 14(6):763-766.
-
(1997)
Pharm. Res
, vol.14
, Issue.6
, pp. 763-766
-
-
YEE, S.1
-
61
-
-
33748887871
-
Caco-2 cell permeability assays to measure drug absorption
-
VAN BREEMEN RB, LI Y: Caco-2 cell permeability assays to measure drug absorption. Expert Opin. Drug Metab. Toxicol. (2005) 2005(1):175-185.
-
(2005)
Expert Opin. Drug Metab. Toxicol
, vol.2005
, Issue.1
, pp. 175-185
-
-
VAN BREEMEN RB, L.Y.1
-
62
-
-
0032903499
-
First-pass midazolam metabolism catalyzed by 1α,25-dihydroxy vitamin D3-modified Caco-2 cell monolayers
-
FISHER JM, WRIGHTON SA. WATKINS PB et al.: First-pass midazolam metabolism catalyzed by 1α,25-dihydroxy vitamin D3-modified Caco-2 cell monolayers. J. Pharmacol. Exp. Ther. (1999) 289(2):1134-1142.
-
(1999)
J. Pharmacol. Exp. Ther
, vol.289
, Issue.2
, pp. 1134-1142
-
-
FISHER, J.M.1
WRIGHTON, S.A.2
WATKINS, P.B.3
-
63
-
-
0027312774
-
Selective paracellular permeability in two models of intestinal absorption: Cultured monolayers of human intestinal epithelial cells and rat intestinal segments
-
ARTURSSON P, UNGELL AL, LOFROTH JE: Selective paracellular permeability in two models of intestinal absorption: cultured monolayers of human intestinal epithelial cells and rat intestinal segments. Pharm. Res. (1993) 10(8):1123-1129.
-
(1993)
Pharm. Res
, vol.10
, Issue.8
, pp. 1123-1129
-
-
ARTURSSON, P.1
UNGELL, A.L.2
LOFROTH, J.E.3
-
64
-
-
11144357474
-
-
LIN LS, LANZA TJ, JR., CASTONGUAY LA et al.: Bioisosteric replacement of anilide with benzoxazole: potent and orally bioavailable antagonists of VLA-4. Bioorg. Med. Chem. Lett. (2004) 14(9):2331-2334.
-
LIN LS, LANZA TJ, JR., CASTONGUAY LA et al.: Bioisosteric replacement of anilide with benzoxazole: potent and orally bioavailable antagonists of VLA-4. Bioorg. Med. Chem. Lett. (2004) 14(9):2331-2334.
-
-
-
-
65
-
-
0034771889
-
Absorption, distribution, metabolism, and excretion considerations in selection of orally active indole-containing endothelin antagonist
-
WALKER DK, DACK KN, DICKINSON RP et al.: Absorption, distribution, metabolism, and excretion considerations in selection of orally active indole-containing endothelin antagonist. Drug Metab. Dispos. (2001) 29(10:1424-1431.
-
(2001)
Drug Metab. Dispos
, vol.29
, Issue.10
, pp. 1424-1431
-
-
WALKER, D.K.1
DACK, K.N.2
DICKINSON, R.P.3
-
66
-
-
13244294957
-
Acid-base cosolvent method for determining aqueous permeability of amiodarone, itraconazole, tamoxifen, terfenadine and other very insoluble molecules
-
RUELL JA, TSINMAN O, AVDEEF A: Acid-base cosolvent method for determining aqueous permeability of amiodarone, itraconazole, tamoxifen, terfenadine and other very insoluble molecules. Chem. Pharm. Bull. (2004) 52(5):561-565.
-
(2004)
Chem. Pharm. Bull
, vol.52
, Issue.5
, pp. 561-565
-
-
RUELL, J.A.1
TSINMAN, O.2
AVDEEF, A.3
-
67
-
-
2942592476
-
Synthesis and biological evaluation of imidazole-based small molecule antagonists of the melanocortin 4 receptor (MC4-R)
-
MARSILJE TH, ROSES JB, CALDERWOOD EF et al.: Synthesis and biological evaluation of imidazole-based small molecule antagonists of the melanocortin 4 receptor (MC4-R). Bioorg. Med. Chem. Lett. (2004) 14(14):3721-3725.
