메뉴 건너뛰기




Volumn 6, Issue 3, 2006, Pages 231-241

STAT3 as a therapeutic target in head and neck cancer

Author keywords

Head and neck cancer; STAT3 inhibitors; STAT3 targeted therapy

Indexed keywords

APTAMER; BEXAROTENE; CUCURBITACIN GLYCOSIDE; CYTOKINE RECEPTOR; EPIDERMAL GROWTH FACTOR RECEPTOR; JSI 124; OLIGONUCLEOTIDE; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR ALPHA AGONIST; PROTEIN TYROSINE KINASE; RETINOID X RECEPTOR ALPHA; STAT3 PROTEIN; SULINDAC; TRANSFORMING GROWTH FACTOR ALPHA;

EID: 33644773438     PISSN: 14712598     EISSN: None     Source Type: Journal    
DOI: 10.1517/14712598.6.3.231     Document Type: Review
Times cited : (216)

References (125)
  • 1
    • 0028931604 scopus 로고
    • Choice of STATs and other substrates specified by modular tyrosine-based motifs in cytokine receptors
    • STAHL N, FARRUGGELLA TJ, BOULTON TG, ZHONG Z, DARNELL JE, YANCOPOULOS GD: Choice of STATs and other substrates specified by modular tyrosine-based motifs in cytokine receptors. Science (1995) 267:1349-1353.
    • (1995) Science , vol.267 , pp. 1349-1353
    • Stahl, N.1    Farruggella, T.J.2    Boulton, T.G.3    Zhong, Z.4    Darnell, J.E.5    Yancopoulos, G.D.6
  • 2
    • 0028234529 scopus 로고
    • Jak-STAT pathway and transcriptional activation in response to IFNs and other extracellular signaling proteins
    • DARNELL J, KERR IM, STARK GR: Jak-STAT pathway and transcriptional activation in response to IFNs and other extracellular signaling proteins. Science (1994) 264:1415-1421.
    • (1994) Science , vol.264 , pp. 1415-1421
    • Darnell, J.1    Kerr, I.M.2    Stark, G.R.3
  • 3
    • 0027371337 scopus 로고
    • Ras-independent growth factor signaling by transcription factor tyrosine phosphorylation
    • SILVENNOINEN O, SCHINDLER C, SCHLESSINGER J, LEVY DE: Ras-independent growth factor signaling by transcription factor tyrosine phosphorylation. Science (1993) 261:1736-1739.
    • (1993) Science , vol.261 , pp. 1736-1739
    • Silvennoinen, O.1    Schindler, C.2    Schlessinger, J.3    Levy, D.E.4
  • 4
    • 0033135346 scopus 로고    scopus 로고
    • Advances in cytokine signaling: The role of Jaks and STATs
    • CHEN E, GADINA M, CHEN M, O'SHEA JJ: Advances in cytokine signaling: the role of Jaks and STATs. Transplant. Proc. (1999) 31:1482-1487.
    • (1999) Transplant. Proc. , vol.31 , pp. 1482-1487
    • Chen, E.1    Gadina, M.2    Chen, M.3    O'Shea, J.J.4
  • 6
    • 0028921573 scopus 로고
    • Jaks and Stats in signaling by the cytokine receptor superfamily
    • IHLE JN, KERR IM: Jaks and Stats in signaling by the cytokine receptor superfamily. Trends Genet. (1995) 11(2):69-74.
    • (1995) Trends Genet. , vol.11 , Issue.2 , pp. 69-74
    • Ihle, J.N.1    Kerr, I.M.2
  • 7
    • 0026770248 scopus 로고
    • Interferon-dependent tyrosine phosphorylation of a latent cytoplasmic transcription factor
    • SCHINDLER C, SHUAI K, PREZIOSO VR, DARNELL JE: Interferon-dependent tyrosine phosphorylation of a latent cytoplasmic transcription factor. Science (1992) 257:809-813.
    • (1992) Science , vol.257 , pp. 809-813
    • Schindler, C.1    Shuai, K.2    Prezioso, V.R.3    Darnell, J.E.4
  • 8
    • 0028175454 scopus 로고
    • Ligand-induced interferon gamma receptor tyrosine phosphorylation couples the receptor to its signal transduction system (p91)
    • GREENLUND AC, FARRAR MA, VIVIAN BL, SCHREIBER RD: Ligand-induced interferon gamma receptor tyrosine phosphorylation couples the receptor to its signal transduction system (p91). EMBO J. (1994) 13(7):1591-1600.
    • (1994) EMBO J. , vol.13 , Issue.7 , pp. 1591-1600
    • Greenlund, A.C.1    Farrar, M.A.2    Vivian, B.L.3    Schreiber, R.D.4
  • 9
    • 0029133520 scopus 로고
    • Phosphorylation and activation of the DNA binding activity of purified Stat1 by the Janus protein-tyrosine kinases and the epidermal growth factor receptor
    • QUELLE FW, THIERFELDER W, WITTHUHN BA, TANG B, COHEN S, IHLE JN: Phosphorylation and activation of the DNA binding activity of purified Stat1 by the Janus protein-tyrosine kinases and the epidermal growth factor receptor. J. Biol. Chem. (1995) 35:20775-20780.
    • (1995) J. Biol. Chem. , vol.35 , pp. 20775-20780
    • Quelle, F.W.1    Thierfelder, W.2    Witthuhn, B.A.3    Tang, B.4    Cohen, S.5    Ihle, J.N.6
  • 10
    • 0029966664 scopus 로고    scopus 로고
    • Platelet-derived growth factor induces phosphorylation of multiple JAK family kinases and STAT proteins
    • VIGNAIS M, SADOWSKI HB, WATLING D, ROGERS NC, GILMAN M: Platelet-derived growth factor induces phosphorylation of multiple JAK family kinases and STAT proteins. Mol. Cell. Biol. (1996) 16(4):1759-1769.
    • (1996) Mol. Cell. Biol. , vol.16 , Issue.4 , pp. 1759-1769
    • Vignais, M.1    Sadowski, H.B.2    Watling, D.3    Rogers, N.C.4    Gilman, M.5
  • 11
    • 0028085525 scopus 로고
    • Epidermal growth factor and lipopolysaccharide activate Stat3 transcription factor in mouse liver
    • RUFF-JAMISON S, ZHONG Z, WEN Z, CHEN K, DARNELL JE, COHEN S: Epidermal growth factor and lipopolysaccharide activate Stat3 transcription factor in mouse liver. J. Biol. Chem. (1994) 269(35):21933-21935.
    • (1994) J. Biol. Chem. , vol.269 , Issue.35 , pp. 21933-21935
    • Ruff-Jamison, S.1    Zhong, Z.2    Wen, Z.3    Chen, K.4    Darnell, J.E.5    Cohen, S.6
  • 12
    • 0030840464 scopus 로고    scopus 로고
    • STATs and gene regulation
    • DARNELL JE: STATs and gene regulation. Science (1997) 277:1630-1635.
    • (1997) Science , vol.277 , pp. 1630-1635
    • Darnell, J.E.1
  • 13
    • 0043175471 scopus 로고    scopus 로고
    • Identification and characterization of signal transducer and activator of transcription 3 recruitment sites within the epidermal growth factor receptor
    • SHAO H, CHENG HY, COOK RG, TWEARDY DJ: Identification and characterization of signal transducer and activator of transcription 3 recruitment sites within the epidermal growth factor receptor. Cancer Res. (2003) 63(14):3923-3930.
    • (2003) Cancer Res. , vol.63 , Issue.14 , pp. 3923-3930
    • Shao, H.1    Cheng, H.Y.2    Cook, R.G.3    Tweardy, D.J.4
  • 14
    • 0028817880 scopus 로고
    • Jak-STAT signaling induced by the v-abl oncogene
    • DANIAL NN, ALESSANDRA P, ROTHMAN PB: Jak-STAT signaling induced by the v-abl oncogene. Science (1995) 269:1875-1877.
    • (1995) Science , vol.269 , pp. 1875-1877
    • Danial, N.N.1    Alessandra, P.2    Rothman, P.B.3
  • 15
    • 0031953831 scopus 로고    scopus 로고
    • Stat3 activation by Src induces specific gene regulation and is required for cell transformation
    • TURKSON J, BOWMAN T, GARCIA R, CALDENHOVEN E, DE GROOT RP, JOVE R: Stat3 activation by Src induces specific gene regulation and is required for cell transformation. Mol. Cell. Biol. (1998) 18(5):2545-2552.
