Cell death in NF-κB-dependent tumour cell lines as a result of NF-κB trapping by linker-modified hairpin decoy oligonucleotide

FEBS Letters

Volumn 581, Issue 6, 2007, Pages 1143-1150

  Laguillier, Christelle ^a,b   Hbibi, Ali Tadlaoui ^a,b   Baran Marszak, Fanny ^a,b   Metelev, Valeri ^c   Cao, An ^d   Cymbalista, Florence ^a,b   Bogdanov Jr , Alexei ^e   Fagard, Remi ^a,b  

^a UNIVERSITÉ PARIS 13   (France)

^b AVICENNE HOSPITAL   (France)

^c MOSCOW STATE UNIVERSITY   (Russian Federation)

^d CNRS/LCSB/UMR 7033   (France)

^e UNIVERSITY OF MASSACHUSETTS MEDICAL SCHOOL   (United States)

Author keywords

Cell death; Decoy oligonucleotide; Linker modification; NF B; Tumour cell lines

Indexed keywords

IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; OLIGODEOXYNUCLEOTIDE; OLIGONUCLEOTIDE; PROTEIN P50; TUMOR NECROSIS FACTOR ALPHA;

ARTICLE; CANCER CELL CULTURE; CANCER INHIBITION; CANCER THERAPY; CELL DEATH; CELL NUCLEUS; CONTROLLED STUDY; GENE TRANSCRIPTION INHIBITION; GENETIC TRANSCRIPTION; HUMAN; HUMAN CELL; MOLECULAR INTERACTION; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN TARGETING; TRANSCRIPTION REGULATION;

BINDING SITES; CELL DEATH; CELL LINE, TUMOR; CYTOPLASM; HUMANS; NEOPLASMS; NF-KAPPA B; NF-KAPPA B P50 SUBUNIT; NUCLEIC ACID CONFORMATION; OLIGODEOXYRIBONUCLEOTIDES; PROTEIN BINDING; TRANSCRIPTION, GENETIC;

EID: 33947103197     PISSN: 00145793     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.febslet.2007.02.024     Document Type: Article

References (43)

