RNA interference-mediated downregulation of hypoxia-inducible factor-1α inhibits angiogenesis and survival of oral squamous cell carcinoma in vitro and in vivo

European Journal of Cancer Prevention

Volumn 21, Issue 3, 2012, Pages 289-299

  Zhou, Hao ^a   Fei, Wei ^b   Bai, Yun ^a   Zhu, Songsong ^a   Luo, En ^a   Chen, Kai ^c   Hu, Jing ^a  

^a SICHUAN UNIVERSITY   (China)

^b SICHUAN PROVINCIAL PEOPLE'S HOSPITAL   (China)

^c SOUTHWEST MEDICAL UNIVERSITY   (China)

Author keywords

angiogenesis; apoptosis; hypoxia inducible factor 1a; proliferation; RNA interference

Indexed keywords

HYPOXIA INDUCIBLE FACTOR 1ALPHA; KI 67 ANTIGEN; MESSENGER RNA; SMALL INTERFERING RNA; VASCULOTROPIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; APOPTOSIS; ARTICLE; CANCER CELL; CANCER GROWTH; CANCER INHIBITION; CANCER SURVIVAL; CARCINOGENESIS; CELL DENSITY; CELL PROLIFERATION; CONTROLLED STUDY; DOWN REGULATION; FEMALE; GENE EXPRESSION; GENE SILENCING; GENE TARGETING; GENETIC TRANSFECTION; HUMAN; HUMAN CELL; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; IN VITRO STUDY; IN VIVO STUDY; MOLECULARLY TARGETED THERAPY; MOUSE; MOUTH CARCINOMA; NONHUMAN; PRIORITY JOURNAL; QUANTITATIVE ANALYSIS; REAL TIME POLYMERASE CHAIN REACTION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; RNA INTERFERENCE; TUMOR XENOGRAFT; WESTERN BLOTTING;

ANIMALS; APOPTOSIS; CARCINOMA, SQUAMOUS CELL; CELL LINE, TUMOR; DOWN-REGULATION; FEMALE; HUMANS; HYPOXIA-INDUCIBLE FACTOR 1, ALPHA SUBUNIT; MICE; MICE, NUDE; MOUTH NEOPLASMS; NEOVASCULARIZATION, PATHOLOGIC; RANDOM ALLOCATION; RNA INTERFERENCE; RNA, SMALL INTERFERING;

EID: 84859433605     PISSN: 09598278     EISSN: 14735709     Source Type: Journal    
DOI: 10.1097/CEJ.0b013e32834dbbda     Document Type: Article

References (45)

