The importance of oncogenic transcription factors for oral cancer pathogenesis and treatment

Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology

Volumn 116, Issue 2, 2013, Pages 179-188

  Yedida, Govinda Raju ^a   Nagini, Siddavaram ^b   Mishra, Rajakishore ^a  

^a CENTRAL UNIVERSITY OF JHARKHAND   (India)

^b ANNAMALAI UNIVERSITY   (India)

Author keywords

[No Author keywords available]

Indexed keywords

EID: 84880204119     PISSN: 22124403     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.oooo.2013.02.010     Document Type: Review

References (139)

1. A. Jemal, F. Bray, M.M. Center, J. Ferlay, E. Ward, and D. Forman Global cancer statistics CA Cancer J Clin 61 2011 69 90
2. C. Scully Oral cancer aetiopathogenesis; past, present and future aspects Med Oral Patol Oral Cir Bucal 16 2011 e306 e311
3. D.M. Parkin, F. Bray, J. Ferlay, and P. Pisani Global cancer statistics, 2002 CA Cancer J Clin 55 2005 74 108
4. C. Scully, and J.V. Bagan Recent advances in oral oncology 2008; squamous cell carcinoma imaging, treatment, prognostication and treatment outcomes Oral Oncol 45 2009 e25 e30
5. H. Hamakawa, K. Nakashiro, and T. Sumida Basic evidence of molecular targeted therapy for oral cancer and salivary gland cancer Head Neck 30 2008 800 809
6. D. Pei Regulation of pluripotency and reprogramming by transcription factors J Biol Chem 284 2009 3365 3369
7. T.A. Libermann, and L.F. Zerbini Targeting transcription factors for cancer gene therapy Curr Gene Ther 6 2006 17 33
8. J. Lim, J.H. Kim, and J.Y. Paeng Prognostic value of activated Akt expression in oral squamous cell carcinoma J Clin Pathol 58 2005 1199 1205
9. H.T. Wu, S.Y. Ko, J.H. Fong, K.W. Chang, T.Y. Liu, and S.Y. Kao Expression of phosphorylated Akt in oral carcinogenesis and its induction by nicotine and alkaline stimulation J Oral Pathol Med 38 2009 206 213
10. A. Iamaroon, and S. Krisanaprakornkit Overexpression and activation of Akt2 protein in oral squamous cell carcinoma Oral Oncol 45 2009 e175 e179
11. R. Mishra Glycogen synthase kinase 3 beta: can it be a target for oral cancer Mol Cancer 9 2010 144
12. M. Masuda, T. Wakasaki, M. Suzui, S. Toh, A.K. Joe, and I.B. Weinstein Stat3 orchestrates tumor development and progression: the Achilles' heel of head and neck cancers? Curr Cancer Drug Targets 10 2010 117 126
13. M.S. Brown, O.T. Diallo, and M. Hu CK2 modulation of NF-kappaB, TP53, and the malignant phenotype in head and neck cancer by anti-CK2 oligonucleotides in vitro or in vivo via sub-50-nm nanocapsules Clin Cancer Res 16 2010 2295 2307
14. S.O. de Sousa, R.A. Mesquita, D.S. Pinto Jr., and S. Gutkind Immunolocalization of c-Fos and c-Jun in human oral mucosa and in oral squamous cell carcinoma J Oral Pathol Med 31 2002 78 81
15. E. Turatti, A. da Costa Neves, M.H. de Magalhaes, and S.O. de Sousa Assessment of c-Jun, c-Fos and cyclin D1 in premalignant and malignant oral lesions J Oral Sci 47 2005 71 76
16. A.O. Rehman, and C.Y. Wang SDF-1alpha promotes invasion of head and neck squamous cell carcinoma by activating NF-kappaB J Biol Chem 283 2008 19888 19894
17. D.G. Jackson-Bernitsas, H. Ichikawa, and Y. Takada Evidence that TNF-TNFR1-TRADD-TRAF2-RIP-TAK1-IKK pathway mediates constitutive NF-kappaB activation and proliferation in human head and neck squamous cell carcinoma Oncogene 26 2007 1385 1397