    • (1998) Mol. Cell. Biol. , vol.18 , Issue.5 , pp. 2545-2552
    • Turkson, J.1    Bowman, T.2    Garcia, R.3    Caldenhoven, E.4    De Groot, R.P.5    Jove, R.6
  • 16
    • 0027090310 scopus 로고
    • Activation of transcription by IFN-γ: Tyrosine phosphorylation of a 91-kD DNA binding protein
    • SHUAI K, SCHINDLER C, PREZIOSO VR, DARNELL JE: Activation of transcription by IFN-γ: tyrosine phosphorylation of a 91-kD DNA binding protein. Science (1992) 258(5089):1808-1812.
    • (1992) Science , vol.258 , Issue.5089 , pp. 1808-1812
    • Shuai, K.1    Schindler, C.2    Prezioso, V.R.3    Darnell, J.E.4
  • 17
    • 20444400857 scopus 로고    scopus 로고
    • STAT3 nuclear import is independent of tyrosine phosphorylation and mediated by importin-α3
    • LIU L, MCBRIDE KM, REICH NC: STAT3 nuclear import is independent of tyrosine phosphorylation and mediated by importin-α3. Proc. Natl. Acad. Sci. USA (2005) 102(23):8150-8155.
    • (2005) Proc. Natl. Acad. Sci. USA , vol.102 , Issue.23 , pp. 8150-8155
    • Liu, L.1    Mcbride, K.M.2    Reich, N.C.3
  • 19
    • 0035831040 scopus 로고    scopus 로고
    • Arginine methylation of STAT1 modulates IFNα/β-induced transcription
    • MOWEN K, TANG J, ZHU W et al.: Arginine methylation of STAT1 modulates IFNα/β-induced transcription. Cell (2001) 104:731-741.
    • (2001) Cell , vol.104 , pp. 731-741
    • Mowen, K.1    Tang, J.2    Zhu, W.3
  • 20
    • 12244251445 scopus 로고    scopus 로고
    • Stat3 dimerization regulated by reversible acetylation of a single lysine residue
    • YUAN Z, GUAN Y, CHATTERJEE D, CHIN YE: Stat3 dimerization regulated by reversible acetylation of a single lysine residue. Science (2005) 307:269-273.
    • (2005) Science , vol.307 , pp. 269-273
    • Yuan, Z.1    Guan, Y.2    Chatterjee, D.3    Chin, Y.E.4
  • 21
    • 0028349735 scopus 로고
    • Stat3: A STAT family member activated by tyrosine phosphorylation in response to epidermal growth factor and interleukin-6
    • ZHONG Z, WEN Z, DARNELL JE: Stat3: a STAT family member activated by tyrosine phosphorylation in response to epidermal growth factor and interleukin-6. Science (1994) 264:95-98.
    • (1994) Science , vol.264 , pp. 95-98
    • Zhong, Z.1    Wen, Z.2    Darnell, J.E.3
  • 22
    • 0026019924 scopus 로고
    • Cytoplasmic activation of GAF, an IFN-γ-regulated DNA-binding factor
    • DECKER T, LEW DJ, MIRKOVITCH J, DARNELL JE: Cytoplasmic activation of GAF, an IFN-γ-regulated DNA-binding factor. EMBO J. (1991) 10(4):927-932.
    • (1991) EMBO J. , vol.10 , Issue.4 , pp. 927-932
    • Decker, T.1    Lew, D.J.2    Mirkovitch, J.3    Darnell, J.E.4
  • 23
    • 0037204953 scopus 로고    scopus 로고
    • A road map for those who don't know JAK-STAT
    • AARONSON DS, HORVATH CM: A road map for those who don't know JAK-STAT Science (2002) 296:1653-1655.
    • (2002) Science , vol.296 , pp. 1653-1655
    • Aaronson, D.S.1    Horvath, C.M.2
  • 24
    • 0029624350 scopus 로고
    • Identification of the interleukin-6/oncostatin M response element in the rat tissue inhibitor of metalloproteinase-1 (TIMP-1) promoter
    • BUGNO M, GRAEVE L, GATSIOS P et al.: Identification of the interleukin-6/oncostatin M response element in the rat tissue inhibitor of metalloproteinase-1 (TIMP-1) promoter. Nucl. Acid Res. (1995) 23(24):5041-5047.
    • (1995) Nucl. Acid Res. , vol.23 , Issue.24 , pp. 5041-5047
    • Bugno, M.1    Graeve, L.2    Gatsios, P.3
  • 25
    • 0029075875 scopus 로고
    • Cooperative transcriptional activity of Jun and Stat3β, a short form of Stat3
    • SCHAEFER TS, SANDERS LK, NATHANS D: Cooperative transcriptional activity of Jun and Stat3β, a short form of Stat3. Proc. Natl. Acad. Sci. USA (1995) 92:9097-9101.
    • (1995) Proc. Natl. Acad. Sci. USA , vol.92 , pp. 9097-9101
    • Schaefer, T.S.1    Sanders, L.K.2    Nathans, D.3
  • 26
    • 0242285719 scopus 로고    scopus 로고
    • STAT proteins: From normal control of cellular events to tumorigenesis
    • CALO V, MIGLIAVACCA M, BAZAN V et al.: STAT proteins: from normal control of cellular events to tumorigenesis. J. Cell. Physiol. (2003) 197:157-168.
    • (2003) J. Cell. Physiol. , vol.197 , pp. 157-168
    • Calo, V.1    Migliavacca, M.2    Bazan, V.3
  • 28
    • 0033529704 scopus 로고    scopus 로고
    • Stat3 as an oncogene
    • BROMBERG JF, WRZESZCZYNSKA MH, DEVGAN G et al.: Stat3 as an oncogene. Cell. (1999) 98:295-303. An original work revealing the oncogenic activity of STAT3.
    • (1999) Cell. , vol.98 , pp. 295-303
    • Bromberg, J.F.1    Wrzeszczynska, M.H.2    Devgan, G.3
  • 30
    • 0013689209 scopus 로고    scopus 로고
    • Requirement of Stat3 but not Stat1 activation for epidermal growth factor receptor-mediated cell growth in vitro
    • GRANDIS JR, DRENNING SD, CHAKRABORTY A et al.: Requirement of Stat3 but not Stat1 activation for epidermal growth factor receptor-mediated cell growth in vitro. J. Clin. Invest. (1998) 102(7):1385-1392.
    • (1998) J. Clin. Invest. , vol.102 , Issue.7 , pp. 1385-1392
    • Grandis, J.R.1    Drenning, S.D.2    Chakraborty, A.3
  • 31
    • 0032984589 scopus 로고    scopus 로고
    • Constitutive activation of Stat3 signaling confers resistance to apoptosis in human U266 myeloma cells
    • CATLETT-FALCONE R, LANDOWSKI TH, OSHIRO MM et al.: Constitutive activation of Stat3 signaling confers resistance to apoptosis in human U266 myeloma cells. Immunity (1999) 10:105-115.
    • (1999) Immunity , vol.10 , pp. 105-115
    • Catlett-Falcone, R.1    Landowski, T.H.2    Oshiro, M.M.3
  • 32
    • 0032718891 scopus 로고    scopus 로고
    • Gene therapy with dominant-negative Stat3 supresses growth of the murine melanoma B16 tumor in vivo
    • NIU G, HELLER R, CATLETT-FALCONE R et al.: Gene therapy with dominant-negative Stat3 supresses growth of the murine melanoma B16 tumor in vivo. Cancer Res. (1999) 59:5059-5063.
    • (1999) Cancer Res. , vol.59 , pp. 5059-5063
    • Niu, G.1    Heller, R.2    Catlett-Falcone, R.3
  • 33
    • 0035799531 scopus 로고    scopus 로고
    • Constitutive activation of Stat3 by the Src and Jak tyrosine kinases participates in growth regulation of human breast carcinoma cells
    • GARCIA R, BOWMAN T, NIU G et al.: Constitutive activation of Stat3 by the Src and Jak tyrosine kinases participates in growth regulation of human breast carcinoma cells. Oncogene (2001) 20:2499-2513.
    • (2001) Oncogene , vol.20 , pp. 2499-2513
    • Garcia, R.1    Bowman, T.2    Niu, G.3
  • 34
    • 18644380911 scopus 로고    scopus 로고
    • Roles of activated Src and Stat3 signaling in melanoma tumor cell growth
    • NIU G, BOWMAN T, HUANG M et al.: Roles of activated Src and Stat3 signaling in melanoma tumor cell growth. Oncogene (2002) 21:7001-7010.
    • (2002) Oncogene , vol.21 , pp. 7001-7010
    • Niu, G.1    Bowman, T.2    Huang, M.3
  • 35
    • 0036433076 scopus 로고    scopus 로고
    • IL-6 rescues the hyporesponsiveness of c-Rel deficient B cells independent of Bcl-xL, Mcl-1, and Bcl-2
    • TUMANG J, HSIA CY, TIAN W, BROMBERG JF, LIOU H: IL-6 rescues the hyporesponsiveness of c-Rel deficient B cells independent of Bcl-xL, Mcl-1, and Bcl-2. Cell. Immunol. (2002) 217:47-57.