1. Agami R (2002). RNAi and related mechanisms and their potential use for therapy. Curr Opin Chem Biol 6:829-834. (Pubitemid 35449344)
2. Akakura N, Kobayashi M, Horiuchi I, Suzuki A, Wang J, Chen J, et al. (2001). Constitutive expression of hypoxia-inducible factor-1alpha renders pancreatic cancer cells resistant to apoptosis induced by hypoxia and nutrient deprivation. Cancer Res 61:6548-6554. (Pubitemid 32783263)
3. Berra E, Milanini J, Richard DE, Le Gall M, Viñals F, GothiéE, et al. (2000). Signaling angiogenesis via p42/p44 MAP kinase and hypoxia. Biochem Pharmacol 60:1171-1178.
4. Bos R, Zhong H, Hanrahan CF, Mommers EC, Semenza GL, Pinedo HM, et al. (2000). Levels of hypoxia-inducible factor 1a during breast carcinogenesis. J Natl Cancer Inst 93:309-314.
5. Brown JM, Giaccia AJ (1998). The unique physiology of solid tumors: opportunities (and problems) for cancer therapy. Cancer Res 58:1408-1416. (Pubitemid 28193601)
6. Carmeliet P, Dor Y, Herbert JM, Fukumura D, Brusselmans K, Dewerchin M, et al. (1998). Role of HIF-1alpha in hypoxia-mediated apoptosis, cell proliferation and tumour angiogenesis. Nature 394:485-490. (Pubitemid 28373960)
7. de Fraipont F, Nicholson AC, Feige JJ, Van Meir EG (2001). Thrombospondins and tumor angiogenesis. Trends Mol Med 7:401-407. (Pubitemid 32823989)
8. Giatromanolaki A, Koukourakis MI, Sivridis E, Turley H, Talks K, Pezzella F, et al. (2001). Relation of hypoxia inducible factor 1 alpha and 2 alpha in operable non-small cell lung cancer to angiogenic/molecular profile of tumours and survival. Br J Cancer 85:881-890. (Pubitemid 33010557)
9. Gillespie DL, Whang K, Ragel BT, Flynn JR, Kelly DA, Jensen RL (2007). Silencing of hypoxia inducible factor-1alpha by RNA interference attenuates human glioma cell growth in vivo. Clin Cancer Res 13:2441-2448. (Pubitemid 46698595)
10. Greijer AE, Van derWall E (2004). The role of hypoxia inducible factor 1 (HIF-1) in hypoxia induced apoptosis. J Clin Pathol 57:1009-1014. (Pubitemid 39331346)
11. Hanahan D, Folkman J (1996). Patterns and emerging mechanisms of the angiogenic switch during tumorigenesis. Cell 86:353-364. (Pubitemid 26272076)
12. Hanahan D, Weinberg RA (2000). The hallmarks of cancer. Cell 100:57-70. (Pubitemid 30046295)
13. Harris AL (2002). Hypoxia: a key regulatory factor in tumour growth. Nat Rev Cancer 2:38-47. (Pubitemid 37328806)
14. Hirota K, Semenza GL (2006). Regulation of angiogenesis by hypoxia-inducible factor 1. Crit Rev Oncol Hematol 59:15-26. (Pubitemid 43903276)
15. Kademani D, Bell RB, Bagheri S, Holmgren E, Dierks E, Potter B, et al. (2005). Prognostic factors in intraoral squamous cell carcinoma: the influence of histologic grade. J Oral Maxillofac Surg 63:1599-1605. (Pubitemid 41525416)
16. Laughner E, Taghavi P, Chiles K, Mahon PC, Semenza GL (2001). HER2 (neu) signaling increases the rate of hypoxia-inducible factor 1alpha (HIF-1alpha) synthesis: novel mechanism for HIF-1-mediated vascular endothelial growth factor expression. Mol Cell Biol 21:3995-4004. (Pubitemid 32476461)
17. Levy AP, Levy NS, Goldberg MA (1996). Post-transcriptional regulation of vascular endothelial growth factor by hypoxia. J Biol Chem 271: 2746-2753. (Pubitemid 26047892)
18. Ling YX, Tao J, Fang SF, Hui Z, Fang QR (2011). Downregulation of Id1 by small interfering RNA in prostate cancer PC3 cells in vivo and in vitro. Eur J Cancer Prev 20:9-17.
19. Masiero M, Nardo G, Indraccolo S, Favaro E (2007). RNA interference: implications for cancer treatment. Mol Aspects Med 28:143-166.
20. Maxwell PH, Dachs GU, Gleadle JM, Nicholls LG, Harris AL, Stratford IJ, et al. (1997). Hypoxia-inducible factor-1 modulates gene expression in solid tumors and influences both angiogenesis and tumor growth. Proc Natl Acad Sci USA 94:8104-8109. (Pubitemid 27343784)
21. Maxwell PH, Wiesener MS, Chang GW, Clifford SC, Vaux EC, Cockman ME, et al. (1999). The tumour suppressor protein VHL targets hypoxia-inducible factors for oxygen-dependent proteolysis. Nature 399:271-275. (Pubitemid 29246458)
22. Miele C, Rochford JJ, Filippa N, Giorgetti-Peraldi S, Van Obberghen E (2000). Insulin and insulin-like growth factor-I induce vascular endothelial growth factor mRNA expression via different signaling pathways. J Biol Chem 275:21695-21702. (Pubitemid 30481878)
