Let-7d functions as novel regulator of epithelial-mesenchymal transition and chemoresistant property in oral cancer

Oncology Reports

Volumn 26, Issue 4, 2011, Pages 1003-1010

  Chang, Charn Jung ^a   Hsu, Chuan Chih ^b   Chang, Chin Hong ^b   Tsai, Lo Lin ^c   Chang, Yu Chao ^c   Lu, Shao Wei ^a   Yu, Cuuan Hang ^c   Huang, Hsu Shan ^a   Wang, Jhi Joung ^b   Tsai, Chung Hung ^c   Chou, Ming Yung ^c   Yu, Cheng Chia ^c,d   Hu, Fang Wei ^c,d  

^a TRI SERVICE GENERAL HOSPITAL   (Taiwan)

^b CHIA NAN UNIVERSITY OF PHARMACY AND SCIENCE   (Taiwan)

^c CHUNG SHAN MEDICAL UNIVERSITY   (Taiwan)

^d CHUNG SHAN MEDICAL UNIVERSITY HOSPITAL   (Taiwan)

Author keywords

Chemo resistance; Epithelial mesenchymal transition; Let 7d; Snail; Twist

Indexed keywords

ALDEHYDE DEHYDROGENASE; CISPLATIN; FLUOROURACIL; LET 7D PROTEIN; MICRORNA; PACLITAXEL; TRANSCRIPTION FACTOR SNAIL; TRANSCRIPTION FACTOR TWIST; UNCLASSIFIED DRUG;

ARTICLE; CANCER CHEMOTHERAPY; CANCER INVASION; CANCER RESISTANCE; CELL MIGRATION; CELL RENEWAL; CELL VIABILITY; CHEMOSENSITIVITY; CONCENTRATION RESPONSE; CONTROLLED STUDY; DOWN REGULATION; EPITHELIAL MESENCHYMAL TRANSITION; GENE EXPRESSION REGULATION; GENE SILENCING; HUMAN; HUMAN CELL; IN VITRO STUDY; LYMPH NODE METASTASIS; MOUTH CANCER; NUCLEOTIDE SEQUENCE; PHENOTYPIC VARIATION; PRIMARY TUMOR; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; SQUAMOUS CELL CARCINOMA;

CARCINOMA, SQUAMOUS CELL; CELL LINE, TUMOR; DOWN-REGULATION; DRUG RESISTANCE, NEOPLASM; EPITHELIAL-MESENCHYMAL TRANSITION; GENE KNOCKDOWN TECHNIQUES; HUMANS; MICRORNAS; MOUTH NEOPLASMS; NUCLEAR PROTEINS; TRANSCRIPTION FACTORS; TRANSFECTION; TWIST TRANSCRIPTION FACTOR;

EID: 79960799901     PISSN: 1021335X     EISSN: 17912431     Source Type: Journal    
DOI: 10.3892/or.2011.1360     Document Type: Article

References (55)