    • (2002) Cell. Immunol. , vol.217 , pp. 47-57
    • Tumang, J.1    Hsia, C.Y.2    Tian, W.3    Bromberg, J.F.4    Liou, H.5
  • 36
    • 19444385692 scopus 로고    scopus 로고
    • Stat3 regulates genes common to both wound healing and cancer
    • DAUER DJ, FERRARO B, SONG L et al.: Stat3 regulates genes common to both wound healing and cancer. Oncogene (2005) 21(21):3397-3408. A good resource for STAT3 target genes.
    • (2005) Oncogene , vol.21 , Issue.21 , pp. 3397-3408
    • Dauer, D.J.1    Ferraro, B.2    Song, L.3
  • 37
    • 13444309088 scopus 로고    scopus 로고
    • Novel roles of unphosphorylated STAT3 in oncogenesis and transcriptional regulation
    • YANG J, CHATTERJEE-KISHORE M, STAUGAITIS SM et al.: Novel roles of unphosphorylated STAT3 in oncogenesis and transcriptional regulation. Cancer Res. (2005) 65(3):939-947. An interesting study on the role of unphosphorylated STAT3.
    • (2005) Cancer Res. , vol.65 , Issue.3 , pp. 939-947
    • Yang, J.1    Chatterjee-Kishore, M.2    Staugaitis, S.M.3
  • 38
    • 1842791537 scopus 로고    scopus 로고
    • Pharmacokinetic and pharmacodynamic properties of EGFR inhibitors under clinical investigation
    • THOMAS SM, GRANDIS JR: Pharmacokinetic and pharmacodynamic properties of EGFR inhibitors under clinical investigation. Cancer Treat. Rev. (2004) 30:255-268.
    • (2004) Cancer Treat. Rev. , vol.30 , pp. 255-268
    • Thomas, S.M.1    Grandis, J.R.2
  • 39
    • 0035910753 scopus 로고    scopus 로고
    • CIS3/SOCS3/SSI3 plays a negative regulatory role in STAT3 activation and intestinal inflammation
    • SUZUKI A, HANADA T, MITSUYAMA K et al.: CIS3/SOCS3/SSI3 plays a negative regulatory role in STAT3 activation and intestinal inflammation. J. Exp. Med. (2001) 193(4):471-481
    • (2001) J. Exp. Med. , vol.193 , Issue.4 , pp. 471-481
    • Suzuki, A.1    Hanada, T.2    Mitsuyama, K.3
  • 40
    • 0030725378 scopus 로고    scopus 로고
    • Specific inhibition of Stat3 signal transduction by PIAS3
    • CHUNG CD, LIAO J, LIU B et al.: Specific inhibition of Stat3 signal transduction by PIAS3. Science (1997) 278(5344):1803-1805.
    • (1997) Science , vol.278 , Issue.5344 , pp. 1803-1805
    • Chung, C.D.1    Liao, J.2    Liu, B.3
  • 41
    • 0037451235 scopus 로고    scopus 로고
    • GRIM-19, a death-regulatory gene product, suppresses Stat3 activity via functional interaction
    • LUFEI C, MA J, HUANG G et al.: GRIM-19, a death-regulatory gene product, suppresses Stat3 activity via functional interaction. EMBO J. (2003) 22(6):1325-1335.
    • (2003) EMBO J. , vol.22 , Issue.6 , pp. 1325-1335
    • Lufei, C.1    Ma, J.2    Huang, G.3
  • 42
    • 0037215106 scopus 로고    scopus 로고
    • Targeting epidermal growth factor receptor in head and neck cancer
    • FORD AC, GRANDIS JR: Targeting epidermal growth factor receptor in head and neck cancer. Head Neck (2003) 25:67-73.
    • (2003) Head Neck , vol.25 , pp. 67-73
    • Ford, A.C.1    Grandis, J.R.2
  • 43
    • 28244496095 scopus 로고    scopus 로고
    • A JAK2 mutation in myeloproliferative disorders: Pathogenesis and therapeutic and scientific prospects
    • JAMES C, UGO V, CASADEVALL N, CONSTANTINESCU SN, VAINCHENKER W: A JAK2 mutation in myeloproliferative disorders: pathogenesis and therapeutic and scientific prospects. Trends Mol. Med. (2005) 11(12):546-554.
    • (2005) Trends Mol. Med. , vol.11 , Issue.12 , pp. 546-554
    • James, C.1    Ugo, V.2    Casadevall, N.3    Constantinescu, S.N.4    Vainchenker, W.5
  • 44
    • 17844383458 scopus 로고    scopus 로고
    • A unique clonal JAK2 mutation leading to constitutive signalling causes polycythaemia vera
    • JAMES C, UGO V, LE COUEDIC J et al.: A unique clonal JAK2 mutation leading to constitutive signalling causes polycythaemia vera. Nature (2005) 434:1144-1148.
    • (2005) Nature , vol.434 , pp. 1144-1148
    • James, C.1    Ugo, V.2    Le Couedic, J.3
  • 45
    • 0035912763 scopus 로고    scopus 로고
    • Stat3-mediated Myc expression is required for Src transformation and PDGF-induced mitogenesis
    • BOWMAN T, BROOME MA, SINIBALDI D et al.: Stat3-mediated Myc expression is required for Src transformation and PDGF-induced mitogenesis. Proc. Natl. Acad. Sci. USA (2001) 98(13):7319-7324.
    • (2001) Proc. Natl. Acad. Sci. USA , vol.98 , Issue.13 , pp. 7319-7324
    • Bowman, T.1    Broome, M.A.2    Sinibaldi, D.3
  • 46
    • 1042302005 scopus 로고    scopus 로고
    • The STATs of cancer - New molecular targets come of age
    • YU H, JOVE R: The STATs of cancer- new molecular targets come of age. Nature Rev. (2004) 4:97-105. A thorough review of STATs.
    • (2004) Nature Rev. , vol.4 , pp. 97-105
    • Yu, H.1    Jove, R.2
  • 47
    • 0032966863 scopus 로고    scopus 로고
    • Negative regulation of the JAK/STAT pathway
    • STARR R, HILTON DJ: Negative regulation of the JAK/STAT pathway. BioEssays (1999) 21:47-52.
    • (1999) BioEssays , vol.21 , pp. 47-52
    • Starr, R.1    Hilton, D.J.2
  • 48
    • 0035042611 scopus 로고    scopus 로고
    • SOCS-1, a negative regulator of the JAK/STAT pathway, is silenced by methylation in human hepatocellular carcinoma and shows growth-suppression activity
    • YOSHIKAWA H, MATSUBARA K, QIAN G et al.: SOCS-1, a negative regulator of the JAK/STAT pathway, is silenced by methylation in human hepatocellular carcinoma and shows growth-suppression activity. Nat. Genet. (2001) 28:29-35.
    • (2001) Nat. Genet. , vol.28 , pp. 29-35
    • Yoshikawa, H.1    Matsubara, K.2    Qian, G.3
  • 49
    • 0038784365 scopus 로고    scopus 로고
    • SOCS-1, a negative regulator of cytokine signaling, is frequently silenced by methylation in multiple myeloma
    • GALM O, YOSHIKAWA H, ESTELLER M, OSIEKA R, HERMAN J: SOCS-1, a negative regulator of cytokine signaling, is frequently silenced by methylation in multiple myeloma. Blood (2003) 101(7):2784-2788.
    • (2003) Blood , vol.101 , Issue.7 , pp. 2784-2788
    • Galm, O.1    Yoshikawa, H.2    Esteller, M.3    Osieka, R.4    Herman, J.5
  • 50
    • 18344415251 scopus 로고    scopus 로고
    • Hypermethylation-associated inactivation of the SOCS-1 gene, a JAK/STAT inhibitor, in human pancreatic cancers
    • KOMAZAKI T, NAGAI H, EMI M et al.: Hypermethylation-associated inactivation of the SOCS-1 gene, a JAK/STAT inhibitor, in human pancreatic cancers. Jpn. J. Clin. Oncol. (2004) 34(4):191-194.
    • (2004) Jpn. J. Clin. Oncol. , vol.34 , Issue.4 , pp. 191-194
    • Komazaki, T.1    Nagai, H.2    Emi, M.3
  • 51
    • 0037227602 scopus 로고    scopus 로고
    • Hypermethylation associated with inactivation of the SOCS-1 gene, a JAK/ STAT inhibitor, in human hepatoblastomas
    • NAGAI H, NAKA T, TERADA Y et al.: Hypermethylation associated with inactivation of the SOCS-1 gene, a JAK/ STAT inhibitor, in human hepatoblastomas. J. Hum. Genet. (2003) 48:65-69.