18. A. Mishra, A.C. Bharti, P. Varghese, D. Saluja, and B.C. Das Differential expression and activation of NF-kappaB family proteins during oral carcinogenesis: role of high risk human papillomavirus infection Int J Cancer 119 2006 2840 2850
19. R. Baral, S. Patnaik, and B.R. Das Co-overexpression of p53 and c-myc proteins linked with advanced stages of betel- and tobacco-related oral squamous cell carcinomas from eastern India Eur J Oral Sci 106 1998 907 913
20. M. Perez-Sayans, J.M. Suarez-Penaranda, G.D. Pilar, F. Barros-Angueira, J.M. Gandara-Rey, and A. Garcia-Garcia What real influence does the proto-oncogene c-myc have in OSCC behavior? Oral Oncol 47 2011 688 692
21. A.F. Waitzberg, S. Nonogaki, and I.N. Nishimoto Clinical significance of c-myc and p53 expression in head and neck squamous cell carcinomas Cancer Detect Prev 28 2004 178 186
22. R. Pai, S. Pai, and R. Lalitha Over-expression of c-Myc oncoprotein in oral squamous cell carcinoma in the South Indian population Ecancermedicalscience 3 2009 128
23. R.J. Leeman, V.W. Lui, and J.R. Grandis STAT3 as a therapeutic target in head and neck cancer Expert Opin Biol Ther 6 2006 231 241
24. M.A. Macha, A. Matta, and J. Kaur Prognostic significance of nuclear pSTAT3 in oral cancer Head Neck 33 2011 482 489
25. A. Gasparoni, A. Chaves, L. Fonzi, G.K. Johnson, G.B. Schneider, and C.A. Squier Subcellular localization of beta-catenin in malignant cell lines and squamous cell carcinomas of the oral cavity J Oral Pathol Med 31 2002 385 394
26. A. Bankfalvi, M. Krassort, A. Vegh, E. Felszeghy, and J. Piffko Deranged expression of the E-cadherin/beta-catenin complex and the epidermal growth factor receptor in the clinical evolution and progression of oral squamous cell carcinomas J Oral Pathol Med 31 2002 450 457
27. M.J. Joseph, S. Dangi-Garimella, and M.A. Shields Slug is a downstream mediator of transforming growth factor-beta1-induced matrix metalloproteinase-9 expression and invasion of oral cancer cells J Cell Biochem 108 2009 726 736
28. B. Qiao, N.W. Johnson, and J. Gao Epithelial-mesenchymal transition in oral squamous cell carcinoma triggered by transforming growth factor-beta1 is Snail family-dependent and correlates with matrix metalloproteinase-2 and -9 expressions Int J Oncol 37 2010 663 668
29. M. Franz, K. Spiegel, and C. Umbreit Expression of Snail is associated with myofibroblast phenotype development in oral squamous cell carcinoma Histochem Cell Biol 131 2009 651 660
30. S.S. Lee, C.H. Tsai, S.F. Yang, Y.C. Ho, and Y.C. Chang Hypoxia inducible factor-1alpha expression in areca quid chewing-associated oral squamous cell carcinomas Oral Dis 16 2010 696 701
31. A.W. Eckert, A. Schutze, M.H. Lautner, H. Taubert, J. Schubert, and U. Bilkenroth HIF-1alpha is a prognostic marker in oral squamous cell carcinomas Int J Biol Markers 25 2010 87 92
32. J.A. Brennan, J.O. Boyle, and W.M. Koch Association between cigarette smoking and mutation of the p53 gene in squamous-cell carcinoma of the head and neck N Engl J Med 332 1995 712 717