1. Jemal A, Siegel R, Ward E, et al: Cancer statistics, 2008. CA Cancer J Clin 58: 71-96, 2008. (Pubitemid 351521864)
2. Perez-Sayans M, Somoza-Martin JM, Barros-Angueira F, Reboiras-Lopez MD, Gandara Rey JM and Garcia-Garcia A: Genetic and molecular alterations associated with oral squamous cell cancer (Review). Oncol Rep 22: 1277-1282, 2009.
3. Visvader JE and Lindeman GJ: Cancer stem cells in solid tumours: accumulating evidence and unresolved questions. Nat Rev Cancer 8: 755-768, 2008.
4. Croce CM: Causes and consequences of microRNA dysregulationin cancer. Nat Rev Genet 10: 704-714, 2009.
5. Takamizawa J, Konishi H, Yanagisawa K, et al: Reduced expressionof the let-7 microRNAs in human lung cancers in association with shortened postoperative survival. Cancer Res 64: 3753-3756, 2004. (Pubitemid 38697282)
6. Johnson SM, Grosshans H, Shingara J, et al: RAS is regulated by the let-7 microRNA family. Cell 120: 635-647, 2005. (Pubitemid 40343076)
7. Yanaihara N, Caplen N, Bowman E, et al: Unique microRNA molecular profiles in lung cancer diagnosis and prognosis. Cancer Cell 9: 189-198, 2006. (Pubitemid 43357945)
8. Akao Y, Nakagawa Y and Naoe T: Let-7 microRNA functions as a potential growth suppressor in human colon cancer cells. Biol Pharm Bull 29: 903-906, 2006.
9. Shell S, Park SM, Radjabi AR, et al: Let-7 expression defines two differentiation stages of cancer. Proc Natl Acad Sci USA 104: 11400-11405, 2007. (Pubitemid 47175152)
10. Motoyama K, Inoue H, Nakamura Y, Uetake H, Sugihara K and Mori M: Clinical significance of high mobility group A2 in human gastric cancer and its relationship to let-7 microRNA family. Clin Cancer Res 14: 2334-2340, 2008. (Pubitemid 351551065)
11. Peng Y, Laser J, Shi G, et al: Antiproliferative effects by let-7 repression of high-mobility group A2 in uterine leiomyoma. Mol Cancer Res 6: 663-673, 2008. (Pubitemid 351521848)
12. Schultz J, Lorenz P, Gross G, Ibrahim S and Kunz M: MicroRNA let-7b targets important cell cycle molecules in malignant melanoma cells and interferes with anchorage-independent growth. Cell Res 18: 549-557, 2008. (Pubitemid 351630945)
13. Nam EJ, Yoon H, Kim SW, et al: MicroRNA expression profiles in serous ovarian carcinoma. Clin Cancer Res 14: 2690-2695, 2008.
14. Yu ML, Wang JF, Wang GK, et al: Vascular smooth muscle cell proliferation is influenced by let-7d microRNA and its interaction with KRAS. Circ J 75: 703-709, 2011.
15. Pandit KV, Corcoran D, Yousef H, et al: Inhibition and role of let-7d in idiopathic pulmonary fibrosis. Am J Respir Crit Care Med 182: 220-229, 2010.
16. Lee S, Jung JW, Park SB, et al: Histone deacetylase regulates high mobility group A2-targeting microRNAs in human cord blood-derived multipotent stem cell aging. Cell Mol Life Sci 68: 325-336, 2011.
17. Li Y, VandenBoom TG II, Kong D, et al: Up-regulation of miR-200 and let-7 by natural agents leads to the reversal of epithelial-to-mesenchymal transition in gemcitabine-resistant pancreatic cancer cells. Cancer Res 69: 6704-6712, 2009.
18. Shao M, Rossi S, Chelladurai B, et al: PDGF induced microRNA alterations in cancer cells. Nucleic Acids Res: Jan 25, 2011 (Epub ahead of print).
19. Davidson LA, Wang N, Shah MS, Lupton JR, Ivanov I and Chapkin RS: n-3 Polyunsaturated fatty acids modulate carcinogen-directed non-coding microRNA signatures in rat colon. Carcinogenesis 30: 2077-2084, 2009.
20. Garzon R, Pichiorri F, Palumbo T, et al: MicroRNA gene expressionduring retinoic acid-induced differentiation of human acute promyelocytic leukemia. Oncogene 26: 4148-4157, 2007. (Pubitemid 46920170)
21. Childs G, Fazzari M, Kung G, et al: Low-level expression of microRNAs let-7d and miR-205 are prognostic markers of head and neck squamous cell carcinoma. Am J Pathol 174: 736-745, 2009.
22. Lo WL, Yu CC, Chiou GY, et al: MicroRNA-200c attenuates tumour growth and metastasis of presumptive head and neck squamous cell carcinoma stem cells. J Pathol 223: 482-495, 2011.
23. Yu CC, Lo WL, Chen YW, et al: Bmi-1 regulates snail expressionand promotes metastasis ability in head and neck squamous cancer-derived ALDH1 positive cells. J Oncol 2011: 609259, 2011.
24. Ebert MS, Neilson JR and Sharp PA: MicroRNA sponges: competitive inhibitors of small RNAs in mammalian cells. Nat Methods 4: 721-726, 2007. (Pubitemid 47338166)
25. Tsai LL, Yu CC, Chang YC, Yu CH and Chou MY: Markedly increased Oct4 and Nanog expression correlates with cisplatin resistance in oral squamous cell carcinoma. J Oral Pathol Med: Feb 22, 2011 (Epub ahead of print).
26. Wu MJ, Jan CI, Tsay YG, et al: Elimination of head and neck cancer initiating cells through targeting glucose regulated protein78 signaling. Mol Cancer 9: 283, 2010.
27. Polyak K and Weinberg RA: Transitions between epithelial and mesenchymal states: acquisition of malignant and stem cell traits. Nat Rev Cancer 9: 265-273, 2009.
28. Blower PE, Chung JH, Verducci JS, et al: MicroRNAs modulate the chemosensitivity of tumor cells. Mol Cancer Ther 7: 1-9, 2008.