-
(2004)
Bioorg. Med. Chem. Lett
, vol.14
, Issue.14
, pp. 3721-3725
-
-
MARSILJE, T.H.1
ROSES, J.B.2
CALDERWOOD, E.F.3
-
68
-
-
0031687181
-
Characterization of P-glycoprotein mediated transport of KO2, a novel vinylsulfone peptidomimetic cysteine protease inhibitor, across MDR1-MDCK and Caco-2 monolayers
-
ZHANG Z, BENET LZ: Characterization of P-glycoprotein mediated transport of KO2, a novel vinylsulfone peptidomimetic cysteine protease inhibitor, across MDR1-MDCK and Caco-2 monolayers. Pharm. Res. (1998) 15(10):1520-1524.
-
(1998)
Pharm. Res
, vol.15
, Issue.10
, pp. 1520-1524
-
-
ZHANG, Z.1
BENET, L.Z.2
-
69
-
-
0042468096
-
Impact of drug transporter studies on drug discovery and development
-
MIZUNO N, NIWA T, YOTSUMOTO Y, SUGIYAMA Y: Impact of drug transporter studies on drug discovery and development. Pbarmacol Rev. (2003) 55(3):425-461.
-
(2003)
Pbarmacol Rev
, vol.55
, Issue.3
, pp. 425-461
-
-
MIZUNO, N.1
NIWA, T.2
YOTSUMOTO, Y.3
SUGIYAMA, Y.4
-
70
-
-
15344350690
-
-
WALKER DK, ABEL S, COMBY P et al.: Species differences in the disposition of the CCR5 antagonist, UK-427,857, a new potential treatment for HIV. Drug Metab. Dispos. (2005) 33(4):587-595. A very well-designed study to determine the impact of species difference.
-
WALKER DK, ABEL S, COMBY P et al.: Species differences in the disposition of the CCR5 antagonist, UK-427,857, a new potential treatment for HIV. Drug Metab. Dispos. (2005) 33(4):587-595. A very well-designed study to determine the impact of species difference.
-
-
-
-
71
-
-
0029997940
-
Transport and epithelial secreation of the cardiac glycoside, digoxin, by human intestinal epithelial (Caco-2) cells
-
CAVET ME, WEST M, SIMMIONS NL: Transport and epithelial secreation of the cardiac glycoside, digoxin, by human intestinal epithelial (Caco-2) cells. Br. J. Pharmacol. (1996) 118:1389-1396.
-
(1996)
Br. J. Pharmacol
, vol.118
, pp. 1389-1396
-
-
CAVET, M.E.1
WEST, M.2
SIMMIONS, N.L.3
-
73
-
-
0034059327
-
Atorvastatin transport in the Caco-2 cell model: Contributions of P-glycoprotein and the proton-monocarboxylic acid co-transporter
-
WU X, WHITFIELD LR, STEWART BH: Atorvastatin transport in the Caco-2 cell model: contributions of P-glycoprotein and the proton-monocarboxylic acid co-transporter. Pharm. Res. (2000) 17(2):209-215.
-
(2000)
Pharm. Res
, vol.17
, Issue.2
, pp. 209-215
-
-
WU, X.1
WHITFIELD, L.R.2
STEWART, B.H.3
-
74
-
-
0033678688
-
Atorvastatin coadministration may increase digoxin concentrations by inhibition of intestinal P-glycoprotein-mediated secretion
-
BOYD RA, STERN RH, STEWART BH et al.: Atorvastatin coadministration may increase digoxin concentrations by inhibition of intestinal P-glycoprotein-mediated secretion. J. Clin. Pharmacol. (2000) 40(1):91-98.
-
(2000)
J. Clin. Pharmacol
, vol.40
, Issue.1
, pp. 91-98
-
-
BOYD, R.A.1
STERN, R.H.2
STEWART, B.H.3
-
75
-
-
0027402753
-
A saturable transport mechanism in the intestinal absorption of gabapentin is the underlying cause of the lack of proportionality between increasing dose and drug levels in plasma
-
STEWART BH, KUGLER AR, THOMPSON PR, BOCKBRADER HN: A saturable transport mechanism in the intestinal absorption of gabapentin is the underlying cause of the lack of proportionality between increasing dose and drug levels in plasma. Pharm. Res. (1993) 10(2):276-281.
