-
1
-
-
0003403775
-
-
Lippincott, Williams and Wilkins: Philadelphia, PA
-
Rowland, M.; Tozer, T. N. Clinical Pharmacokinetics, Concepts and Applications, 3rd ed.; Lippincott, Williams and Wilkins: Philadelphia, PA, 1995; pp 143-155.
-
(1995)
Clinical Pharmacokinetics, Concepts and Applications, 3rd Ed.
, pp. 143-155
-
-
Rowland, M.1
Tozer, T.N.2
-
2
-
-
0030937636
-
Prediction of in Vivo Drug Metabolism in the Human Liver from in Vitro Metabolism Data
-
Iwatsubo, T.; Hirota, N.; Ooie, T.; Suzuki, H.; Shimada, N.; Chiba, K.; Ishizaki, T.; Green, C. E.; Tyson, C. A.; Sugiyama, Y. Prediction of in Vivo Drug Metabolism in the Human Liver from in Vitro Metabolism Data. Pharmacol. Ther. 1997, 73, 5147-5171.
-
(1997)
Pharmacol. Ther.
, vol.73
, pp. 5147-5171
-
-
Iwatsubo, T.1
Hirota, N.2
Ooie, T.3
Suzuki, H.4
Shimada, N.5
Chiba, K.6
Ishizaki, T.7
Green, C.E.8
Tyson, C.A.9
Sugiyama, Y.10
-
3
-
-
0344333422
-
Prediction of Hepatic Clearance from Microsomes, Hepatocytes, and Liver Slices
-
Houston, J. B.; Carlile, D. J. Prediction of Hepatic Clearance from Microsomes, Hepatocytes, and Liver Slices. Drug Metab. Rev. 1997, 29, 891-922.
-
(1997)
Drug Metab. Rev.
, vol.29
, pp. 891-922
-
-
Houston, J.B.1
Carlile, D.J.2
-
4
-
-
0032921527
-
Prediction of hepatic metabolic clearance based on interspecies allometric scaling techniques and in vitro-in vivo correlations
-
Lave, T.; Coassolo, P.; Reigner, B. Prediction of hepatic metabolic clearance based on interspecies allometric scaling techniques and in vitro-in vivo correlations. Clin. Pharmacokinet. 1999, 36, 211-231.
-
(1999)
Clin. Pharmacokinet.
, vol.36
, pp. 211-231
-
-
Lave, T.1
Coassolo, P.2
Reigner, B.3
-
5
-
-
0030799001
-
The Prediction of Human Pharmacokinetic Parameters from Preclinical and in Vitro Metabolism Data
-
Obach, R. S.; Baxter, J. G.; Liston, T. E.; Silber, B. M.; Jones, B. C.; MacIntyre, F.; Rance, D. J.; Wastall, P. The Prediction of Human Pharmacokinetic Parameters from Preclinical and in Vitro Metabolism Data. J. Pharmacol. Exp. Ther. 1997, 283, 46-58.
-
(1997)
J. Pharmacol. Exp. Ther.
, vol.283
, pp. 46-58
-
-
Obach, R.S.1
Baxter, J.G.2
Liston, T.E.3
Silber, B.M.4
Jones, B.C.5
MacIntyre, F.6
Rance, D.J.7
Wastall, P.8
-
6
-
-
0037142338
-
Prediction of Volume of Distribution in Humans for Neutral and Basic Drugs Using Physicochemical Measurements and Plasma Protein Binding Data
-
Lombardo, F.; Obach, R. S.; Shalaeva, M. Y.; Gao, F. Prediction of Volume of Distribution in Humans for Neutral and Basic Drugs Using Physicochemical Measurements and Plasma Protein Binding Data. J. Med. Chem. 2002, 45, 2867-2876.
-
(2002)
J. Med. Chem.
, vol.45
, pp. 2867-2876
-
-
Lombardo, F.1
Obach, R.S.2
Shalaeva, M.Y.3
Gao, F.4
-
7
-
-
0018668570
-
Effect of Altered Plasma Protein Binding on Apparent Volume of Distribution
-
Øie, S.; Tozer, T. N. Effect of Altered Plasma Protein Binding on Apparent Volume of Distribution. J. Pharm. Sci. 1979, 68, 1203-1205.