29. Wendler A, Keller D, Albrecht C, Peluso JJ and Wehling M: Involvement of let-7/miR-98 microRNAs in the regulation of progesterone receptor membrane component 1 expression in ovarian cancer cells. Oncol Rep 25: 273-279, 2011.
30. Feng D, Peng C, Li C, et al: Identification and characterization of cancer stem-like cells from primary carcinoma of the cervix uteri. Oncol Rep 22: 1129-1134, 2009.
31. Chen LH, Tsai KL, Chen YW, et al: MicroRNA as a novel modulator in head and neck squamous carcinoma. J Oncol 2010: 135632, 2010.
32. Li J, Huang H, Sun L, et al: miR-21 indicates poor prognosis in tongue squamous cell carcinomas as an apoptosis inhibitor. Clin Cancer Res 15: 3998-4008, 2009.
33. Wong TS, Liu XB, Wong BY, Ng RW, Yuen AP and Wei WI: Mature miR-184 as potential oncogenic microRNA of squamous cell carcinoma of tongue. Clin Cancer Res 14: 2588-2592, 2008.
34. Wong TS, Liu XB, Chung-Wai Ho A, Po-Wing Yuen A, Wai-Man Ng R and Ignace Wei W: Identification of pyruvate kinase type M2 as potential oncoprotein in squamous cell carcinoma of tongue through microRNA profiling. Int J Cancer 123: 251-257, 2008.
35. Wald AI, Hoskins EE, Wells SI, Ferris RL and Khan SA: Alteration of microRNA profiles in squamous cell carcinoma of the head and neck cell lines by human papillomavirus. Head Neck 33: 504-512, 2011.
36. Tran N, O'Brien CJ, Clark J and Rose B: Potential role of micro-RNAs in head and neck tumorigenesis. Head Neck 32: 1099-1111, 2010.
37. Kumar MS, Lu J, Mercer KL, Golub TR and Jacks T: Impaired microRNA processing enhances cellular transformation and tumorigenesis. Nat Genet 39: 673-677, 2007. (Pubitemid 46676103)
38. Mayr C, Hemann MT and Bartel DP: Disrupting the pairing between let-7 and Hmga2 enhances oncogenic transformation. Science 315: 1576-1579, 2007. (Pubitemid 46449474)
39. Lee YS and Dutta A: The tumor suppressor microRNA let-7 represses the HMGA2 oncogene. Genes Dev 21: 1025-1030, 2007.
40. Christensen BC, Moyer BJ, Avissar M, et al: A let-7 microRNA-binding site polymorphism in the KRAS 3' UTR is associated with reduced survival in oral cancers. Carcinogenesis 30: 1003-1007, 2009.
41. Jakymiw A, Patel RS, Deming N, et al: Overexpression of dicer as a result of reduced let-7 MicroRNA levels contributes to increased cell proliferation of oral cancer cells. Genes Chromosomes Cancer 49: 549-559, 2010.
42. Thiery JP: Epithelial-mesenchymal transitions in tumour progression. Nat Rev Cancer 2: 442-454, 2002.
43. Wang SP, Wang WL, Chang YL, et al: p53 controls cancer cell invasion by inducing the MDM2-mediated degradation of Slug. Nat Cell Biol 11: 694-704, 2009.
44. Mani SA, Guo W, Liao MJ, et al: The epithelial-mesenchymal transition generates cells with properties of stem cells. Cell 133: 704-715, 2008. (Pubitemid 351636299)
45. Ben-Porath I, Thomson MW, Carey VJ, et al: An embryonic stem cell-like gene expression signature in poorly differentiated aggressivehuman tumors. Nat Genet 40: 499-507, 2008. (Pubitemid 351601215)
46. Yang MH, Hsu DS, Wang HW, et al: Bmi1 is essential in Twist1-induced epithelial-mesenchymal transition. Nat Cell Biol 12: 982-992, 2010.
47. Molofsky AV, Pardal R, Iwashita T, Park IK, Clarke MF and Morrison SJ: Bmi-1 dependence distinguishes neural stem cell self-renewal from progenitor proliferation. Nature 425: 962-967, 2003. (Pubitemid 37376927)
48. Zhou M, Liu Z, Zhao Y, et al: MicroRNA-125b confers the resistanceof breast cancer cells to paclitaxel through suppression of pro-apoptotic Bcl-2 antagonist killer 1 (Bak1) expression. J Biol Chem 285: 21496-21507, 2010.
49. Giovannetti E, Funel N, Peters GJ, et al: MicroRNA-21 in pancreaticcancer: correlation with clinical outcome and pharmacologic aspects underlying its role in the modulation of gemcitabine activity. Cancer Res 70: 4528-4538, 2010.
50. Valeri N, Gasparini P, Braconi C, et al: MicroRNA-21 induces resistance to 5-fluorouracil by down-regulating human DNA MutS homolog 2 (hMSH2). Proc Natl Acad Sci USA 107: 21098-21103, 2010.
51. Huang Y, Chuang A, Hao H, et al: Phospho-ÄNp63á is a key regulator of the cisplatin-induced microRNAome in cancer cells. Cell Death Differ: Jan 28, 2011 (Epub ahead of print).
52. Boni V, Bitarte N, Cristobal I, et al: miR-192/miR-215 influence 5-fluorouracil resistance through cell cycle-mediated mechanismscomplementary to its post-transcriptional thymidilate synthase regulation. Mol Cancer Ther 9: 2265-2275, 2010.
53. Hatakeyama H, Cheng H, Wirth P, et al: Regulation of heparin-binding EGF-like growth factor by miR-212 and acquired cetuximab-resistance in head and neck squamous cell carcinoma. PLoS One 5: e12702, 2010.
54. Rao X, Di Leva G, Li M, et al: MicroRNA-221/222 confers breast cancer fulvestrant resistance by regulating multiple signaling pathways. Oncogene 30: 1082-1097, 2011.
55. Hong L, Han Y, Zhang H, et al: The prognostic and chemotherapeuticvalue of miR-296 in esophageal squamous cell carcinoma. Ann Surg 251: 1056-1063, 2010.