    • (2003) J. Hum. Genet. , vol.48 , pp. 65-69
    • Nagai, H.1    Naka, T.2    Terada, Y.3
  • 52
    • 0345492424 scopus 로고    scopus 로고
    • SOCS-3 is frequently silenced by hypermethylation and suppresses cell growth in human lung cancer
    • HE B, YOU L, UEMATSU K et al.: SOCS-3 is frequently silenced by hypermethylation and suppresses cell growth in human lung cancer. Proc. Natl. Acad. Sci. USA (2003) 100(24):14133-14138.
    • (2003) Proc. Natl. Acad. Sci. USA , vol.100 , Issue.24 , pp. 14133-14138
    • He, B.1    You, L.2    Uematsu, K.3
  • 53
    • 0036134884 scopus 로고    scopus 로고
    • Multilevel dysregulation of STAT3 activation in anaplastic lymphoma kinase-positive T/null-cell lymphoma
    • ZHANG Q, RAGHUNATH PN, XUE L et al.: Multilevel dysregulation of STAT3 activation in anaplastic lymphoma kinase-positive T/null-cell lymphoma. J. Immunol. (2002) 168:466-474.
    • (2002) J. Immunol. , vol.168 , pp. 466-474
    • Zhang, Q.1    Raghunath, P.N.2    Xue, L.3
  • 54
    • 0037112439 scopus 로고    scopus 로고
    • Gene silencing of the tyrosine phosphatase SHP1 gene by aberrant methylation in leukemias/lymphomas
    • OKA T, OUCHIDA M, KOYAMA M et al.: Gene silencing of the tyrosine phosphatase SHP1 gene by aberrant methylation in leukemias/lymphomas. Cancer Res. (2002) 62(22):6390-6394.
    • (2002) Cancer Res. , vol.62 , Issue.22 , pp. 6390-6394
    • Oka, T.1    Ouchida, M.2    Koyama, M.3
  • 55
    • 2942584857 scopus 로고    scopus 로고
    • SOCS1 and SHP1 hypermethylation in multiple myeloma: Implications for epigenetic activation of the Jak/STAT pathway
    • CHIM C, FUNG T, CHEUNG W, LIANG R, KWONG Y: SOCS1 and SHP1 hypermethylation in multiple myeloma: implications for epigenetic activation of the Jak/STAT pathway. Blood (2004) 103(12):4630-4635.
    • (2004) Blood , vol.103 , Issue.12 , pp. 4630-4635
    • Chim, C.1    Fung, T.2    Cheung, W.3    Liang, R.4    Kwong, Y.5
  • 56
    • 0030839112 scopus 로고    scopus 로고
    • A new protein containing an SH2 domain that inhibits JAK kinases
    • ENDO TA, MASUHARA M, YOKOUCHI M et al.: A new protein containing an SH2 domain that inhibits JAK kinases. Nature (1997) 387:921-924.
    • (1997) Nature , vol.387 , pp. 921-924
    • Endo, T.A.1    Masuhara, M.2    Yokouchi, M.3
  • 57
    • 0033213901 scopus 로고    scopus 로고
    • Negative regulation of cytokine signaling: STAT-induced STAT inhibitor
    • NAKA T, FUJIMOTO M, KISHIMOTO T: Negative regulation of cytokine signaling: STAT-induced STAT inhibitor. Trends Biochem. Sci. (1999) 24:394-398.
    • (1999) Trends Biochem. Sci. , vol.24 , pp. 394-398
    • Naka, T.1    Fujimoto, M.2    Kishimoto, T.3
  • 58
    • 0030755934 scopus 로고    scopus 로고
    • Structure and function of a new STAT-induced STAT inhibitor
    • NAKA T, NARAZAKI M, HIRATA M et al.: Structure and function of a new STAT-induced STAT inhibitor. Nature (1997) 387:924-929.
    • (1997) Nature , vol.387 , pp. 924-929
    • Naka, T.1    Narazaki, M.2    Hirata, M.3
  • 59
    • 16444371427 scopus 로고    scopus 로고
    • A SOCS-1 peptide mimetic inhibits both constitutive and IL-6 induced activation of STAT3 in prostate cancer cells
    • FLOWERS L, SUBRAMANIAM PS, JOHNSON HM: A SOCS-1 peptide mimetic inhibits both constitutive and IL-6 induced activation of STAT3 in prostate cancer cells. Oncogene (2005) 24:2114-2120.
    • (2005) Oncogene , vol.24 , pp. 2114-2120
    • Flowers, L.1    Subramaniam, P.S.2    Johnson, H.M.3
  • 60
    • 0036986179 scopus 로고    scopus 로고
    • Suppressors of cytokine signalling: SOCS
    • LARSEN L, ROPKE C: Suppressors of cytokine signalling: SOCS. APMIS (2002) 110(12):833-844.
    • (2002) APMIS , vol.110 , Issue.12 , pp. 833-844
    • Larsen, L.1    Ropke, C.2
  • 61
    • 0034657917 scopus 로고    scopus 로고
    • Modulation of STAT signaling by STAT-interacting proteins
    • SHUAI K: Modulation of STAT signaling by STAT-interacting proteins. Oncogene (2000) 19:2638-2644.
    • (2000) Oncogene , vol.19 , pp. 2638-2644
    • Shuai, K.1
  • 62
    • 0028972719 scopus 로고
    • Differential regulation of the alpha/beta interferon-stimulated Jak/Stat pathway by the SH2 domain-containing tyrosine phosphatase SHPTP1
    • DAVID M, CHEN HE, GOELZ S, LARNER AC, NEEL BG: Differential regulation of the alpha/beta interferon-stimulated Jak/Stat pathway by the SH2 domain-containing tyrosine phosphatase SHPTP1. Mol. Cell. Biol. (1995) 15(12):7050-7058.
    • (1995) Mol. Cell. Biol. , vol.15 , Issue.12 , pp. 7050-7058
    • David, M.1    Chen, H.E.2    Goelz, S.3    Larner, A.C.4    Neel, B.G.5
  • 63
    • 0029973560 scopus 로고    scopus 로고
    • Direct association with and dephosphorylation of Jak2 kinase by the SH2-domain-containing protein tyrosine phosphatase SHP-1
    • JIAO H, BERRADA K, YANG W, TABRIZI M, PLATANIAS LC, YI T: Direct association with and dephosphorylation of Jak2 kinase by the SH2-domain-containing protein tyrosine phosphatase SHP-1. Mol. Cell. Biol. (1996) 16(12):6985-6992.
    • (1996) Mol. Cell. Biol. , vol.16 , Issue.12 , pp. 6985-6992
    • Jiao, H.1    Berrada, K.2    Yang, W.3    Tabrizi, M.4    Platanias, L.C.5    Yi, T.6
  • 64
    • 0036731485 scopus 로고    scopus 로고
    • STATs: Transcriptional control and biological impact
    • LEVY DE, DARNELL JE JR: STATs: transcriptional control and biological impact. Nature Rev. (2002) 3:651-662.
    • (2002) Nature Rev. , vol.3 , pp. 651-662
    • Levy, D.E.1    Darnell Jr., J.E.2
  • 65
    • 0034730176 scopus 로고    scopus 로고
    • A Stat3-interacting protein (StIP1) regulates cytokine signal transduction
    • COLLUM RG, BRUTSAERT S, LEE G, SCHINDLER C: A Stat3-interacting protein (StIP1) regulates cytokine signal transduction. Proc. Natl. Acad. Sci. USA (2000) 97(18):10120-10125.
    • (2000) Proc. Natl. Acad. Sci. USA , vol.97 , Issue.18 , pp. 10120-10125
    • Collum, R.G.1    Brutsaert, S.2    Lee, G.3    Schindler, C.4
  • 66
    • 0042925385 scopus 로고    scopus 로고
    • The cell death regulator GRIM-19 is an inhibitor of signal transducer and activator of transcription 3
    • ZHANG J, YANG J, ROY SK et al.: The cell death regulator GRIM-19 is an inhibitor of signal transducer and activator of transcription 3. Proc. Natl. Acad. Sci. USA (2003) 100(16):9342-9347.
    • (2003) Proc. Natl. Acad. Sci. USA , vol.100 , Issue.16 , pp. 9342-9347
    • Zhang, J.1    Yang, J.2    Roy, S.K.3
  • 67
    • 12944272024 scopus 로고    scopus 로고
    • Constitutive activation of Stat3 signaling abrogates apoptosis in squamous cell carcinogenesis in vivo
    • GRANDIS JR, DRENNING SD, ZENG Q et al.: Constitutive activation of Stat3 signaling abrogates apoptosis in squamous cell carcinogenesis in vivo. Proc. Natl. Acad. Sci. USA (2000) 97(8):4227-4232.
