Dioscorea nipponica Makino inhibits migration and invasion of human oral cancer HSC-3 cells by transcriptional inhibition of matrix metalloproteinase-2 through modulation of CREB and AP-1 activity

Food and Chemical Toxicology

Volumn 50, Issue 3-4, 2012, Pages 558-566

  Chien, Ming Hsien ^a,b   Ying, Tsung Ho ^c,d   Hsieh, Yih Shou ^c   Chang, Yu Chao ^c   Yeh, Chia Ming ^c   Ko, Jiunn Liang ^c   Lee, Wen Sen ^e   Chang, Jer Hua ^a,f   Yang, Shun Fa ^c,d  

^a TAIPEI MEDICAL UNIVERSITY   (Taiwan)

^b TAIPEI MEDICAL UNIVERSITY   (Taiwan)

^c CHUNG SHAN MEDICAL UNIVERSITY   (Taiwan)

^d CHUNG SHAN MEDICAL UNIVERSITY HOSPITAL   (Taiwan)

^e TAIPEI MEDICAL UNIVERSITY   (Taiwan)

^f TAIPEI MEDICAL UNIVERSITY   (Taiwan)

Author keywords

Dioscorea nipponica; Invasion; Migration; MMP 2; Oral cancer

Indexed keywords

ACTIVATING PROTEIN 1; ANTINEOPLASTIC AGENT; CARRIER PROTEIN; CYCLIC AMP RESPONSIVE ELEMENT BINDING PROTEIN; DIOSCOREA NIPPONICA EXTRACT; GELATINASE A; PLANT EXTRACT; UNCLASSIFIED DRUG;

ANTINEOPLASTIC ACTIVITY; ARTICLE; CANCER CELL CULTURE; CANCER INHIBITION; CELL INVASION; CONCENTRATION RESPONSE; CONTROLLED STUDY; DIOSCOREA NIPPONICA; DIOSCOREACEAE; DNA BINDING; ENZYME ACTIVITY; ENZYME INHIBITION; GENE EXPRESSION; HUMAN; HUMAN CELL; MIGRATION INHIBITION; MODULATION; MOUTH CANCER; PROTEIN EXPRESSION; REAL TIME POLYMERASE CHAIN REACTION; UPREGULATION; WESTERN BLOTTING; ZYMOGRAPHY;

BASE SEQUENCE; CELL LINE, TUMOR; CHROMATIN IMMUNOPRECIPITATION; CYCLIC AMP RESPONSE ELEMENT-BINDING PROTEIN; DIOSCOREA; DNA PRIMERS; FLOW CYTOMETRY; HUMANS; MATRIX METALLOPROTEINASE 2; MOUTH NEOPLASMS; PLANT EXTRACTS; REAL-TIME POLYMERASE CHAIN REACTION; TRANSCRIPTION FACTOR AP-1; TRANSCRIPTION, GENETIC;

DIOSCOREA NIPPONICA;

EID: 84863261589     PISSN: 02786915     EISSN: 18736351     Source Type: Journal    
DOI: 10.1016/j.fct.2011.12.016     Document Type: Article

References (53)