-
(1993)
Pharm. Res
, vol.10
, Issue.2
, pp. 276-281
-
-
STEWART, B.H.1
KUGLER, A.R.2
THOMPSON, P.R.3
BOCKBRADER, H.N.4
-
76
-
-
0036453655
-
An in vitro examination of the impact of polyethylene glycol 400, pluronic P85, and vitamin E D-α-tocopheryl polyethylene glycol 1000 succinate on P-glycoprotein efflux and enterocyte-based metabolism in excised rat intestine
-
JOHNSON BM, CHARMAN WN, PORTER CJH: An in vitro examination of the impact of polyethylene glycol 400, pluronic P85, and vitamin E D-α-tocopheryl polyethylene glycol 1000 succinate on P-glycoprotein efflux and enterocyte-based metabolism in excised rat intestine. AAPS PharmaSci (2002) 4(4):1-13.
-
(2002)
AAPS PharmaSci
, vol.4
, Issue.4
, pp. 1-13
-
-
JOHNSON, B.M.1
CHARMAN, W.N.2
PORTER, C.J.H.3
-
77
-
-
18344364851
-
Application of three-dimensional quantitative structure-activity relationships of P-glycoprotein inhibitors and substrates
-
EKINS S, KIM RB, LEAKE BF et al.: Application of three-dimensional quantitative structure-activity relationships of P-glycoprotein inhibitors and substrates. Mol. Pharmacol. (2002) 61(5):974-981.
-
(2002)
Mol. Pharmacol
, vol.61
, Issue.5
, pp. 974-981
-
-
EKINS, S.1
KIM, R.B.2
LEAKE, B.F.3
-
78
-
-
0031472588
-
Role of pharmacokinetics and metabolism in drug discovery and development
-
403-449. A good overview
-
LIN JH, LU AYH: Role of pharmacokinetics and metabolism in drug discovery and development. Pharmacol. Rev. (1997) 49(4):403-449. A good overview.
-
(1997)
Pharmacol. Rev
, vol.49
, Issue.4
-
-
LIN, J.H.1
LU, A.Y.H.2
-
79
-
-
0034281087
-
Drug-metabolizing enzymes: Mechanisms and functions
-
SHEWEITA SA: Drug-metabolizing enzymes: mechanisms and functions. Curr. Drug Metab. (2000) 1(2):107-132.
-
(2000)
Curr. Drug Metab
, vol.1
, Issue.2
, pp. 107-132
-
-
SHEWEITA, S.A.1
-
80
-
-
0031856787
-
Characterization of CYP2C19 and CYP2C9 from human liver: Respective roles in microsomal tolbutamide, S-mephenytoin, and omeprazole hydroxylations
-
LASKER JM, WESTER MR, ARAMSOMBATDEE E, RAUCY JL: Characterization of CYP2C19 and CYP2C9 from human liver: respective roles in microsomal tolbutamide, S-mephenytoin, and omeprazole hydroxylations. Arch. Biochem. Biophys. (1998) 353(1):16-28.
-
(1998)
Arch. Biochem. Biophys
, vol.353
, Issue.1
, pp. 16-28
-
-
LASKER, J.M.1
WESTER, M.R.2
ARAMSOMBATDEE, E.3
RAUCY, J.L.4
-
81
-
-
0024557660
-
Dextromethorphan O-demethylation in liver microsomes as a prototype reaction to monitor cytochrome P450 dbl activity
-
DAYER P, LEEMANN T, STRIBERNI R: Dextromethorphan O-demethylation in liver microsomes as a prototype reaction to monitor cytochrome P450 dbl activity. Clin. Pharmacol. Ther. (1989) 45(1):34-40.