-
(1979)
J. Pharm. Sci.
, vol.68
, pp. 1203-1205
-
-
Øie, S.1
Tozer, T.N.2
-
8
-
-
0033820354
-
The influence of lipophilicity on the pharmacokinetic behavior ofdrugs: Concepts and examples
-
Testa, B.; Crivori, P.; Reist, M.; Carrupt, P.-A. The influence of lipophilicity on the pharmacokinetic behavior ofdrugs: Concepts and examples. Perspect. Drug Discovery Des. 2000, 19, 179-211.
-
(2000)
Perspect. Drug Discovery Des.
, vol.19
, pp. 179-211
-
-
Testa, B.1
Crivori, P.2
Reist, M.3
Carrupt, P.-A.4
-
9
-
-
0029865450
-
Design of Drugs Involving the Concepts and Theories of Drug Metabolism and Pharmacokinetics
-
Smith, D. A.; Jones, B. C.; Walker, D. K. Design of Drugs Involving the Concepts and Theories of Drug Metabolism and Pharmacokinetics. Med. Res. Rev. 1996, 16, 243-266.
-
(1996)
Med. Res. Rev.
, vol.16
, pp. 243-266
-
-
Smith, D.A.1
Jones, B.C.2
Walker, D.K.3
-
10
-
-
0028282481
-
Quantitative Structure-Pharmacokinetic Relationships for Systemic Drug Distribution Kinetics Not Confined to a Congeneric Series
-
Herman, R. A.; Veng-Pedersen, P. Quantitative Structure-Pharmacokinetic Relationships for Systemic Drug Distribution Kinetics Not Confined to a Congeneric Series. J. Pharm. Sci. 1994, 83, 423-428.
-
(1994)
J. Pharm. Sci.
, vol.83
, pp. 423-428
-
-
Herman, R.A.1
Veng-Pedersen, P.2
-
11
-
-
0035044107
-
Prediction of Adipose Tissue:Plasma Partition Coefficients for Structurally Unrelated Drugs
-
Poulin, P.; Schoenlein, K.; Theil, F.-P. Prediction of Adipose Tissue:Plasma Partition Coefficients for Structurally Unrelated Drugs. J. Pharm. Sci. 2001, 90, 436-447.
-
(2001)
J. Pharm. Sci.
, vol.90
, pp. 436-447
-
-
Poulin, P.1
Schoenlein, K.2
Theil, F.-P.3
-
12
-
-
0033966128
-
A Priori Prediction of Tissue:Plasma Partition Coefficients of Drugs to Facilitate the Use of Physiologically-Based Pharmacokinetic Models in Drug Discovery
-
Poulin, P.; Theil, F.-P. A Priori Prediction of Tissue:Plasma Partition Coefficients of Drugs To Facilitate the Use of Physiologically-Based Pharmacokinetic Models in Drug Discovery. J. Pharm. Sci. 2000, 89, 16-35.
-
(2000)
J. Pharm. Sci.
, vol.89
, pp. 16-35
-
-
Poulin, P.1
Theil, F.-P.2
-
13
-
-
0028289107
-
Factors Affecting the Storage of Drugs and Other Xenobiotics in Adipose Tissue
-
Bickel, M. H. Factors Affecting the Storage of Drugs and Other Xenobiotics in Adipose Tissue. Adv. Drug. Res. 1994, 25, 55-86.
-
(1994)
Adv. Drug. Res.
, vol.25
, pp. 55-86
-
-
Bickel, M.H.1
-
14
-
-
0030875019
-
Pharmacokinetics of β-adrenoceptors blockers in obese and normal volunteers
-
Cheymol, G.; Poirier, J.-M.; Carrupt, P.-A.; Testa, B.; Weissenburger, J.; Levron, J.-C.; Snoeck, E. Pharmacokinetics of β-adrenoceptors blockers in obese and normal volunteers. Br. J. Clin. Pharmacol. 1997, 43, 563-570.