1. Ahn S.M., Jeong S.J., Kim Y.S., Sohn Y., Moon A. Retroviral delivery of TIMP-2 inhibits H-ras-induced migration and invasion in MCF10A human breast epithelial cells. Cancer Lett. 2004, 207:49-57.
2. Benbow U., Brinckerhoff C.E. The AP-1 site and MMP gene regulation: what is all the fuss about?. Matrix Biol. 1997, 15:519-526.
3. Bjorklund M., Koivunen E. Gelatinase-mediated migration and invasion of cancer cells. Biochim. Biophys. Acta 2005, 1755:37-69.
4. Cakarovski K., Leung J.Y., Restall C., Carin-Carlson A., Yang E., Perlmutter P., Anderson R., Medcalf R., Dear A.E. Novel inhibitors of urokinase-type plasminogen activator and matrix metalloproteinase expression in metastatic cancer cell lines. Int. J. Cancer 2004, 110:610-616.
5. Chen P.N., Hsieh Y.S., Chiou H.L., Chu S.C. Silibinin inhibits cell invasion through inactivation of both PI3K-Akt and MAPK signaling pathways. Chem. Biol. Interact. 2005, 156:141-150.
6. Coussens L.M., Werb Z. Matrix metalloproteinases and the development of cancer. Chem. Biol. 1996, 3:895-904.
7. Guruvayoorappan C., Kuttan G. Amentoflavone inhibits experimental tumor metastasis through a regulatory mechanism involving MMP-2, MMP-9, prolyl hydroxylase, lysyl oxidase, VEGF, ERK-1, ERK-2, STAT-1, NM23 and cytokines in lung tissues of C57BL/6 mice. Immunopharmacol. Immunotoxicol. 2008, 30:711-727.
8. Ho M.L., Hsieh Y.S., Chen J.Y., Chen K.S., Chen J.J., Kuo W.H., Lin S.J., Chen P.N. Antimetastatic potentials of Dioscorea nipponica on melanoma in vitro and in vivo. Evid. Based Complement. Altern. Med. 2011, 2011:507920.
9. Huang H.P., Shih Y.W., Chang Y.C., Hung C.N., Wang C.J. Chemoinhibitory effect of mulberry anthocyanins on melanoma metastasis involved in the Ras/PI3K pathway. J. Agric. Food. Chem. 2008, 56:9286-9293.
10. Hwang E.S., Lee H.J. Benzyl isothiocyanate inhibits metalloproteinase-2/-9 expression by suppressing the mitogen-activated protein kinase in SK-Hep1 human hepatoma cells. Food Chem. Toxicol. 2008, 46:2358-2364.
11. Jean D., Bar-Eli M. Regulation of tumor growth and metastasis of human melanoma by the CREB transcription factor family. Mol. Cell. Biochem. 2000, 212:19-28.
12. Jia W., Gao W., Tang L. Antidiabetic herbal drugs officially approved in China. Phytother Res 2003, 17:1127-1134.
13. Joo Y.E., Seo Y.H., Lee W.S., Kim H.S., Choi S.K., Rew J.S., Park C.S., Kim S.J. Expression of tissue inhibitors of metalloproteinases (TIMPs) in hepatocellular carcinoma. Korean J. Intern. Med. 2000, 15:171-178.
14. Katayama A., Bandoh N., Kishibe K., Takahara M., Ogino T., Nonaka S., Harabuchi Y. Expressions of matrix metalloproteinases in early-stage oral squamous cell carcinoma as predictive indicators for tumor metastases and prognosis. Clin. Cancer Res. 2004, 10:634-640.
15. Kim M.H., Bodenstine T.M., Sumerel L.A., Rivera A.A., Baker A.H., Douglas J.T. Tissue inhibitor of metalloproteinases-2 improves antitumor efficacy of a replicating adenovirus in vivo. Cancer Biol. Ther. 2006, 5:1647-1653.
16. Kurahara S., Shinohara M., Ikebe T., Nakamura S., Beppu M., Hiraki A., Takeuchi H., Shirasuna K. Expression of MMPS, MT-MMP, and TIMPs in squamous cell carcinoma of the oral cavity: correlations with tumor invasion and metastasis. Head Neck 1999, 21:627-638.
17. Kang T.H., Moon E., Hong B.N., Choi S.Z., Son M., Park J.H., Kim S.Y. Diosgenin from Dioscorea nipponica ameliorates diabetic neuropathy by inducing nerve growth factor. Biol. Pharm. Bull. 2011, 34:1493-1498.
18. Kusukawa J., Sasaguri Y., Shima I., Kameyama T., Morimatsu M. Expression of matrix metalloproteinase-2 related to lymph node metastasis of oral squamous cell carcinoma. A clinicopathologic study. Am. J. Clin. Pathol. 1993, 99:18-23.