-
(1989)
Clin. Pharmacol. Ther
, vol.45
, Issue.1
, pp. 34-40
-
-
DAYER, P.1
LEEMANN, T.2
STRIBERNI, R.3
-
82
-
-
0032611495
-
Metabolism of xenobiotics and chemical carcinogenesis
-
LANG M, PELKONEN O: Metabolism of xenobiotics and chemical carcinogenesis. IARC Sci. Publ. (1999) 148:13-22.
-
(1999)
IARC Sci. Publ
, vol.148
, pp. 13-22
-
-
LANG, M.1
PELKONEN, O.2
-
83
-
-
0032605490
-
Xenobiotic-metabolizing enzymes and cancer risk: Correspondence between genotype and phenotype
-
PELKONEN O, RAUNIO H, RAUTIO A, LANG M: Xenobiotic-metabolizing enzymes and cancer risk: correspondence between genotype and phenotype. IARC Sci. Publ. (1999) 148:77-88.
-
(1999)
IARC Sci. Publ
, vol.148
, pp. 77-88
-
-
PELKONEN, O.1
RAUNIO, H.2
RAUTIO, A.3
LANG, M.4
-
84
-
-
11144276585
-
The roles of transporters and enzymes in hepatic drug processing
-
LIU L, PANG KS: The roles of transporters and enzymes in hepatic drug processing. Drug Metab. Dispos. (2005) 33(1):1-9.
-
(2005)
Drug Metab. Dispos
, vol.33
, Issue.1
, pp. 1-9
-
-
LIU, L.1
PANG, K.S.2
-
85
-
-
0036290013
-
How important are gender differences in pharmacokinetics?
-
MEIBOHM B, BEIERLE I, DERENDORF H: How important are gender differences in pharmacokinetics? Clin. Pharmacokinet. (2002) 41(5):329-342.
-
(2002)
Clin. Pharmacokinet
, vol.41
, Issue.5
, pp. 329-342
-
-
MEIBOHM, B.1
BEIERLE, I.2
DERENDORF, H.3
-
86
-
-
0035695389
-
Liver function and phase I drug metabolism in the elderly: A paradox
-
SCHMUCKER DL: Liver function and phase I drug metabolism in the elderly: a paradox. Drugs Aging (2001) 18(11):837-851.
-
(2001)
Drugs Aging
, vol.18
, Issue.11
, pp. 837-851
-
-
SCHMUCKER, D.L.1
-
87
-
-
0034770465
-
Human drug metabolism and the cytochromes P450: Application and relevance of in vitro models
-
VENKATAKRISHNAN K, VON MOLTKE LL, GREENBLATT DJ: Human drug metabolism and the cytochromes P450: application and relevance of in vitro models. J. Clin. Pharmacol. (2001) 41(11):1149-1179.
-
(2001)
J. Clin. Pharmacol
, vol.41
, Issue.11
, pp. 1149-1179
-
-
VENKATAKRISHNAN, K.1
VON MOLTKE, L.L.2
GREENBLATT, D.J.3
-
88
-
-
23344450788
-
Induction of phase I, II and III drug metabolism/transport by xenobiotics
-
XU C, LI CY, KONG AN: Induction of phase I, II and III drug metabolism/transport by xenobiotics. Arch. Pharm. Res. (2005) 28(3):249-268.
-
(2005)
Arch. Pharm. Res
, vol.28
, Issue.3
, pp. 249-268
-
-
XU, C.1
LI, C.Y.2
KONG, A.N.3
-
89
-
-
0004037003
-
-
Appleton & Lange, Stamford, CT, USA
-
SHARGEL L, YU A: Applied Biopharmaceutics and Pharmacokinetics. Appleton & Lange, Stamford, CT, USA (1999):353-398.
-
(1999)
Applied Biopharmaceutics and Pharmacokinetics
, pp. 353-398
-
-
SHARGEL, L.1
YU, A.2
-
90
-
-
0037304032
-
TILMISANYAK: Cancer and phase II drug-metabolizing enzymes
-
SHEWEITA SA, TILMISANYAK: Cancer and phase II drug-metabolizing enzymes. Curr. Drug Metab. (2003) 4(1):45-58.