    • (2000) Proc. Natl. Acad. Sci. USA , vol.97 , Issue.8 , pp. 4227-4232
    • Grandis, J.R.1    Drenning, S.D.2    Zeng, Q.3
  • 68
    • 0036024855 scopus 로고    scopus 로고
    • STAT3 activation abrogates growth factor dependence and contributes to head and neck squamous cell carcinoma tumor growth in vivo
    • KIJIMA T, NIWA H, STEINMAN RA et al.: STAT3 activation abrogates growth factor dependence and contributes to head and neck squamous cell carcinoma tumor growth in vivo. Cell. Growth Diff. (2002) 13:355-362.
    • (2002) Cell. Growth Diff. , vol.13 , pp. 355-362
    • Kijima, T.1    Niwa, H.2    Steinman, R.A.3
  • 69
    • 0038581774 scopus 로고    scopus 로고
    • Epidermal growth factor receptor-independent constitutive activation of STAT3 in head and neck squamous cell carcinoma is mediated by the autocrine/paracrine stimulation of the interleukin 6/gp130 cytokine system
    • SRIURANPONG V, PARK JI, AMORNPHIMOLTHAM P, PATEL V, NELKIN BD, GUTKIND JS: Epidermal growth factor receptor-independent constitutive activation of STAT3 in head and neck squamous cell carcinoma is mediated by the autocrine/paracrine stimulation of the interleukin 6/gp130 cytokine system. Cancer Res. (2003) 63(11):2948-2956.
    • (2003) Cancer Res. , vol.63 , Issue.11 , pp. 2948-2956
    • Sriuranpong, V.1    Park, J.I.2    Amornphimoltham, P.3    Patel, V.4    Nelkin, B.D.5    Gutkind, J.S.6
  • 70
    • 0034021563 scopus 로고    scopus 로고
    • Epidermal growth factor receptor-mediated Stat3 signaling blocks apoptosis in head and neck cancer
    • GRANDIS JR, ZENG Q, DRENNING SD: Epidermal growth factor receptor-mediated Stat3 signaling blocks apoptosis in head and neck cancer. Laryngoscope (2000) 110:868-874.
    • (2000) Laryngoscope , vol.110 , pp. 868-874
    • Grandis, J.R.1    Zeng, Q.2    Drenning, S.D.3
  • 71
    • 0042357187 scopus 로고    scopus 로고
    • Src kinases mediate STAT growth pathways in squamous cell carcinoma of the head and neck
    • XI S, ZHANG Q, DYER KF et al.: Src kinases mediate STAT growth pathways in squamous cell carcinoma of the head and neck. J. Biol. Chem. (2003) 278:31574-31583.
    • (2003) J. Biol. Chem. , vol.278 , pp. 31574-31583
    • Xi, S.1    Zhang, Q.2    Dyer, K.F.3
  • 72
    • 0036569522 scopus 로고    scopus 로고
    • Activation of Stat-3 as one of the early events in tobacco chewing-mediated oral carcinogenesis
    • NAGPAL JK, MISHRA R, DAS BR: Activation of Stat-3 as one of the early events in tobacco chewing-mediated oral carcinogenesis. Cancer (2002) 94:2393-2400.
    • (2002) Cancer , vol.94 , pp. 2393-2400
    • Nagpal, J.K.1    Mishra, R.2    Das, B.R.3
  • 73
    • 0041878875 scopus 로고    scopus 로고
    • Differentiation-dependent expression of signal transducers and activators of transcription (STATs) might modify responses to growth factors in the cancers of the head and neck
    • ARANY I, CHEN S, MEGYESI JK et al.: Differentiation-dependent expression of signal transducers and activators of transcription (STATs) might modify responses to growth factors in the cancers of the head and neck. Cancer Lett. (2003) 199:83-89.
    • (2003) Cancer Lett. , vol.199 , pp. 83-89
    • Arany, I.1    Chen, S.2    Megyesi, J.K.3
  • 74
    • 0037096876 scopus 로고    scopus 로고
    • Constitutive activation of signal transducers and activators of transcription 3 correlates with Cyclin D1 overexpression and may provide a novel prognostic marker in head and neck squamous cell carcinoma
    • MASUDA M, SUZUI M, YASUMATU R et al.: Constitutive activation of signal transducers and activators of transcription 3 correlates with Cyclin D1 overexpression and may provide a novel prognostic marker in head and neck squamous cell carcinoma. Cancer Res. (2002) 62:3351-3355.
    • (2002) Cancer Res. , vol.62 , pp. 3351-3355
    • Masuda, M.1    Suzui, M.2    Yasumatu, R.3
  • 75
    • 0037444373 scopus 로고    scopus 로고
    • Discovery of JSI-124 (curcurbitacin I), a selective janus kinase/signal transducer and activator of transcription 3 signaling pathway inhibitor with potent antitumor activity against human and murine cancer cells in mice
    • BLASKOVICH MA, SUN J, CANTOR A, TURKSON J, JOVE R, SEBTI SM: Discovery of JSI-124 (curcurbitacin I), a selective janus kinase/signal transducer and activator of transcription 3 signaling pathway inhibitor with potent antitumor activity against human and murine cancer cells in mice. Cancer Res. (2003) 63:1270-1279.
    • (2003) Cancer Res. , vol.63 , pp. 1270-1279
    • Blaskovich, M.A.1    Sun, J.2    Cantor, A.3    Turkson, J.4    Jove, R.5    Sebti, S.M.6
  • 76
    • 0037133575 scopus 로고    scopus 로고
    • Small-molecule antagonists of myc/max dimerization inhibit myc-induced transformation of chicken embryo fibroblasts
    • BERG T, COHEN SB, DESHARNAIS J et al.: Small-molecule antagonists of myc/ max dimerization inhibit myc-induced transformation of chicken embryo fibroblasts. Proc. Natl. Acad. Sci. USA (2002) 99(6):3830-3835.
    • (2002) Proc. Natl. Acad. Sci. USA , vol.99 , Issue.6 , pp. 3830-3835
    • Berg, T.1    Cohen, S.B.2    Desharnais, J.3
  • 77
    • 3543055012 scopus 로고    scopus 로고
    • Novel peptidomimetic inhibitors of signal transducer and activator of transcription 3 dimerization and biological activity
    • TURKSON J, KIM JS, ZHANG S et al.: Novel peptidomimetic inhibitors of signal transducer and activator of transcription 3 dimerization and biological activity. Mol. Cancer Ther. (2004) 3(3):261-269.
    • (2004) Mol. Cancer Ther. , vol.3 , Issue.3 , pp. 261-269
    • Turkson, J.1    Kim, J.S.2    Zhang, S.3
  • 78
    • 0035977055 scopus 로고    scopus 로고
    • Phosphotyrosyl peptides block Stat3-mediated DNA binding activity, gene regulation, and cell transformation
    • TURKSON J, RYAN D, KIM JS et al.: Phosphotyrosyl peptides block Stat3-mediated DNA binding activity, gene regulation, and cell transformation. J. Biol. Chem. (2001) 276(48):45443-45455.
    • (2001) J. Biol. Chem. , vol.276 , Issue.48 , pp. 45443-45455
    • Turkson, J.1    Ryan, D.2    Kim, J.S.3
  • 80
    • 0347478160 scopus 로고    scopus 로고
    • Bifunctional recombinant proteins in cancer therapy: Cell penetrating peptide aptamers as inhibitors of growth factor signaling
    • BUERGER C, GRONER B: Bifunctional recombinant proteins in cancer therapy: cell penetrating peptide aptamers as inhibitors of growth factor signaling. J. Cancer Res. Clin. Oncol. (2003) 129:669-675.
    • (2003) J. Cancer Res. Clin. Oncol. , vol.129 , pp. 669-675
    • Buerger, C.1    Groner, B.2
  • 81
    • 0141733147 scopus 로고    scopus 로고
    • Sequence-specific peptide aptamers, interacting with the intracellular domain of the epidermal growth factor receptor, interfere with Stat3 activation and inhibit the growth of tumor cells
    • BUERGER C, NAGEL-WOLFRUM K, KUNZ C et al.: Sequence-specific peptide aptamers, interacting with the intracellular domain of the epidermal growth factor receptor, interfere with Stat3 activation and inhibit the growth of tumor cells. J. Biol. Chem. (2003) 278(39):37610-37621.
    • (2003) J. Biol. Chem. , vol.278 , Issue.39 , pp. 37610-37621
    • Buerger, C.1    Nagel-Wolfrum, K.2    Kunz, C.3
  • 82
    • 3543070089 scopus 로고    scopus 로고
    • The interaction of specific peptide aptamers with the DNA binding domain and the dimerization domain of the transcription factor Stat3 inhibits transactivation and induces apoptosis in tumor cells
    • NAGEL-WOLFRUM K, BUERGER C, WITTIG I, BUTZ K, HOPPE-SEYLER F, GRONER B: The interaction of specific peptide aptamers with the DNA binding domain and the dimerization domain of the transcription factor Stat3 inhibits transactivation and induces apoptosis in tumor cells. Mol. Cancer Res. (2004) 2:170-182.