33. R. Vidya Priyadarsini, N. Kumar, I. Khan, P. Thiyagarajan, P. Kondaiah, and S. Nagini Gene expression signature of DMBA-induced hamster buccal pouch carcinomas: modulation by chlorophyllin and ellagic acid PLoS One 7 2012 e34628
34. R.G. Roeder, and W.J. Rutter Multiple forms of DNA-dependent RNA polymerase in eukaryotic organisms Nature 224 1969 234 237
35. D.B. Nikolov, and S.K. Burley RNA polymerase II transcription initiation: a structural view Proc Natl Acad Sci U S A 94 1997 15 22
36. J.T. Kadonaga Regulation of RNA polymerase II transcription by sequence-specific DNA binding factors Cell 116 2004 247 257
37. R.R. Acay, E. dos Santos, and S.O. de Sousa Correlation between c-Jun and human papillomavirus in oral premalignant and malignant lesions Oral Oncol 44 2008 698 702
38. L. Zhang, H.Y. Pan, and L.P. Zhong Fos-related activator-1 is overexpressed in oral squamous cell carcinoma and associated with tumor lymph node metastasis J Oral Pathol Med 39 2010 470 476
39. A. Mishra, A.C. Bharti, D. Saluja, and B.C. Das Transactivation and expression patterns of Jun and Fos/AP-1 super-family proteins in human oral cancer Int J Cancer 126 2010 819 829
40. M.H. Chien, T.H. Ying, and Y.S. Hsieh Dioscorea nipponica Makino inhibits migration and invasion of human oral cancer HSC-3 cells by transcriptional inhibition of matrix metalloproteinase-2 through modulation of CREB and AP-1 activity Food Chem Toxicol 50 2012 558 566
41. T. Shiratsuchi, H. Ishibashi, and K. Shirasuna Inhibition of epidermal growth factor-induced invasion by dexamethasone and AP-1 decoy in human squamous cell carcinoma cell lines J Cell Physiol 193 2002 340 348
42. P. Arun, M.S. Brown, R. Ehsanian, Z. Chen, and C. Van Waes Nuclear NF-kappaB p65 phosphorylation at serine 276 by protein kinase A contributes to the malignant phenotype of head and neck cancer Clin Cancer Res 15 2009 5974 5984
43. A.O. Rehman, and C.Y. Wang CXCL12/SDF-1 alpha activates NF-kappaB and promotes oral cancer invasion through the Carma3/Bcl10/Malt1 complex Int J Oral Sci 1 2009 105 118
44. M. Lun, P.L. Zhang, P.K. Pellitteri, A. Law, T.L. Kennedy, and R.E. Brown Nuclear factor-kappaB pathway as a therapeutic target in head and neck squamous cell carcinoma: pharmaceutical and molecular validation in human cell lines using Velcade and siRNA/NF-kappaB Ann Clin Lab Sci 35 2005 251 258
45. G. Martin-Ezquerra, R. Salgado, and A. Toll Multiple genetic copy number alterations in oral squamous cell carcinoma: study of MYC, TP53, CCDN1, EGFR and ERBB2 status in primary and metastatic tumours Br J Dermatol 163 2010 1028 1035
46. N. Bhattacharya, A. Roy, B. Roy, S. Roychoudhury, and C.K. Panda MYC gene amplification reveals clinical association with head and neck squamous cell carcinoma in Indian patients J Oral Pathol Med 38 2009 759 763
47. R. Mishra, and B.R. Das Early overexpression of Cdk4 and possible role of KRF and c-myc in chewing tobacco mediated oral cancer development Mol Biol Rep 30 2003 207 213
48. P. Saintigny, L. Zhang, and Y.H. Fan Gene expression profiling predicts the development of oral cancer Cancer Prev Res (Phila) 4 2011 218 229
49. Y. Sambandam, K. Sundaram, A. Liu, K.L. Kirkwood, W.L. Ries, and S.V. Reddy CXCL13 activation of c-Myc induces RANK ligand expression in stromal/preosteoblast cells in the oral squamous cell carcinoma tumor-bone microenvironment Oncogene 32 2013 97 105