-
(2003)
Curr. Drug Metab
, vol.4
, Issue.1
, pp. 45-58
-
-
SHEWEITA, S.A.1
-
91
-
-
0027275566
-
Physiological parameters in laboratory animals and humans
-
DAVIES B, MORRIS T: Physiological parameters in laboratory animals and humans. Pharm. Res. (1993) 10(7):1093-1095.
-
(1993)
Pharm. Res
, vol.10
, Issue.7
, pp. 1093-1095
-
-
DAVIES, B.1
MORRIS, T.2
-
92
-
-
0027446505
-
The P450 superfamily: Update on new sequences, gene mapping, accession numbers, early trivial names of enzymes, and nomenclature
-
NELSON DR, KAMATAKI T, WAXMAN DJ et al.: The P450 superfamily: update on new sequences, gene mapping, accession numbers, early trivial names of enzymes, and nomenclature. DNA Cell Biol (1993) 12(1):1-51.
-
(1993)
DNA Cell Biol
, vol.12
, Issue.1
, pp. 1-51
-
-
NELSON, D.R.1
KAMATAKI, T.2
WAXMAN, D.J.3
-
93
-
-
0028595707
-
Use of cloned and expressed human liver UDP-glucuronosyltransferases for analysis of drug glucuronide formation and assessment of drug toxicity
-
BURCHELL B, EBNER T, BAIRD S et al.: Use of cloned and expressed human liver UDP-glucuronosyltransferases for analysis of drug glucuronide formation and assessment of drug toxicity. Environ. Health Perspect. (1994) 102(Suppl. 9):19-23.
-
(1994)
Environ. Health Perspect
, vol.102
, Issue.SUPPL. 9
, pp. 19-23
-
-
BURCHELL, B.1
EBNER, T.2
BAIRD, S.3
-
94
-
-
0025261405
-
Characterization of molecular species of liver microsomal carboxylesterases of several animal species and humans
-
HOSOKAWA M, MAKI T, SATOH T: Characterization of molecular species of liver microsomal carboxylesterases of several animal species and humans. Arch. Biochem. Biophys. (1990) 277(2):219-227.
-
(1990)
Arch. Biochem. Biophys
, vol.277
, Issue.2
, pp. 219-227
-
-
HOSOKAWA, M.1
MAKI, T.2
SATOH, T.3
-
95
-
-
0027416228
-
Disposition of remoxipride in different species. Species differences in metabolism
-
WIDMAN M, NILSSON LB, BRYSKE B, LUNDSTROM J: Disposition of remoxipride in different species. Species differences in metabolism. Arzneim. Forsch. (1993) 43(3):287-297.
-
(1993)
Arzneim. Forsch
, vol.43
, Issue.3
, pp. 287-297
-
-
WIDMAN, M.1
NILSSON, L.B.2
BRYSKE, B.3
LUNDSTROM, J.4
-
96
-
-
0034438860
-
Pharmacokinetics of reboxetine in healthy, elderly volunteers
-
BERGMANN JF, LANEURY JP, DUCHENE P et al.: Pharmacokinetics of reboxetine in healthy, elderly volunteers. Eur. J. Drug Metab. Pharmacokinet. (2000) 25(3-4):195-198.
-
(2000)
Eur. J. Drug Metab. Pharmacokinet
, vol.25
, Issue.3-4
, pp. 195-198
-
-
BERGMANN, J.F.1
LANEURY, J.P.2
DUCHENE, P.3
-
97
-
-
0026037163
-
Comparison of the disposition and of the metabolic pattern of Reboxetine, a new antidepressant, in the rat, dog, monkey and man
-
COCCHIARA G, BATTAGLIA R, PEVARELLO P, STROLIN BENEDETTI M: Comparison of the disposition and of the metabolic pattern of Reboxetine, a new antidepressant, in the rat, dog, monkey and man. Eur. J. Drug Metab. Pharmacokinet. (1991) 16(3):231-239.