-
(1997)
Br. J. Clin. Pharmacol.
, vol.43
, pp. 563-570
-
-
Cheymol, G.1
Poirier, J.-M.2
Carrupt, P.-A.3
Testa, B.4
Weissenburger, J.5
Levron, J.-C.6
Snoeck, E.7
-
15
-
-
0035913059
-
oct: A Tool for Lipophilicity Determination in Drug Discovery. 2. Basic and Neutral Compounds
-
oct: A Tool for Lipophilicity Determination in Drug Discovery. 2. Basic and Neutral Compounds. J. Med. Chem. 2001, 44, 2490-2497.
-
(2001)
J. Med. Chem.
, vol.44
, pp. 2490-2497
-
-
Lombardo, F.1
Shalaeva, M.Y.2
Tupper, K.A.3
Gao, F.4
-
16
-
-
0034744471
-
a screening of pharmaceuticals by pressure-assisted capillary electrophoresis
-
a screening of pharmaceuticals by pressure-assisted capillary electrophoresis. Electrophoresis 2001, 22, 1112-1118.
-
(2001)
Electrophoresis
, vol.22
, pp. 1112-1118
-
-
Jia, Z.1
Ramstad, T.2
Zhong, M.3
-
17
-
-
0032146512
-
Multiwavelength Spectrophotometric Determination of Acid Dissociation Constants of Ionizable Drugs
-
Allen, R. I.; Box, K. J.; Comer, J. E. A.; Peake, C.; Tam, K. Y. Multiwavelength Spectrophotometric Determination of Acid Dissociation Constants of Ionizable Drugs. J. Pharm. Biomed. Anal. 1998, 17, 699-712.
-
(1998)
J. Pharm. Biomed. Anal.
, vol.17
, pp. 699-712
-
-
Allen, R.I.1
Box, K.J.2
Comer, J.E.A.3
Peake, C.4
Tam, K.Y.5
-
18
-
-
0035150465
-
High Throughput Physicochemical Profiling for Drug Discovery
-
Kerns, E. H. High Throughput Physicochemical Profiling for Drug Discovery. J. Pharm. Sci. 2001, 90, 1838-1858.
-
(2001)
J. Pharm. Sci.
, vol.90
, pp. 1838-1858
-
-
Kerns, E.H.1
-
19
-
-
0035038596
-
Development of a High Throughput Equilibrium Dialysis Method
-
Kariv, I.; Cao, H.; Oldenburg, K. R. Development of a High Throughput Equilibrium Dialysis Method. J. Pharm. Sci. 2001, 90, 580-587.
-
(2001)
J. Pharm. Sci.
, vol.90
, pp. 580-587
-
-
Kariv, I.1
Cao, H.2
Oldenburg, K.R.3
-
20
-
-
0037407697
-
Development and Validation of a 96-Well Equilibrium Apparatus for Measuring Plasma Protein Binding
-
Banker, M. J.; Clark, T. H.; Williams, J. A. Development and Validation of a 96-Well Equilibrium Apparatus for Measuring Plasma Protein Binding. J. Pharm. Sci. 2003, 92, 967-974.
-
(2003)
J. Pharm. Sci.
, vol.92
, pp. 967-974
-
-
Banker, M.J.1
Clark, T.H.2
Williams, J.A.3
-
21
-
-
0036569923
-
Recognition forces involved in mitochondrial binding to a low-affinity trimetazidine binding site related to anti-ischemic activity
-
Plemper van Balen, G.; Carrupt, P.-A.; Morin, D.; Tillement, J.-P.; Le Ridant, A.; Testa, B. Recognition forces involved in mitochondrial binding to a low-affinity trimetazidine binding site related to anti-ischemic activity. Biochem. Pharmacol. 2002, 63, 1691-1697.
-
(2002)
Biochem. Pharmacol.