50. J.K. Nagpal, R. Mishra, and B.R. Das Activation of Stat-3 as one of the early events in tobacco chewing-mediated oral carcinogenesis Cancer 94 2002 2393 2400
51. R. Mishra, and B.R. Das Activation of STAT 5-cyclin D1 pathway in chewing tobacco mediated oral squamous cell carcinoma Mol Biol Rep 32 2005 159 166
52. P. Kar, and P.C. Supakar Expression of Stat5A in tobacco chewing-mediated oral squamous cell carcinoma Cancer Lett 240 2006 306 311
53. J.R. Grandis, A. Chakraborty, Q. Zeng, M.F. Melhem, and D.J. Tweardy Downmodulation of TGF-alpha protein expression with antisense oligonucleotides inhibits proliferation of head and neck squamous carcinoma but not normal mucosal epithelial cells J Cell Biochem 69 1998 55 62
54. S.K. Rao, Z. Pavicevic, and Z. Du Pro-inflammatory genes as biomarkers and therapeutic targets in oral squamous cell carcinoma J Biol Chem 285 2010 32512 32521
55. C. Fung, and J.R. Grandis Emerging drugs to treat squamous cell carcinomas of the head and neck Expert Opin Emerg Drugs 15 2010 355 373
56. N. Tanaka, T. Odajima, K. Ogi, T. Ikeda, and M. Satoh Expression of E-cadherin, alpha-catenin, and beta-catenin in the process of lymph node metastasis in oral squamous cell carcinoma Br J Cancer 89 2003 557 563
57. F. Mahomed, M. Altini, and S. Meer Altered E-cadherin/beta-catenin expression in oral squamous carcinoma with and without nodal metastasis Oral Dis 13 2007 386 392
58. A. Freitas Rde, E.J. Silveira, J.P. Silveira, F.M. Silva, and R.F. Amorim Correlation of beta-catenin expresssion and metastasis in tongue squamous cell carcinoma Acta Cir Bras 25 2010 513 517
59. M. Goto, R.S. Mitra, and M. Liu Rap1 stabilizes beta-catenin and enhances beta-catenin-dependent transcription and invasion in squamous cell carcinoma of the head and neck Clin Cancer Res 16 2010 65 76
60. A. Wushou, H.Y. Pan, and W. Liu Correlation of increased twist with lymph node metastasis in patients with oral squamous cell carcinoma J Oral Maxillofac Surg 70 2011 1473 1479
61. L. Sun, M.E. Diamond, A.J. Ottaviano, M.J. Joseph, V. Ananthanarayan, and H.G. Munshi Transforming growth factor-beta 1 promotes matrix metalloproteinase-9-mediated oral cancer invasion through snail expression Mol Cancer Res 6 2008 10 20
62. C.C. Yu, W.L. Lo, and Y.W. Chen Bmi-1 regulates Snail expression and promotes metastasis ability in head and neck squamous cancer-derived ALDH1 positive cells J Oncol 2011 Epub ahead of press; doi: 10.1155/2011/609259
63. P.Y. Lin, C.H. Yu, and J.T. Wang Expression of hypoxia-inducible factor-1 alpha is significantly associated with the progression and prognosis of oral squamous cell carcinomas in Taiwan J Oral Pathol Med 37 2008 18 25
64. A.W. Eckert, M.H. Lautner, A. Schutze, H. Taubert, J. Schubert, and U. Bilkenroth Coexpression of hypoxia-inducible factor-1alpha and glucose transporter-1 is associated with poor prognosis in oral squamous cell carcinoma patients Histopathology 58 2011 1136 1147
65. M. Perez-Sayans, J.M. Suarez-Penaranda, G.D. Pilar, F. Barros-Angueira, J.M. Gandara-Rey, and A. Garcia-Garcia Hypoxia-inducible factors in OSCC Cancer Lett 313 2011 1 8