-
(1991)
Eur. J. Drug Metab. Pharmacokinet
, vol.16
, Issue.3
, pp. 231-239
-
-
COCCHIARA, G.1
BATTAGLIA, R.2
PEVARELLO, P.3
STROLIN, B.M.4
-
98
-
-
0029974065
-
Species differences in the pharmacokinetics and metabolism of indinavir, a potent human immunodeficiency virus protease inhibitor
-
LIN JH, CHIBA M, BALANI SK et al.: Species differences in the pharmacokinetics and metabolism of indinavir, a potent human immunodeficiency virus protease inhibitor. Drug Metab. Dispos. (1996) 24(10):1111-1120.
-
(1996)
Drug Metab. Dispos
, vol.24
, Issue.10
, pp. 1111-1120
-
-
LIN, J.H.1
CHIBA, M.2
BALANI, S.K.3
-
99
-
-
0035147471
-
The prediction of human clearance from hepatic microsomal metabolism data
-
20014(1):36-44. Provides an overview to the use of microsomes in a discovery setting
-
OBACH RS: The prediction of human clearance from hepatic microsomal metabolism data. Curr. Opin. Drug Discov. Devel (2001)4(1):36-44. Provides an overview to the use of microsomes in a discovery setting.
-
Curr. Opin. Drug Discov. Devel
-
-
OBACH, R.S.1
-
100
-
-
0030799001
-
The prediction of human pharmacokinetic parameters from preclinical and in vitro metabolism data
-
OBACH RS, BAXTER JG, LISTON TE et al.: The prediction of human pharmacokinetic parameters from preclinical and in vitro metabolism data. J. Pharmacol. Exp. Ther. (1997) 283(1):46-58.
-
(1997)
J. Pharmacol. Exp. Ther
, vol.283
, Issue.1
, pp. 46-58
-
-
OBACH, R.S.1
BAXTER, J.G.2
LISTON, T.E.3
-
101
-
-
0001280443
-
Substrate SARs in human P450s
-
LEWIS DF, DICKINS M: Substrate SARs in human P450s. Drug Discov. Today (2002) 7(17):918-925.
-
(2002)
Drug Discov. Today
, vol.7
, Issue.17
, pp. 918-925
-
-
LEWIS, D.F.1
DICKINS, M.2
-
102
-
-
14544302297
-
The impact of lipophilicity in drug research: A case report on β-blockers
-
MANNHOLD R: The impact of lipophilicity in drug research: a case report on β-blockers. Mini. Rev. Med. Chem. (2005) 5(2):197-205.
-
(2005)
Mini. Rev. Med. Chem
, vol.5
, Issue.2
, pp. 197-205
-
-
MANNHOLD, R.1
-
103
-
-
0037060908
-
Structure-based design, synthesis, and biological evaluation of irreversible human rhinovirus 3C protease inhibitors. Part 7: Structure-activity studies of bicyclic 2-pyridone-containing peptidomimetics
-
DRAGOVICH PS, PRINS TJ, ZHOU R et al.: Structure-based design, synthesis, and biological evaluation of irreversible human rhinovirus 3C protease inhibitors. Part 7: structure-activity studies of bicyclic 2-pyridone-containing peptidomimetics. Bioorg. Med. Chem. Lett. (2002) 12(5):733-738.
-
(2002)
Bioorg. Med. Chem. Lett
, vol.12
, Issue.5
, pp. 733-738
-
-
DRAGOVICH, P.S.1
PRINS, T.J.2
ZHOU, R.3
-
104
-
-
2342544143
-
Piperazine-based CCR5 antagonists as HIV-1 inhibitors. IV. Discovery of 1-[(4,6-dimethyl-5- pyrimidinyl)carbonyl]-4-[4-[2-methoxy-1(R)-4-(trifluoromethyl) phenyl]ethyl-3(S)-methyl-1-piperazinyl]-4-methylpiperidine (Sch-417690/Sch-D), a potent, highly selective, and orally bioavailable CCR5 antagonist
-
TAGAT JR, MCCOMBIE SW, NAZARENO D et al.: Piperazine-based CCR5 antagonists as HIV-1 inhibitors. IV. Discovery of 1-[(4,6-dimethyl-5- pyrimidinyl)carbonyl]-4-[4-[2-methoxy-1(R)-4-(trifluoromethyl) phenyl]ethyl-3(S)-methyl-1-piperazinyl]-4-methylpiperidine (Sch-417690/Sch-D), a potent, highly selective, and orally bioavailable CCR5 antagonist. J. Med. Chem. (2004) 47(10):2405-2408.