    • (2004) Mol. Cancer Res. , vol.2 , pp. 170-182
    • Nagel-Wolfrum, K.1    Buerger, C.2    Wittig, I.3    Butz, K.4    Hoppe-Seyler, F.5    Groner, B.6
  • 83
    • 0033543548 scopus 로고    scopus 로고
    • Antiproliferative activity of G-rich oligonucleotides correlates with protein binding
    • BATES P, KAHLON JB, THOMAS SD, TRENT JO, MILLER DM: Antiproliferative activity of G-rich oligonucleotides correlates with protein binding. J. Biol. Chem. (1999) 10(274):26369-26377.
    • (1999) J. Biol. Chem. , vol.10 , Issue.274 , pp. 26369-26377
    • Bates, P.1    Kahlon, J.B.2    Thomas, S.D.3    Trent, J.O.4    Miller, D.M.5
  • 84
    • 0344984245 scopus 로고    scopus 로고
    • Targeting Stat3 with G-quartet oligodeoxynucleotides in human cancer cells
    • JING N, LI Y, XU X et al.: Targeting Stat3 with G-quartet oligodeoxynucleotides in human cancer cells. DNA Cell Biol. (2003) 22(11):685-696.
    • (2003) DNA Cell Biol. , vol.22 , Issue.11 , pp. 685-696
    • Jing, N.1    Li, Y.2    Xu, X.3
  • 85
    • 4644325545 scopus 로고    scopus 로고
    • G-quartet oligonucleotides: A new class of signal transducer and activator of transcription 3 inhibitors that suppresses growth of prostate and breast tumors through induction of apoptosis
    • JING N, LI Y, XIONG W, SHA W, JING L, TWEARDY DJ: G-quartet oligonucleotides: a new class of signal transducer and activator of transcription 3 inhibitors that suppresses growth of prostate and breast tumors through induction of apoptosis. Cancer Res. (2004) 64:6603-6609.
    • (2004) Cancer Res. , vol.64 , pp. 6603-6609
    • Jing, N.1    Li, Y.2    Xiong, W.3    Sha, W.4    Jing, L.5    Tweardy, D.J.6
  • 86
    • 20844444135 scopus 로고    scopus 로고
    • Targeting Stat3 in cancer therapy
    • JING N, TWEARDY DJ: Targeting Stat3 in cancer therapy. Anticancer Drugs (2005) 16(6):601-607.
    • (2005) Anticancer Drugs , vol.16 , Issue.6 , pp. 601-607
    • Jing, N.1    Tweardy, D.J.2
  • 87
    • 22944438723 scopus 로고    scopus 로고
    • Rational drug design of G-quartet DNA as anti-cancer agents
    • JING N, SHA W, LI Y, XIONG W, TWEARDY DJ: Rational drug design of G-quartet DNA as anti-cancer agents. Curr. Pharm. Des. (2005) 11(22):2841-2854.
    • (2005) Curr. Pharm. Des. , vol.11 , Issue.22 , pp. 2841-2854
    • Jing, N.1    Sha, W.2    Li, Y.3    Xiong, W.4    Tweardy, D.J.5
  • 88
    • 22944438395 scopus 로고    scopus 로고
    • Oligonucleotides as anticancer agents: From the benchside to clinic and beyond
    • COPPELLI F, GRANDIS JR: Oligonucleotides as anticancer agents: from the benchside to clinic and beyond. Curr. Pharm. Des. (2005) 11(22):2825-2840.
    • (2005) Curr. Pharm. Des. , vol.11 , Issue.22 , pp. 2825-2840
    • Coppelli, F.1    Grandis, J.R.2
  • 89
    • 15244350338 scopus 로고    scopus 로고
    • Inhibition of STAT3 expression by siRNA suppresses growth and induces apoptosis in laryngeal cancer cells
    • GAO LE XU DQ, WEN LJ, ZHANG XY, SHAO YT, ZHAO XJ: Inhibition of STAT3 expression by siRNA suppresses growth and induces apoptosis in laryngeal cancer cells. Acta Pharmacol. Sin. (2005) 26(3):377-383.
    • (2005) Acta Pharmacol. Sin. , vol.26 , Issue.3 , pp. 377-383
    • Gao, L.E.1    Xu, D.Q.2    Wen, L.J.3    Zhang, X.Y.4    Shao, Y.T.5    Zhao, X.J.6
  • 90
    • 3042748279 scopus 로고    scopus 로고
    • Knockdown of STAT3 expression by RNAi induces apoptosis in astrocytoma cells
    • KONNIKOVA L. KOTECKI M, KRUGER MM, COCHRAN BH: Knockdown of STAT3 expression by RNAi induces apoptosis in astrocytoma cells. BMC Cancer (2003) 3:23.
    • (2003) BMC Cancer , vol.3 , pp. 23
    • Konnikova, L.1    Kotecki, M.2    Kruger, M.M.3    Cochran, B.H.4
  • 91
    • 0034949959 scopus 로고    scopus 로고
    • Intravenous injection of oligodeoxynucleotides to the NF-kappaB binding site inhibits hepatic metastasis of M5076 reticulosarcoma in mice
    • KAWAMURA I, MORISHITA R, TSUJIMOTO S et al.: Intravenous injection of oligodeoxynucleotides to the NF-kappaB binding site inhibits hepatic metastasis of M5076 reticulosarcoma in mice. Gene Ther. (2001) 8(12):905-912.
    • (2001) Gene Ther. , vol.8 , Issue.12 , pp. 905-912
    • Kawamura, I.1    Morishita, R.2    Tsujimoto, S.3
  • 92
    • 0037386568 scopus 로고    scopus 로고
    • Targeted inhibition of Stat3 with a decoy oligonucleotide abrogates head and neck cancer cell growth
    • LEONG PL, ANDREWS GA, JOHNSON DE et al.: Targeted inhibition of Stat3 with a decoy oligonucleotide abrogates head and neck cancer cell growth. Proc. Natl. Acad. Sci. USA (2003) 100(7):4138-4143.
    • (2003) Proc. Natl. Acad. Sci. USA , vol.100 , Issue.7 , pp. 4138-4143
    • Leong, P.L.1    Andrews, G.A.2    Johnson, D.E.3
  • 93
    • 13944250650 scopus 로고    scopus 로고
    • In vivo antitumor efficacy of STAT3 blockade using a transcription factor decoy approach: Implications for cancer therapy
    • XI S, GOODING WE, GRANDIS JR: In vivo antitumor efficacy of STAT3 blockade using a transcription factor decoy approach: implications for cancer therapy. Oncogene (2005) 24:970-979.
    • (2005) Oncogene , vol.24 , pp. 970-979
    • Xi, S.1    Gooding, W.E.2    Grandis, J.R.3
  • 94
    • 4944239032 scopus 로고    scopus 로고
    • Disruption of Stat3 reveals a critical role in both the initiation and the promotion stages of epithelial carcinogenesis
    • CHAN KS, SANO S, KIGUCHI K et al.: Disruption of Stat3 reveals a critical role in both the initiation and the promotion stages of epithelial carcinogenesis. J. Clin. Invest. (2004) 114(5):720-728. An interesting study revealing the role of STAT3 in epithelial carcinogenesis in animal models.
    • (2004) J. Clin. Invest. , vol.114 , Issue.5 , pp. 720-728
    • Chan, K.S.1    Sano, S.2    Kiguchi, K.3
  • 95
    • 0001611720 scopus 로고    scopus 로고
    • Dual blockade of cyclic AMP response element-(CRE) and AP-1-directed transcription by CRE-transcription factor decoy oligonucleotide
    • PARK Y, NESTEROVA M, AGRAWAL S, CHO-CHUNG YS: Dual blockade of cyclic AMP response element-(CRE) and AP-1-directed transcription by CRE-transcription factor decoy oligonucleotide. J. Biol. Chem. (1999) 274:1573-1580.
    • (1999) J. Biol. Chem. , vol.274 , pp. 1573-1580
    • Park, Y.1    Nesterova, M.2    Agrawal, S.3    Cho-Chung, Y.S.4
  • 96
    • 7444238184 scopus 로고    scopus 로고
    • Novel single-stranded oligonucleotides that inhibit signal transducer and activator of transcription 3 induce apoptosis in vitro and in vivo in prostate cancer cell lines
    • BARTON B, MURPHY TF, SHU P, HUANG HF, MEYENHOFEN M, BARTON A: Novel single-stranded oligonucleotides that inhibit signal transducer and activator of transcription 3 induce apoptosis in vitro and in vivo in prostate cancer cell lines. Mol. Cancer Ther. (2004) 3(10):1183-1191.