66. M.H. Ryu, H.M. Park, J. Chung, C.H. Lee, and H.R. Park Hypoxia-inducible factor-1alpha mediates oral squamous cell carcinoma invasion via upregulation of alpha5 integrin and fibronectin Biochem Biophys Res Commun 393 2010 11 15
67. C.C. Chang, B.R. Lin, S.T. Chen, T.H. Hsieh, Y.J. Li, and M.Y. Kuo HDAC2 promotes cell migration/invasion abilities through HIF-1alpha stabilization in human oral squamous cell carcinoma J Oral Pathol Med 40 2011 567 575
68. H. Zhou, W. Fei, and Y. Bai RNA interference-mediated downregulation of hypoxia-inducible factor-1alpha inhibits angiogenesis and survival of oral squamous cell carcinoma in vitro and in vivo Eur J Cancer Prev 21 2012 289 299
69. S. Acin, Z. Li, O. Mejia, D.R. Roop, A.K. El-Naggar, and C. Caulin Gain-of-function mutant p53 but not p53 deletion promotes head and neck cancer progression in response to oncogenic K-ras J Pathol 225 2011 479 489
70. N.M. Hassan, M. Tada, and J. Hamada Presence of dominant negative mutation of TP53 is a risk of early recurrence in oral cancer Cancer Lett 270 2008 108 119
71. H. Kawamata, F. Omotehara, and K. Nakashiro Oncogenic mutation of the p53 gene derived from head and neck cancer prevents cells from undergoing apoptosis after DNA damage Int J Oncol 30 2007 1089 1097
72. S. Strano, S. Dell'Orso, and A.M. Mongiovi Mutant p53 proteins: between loss and gain of function Head Neck 29 2007 488 496
73. L. Weisz, A. Damalas, and M. Liontos Mutant p53 enhances nuclear factor kappaB activation by tumor necrosis factor alpha in cancer cells Cancer Res 67 2007 2396 2401
74. G. Bossi, F. Marampon, and R. Maor-Aloni Conditional RNA interference in vivo to study mutant p53 oncogenic gain of function on tumor malignancy Cell Cycle 7 2008 1870 1879
75. J. Edelman, and J. Nemunaitis Adenoviral p53 gene therapy in squamous cell cancer of the head and neck region Curr Opin Mol Ther 5 2003 611 617
76. G. Russo, A. Zamparelli, and C.M. Howard Expression of cell cycle-regulated proteins pRB2/p130, p107, E2F4, p27, and pCNA in salivary gland tumors: prognostic and diagnostic implications Clin Cancer Res 11 2005 3265 3273
77. M.F. De Souza Setubal Destro, C.C. Bitu, and K.G. Zecchin Overexpression of HOXB7 homeobox gene in oral cancer induces cellular proliferation and is associated with poor prognosis Int J Oncol 36 2010 141 149
78. K. Freier, K. Knoepfle, and C. Flechtenmacher Recurrent copy number gain of transcription factor SOX2 and corresponding high protein expression in oral squamous cell carcinoma Genes Chromosomes Cancer 49 2010 9 16
79. T. Tsunematsu, Y. Kudo, and S. Iizuka RUNX3 has an oncogenic role in head and neck cancer PLoS One 4 2009 e5892
80. S. Arora, J. Kaur, and C. Sharma Stromelysin 3, Ets-1, and vascular endothelial growth factor expression in oral precancerous and cancerous lesions: correlation with microvessel density, progression, and prognosis Clin Cancer Res 11 2005 2272 2284
81. L. Fang, H. Wang, L. Zhou, and D. Yu Akt-FOXO3a signaling axis dysregulation in human oral squamous cell carcinoma and potent efficacy of FOXO3a-targeted gene therapy Oral Oncol 47 2011 16 21
82. P.K. Ha, N.E. Benoit, and R. Yochem A transcriptional progression model for head and neck cancer Clin Cancer Res 9 2003 3058 3064