19. Kwon C.S., Sohn H.Y., Kim S.H., Kim J.H., Son K.H., Lee J.S., Lim J.K., Kim J.S. Anti-obesity effect of Dioscorea nipponica Makino with lipase-inhibitory activity in rodents. Biosci. Biotechnol. Biochem. 2003, 67:1451-1456.
20. Lee Y.K., So I.S., Lee S.C., Lee J.H., Lee C.W., Kim W.M., Park M.K., Lee S.T., Park D.Y., Shin D.Y., Park C.U., Kim Y.S. Suppression of distant pulmonary metastasis of MDA-MB 435 human breast carcinoma established in mammary fat pads of nude mice by retroviral-mediated TIMP-2 gene transfer. J. Gene Med. 2005, 7:145-157.
21. Li X., Wang H. Chinese herbal medicine in the treatment of chronic kidney disease. Adv. Chronic Kidney Dis. 2005, 12:276-281.
22. Lin S., Wang D., Yang D., Yao J., Tong Y., Chen J. Characterization of steroidal saponins in crude extract from Dioscorea nipponica Makino by liquid chromatography tandem multi-stage mass spectrometry. Anal. Chim. Acta 2007, 599:98-106.
23. Lin S.Y., Chang Y.T., Liu J.D., Yu C.H., Ho Y.S., Lee Y.H., Lee W.S. Molecular mechanisms of apoptosis induced by magnolol in colon and liver cancer cells. Mol. Carcinog. 2001, 32:73-83.
24. Liotta L.A., Stetler-Stevenson W.G. Tumor invasion and metastasis: an imbalance of positive and negative regulation. Cancer Res. 1991, 51:5054s-5059s.
25. Liu C.Z., Zhou H.Y., Yan Q. Fingerprint analysis of Dioscorea nipponica by high-performance liquid chromatography with evaporative light scattering detection. Anal. Chim. Acta 2007, 582:61-68.
26. Mackay A.R., Corbitt R.H., Hartzler J.L., Thorgeirsson U.P. Basement membrane type IV collagen degradation: evidence for the involvement of a proteolytic cascade independent of metalloproteinases. Cancer Res. 1990, 50:5997-6001.
27. Nelson A.R., Fingleton B., Rothenberg M.L., Matrisian L.M. Matrix metalloproteinases: biologic activity and clinical implications. J. Clin. Oncol. 2000, 18:1135-1149.
28. Okada N., Ishida H., Murata N., Hashimoto D., Seyama Y., Kubota S. Matrix metalloproteinase-2 and -9 in bile as a marker of liver metastasis in colorectal cancer. Biochem. Biophys. Res. Commun. 2001, 288:212-216.
29. Oke O.L. Yam - a valuable source of food and drugs. World Rev. Nutr. Diet. 1972, 15:156-184.
30. Patel B.P., Shah S.V., Shukla S.N., Shah P.M., Patel P.S. Clinical significance of MMP-2 and MMP-9 in patients with oral cancer. Head Neck 2007, 29:564-572.
31. Qin H., Sun Y., Benveniste E.N. The transcription factors Sp1, Sp3, and AP-2 are required for constitutive matrix metalloproteinase-2 gene expression in astroglioma cells. J. Biol. Chem. 1999, 274:29130-29137.
32. Rao J.S. Molecular mechanisms of glioma invasiveness: the role of proteases. Nat. Rev. Cancer 2003, 3:489-501.
33. Ravindranath M.H., Ramasamy V., Moon S., Ruiz C., Muthugounder S. Differential growth suppression of human melanoma cells by tea (Camellia sinensis) epicatechins (ECG, EGC and EGCG). Evid. Based Complement. Altern. Med. 2009, 6:523-530.
34. Satpathy M., Shao M., Emerson R., Donner D.B., Matei D. Tissue transglutaminase regulates matrix metalloproteinase-2 in ovarian cancer by modulating cAMP-response element-binding protein activity. J. Biol. Chem. 2009, 284:15390-15399.
35. Shankar S., Ganapathy S., Hingorani S.R., Srivastava R.K. EGCG inhibits growth, invasion, angiogenesis and metastasis of pancreatic cancer. Front. Biosci. 2008, 13:440-452.
36. Shapiro S.D. Matrix metalloproteinase degradation of extracellular matrix: biological consequences. Curr. Opin. Cell Biol. 1998, 10:602-608.