1. Rayet B., and Gelinas C. Aberrant rel/nfkb genes and activity in human cancer. Oncogene 18 (1999) 6938-6947
2. Shishodia S., and Aggarwal B.B. Nuclear factor-kappaB: a friend or a foe in cancer?. Biochem. Pharmacol. 68 (2004) 1071-1080
3. Dejardin E., Deregowski V., Chapelier M., Jacobs N., Gielen J., Merville M.P., and Bours V. Regulation of NF-kappaB activity by I kappaB-related proteins in adenocarcinoma cells. Oncogene 18 (1999) 2567-2577
4. Lind D.S., Hochwald S.N., Malaty J., Rekkas S., Hebig P., Mishra G., Moldawer L.L., Copeland III E.M., and Mackay S. Nuclear factor-kappa B is upregulated in colorectal cancer. Surgery 130 (2001) 363-369
5. Kim H.J., Hawke N., and Baldwin A.S. NF-kappaB and IKK as therapeutic targets in cancer. Cell Death Differ. 13 (2006) 738-747
6. Redell M.S., and Tweardy D.J. Targeting transcription factors for cancer therapy. Curr. Pharm. Des. 11 (2005) 2873-2887
7. Griesenbach U., Scheid P., Hillery E., de Martin R., Huang L., Geddes D.M., and Alton E.W. Anti-inflammatory gene therapy directed at the airway epithelium. Gene Ther. 7 (2000) 306-313
8. Xu M.Q., Suo Y.P., Gong J.P., Zhang M.M., and Yan L.N. Prolongation of liver allograft survival by dendritic cells modified with NF-kappaB decoy oligodeoxynucleotides. World J. Gastroenterol. 10 (2004) 2361-2368
9. Xu M.Q., Suo Y.P., Gong J.P., Zhang M.M., and Yan L.N. Augmented regeneration of partial liver allograft induced by nuclear factor-kappaB decoy oligodeoxynucleotides-modified dendritic cells. World J. Gastroenterol. 10 (2004) 573-578
10. Vos I.H., Govers R., Grone H.J., Kleij L., Schurink M., De Weger R.A., Goldschmeding R., and Rabelink T.J. NFkappaB decoy oligodeoxynucleotides reduce monocyte infiltration in renal allografts. Faseb J. 14 (2000) 815-822
11. Morishita R. Recent progress in gene therapy for cardiovascular disease. Circ. J. 66 (2002) 1077-1086
12. Morishita R., Higaki J., Tomita N., and Ogihara T. Application of transcription factor "decoy" strategy as means of gene therapy and study of gene expression in cardiovascular disease. Circ. Res. 82 (1998) 1023-1028
13. Morishita R., Sugimoto T., Aoki M., Kida I., Tomita N., Moriguchi A., Maeda K., Sawa Y., Kaneda Y., et al. In vivo transfection of cis element "decoy" against nuclear factor-kappaB binding site prevents myocardial infarction. Nat. Med. 3 (1997) 894-899
14. Sawa Y., Morishita R., Suzuki K., Kagisaki K., Kaneda Y., Maeda K., Kadoba K., and Matsuda H. A novel strategy for myocardial protection using in vivo transfection of cis element 'decoy' against NFkappaB binding site: evidence for a role of NFkappaB in ischemia-reperfusion injury. Circulation 96 (1997) II-280-4 discussion II-285
15. Cao C.C., Ding X.Q., Ou Z.L., Liu C.F., Li P., Wang L., and Zhu C.F. In vivo transfection of NF-kappaB decoy oligodeoxynucleotides attenuate renal ischemia/reperfusion injury in rats. Kidney Int. 65 (2004) 834-845
16. Yoshimura S., Morishita R., Hayashi K., Yamamoto K., Nakagami H., Kaneda Y., Sakai N., and Ogihara T. Inhibition of intimal hyperplasia after balloon injury in rat carotid artery model using cis-element 'decoy' of nuclear factor-kappaB binding site as a novel molecular strategy. Gene Ther. 8 (2001) 1635-1642
17. Desmet C., Gosset P., Pajak B., Cataldo D., Bentires-Alj M., Lekeux P., and Bureau F. Selective blockade of NF-kappa B activity in airway immune cells inhibits the effector phase of experimental asthma. J. Immunol. 173 (2004) 5766-5775
18. Tomita T., Takano H., Tomita N., Morishita R., Kaneko M., Shi K., Takahi K., Nakase T., Kaneda Y., et al. Transcription factor decoy for NFkappaB inhibits cytokine and adhesion molecule expressions in synovial cells derived from rheumatoid arthritis. Rheumatology (Oxford) 39 (2000) 749-757
19. Nakamura H., Aoki M., Tamai K., Oishi M., Ogihara T., Kaneda Y., and Morishita R. Prevention and regression of atopic dermatitis by ointment containing NF-kB decoy oligodeoxynucleotides in NC/Nga atopic mouse model. Gene Ther. 9 (2002) 1221-1229
20. Higgins K.A., Perez J.R., Coleman T.A., Dorshkind K., McComas W.A., Sarmiento U.M., Rosen C.A., and Narayanan R. Antisense inhibition of the p65 subunit of NF-kappa B blocks tumorigenicity and causes tumor regression. Proc. Natl. Acad. Sci. USA 90 (1993) 9901-9905
21. Kawamura I., Morishita R., Tomita N., Lacey E., Aketa M., Tsujimoto S., Manda T., Tomoi M., Kida I., et al. Intratumoral injection of oligonucleotides to the NF kappa B binding site inhibits cachexia in a mouse tumor model. Gene Ther. 6 (1999) 91-97