23. Mignogna MD, Fedele S, Lo Russo L (2004). The World Cancer Report and the burden of oral cancer. Eur J Cancer Prev 13:139-142. (Pubitemid 38585334)
24. Mizuno T, Nagao M, Yamada Y, Narikiyo M, Ueno M, Miyagishi M, et al. (2006). Small interfering RNA expression vector targeting hypoxia-inducible factor 1 alpha inhibits tumor growth in hepatobiliary and pancreatic cancers. Cancer Gene Ther 13:131-140. (Pubitemid 43113414)
25. Mohamed KM, Le A, Duong H,Wu Y, Zhang Q, Messadi DV (2004). Correlation between VEGF and HIF-1alpha expression in human oral squamous cell carcinoma. Exp Mol Pathol 76:143-152. (Pubitemid 38316929)
26. Moritz W, Meier F, Stroka DM, Giuliani M, Kugelmeier P, Nett PC, et al. (2002). Apoptosis in hypoxic human pancreatic islets correlates with HIF-1alpha expression. FASEB J 16:745-747.
27. Novina CD, Sharp PA (2004). The RNAi revolution. Nature 430:161-164. (Pubitemid 38902417)
28. Peng C, Guo W, Yang Y, Zhao H (2008). Downregulation of SS18-SSX1 expression by small interfering RNA inhibits growth and induces apoptosis in human synovial sarcoma cell line HS-SY-II in vitro. Eur J Cancer Prev 17:392-398.
29. Persengiev SP, Zhu X, Green MR (2004). Nonspecific, concentration- dependent stimulation and repression of mammalian gene expression by small interfering RNAs (siRNAs). RNA 10:12-18. (Pubitemid 38018731)
30. Powis G, Kirkpatrick L (2004). Hypoxia inducible factor-1a as a cancer drug target. Mol Cancer Ther 5:647-654. (Pubitemid 39193744)
31. Pugh CW, Ratcliffe PJ (2003). Regulation of angiogenesis by hypoxia: role of the HIF system. Nat Med 9:677-684. (Pubitemid 36749216)
32. Ravi R, Mookerjee B, Bhujwalla ZM, Sutter CH, Artemov D, Zeng Q, et al. (2000). Regulation of tumor angiogenesis by p53-induced degradation of hypoxiainducible factor 1alpha. Genes Dev 14:34-44. (Pubitemid 30051577)
33. Reynolds A, Leake D, Boese Q, Scaringe S, Marshall WS, Khvorova A (2004). Rational siRNA design for RNA interference. Nat Biotechnol 22: 326-330. (Pubitemid 38295766)
34. Schweiki D, Itan A, Soffer D, Keshet E (1992). Vascular endothelial growth factor may mediate hypoxia-initiated angiogenesis. Nature 359:843-845.
35. Seagroves TN, Ryan HE, Lu H, Wouters BG, Knapp M, Thibault P (2001). Transcription factor HIF-1 is a necessary mediator of the Pasteur effect in mammalian cells. Mol Cell Biol 21:3436-3444. (Pubitemid 32381779)
36. Semenza G (2002). Signal transduction to hypoxia-inducible factor 1. Biochem Pharmacol 64:993-998. (Pubitemid 35232274)
37. Semenza GL (2000). Hypoxia, clonal selection, and the role of HIF-1 in tumor progression. Crit Rev Biochem Mol Biol 35:71-103. (Pubitemid 30253678)
38. Semenza GL (2001). Hypoxia-inducible factor 1: oxygen homeostasis and disease pathophysiology. Trends Mol Med 7:345-350. (Pubitemid 32735019)
39. Semenza GL (2003). Targeting HIF-1 for cancer therapy. Nat Rev Cancer 3: 721-732. (Pubitemid 37328811)
40. Soengas MS, Alarcón RM, Yoshida H, Giaccia AJ, Hakem R, Mak TW, et al. (1999). Apaf-1 and caspase-9 in p53-dependent apoptosis and tumor inhibition. Science 284:156-159. (Pubitemid 29282071)
41. Tang N,Wang L, Esko J, Giordano FJ, Huang Y, Gerber HP, et al. (2004). Loss of HIF-1alpha in endothelial cells disrupts a hypoxia-driven VEGF autocrine loop necessary for tumorigenesis. Cancer Cell 6:485-495. (Pubitemid 39469984)
42. Walmsley SR, Print C, Farahi N, Peyssonnaux C, Johnson RS, Cramer T, et al. (2005). Hypoxia-induced neutrophil survival is mediated by HIF-1alphadependent NF-kappaB activity. J Exp Med 201:105-115. (Pubitemid 40130088)
43. Yoshida D, Kim K, Noha M, Teramoto A (2006). Anti-apoptotic action by hypoxia inducible factor 1-alpha in human pituitary adenoma cell line, HP-75 in hypoxic condition. J Neurooncol 78:217-225. (Pubitemid 44018814)
44. Zhong H, De Marzo AM, Laughner E, Lim M, Hilton DA, Zagzag D, et al. (1999). Overexpression of hypoxia-inducible factor 1alpha in common human cancers and their metastases. Cancer Res 59:5830-5835.
45. Zhou J, Schmid T, Schnitzer S, Brüne B (2006). Tumor hypoxia and cancer progression. Cancer Lett 237:10-21.