83. Y. Fang, H. Sun, and J. Zhai Antitumor activity of NF-kB decoy oligodeoxynucleotides in a prostate cancer cell line Asian Pac J Cancer Prev 12 2011 2721 2726
84. G. Son, Y. Iimuro, E. Seki, T. Hirano, Y. Kaneda, and J. Fujimoto Selective inactivation of NF-kappaB in the liver using NF-kappaB decoy suppresses CCl4-induced liver injury and fibrosis Am J Physiol Gastrointest Liver Physiol 293 2007 G631 G639
85. C. Laguillier, A.T. Hbibi, and F. Baran-Marszak Cell death in NF-kappaB-dependent tumour cell lines as a result of NF-kappaB trapping by linker-modified hairpin decoy oligonucleotide FEBS Lett 581 2007 1143 1150
86. I. Souissi, I. Najjar, and L. Ah-Koon A STAT3-decoy oligonucleotide induces cell death in a human colorectal carcinoma cell line by blocking nuclear transfer of STAT3 and STAT3-bound NF-kappaB BMC Cell Biol 12 2011 14
87. M. Sen, S.M. Thomas, and S. Kim First-in-human trial of a STAT3 decoy oligonucleotide abrogates target gene expression in head and neck tumors: implications for cancer therapy Cancer Discov 2 2012 694 705
88. S.Y. Kim, Y.S. Yang, and K.H. Hong Adenovirus-mediated expression of dominant negative c-myb induces apoptosis in head and neck cancer cells and inhibits tumor growth in animal model Oral Oncol 44 2008 383 392
89. S.O. Rahaman, P.C. Harbor, O. Chernova, G.H. Barnett, M.A. Vogelbaum, and S.J. Haque Inhibition of constitutively active Stat3 suppresses proliferation and induces apoptosis in glioblastoma multiforme cells Oncogene 21 2002 8404 8413
90. D.C. Duffey, Z. Chen, and G. Dong Expression of a dominant-negative mutant inhibitor-kappaBalpha of nuclear factor-kappaB in human head and neck squamous cell carcinoma inhibits survival, proinflammatory cytokine expression, and tumor growth in vivo Cancer Res 59 1999 3468 3474
91. S. Xi, Q. Zhang, and K.F. Dyer Src kinases mediate STAT growth pathways in squamous cell carcinoma of the head and neck J Biol Chem 278 2003 31574 31583
92. H. Zhou, Y. Tang, and X. Liang RNAi targeting urokinase-type plasminogen activator receptor inhibits metastasis and progression of oral squamous cell carcinoma in vivo Int J Cancer 125 2009 453 462
93. G. Jiang, J. Li, Z. Zeng, and L. Xian Lentivirus-mediated gene therapy by suppressing survivin in BALB/c nude mice bearing oral squamous cell carcinoma Cancer Biol Ther 5 2006 435 440
94. W.A. Yeudall, C.A. Vaughan, and H. Miyazaki Gain-of-function mutant p53 upregulates CXC chemokines and enhances cell migration Carcinogenesis 33 2012 442 451
95. H. Andersen, J. Mejlvang, and S. Mahmood Immediate and delayed effects of E-cadherin inhibition on gene regulation and cell motility in human epidermoid carcinoma cells Mol Cell Biol 25 2005 9138 9150
96. Z.P. Zhang, Y.L. Sun, L. Fu, F. Gu, L. Zhang, and X.S. Hao Correlation of Notch1 expression and activation to cisplatin-sensitivity of head and neck squamous cell carcinoma Ai Zheng 28 2009 100 103
97. F. Gu, Y. Ma, and Z. Zhang Expression of Stat3 and Notch1 is associated with cisplatin resistance in head and neck squamous cell carcinoma Oncol Rep 23 2010 671 676
98. H. Hijioka, T. Setoguchi, and A. Miyawaki Upregulation of Notch pathway molecules in oral squamous cell carcinoma Int J Oncol 36 2010 817 822