37. Simeone A.M., McMurtry V., Nieves-Alicea R., Saavedra J.E., Keefer L.K., Johnson M.M., Tari A.M. TIMP-2 mediates the anti-invasive effects of the nitric oxide-releasing prodrug JS-K in breast cancer cells. Breast Cancer Res. 2008, 10:R44.
38. Spiro R.H., Alfonso A.E., Farr H.W., Strong E.W. Cervical node metastasis from epidermoid carcinoma of the oral cavity and oropharynx. A critical assessment of current staging. Am. J. Surg. 1974, 128:562-567.
39. Toda D., Ota T., Tsukuda K., Watanabe K., Fujiyama T., Murakami M., Naito M., Shimizu N. Gefitinib decreases the synthesis of matrix metalloproteinase and the adhesion to extracellular matrix proteins of colon cancer cells. Anticancer Res. 2006, 26:129-134.
40. Tseng M.Y., Liu S.Y., Chen H.R., Wu Y.J., Chiu C.C., Chan P.T., Chiang W.F., Liu Y.C., Lu C.Y., Jou Y.S., Chen J.Y. Serine protease inhibitor (SERPIN) B1 promotes oral cancer cell motility and is over-expressed in invasive oral squamous cell carcinoma. Oral Oncol. 2009, 45:771-776.
41. Vieira J.R., de Souza I.A., do Nascimento S.C., Leite S.P. Indigofera suffruticosa: an alternative anticancer therapy. Evid. Based Complement. Altern. Med. 2007, 4:355-359.
42. Vincenti M.P., White L.A., Schroen D.J., Benbow U., Brinckerhoff C.E. Regulating expression of the gene for matrix metalloproteinase-1 (collagenase): mechanisms that control enzyme activity, transcription, and mRNA stability. Crit. Rev. Eukaryot. Gene Expr. 1996, 6:391-411.
43. Waas E.T., Wobbes T., Lomme R.M., DeGroot J., Ruers T., Hendriks T. Matrix metalloproteinase 2 and 9 activity in patients with colorectal cancer liver metastasis. Br. J. Surg. 2003, 90:1556-1564.
44. Weiss L. Metastatic inefficiency. Adv. Cancer Res. 1990, 54:159-211.
45. Westermarck J., Kahari V.M. Regulation of matrix metalloproteinase expression in tumor invasion. FASEB J. 1999, 13:781-792.
46. Xiao J., Wang N.L., Sun B., Cai G.P. Estrogen receptor mediates the effects of pseudoprotodiocsin on adipogenesis in 3T3-L1 cells. Am. J. Physiol. Cell Physiol. 2010, 299:C128-138.
47. Yang S.F., Chen M.K., Hsieh Y.S., Chung T.T., Hsieh Y.H., Lin C.W., Su J.L., Tsai M.H., Tang C.H. Prostaglandin E2/EP1 signaling pathway enhances intercellular adhesion molecule 1 (ICAM-1) expression and cell motility in oral cancer cells. J. Biol. Chem. 2010, 285:29808-29816.
48. Yang S.F., Chen M.K., Hsieh Y.S., Yang J.S., Zavras A.I., Hsieh Y.H., Su S.C., Kao T.Y., Chen P.N., Chu S.C. Antimetastatic effects of Terminalia catappa L. on oral cancer via a down-regulation of metastasis-associated proteases. Food Chem. Toxicol. 2010, 48:1052-1058.
49. Yang S.F., Yang W.E., Kuo W.H., Chang H.R., Chu S.C., Hsieh Y.S. Antimetastatic potentials of flavones on oral cancer cell via an inhibition of matrix-degrading proteases. Arch. Oral Biol. 2008, 53:287-294.
50. Yoon S.O., Park S.J., Yun C.H., Chung A.S. Roles of matrix metalloproteinases in tumor metastasis and angiogenesis. J. Biochem. Mol. Biol. 2003, 36:128-137.
51. Yoshikawa M., Xu F., Morikawa T., Pongpiriyadacha Y., Nakamura S., Asao Y., Kumahara A., Matsuda H. Medicinal flowers. XII. (1) New spirostane-type steroid saponins with antidiabetogenic activity from Borassus flabellifer. Chem. Pharm. Bull. (Tokyo) 2007, 55:308-316.
52. Zhang D., Ma Q.Y., Hu H.T., Zhang M. Beta2-adrenergic antagonists suppress pancreatic cancer cell invasion by inhibiting CREB, NFkappaB and AP-1. Cancer Biol. Ther. 2010, 10:19-29.
53. Zhang L., Shi J., Feng J., Klocker H., Lee C., Zhang J. Type IV collagenase (matrix metalloproteinase-2 and -9) in prostate cancer. Prostate Cancer Prostatic Dis. 2004, 7:327-332.