-
(2004)
J. Med. Chem
, vol.47
, Issue.10
, pp. 2405-2408
-
-
TAGAT, J.R.1
MCCOMBIE, S.W.2
NAZARENO, D.3
-
105
-
-
0038440502
-
Predicting drug metabolism: A site of metabolism prediction tool applied to the cytochrome P450 2C9
-
ZAMORA I, AFZELIUS L, CRUCIANI G: Predicting drug metabolism: a site of metabolism prediction tool applied to the cytochrome P450 2C9. J. Med. Chem. (2003) 46(12):2313-2324.
-
(2003)
J. Med. Chem
, vol.46
, Issue.12
, pp. 2313-2324
-
-
ZAMORA, I.1
AFZELIUS, L.2
CRUCIANI, G.3
-
106
-
-
27444434892
-
MetaSite: Understanding metabolism in human cytochromes from the perspective of the chemist
-
CRUCIANI G, CAROSATI E, DE BOECK B et al.: MetaSite: understanding metabolism in human cytochromes from the perspective of the chemist. J. Med. Chem. (2005) 48(22):6970-6979.
-
(2005)
J. Med. Chem
, vol.48
, Issue.22
, pp. 6970-6979
-
-
CRUCIANI, G.1
CAROSATI, E.2
DE BOECK, B.3
-
107
-
-
21244487140
-
Pharmacophore, drug metabolism, and pharmacokinetics models on non-peptide AT1, AT2, and AT1/AT2 angiotensin II receptor antagonists
-
BERELLINI G, CRUCIANI G, MANNHOLD R: Pharmacophore, drug metabolism, and pharmacokinetics models on non-peptide AT1, AT2, and AT1/AT2 angiotensin II receptor antagonists. J. Med. Chem. (2005) 48(13):4389-4399.
-
(2005)
J. Med. Chem
, vol.48
, Issue.13
, pp. 4389-4399
-
-
BERELLINI, G.1
CRUCIANI, G.2
MANNHOLD, R.3
-
108
-
-
28144442034
-
Prediction of metabolic clearance using cryopreserved human hepatocytes: Kinetic characteristics for five benzodiazepines
-
HALLIFAX D, RAWDEN HC, HAKOOZ N, HOUSTON JB: Prediction of metabolic clearance using cryopreserved human hepatocytes: kinetic characteristics for five benzodiazepines. Drug Metab. Dispos. (2005) 33(12):1852-1858.
-
(2005)
Drug Metab. Dispos
, vol.33
, Issue.12
, pp. 1852-1858
-
-
HALLIFAX, D.1
RAWDEN, H.C.2
HAKOOZ, N.3
HOUSTON, J.B.4
-
109
-
-
0036266936
-
Characterization of raloxifene glucuronidation in vitro: Contribution of intestinal metabolism to presystemic clearance
-
KEMP DC, FAN PW, STEVENS JC: Characterization of raloxifene glucuronidation in vitro: contribution of intestinal metabolism to presystemic clearance. Drug Metab. Dispos. (2002) 30(6):694-700.
-
(2002)
Drug Metab. Dispos
, vol.30
, Issue.6
, pp. 694-700
-
-
KEMP, D.C.1
FAN, P.W.2
STEVENS, J.C.3
-
110
-
-
0037255847
-
Pharmacokinetics of selective estrogen receptor modulators
-
MORELLO KC, WURZ GT, DEGREGORIO MW: Pharmacokinetics of selective estrogen receptor modulators. Clin. Pharmacokinet. (2003) 42(4):361-372.
-
(2003)
Clin. Pharmacokinet
, vol.42
, Issue.4
, pp. 361-372
-
-
MORELLO, K.C.1
WURZ, G.T.2
DEGREGORIO, M.W.3
-
111
-
-
1842637373
-
Changes in drug plasma concentrations of an extensively bound and highly extracted drug, propofol, in response to altered plasma binding
-
HIRAOKA H, YAMAMOTO K, OKANO N et al.: Changes in drug plasma concentrations of an extensively bound and highly extracted drug, propofol, in response to altered plasma binding. Clin. Pharmacol. Ther. (2004) 75(4):324-330.