99. M. Hedvat, D. Huszar, and A. Herrmann The JAK2 inhibitor AZD1480 potently blocks Stat3 signaling and oncogenesis in solid tumors Cancer Cell 16 2009 487 497
100. M.A. Macha, A. Matta, S.S. Chauhan, K.W. Siu, and R. Ralhan Guggulsterone (GS) inhibits smokeless tobacco and nicotine-induced NF-kappaB and STAT3 pathways in head and neck cancer cells Carcinogenesis 32 2011 368 380
101. L. Fang, H. Wang, L. Zhou, and D. Yu FOXO3a reactivation mediates the synergistic cytotoxic effects of rapamycin and cisplatin in oral squamous cell carcinoma cells Toxicol Appl Pharmacol 251 2011 8 15
102. X. Ma, L.E. Becker Buscaglia, J.R. Barker, and Y. Li MicroRNAs in NF-kappaB signaling J Mol Cell Biol 3 2011 159 166
103. D. Iliopoulos, H.A. Hirsch, and K. Struhl An epigenetic switch involving NF-kappaB, Lin28, Let-7 microRNA, and IL6 links inflammation to cell transformation Cell 139 2009 693 706
104. D. Iliopoulos, S.A. Jaeger, H.A. Hirsch, M.L. Bulyk, and K. Struhl STAT3 activation of miR-21 and miR-181b-1 via PTEN and CYLD are part of the epigenetic switch linking inflammation to cancer Mol Cell 39 2010 493 506
105. R. Nagel, C. le Sage, and B. Diosdado Regulation of the adenomatous polyposis coli gene by the miR-135 family in colorectal cancer Cancer Res 68 2008 5795 5802
106. C.J. Chang, C.C. Hsu, and C.H. Chang Let-7d functions as novel regulator of epithelial-mesenchymal transition and chemoresistant property in oral cancer Oncol Rep 26 2011 1003 1010
107. K. Kozaki, I. Imoto, S. Mogi, K. Omura, and J. Inazawa Exploration of tumor-suppressive microRNAs silenced by DNA hypermethylation in oral cancer Cancer Res 68 2008 2094 2105
108. B. Ory, M.R. Ramsey, and C. Wilson A microRNA-dependent program controls p53-independent survival and chemosensitivity in human and murine squamous cell carcinoma J Clin Invest 121 2011 809 820
109. J. Krutzfeldt, N. Rajewsky, and R. Braich Silencing of microRNAs in vivo with 'antagomirs' Nature 438 2005 685 689
110. J. Elmen, M. Lindow, and S. Schutz LNA-mediated microRNA silencing in non-human primates Nature 452 2008 896 899
111. R. Gambari Biological activity and delivery of peptide nucleic acids (PNA)-DNA chimeras for transcription factor decoy (TFD) pharmacotherapy Curr Med Chem 11 2004 1253 1263
112. M. Borgatti, A. Finotti, and A. Romanelli Peptide nucleic acids (PNA)-DNA chimeras targeting transcription factors as a tool to modify gene expression Curr Drug Targets 5 2004 735 744
113. A. Faccini, A. Tortori, and T. Tedeschi Circular dichroism study of DNA binding by a potential anticancer peptide nucleic acid targeted against the MYCN oncogene Chirality 20 2008 494 500
114. P.A. Johnston, and J.R. Grandis STAT3 signaling: anticancer strategies and challenges Mol Interv 11 2011 18 26
115. I. Waldmann, S. Walde, and R.H. Kehlenbach Nuclear import of c-Jun is mediated by multiple transport receptors J Biol Chem 282 2007 27685 27692
116. C.E. Malnou, T. Salem, F. Brockly, H. Wodrich, M. Piechaczyk, and I. Jariel-Encontre Heterodimerization with Jun family members regulates c-Fos nucleocytoplasmic traffic J Biol Chem 282 2007 31046 31059
117. T. Sekimoto, Y. Miyamoto, S. Arai, and Y. Yoneda Importin alpha protein acts as a negative regulator for Snail protein nuclear import J Biol Chem 286 2011 15126 15131