22. Lin M.T., Chang C.C., Chen S.T., Chang H.L., Su J.L., Chau Y.P., and Kuo M.L. Cyr61 expression confers resistance to apoptosis in breast cancer MCF-7 cells by a mechanism of NF-kappaB-dependent XIAP up-regulation. J. Biol. Chem. 279 (2004) 24015-24023
23. Lesage D., Metelev V., Borisova O., Baran-Marszak F., Dolinnaya N., Oretskaya T., Taillandier E., Raphaël M., and Fagard R. Specific covalent binding of a NF-kB decoy oligonucleotide targeted to the p50 subunit and induction of apoptosis. FEBS Lett. 547 (2003) 115-118
24. Metelev V., Weissleder R., and Bogdanov Jr. A. Synthesis and properties of fluorescent NF-kappa B-recognizing hairpin oligodeoxyribonucleotide decoys. Bioconjug. Chem. 15 (2004) 1481-1487
25. Reynier P., Briane D., Cao A., Lievre N., Naejus R., Bissieres P., Salzmann J.L., and Taillandier E. In vitro and in vivo transfection of melanoma cells B16-F10 mediated by cholesterol-based cationic liposomes. J. Drug Target 10 (2002) 557-566
26. Feuillard J., Schuhmacher M., Kohanna S., Asso-Bonnet M., Ledeur F., Joubert-Caron R., Bissieres P., Polack A., Bornkamm G.W., et al. Inducible loss of NF-kappa B activity is associated with apoptosis and Bcl-2 down-regulation in Epstein-Barr virus-transformed B lymphocytes. Blood 95 (2000) 2068-2075
27. Maheshwari R.K., Singh A.K., Gaddipati J., and Srimal R.C. Multiple biological activities of curcumin: a short review. Life Sci. 78 (2006) 2081-2087
28. Kim S.K., Ragupathi G., Musselli C., Choi S.J., Park Y.S., and Livingston P.O. Comparison of the effect of different immunological adjuvants on the antibody and T-cell response to immunization with MUC1-KLH and GD3-KLH conjugate cancer vaccines. Vaccine 18 (1999) 597-603
29. Sharma H.W., Perez J.R., Higgins-Sochaski K., Hsiao R., and Narayanan R. Transcription factor decoy approach to decipher the role of NF-kappa B in oncogenesis. Anticancer Res. 16 (1996) 61-69
30. Romano M.F., Lamberti A., Bisogni R., Tassone P., Pagnini D., Storti G., Del Vecchio L., Turco M.C., and Venuta S. Enhancement of cytosine arabinoside-induced apoptosis in human myeloblastic leukemia cells by NF-kappa B/Rel-specific decoy oligodeoxynucleotides. Gene Ther. 7 (2000) 1234-1237
31. Leong P.L., Andrews G.A., Johnson D.E., Dyer K.F., Xi S., Mai J.C., Robbins P.D., Gadiparthi S., Burke N.A., et al. Targeted inhibition of Stat3 with a decoy oligonucleotide abrogates head and neck cancer cell growth. PNAS 100 (2003) 4138-4143
32. Nakshatri H., Bhat-Nakshatri P., Martin D.A., Goulet Jr. R.J., and Sledge Jr. G.W. Constitutive activation of NF-kappaB during progression of breast cancer to hormone-independent growth. Mol. Cell Biol. 17 (1997) 3629-3639
33. Sovak M.A., Bellas R.E., Kim D.W., Zanieski G.J., Rogers A.E., Traish A.M., and Sonenshein G.E. Aberrant nuclear factor-kappaB/Rel expression and the pathogenesis of breast cancer. J. Clin. Invest. 100 (1997) 2952-2960
34. Yang C.H., Murti A., Valentine W.J., Du Z., and Pfeffer L.M. Interferon alpha activates NF-kappaB in JAK1-deficient cells through a TYK2-dependent pathway. J. Biol. Chem. 280 (2005) 25849-25853
35. Griesenbach U., Cassady R.L., Cain R.J., duBois R.M., Geddes D.M., and Alton E.W. Cytoplasmic deposition of NFkappaB decoy oligonucleotides is insufficient to inhibit bleomycin-induced pulmonary inflammation. Gene Ther. 9 (2002) 1109-1115
36. Bene A., Kurten R.C., and Chambers T.C. Subcellular localization as a limiting factor for utilization of decoy oligonucleotides. Nucleic Acids Res. 32 (2004) e142
37. Kimura M., Haisa M., Uetsuka H., Takaoka M., Ohkawa T., Kawashima R., Yamatsuji T., Gunduz M., Kaneda Y., et al. TNF combined with IFN-alpha accelerates NF-kappaB-mediated apoptosis through enhancement of Fas expression in colon cancer cells. Cell Death Differ. 10 (2003) 718-728
38. Huxford T., Huang D.B., Malek S., and Ghosh G. The crystal structure of the IkappaBalpha/NF-kappaB complex reveals mechanisms of NF-kappaB inactivation. Cell 95 (1998) 759-770
39. Hayden M.S., and Ghosh S. Signaling to NF-kappaB. Genes Dev. 18 (2004) 2195-2224
40. Nelson D.E., See V., Nelson G., and White M.R. Oscillations in transcription factor dynamics: a new way to control gene expression. Biochem. Soc. Trans. 32 (2004) 1090-1092
41. Chen L.F., and Greene W.C. Shaping the nuclear action of NF-kappaB. Nat. Rev. Mol. Cell Biol. 5 (2004) 392-401
42. Sperandio S., de Belle I., and Bredesen D.E. An alternative, nonapoptotic form of programmed cell death. Proc. Natl. Acad. Sci. USA 97 (2000) 14376-14381
43. Broker L.E., Kruyt F.A., and Giaccone G. Cell death independent of caspases: a review. Clin. Cancer Res. 11 (2005) 3155-3162