    • (2004) Mol. Cancer Ther. , vol.3 , Issue.10 , pp. 1183-1191
    • Barton, B.1    Murphy, T.F.2    Shu, P.3    Huang, H.F.4    Meyenhofen, M.5    Barton, A.6
  • 97
    • 0141790042 scopus 로고    scopus 로고
    • Responsiveness to the retinoic acid receptor-selective retinoid LGD1550 correlates with abrogation of transforming growth factor α/epidermal growth factor receptor autocrine signaling in head snd neck squamous carcinoma cells
    • LANGO M, WENTZEL AL, SONG JI et al.: Responsiveness to the retinoic acid receptor-selective retinoid LGD1550 correlates with abrogation of transforming growth factor α/epidermal growth factor receptor autocrine signaling in head snd neck squamous carcinoma cells. Clin. Cancer Res. (2003) 9:4205-4213.
    • (2003) Clin. Cancer Res. , vol.9 , pp. 4205-4213
    • Lango, M.1    Wentzel, A.L.2    Song, J.I.3
  • 98
    • 0035422782 scopus 로고    scopus 로고
    • Abrogation of transforming growth factor-α/epidermal growth factor receptor autocrine signaling by an RXR-selective retinoid (LGD1069, Targretin) in head and neck cancer cell lines
    • SONG JI, LANGO MN, HWANG JD et al.: Abrogation of transforming growth factor-α/epidermal growth factor receptor autocrine signaling by an RXR-selective retinoid (LGD1069, Targretin) in head and neck cancer cell lines. J. Cancer Res. (2001) 61:5919-5925.
    • (2001) J. Cancer Res. , vol.61 , pp. 5919-5925
    • Song, J.I.1    Lango, M.N.2    Hwang, J.D.3
  • 99
    • 0036171232 scopus 로고    scopus 로고
    • The nonsteroidal anti-inflammatory drug Sulindac causes down-regulation of signal transducer and activator of transcription 3 in human oral squamous cell carcinoma cells
    • NIKITAKIS NG, HAMBURGER AW, SAUK JJ: The nonsteroidal anti-inflammatory drug Sulindac causes down-regulation of signal transducer and activator of transcription 3 in human oral squamous cell carcinoma cells. Cancer Res. (2002) 62:1004-1007.
    • (2002) Cancer Res. , vol.62 , pp. 1004-1007
    • Nikitakis, N.G.1    Hamburger, A.W.2    Sauk, J.J.3
  • 100
  • 101
    • 0034676267 scopus 로고    scopus 로고
    • Induction of p21WAF1/CIP1 and cyclin D1 expression by the Src oncoprotein in mouse fibroblasts: Role of activated STAT3 signaling
    • SINIBALDI D, WHARTON W, TURKSON J, BOWMAN T, PLEDGER WJ, JOVE R: Induction of p21WAF1/CIP1 and cyclin D1 expression by the Src oncoprotein in mouse fibroblasts: role of activated STAT3 signaling. Oncogene (2000) 19(48):5419-5427.
    • (2000) Oncogene , vol.19 , Issue.48 , pp. 5419-5427
    • Sinibaldi, D.1    Wharton, W.2    Turkson, J.3    Bowman, T.4    Pledger, W.J.5    Jove, R.6
  • 102
    • 0033106168 scopus 로고    scopus 로고
    • Transcriptional regulation of the cyclin D1 promoter by STAT5: Its involvement in cytokine-dependent growth of hematopoietic cells
    • MATSUMURA I, KITAMURA T, WAKAO H et al.: Transcriptional regulation of the cyclin D1 promoter by STAT5: its involvement in cytokine-dependent growth of hematopoietic cells. FMBO J. (1999) 18(5):1367-1377.
    • (1999) FMBO J. , vol.18 , Issue.5 , pp. 1367-1377
    • Matsumura, I.1    Kitamura, T.2    Wakao, H.3
  • 103
    • 3843062504 scopus 로고    scopus 로고
    • Selective inhibition of STAT3 induces apoptosis and G(1) cell cycle arrest in ALK-positive anaplastic large cell lymphoma
    • AMIN HM, MCDONNELL TJ, MA Y et al.: Selective inhibition of STAT3 induces apoptosis and G(1) cell cycle arrest in ALK-positive anaplastic large cell lymphoma. Oncogene (2004) 23(32):5426-5434.
    • (2004) Oncogene , vol.23 , Issue.32 , pp. 5426-5434
    • Amin, H.M.1    Mcdonnell, T.J.2    Ma, Y.3
  • 104
    • 0033521595 scopus 로고    scopus 로고
    • STAT3 is required for the gp130-mediated full activation of the c-myc gene
    • KIUCHI N, NAKAJIMA K, ICHIBA M et al.: STAT3 is required for the gp130-mediated full activation of the c-myc gene. J. Exp. Med. (1999) 189(1):63-73.
    • (1999) J. Exp. Med. , vol.189 , Issue.1 , pp. 63-73
    • Kiuchi, N.1    Nakajima, K.2    Ichiba, M.3
  • 105
    • 0034163579 scopus 로고    scopus 로고
    • The IL-2 receptor promotes lymphocyte proliferation and induction of the c-myc, bcl-2, and bcl-x genes through the trans-activation domain of Stat5
    • LORD JD, MCINTOSH BC, GREENBERG PD, NELSON BH: The IL-2 receptor promotes lymphocyte proliferation and induction of the c-myc, bcl-2, and bcl-x genes through the trans-activation domain of Stat5. J. Immunol. (2000) 164(5):2533-2541.
    • (2000) J. Immunol. , vol.164 , Issue.5 , pp. 2533-2541
    • Lord, J.D.1    Mcintosh, B.C.2    Greenberg, P.D.3    Nelson, B.H.4
  • 106
    • 0031590273 scopus 로고    scopus 로고
    • Association of Stat3-dependent transcriptional activation of p19INK4D with IL-6-induced growth arrest
    • NARIMATSU M, NAKAJIMA K, ICHIBA M, HIRANO T: Association of Stat3-dependent transcriptional activation of p19INK4D with IL-6-induced growth arrest. Biochem. Biophys. Res. Commun. (1997) 238(3):764-768.
    • (1997) Biochem. Biophys. Res. Commun. , vol.238 , Issue.3 , pp. 764-768
    • Narimatsu, M.1    Nakajima, K.2    Ichiba, M.3    Hirano, T.4
  • 107
    • 0032516898 scopus 로고    scopus 로고
    • Transcriptional activation of the p21 (WAF1, CIP1, SDI1) gene by interleukin-6 type cytokines. A prerequisite for their pro-differentiating and anti-apoptotic effects on human osteoblastic cells
    • BELLIDO T, O'BRIEN CA, ROBERSON PK, MANOLAGAS SC: Transcriptional activation of the p21 (WAF1, CIP1, SDI1) gene by interleukin-6 type cytokines. A prerequisite for their pro-differentiating and anti-apoptotic effects on human osteoblastic cells. J. Biol. Chem. (1998) 273(33):21137-21144.
    • (1998) J. Biol. Chem. , vol.273 , Issue.33 , pp. 21137-21144
    • Bellido, T.1    O'Brien, C.A.2    Roberson, P.K.3    Manolagas, S.C.4
  • 109
    • 0033451992 scopus 로고    scopus 로고
    • Synergistic roles for Pim-1 and c-Myc in STAT3-mediated cell cycle progression and antiapoptosis
    • SHIROGANE T, FUKADA T, MULLER JM, SHIMA DT, HIBI M, HIRANO T: Synergistic roles for Pim-1 and c-Myc in STAT3-mediated cell cycle progression and antiapoptosis. Immunity (1999) 11(6):709-719.
    • (1999) Immunity , vol.11 , Issue.6 , pp. 709-719
    • Shirogane, T.1    Fukada, T.2    Muller, J.M.3    Shima, D.T.4    Hibi, M.5    Hirano, T.6
  • 110
    • 0029892399 scopus 로고    scopus 로고
    • Suppression of interleukin-3-induced gene expression by a C-terminal truncated Stat5: Role of Stat5 in proliferation
    • MUI AL, WAKAO H, KINOSHITA T, KITAMURA T, MIYAJIMA A: Suppression of interleukin-3-induced gene expression by a C-terminal truncated Stat5: role of Stat5 in proliferation. EMBO J. (1996) 15(10):2425-2433.
    • (1996) EMBO J. , vol.15 , Issue.10 , pp. 2425-2433
    • Mui, A.L.1    Wakao, H.2    Kinoshita, T.3    Kitamura, T.4    Miyajima, A.5
  • 111
    • 0034612529 scopus 로고    scopus 로고
    • STAT3-mediated differentiation and survival and of myeloid cells in response to granulocyte colony-stimulating factor: Role for the cyclin-dependent kinase inhibitor p27(Kip1)
    • DE KONING JP, SOEDE-BOBOK AA, WARD AC et al.: STAT3-mediated differentiation and survival and of myeloid cells in response to granulocyte colony-stimulating factor: role for the cyclin-dependent kinase inhibitor p27(Kip1). Oncogene (2000) 19(29):3290-3298.