, vol.63
, pp. 1691-1697
-
-
Plemper Van Balen, G.1
Carrupt, P.-A.2
Morin, D.3
Tillement, J.-P.4
Le Ridant, A.5
Testa, B.6
-
22
-
-
0027275566
-
Physiological Parameters in Laboratory Animals and Humans
-
Davies, B.; Morris, T. Physiological Parameters in Laboratory Animals and Humans. Pharm. Res. 1993, 10, 1093-1095.
-
(1993)
Pharm. Res.
, vol.10
, pp. 1093-1095
-
-
Davies, B.1
Morris, T.2
-
23
-
-
0022437395
-
Mechanisms of quinacrine binding and fluorescence in nuclei and chromosomes
-
Sumner, A. T. Mechanisms of quinacrine binding and fluorescence in nuclei and chromosomes. Histochemistry 1986, 84, 566-574.
-
(1986)
Histochemistry
, vol.84
, pp. 566-574
-
-
Sumner, A.T.1
-
24
-
-
0019151738
-
Quinacrine Accumulates in Certain Peptide Hormone-Producing Cells
-
Ekelund, M.; Ahrén, B.; Håkanson, R.; Lundquist, I.; Sundler, F. Quinacrine Accumulates in Certain Peptide Hormone-Producing Cells. Histochemistry 1980, 66, 1-9.
-
(1980)
Histochemistry
, vol.66
, pp. 1-9
-
-
Ekelund, M.1
Ahrén, B.2
Håkanson, R.3
Lundquist, I.4
Sundler, F.5
-
25
-
-
0024412720
-
Submitochondrial Distribution of Basic Drugs in the Isolated Perfused Lung
-
Okumura, K.; Yoshida, H.; Kamiya, A.; Hori, R. Submitochondrial Distribution of Basic Drugs in the Isolated Perfused Lung. Chem. Pharm. Bull. 1989, 37, 1109-1111.
-
(1989)
Chem. Pharm. Bull.
, vol.37
, pp. 1109-1111
-
-
Okumura, K.1
Yoshida, H.2
Kamiya, A.3
Hori, R.4
-
26
-
-
0033846711
-
Uptake of Imipramine in Rat Liver Lysosomes in Vitro and Its Inhibition by Basic Drugs
-
Ishizaki, J.; Yokogawa, K.; Ichimura, F.; Ohkuma, S. Uptake of Imipramine in Rat Liver Lysosomes in Vitro and Its Inhibition by Basic Drugs. J. Pharmacol. Exp. Ther. 2000, 294, 1088-1098.
-
(2000)
J. Pharmacol. Exp. Ther.
, vol.294
, pp. 1088-1098
-
-
Ishizaki, J.1
Yokogawa, K.2
Ichimura, F.3
Ohkuma, S.4
-
27
-
-
0036227660
-
Influence of the Lipophilicity and Lysosomal Accumulation on Tissue Distribution Kinetics of Basic Drugs: A Physiologically Based Pharmacokinetic Model
-
Yokogawa, K.; Ishizaki, J.; Ohkuma, S.; Miyamoto, K. Influence of the Lipophilicity and Lysosomal Accumulation on Tissue Distribution Kinetics of Basic Drugs: A Physiologically Based Pharmacokinetic Model. Methods Find. Exp. Clin. Pharmacol. 2002, 24, 81-93.
-
(2002)
Methods Find. Exp. Clin. Pharmacol.
, vol.24
, pp. 81-93
-
-
Yokogawa, K.1
Ishizaki, J.2
Ohkuma, S.3
Miyamoto, K.4
-
28
-
-
0021746592
-
Prediction of the Volumes of Distribution of Basic Drugs in Humans Based on Data from Animals
-
Sawada, Y.; Hanano, M.; Sugiyama, Y.; Harashima, H.; Iga, T. Prediction of the Volumes of Distribution of Basic Drugs in Humans Based on Data from Animals. J. Pharmacokinet. Biopharm. 1984, 12, 587-596.
-
(1984)
J. Pharmacokinet. Biopharm.
, vol.12
, pp. 587-596
-
-
Sawada, Y.1
Hanano, M.2
Sugiyama, Y.3
Harashima, H.4
Iga, T.5
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