118. C.H. Lee, Y.T. Jeon, S.H. Kim, and Y.S. Song NF-kappaB as a potential molecular target for cancer therapy Biofactors 29 2007 19 35
119. T.R. Kau, and P.A. Silver Nuclear transport as a target for cell growth Drug Discov Today 8 2003 78 85
120. T.R. Kau, J.C. Way, and P.A. Silver Nuclear transport and cancer: from mechanism to intervention Nat Rev Cancer 4 2004 106 117
121. M. Brunori, M. Malerba, H. Kashiwazaki, and R. Iggo Replicating adenoviruses that target tumors with constitutive activation of the wnt signaling pathway J Virol 75 2001 2857 2865
122. I.R. Cho, S.S. Koh, and H.J. Min Down-regulation of HIF-1alpha by oncolytic reovirus infection independently of VHL and p53 Cancer Gene Ther 17 2010 365 372
123. Z. Han, Z. Hong, and C. Chen A novel oncolytic adenovirus selectively silences the expression of tumor-associated STAT3 and exhibits potent antitumoral activity Carcinogenesis 30 2009 2014 2022
124. R.E. Moellering, M. Cornejo, and T.N. Davis Direct inhibition of the NOTCH transcription factor complex Nature 462 2009 182 188
125. J. Sandoval, H.A. Heyn, and S. Moran Validation of a DNA methylation microarray for 450,000 CpG sites in the human genome Epigenetics 6 2011 692 702
126. J.P. Kruse, and W. Gu Modes of p53 regulation Cell 137 2009 609 622
127. M. Yada, S. Hatakeyama, and T. Kamura Phosphorylation-dependent degradation of c-Myc is mediated by the F-box protein Fbw7 EMBO J 23 2004 2116 2125
128. E. Guccione, F. Martinato, and G. Finocchiaro Myc-binding-site recognition in the human genome is determined by chromatin context Nat Cell Biol 8 2006 764 770
129. M. Federico, and L. Bagella Histone deacetylase inhibitors in the treatment of hematological malignancies and solid tumors J Biomed Biotechnol 2011 2011 475641
130. C.M. Overall, and O. Kleifeld Tumour microenvironment - opinion: validating matrix metalloproteinases as drug targets and anti-targets for cancer therapy Nat Rev Cancer 6 2006 227 239
131. D. Hanahan, and R.A. Weinberg The hallmarks of cancer Cell 100 2000 57 70
132. D.A. Frank Targeting transcription factors for cancer therapy IDrugs 12 2009 29 33
133. J.E. Darnell Jr. Transcription factors as targets for cancer therapy Nat Rev Cancer 2 2002 740 749
134. J.L. Thorne, M.J. Campbell, and B.M. Turner Transcription factors, chromatin and cancer Int J Biochem Cell Biol 41 2009 164 175
135. L. Arce, K.T. Pate, and M.L. Waterman Groucho binds two conserved regions of LEF-1 for HDAC-dependent repression BMC Cancer 9 2009 159
136. A.N. Billin, H. Thirlwell, and D.E. Ayer Beta-catenin-histone deacetylase interactions regulate the transition of LEF1 from a transcriptional repressor to an activator Mol Cell Biol 20 2000 6882 6890
137. S.K. Singh, C. Hawkins, and I.D. Clarke Identification of human brain tumour initiating cells Nature 432 2004 396 401
138. M.E. Prince, R. Sivanandan, and A. Kaczorowski Identification of a subpopulation of cells with cancer stem cell properties in head and neck squamous cell carcinoma Proc Natl Acad Sci U S A 104 2007 973 978
139. K. Takahashi, and S. Yamanaka Induction of pluripotent stem cells from mouse embryonic and adult fibroblast cultures by defined factors Cell 126 2006 663 676