    • (2000) Oncogene , vol.19 , Issue.29 , pp. 3290-3298
    • De Koning, J.P.1    Soede-Bobok, A.A.2    Ward, A.C.3
  • 112
    • 0034721080 scopus 로고    scopus 로고
    • Oncostatin M and interleukin 6 inhibit cell cycle progression by prevention of p27kip1 degradation in HepG2 cells
    • KLAUSEN P, PEDERSEN L, JURLANDER J, BAUMANN H: Oncostatin M and interleukin 6 inhibit cell cycle progression by prevention of p27kip1 degradation in HepG2 cells. Oncogene (2000) 19(32):3675-3683.
    • (2000) Oncogene , vol.19 , Issue.32 , pp. 3675-3683
    • Klausen, P.1    Pedersen, L.2    Jurlander, J.3    Baumann, H.4
  • 113
    • 0037441888 scopus 로고    scopus 로고
    • Inhibition of STAT3 signaling induces apoptosis and decreases survivin expression in primary effusion lymphoma
    • AOKI Y, FELDMAN GM, TOSATO G: Inhibition of STAT3 signaling induces apoptosis and decreases survivin expression in primary effusion lymphoma. Blood (2003) 101(4):1535-1542.
    • (2003) Blood , vol.101 , Issue.4 , pp. 1535-1542
    • Aoki, Y.1    Feldman, G.M.2    Tosato, G.3
  • 114
    • 0035136846 scopus 로고    scopus 로고
    • Inhibition of STAT3 signaling leads to apoptosis of leukemic large granular lymphocytes and decreased Mcl-1 expression
    • EPLING-BURNETTE PK, LIU JH, CATLETT-FALCONE R et al.: Inhibition of STAT3 signaling leads to apoptosis of leukemic large granular lymphocytes and decreased Mcl-1 expression. J. Clin. Invest. (2001) 107(3):351-362.
    • (2001) J. Clin. Invest. , vol.107 , Issue.3 , pp. 351-362
    • Epling-Burnette, P.K.1    Liu, J.H.2    Catlett-Falcone, R.3
  • 115
    • 0033557944 scopus 로고    scopus 로고
    • Both Stat3-activation and Stat3-independent BCL2 downregulation are important for interleukin-6-induced apoptosis of 1A9-M cells
    • ORITANI K, TOMIYAMA Y, KINCADE PW et al.: Both Stat3-activation and Stat3-independent BCL2 downregulation are important for interleukin-6-induced apoptosis of 1A9-M cells. Blood (1999) 93(4):1346-1354.
    • (1999) Blood , vol.93 , Issue.4 , pp. 1346-1354
    • Oritani, K.1    Tomiyama, Y.2    Kincade, P.W.3
  • 116
    • 17144427278 scopus 로고    scopus 로고
    • Differential STAT5 signaling by ligand-dependent and constitutively active cytokine receptors
    • MOUCADEL V, CONSTANTINESCU SN: Differential STAT5 signaling by ligand-dependent and constitutively active cytokine receptors. J. Biol. Chem. (2005) 280(14):13364-13373.
    • (2005) J. Biol. Chem. , vol.280 , Issue.14 , pp. 13364-13373
    • Moucadel, V.1    Constantinescu, S.N.2
  • 117
    • 85047695527 scopus 로고    scopus 로고
    • Constitutive Stat3 activity up-regulates VEGF expression and tumor angiogenesis
    • NIU G, WRIGHT KL, HUANG M et al.: Constitutive Stat3 activity up-regulates VEGF expression and tumor angiogenesis. Oncogene (2002) 21(13):2000-2008.
    • (2002) Oncogene , vol.21 , Issue.13 , pp. 2000-2008
    • Niu, G.1    Wright, K.L.2    Huang, M.3
  • 118
    • 2442685645 scopus 로고    scopus 로고
    • Stat3 activation regulates the expression of matrix metalloproteinase-2 and tumor invasion and metastasis
    • XIE TX, WEI D, LIU M et al.: Stat3 activation regulates the expression of matrix metalloproteinase-2 and tumor invasion and metastasis. Oncogene (2004) 23(20):3550-3560.
    • (2004) Oncogene , vol.23 , Issue.20 , pp. 3550-3560
    • Xie, T.X.1    Wei, D.2    Liu, M.3
  • 119
    • 3242676769 scopus 로고    scopus 로고
    • Requirement of matrix metalloproteinase-9 for the transformation of human mammary epithelial cells by Stat3-C
    • DECHOW TN, PEDRANZINI L, LEITCH A et al.: Requirement of matrix metalloproteinase-9 for the transformation of human mammary epithelial cells by Stat3-C. Proc. Natl. Acad. Sci. USA (2004) 101(29):10602-10607.
    • (2004) Proc. Natl. Acad. Sci. USA , vol.101 , Issue.29 , pp. 10602-10607
    • Dechow, T.N.1    Pedranzini, L.2    Leitch, A.3
  • 120
    • 0035865517 scopus 로고    scopus 로고
    • STAT3-mediated constitutive expression of SOCS-3 in cutaneous T-cell lymphoma
    • BRENDER C, NIELSEN M, KALTOFT K et al.: STAT3-mediated constitutive expression of SOCS-3 in cutaneous T-cell lymphoma. Blood (2001) 97(4):1056-1062.
    • (2001) Blood , vol.97 , Issue.4 , pp. 1056-1062
    • Brender, C.1    Nielsen, M.2    Kaltoft, K.3
  • 121
    • 4644234020 scopus 로고    scopus 로고
    • TEL/ETV6 is a signal transducer and activator of transcription 3 (Stat3)-induced repressor of Stat3 activity
    • SCHICK N, OAKELEY EJ, HYNES NE, BADACHE A: TEL/ETV6 is a signal transducer and activator of transcription 3 (Stat3)-induced repressor of Stat3 activity. J. Biol. Chem. (2004) 279(37):38787-38796.
    • (2004) J. Biol. Chem. , vol.279 , Issue.37 , pp. 38787-38796
    • Schick, N.1    Oakeley, E.J.2    Hynes, N.E.3    Badache, A.4
  • 122
    • 0035823547 scopus 로고    scopus 로고
    • Functional importance of Stat3 tetramerization in activation of the alpha 2-macroglobulin gene
    • ZHANG X, DARNELL JR JR: Functional importance of Stat3 tetramerization in activation of the alpha 2-macroglobulin gene. J. Biol. Chem. (2001) 276(36):33576-33581.
    • (2001) J. Biol. Chem. , vol.276 , Issue.36 , pp. 33576-33581
    • Zhang, X.1    Darnell Jr., J.R.2
  • 123
    • 0032822191 scopus 로고    scopus 로고
    • Modulation of hepatic acute phase gene expression by epidermal growth factor and Src protein tyrosine kinases in murine and human hepatic cells
    • WANG Y, RIPPERGER J, FEY GH et al.: Modulation of hepatic acute phase gene expression by epidermal growth factor and Src protein tyrosine kinases in murine and human hepatic cells. Hepatology (1999) 30(3):682-697.
    • (1999) Hepatology , vol.30 , Issue.3 , pp. 682-697
    • Wang, Y.1    Ripperger, J.2    Fey, G.H.3
  • 124
    • 0030024443 scopus 로고    scopus 로고
    • IL-6-inducible complexes on an IL-6 response element of the junB promoter contain Stat3 and 36 kDa CRE-like site binding protein(s)
    • KOJIMA H, NAKAJIMA K, HIRANO T: IL-6-inducible complexes on an IL-6 response element of the junB promoter contain Stat3 and 36 kDa CRE-like site binding protein(s). Oncogene (1996) 12(3):547-554.
    • (1996) Oncogene , vol.12 , Issue.3 , pp. 547-554
    • Kojima, H.1    Nakajima, K.2    Hirano, T.3
  • 125
    • 2442684333 scopus 로고    scopus 로고
    • Signal transducer and activator of transcription-3 activation contributes to high tissue inhibitor of metalloproteinase-1 expression in anaplastic lymphoma kinase-positive anaplastic large cell lymphoma
    • LAI R, RASSIDAKIS GZ, MEDEIROS LJ et al.: Signal transducer and activator of transcription-3 activation contributes to high tissue inhibitor of metalloproteinase-1 expression in anaplastic lymphoma kinase-positive anaplastic large cell lymphoma. Am. J. Pathol. (2004) 164(6):2251-2258.
    • (2004) Am. J. Pathol. , vol.164 , Issue.6 , pp. 2251-2258
    • Lai, R.1    Rassidakis, G.Z.2    Medeiros, L.J.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.