-
(2004)
Clin. Pharmacol. Ther
, vol.75
, Issue.4
, pp. 324-330
-
-
HIRAOKA, H.1
YAMAMOTO, K.2
OKANO, N.3
-
112
-
-
0024452924
-
Pharmacokinetics of nalbuphine in infants, young healthy volunteers, and elderly patients
-
JAILLON P, GARDIN ME, LECOCO B et al.: Pharmacokinetics of nalbuphine in infants, young healthy volunteers, and elderly patients. Clin. Pharmacol. Ther. (1989) 46(2):226-233.
-
(1989)
Clin. Pharmacol. Ther
, vol.46
, Issue.2
, pp. 226-233
-
-
JAILLON, P.1
GARDIN, M.E.2
LECOCO, B.3
-
113
-
-
0029063116
-
Plasma concentrations of morphine, morphine-3-glucuronide, and morphine-6-glucuronide after intravenous and oral administration to healthy volunteers: Relationship to nonanalgesic actions
-
WESTERLING D, PERSSON C, HOGLUND P: Plasma concentrations of morphine, morphine-3-glucuronide, and morphine-6-glucuronide after intravenous and oral administration to healthy volunteers: relationship to nonanalgesic actions. Ther. Drug Monit. (1995) 17(3):287-301.
-
(1995)
Ther. Drug Monit
, vol.17
, Issue.3
, pp. 287-301
-
-
WESTERLING, D.1
PERSSON, C.2
HOGLUND, P.3
-
114
-
-
33846343473
-
-
SHARGEL L, YU A: Applied Biopharmaceutics and Pharmacokinetics. Appleton & Lange, Stamford, CT USA (1999).
-
SHARGEL L, YU A: Applied Biopharmaceutics and Pharmacokinetics. Appleton & Lange, Stamford, CT USA (1999).
-
-
-
-
115
-
-
0037707638
-
Metabolic stability for drug discovery and development: Pharmacokinetic and biochemical challenges
-
MASIMIREMBWA CM, BREDBERG U, ANDERSSON TB: Metabolic stability for drug discovery and development: pharmacokinetic and biochemical challenges. Clin. Pharmacokinet. (2003) 42(6):515-528.
-
(2003)
Clin. Pharmacokinet
, vol.42
, Issue.6
, pp. 515-528
-
-
MASIMIREMBWA, C.M.1
BREDBERG, U.2
ANDERSSON, T.B.3
-
116
-
-
0021171978
-
Suitability of animal models for predictive toxicology: Theoretical and practical considerations
-
CALABRESE EJ: Suitability of animal models for predictive toxicology: theoretical and practical considerations. Drug Metab. Rev. (1984) 15(3):505-523.
-
(1984)
Drug Metab. Rev
, vol.15
, Issue.3
, pp. 505-523
-
-
CALABRESE, E.J.1
-
117
-
-
0025287693
-
The use of laboratory animals in toxicology: An ophthalmoscopic assessment
-
SCHIAVO DM: The use of laboratory animals in toxicology: an ophthalmoscopic assessment. Toxicol. Pathol. (1990) 18(1 Pt 2):222-223.
-
(1990)
Toxicol. Pathol
, vol.18
, Issue.1 PART 2
, pp. 222-223
-
-
SCHIAVO, D.M.1
-
118
-
-
17644380257
-
Predicting drug disposition via application of BCS: Transport/absorption/elimination interplay and development of a biopharmaceutics drug disposition classification system
-
WU CY, BENET LZ: Predicting drug disposition via application of BCS: transport/absorption/elimination interplay and development of a biopharmaceutics drug disposition classification system. Pharm. Res. (2005) 22(1):11-23.
-
(2005)
Pharm. Res
, vol.22
, Issue.1
, pp. 11-23
-
-
WU, C.Y.1
BENET, L.Z.2
|