Overexpression of HOXB7 homeobox gene in oral cancer induces cellular proliferation and is associated with poor prognosis

International Journal of Oncology

Volumn 36, Issue 1, 2010, Pages 141-149

  Destro, Maria Fernanda De Souza Setubal ^a   Bitu, Carolina Cavalcanti ^a   Zecchin, Karina G ^a   Graner, Edgard ^a   Lopes, Marcio A ^a   Kowalski, Luis Paulo ^b   Coletta, Ricardo D ^a  

^a UNIVERSITY OF CAMPINAS   (Brazil)

^b A C CAMARGO CANCER CENTER   (Brazil)

Author keywords

Clinicopathological correlation; Homeobox genes; HOX; HOXB7; Oral cancer; Proliferation; Survival

Indexed keywords

HOMEODOMAIN PROTEIN; HOX PROTEIN; KI 67 ANTIGEN; PROTEIN HOXB13; PROTEIN HOXB2; PROTEIN HOXB7; UNCLASSIFIED DRUG;

ADULT; ANTIGEN EXPRESSION; ARTICLE; CANCER STAGING; CANCER SURVIVAL; CARCINOGENESIS; CARCINOMA CELL; CELL PROLIFERATION; CONTROLLED STUDY; DISEASE FREE SURVIVAL; DOWN REGULATION; EPITHELIUM CELL; FEMALE; GENE CLUSTER; GENE EXPRESSION; GENE OVEREXPRESSION; HOMEOBOX; HOX GENE; HUMAN; HUMAN CELL; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; MALE; MOUTH CANCER; MOUTH CARCINOMA; MOUTH MUCOSA; OVERALL SURVIVAL; PRIORITY JOURNAL; PROGNOSIS; SQUAMOUS CELL CARCINOMA;

AGED; APOPTOSIS; CARCINOMA, SQUAMOUS CELL; CELL PROLIFERATION; DISEASE-FREE SURVIVAL; FEMALE; GENE EXPRESSION PROFILING; GENE EXPRESSION REGULATION, NEOPLASTIC; HOMEODOMAIN PROTEINS; HUMANS; IMMUNOHISTOCHEMISTRY; KI-67 ANTIGEN; MALE; MIDDLE AGED; MOUTH NEOPLASMS; PROGNOSIS; TREATMENT OUTCOME;

EID: 74549210864     PISSN: 10196439     EISSN: 17912423     Source Type: Journal    
DOI: 10.3892/ijo-00000485     Document Type: Article

References (35)

1. Cantile M, Schiavo G, Terracciano L and Cillo C: Homeobox genes in normal and abnormal vasculogenesis. Nutr Metab Cardiovasc Dis 18: 651-658, 2008.
2. Abate-Shen C: Deregulated homeobox gene expression in cancer: cause or consequence? Nat Rev Cancer 2: 777-785, 2002.
3. Chen H and Sukumar S: Role of homeobox genes in normal mammary gland development and breast tumorigenesis. J Mammary Gland Biol Neoplasia 8: 159-175, 2003.
4. Chen H and Sukumar S: HOX genes: emerging stars in cancer. Cancer Biol Ther 2: 524-525, 2003.
5. Del Bene F and Wittbrodt J: Cell cycle control by homeobox genes in development and disease. Semin Cell Dev Biol 16: 449-460, 2005.
6. Samuel S and Naora H: Homeobox gene expression in cancer: insights from developmental regulation and deregulation. Eur J Cancer 41: 2428-2437, 2005.
7. Cillo C, Faiella A, Cantile M and Boncinelli E: Homeobox genes and cancer. Exp Cell Res 10: 1-9, 1999.
8. Chen KN, Gu ZD, Ke Y, Li JY, Shi XT and Xu GW: Expression of 11 HOX genes is deregulated in esophageal squamous cell carcinoma. Clin Cancer Res 11: 1044-1049, 2005.
9. Coletta RD, Jedlicka P, Gutierrez-Hartmann A and Ford HL: Transcriptional control of the cell cycle in mammary gland development and tumorigenesis. J Mammary Gland Biol Neoplasia 9: 39-53, 2004.
10. Lopez R, Garrido E, Vazquez G, Pina P, Perez C, Alvarado I and Salcedo M: A subgroup of HOX Abd-B gene is differentially expressed in cervical cancer. Int J Gynecol Cancer 16: 1289-1296, 2006.
11. Maeda K, Hamada J, Takahashi Y, Tada M, Yamamoto Y, Sugihara T and Moriuchi T: Altered expressions of HOX genes in human cutaneous malignant melanoma. Int J Cancer 114: 436-441, 2005.
12. Maroulakou IG and Spyropoulos DD: The study of HOX gene function in hematopoietic, breast and lung carcinogenesis. Anticancer Res 23: 2101-2110, 2003.
13. McGonigle GJ, Lappin TR and Thompson A: Grappling with the HOX network in hematopoiesis and leukemia. Front Biosci 13: 4297-4308, 2008.
14. Waltregny D, Alami Y, Clausse N, De Leval J and Castronovo V: Overexpression of the homeobox gene HOXC8 in human prostate cancer correlates with loss of tumor differentiation. Prostate 50: 162-169, 2002.
15. Hassan NM, Hamada J, Murai T, Seino A, Takahashi Y, Tada M, Zhang X, Kashiwazaki H, Yamazaki Y, Inoue N and Moriuchi T: Aberrant expression of HOX genes in oral dysplasia and squamous cell carcinoma tissues. Oncol Res 16: 217-224, 2006.
16. Care A, Silvani A, Meccia E, Mattia G, Peschle C and Colombo MP: Transduction of the SkBr3 breast carcinoma cell line with the HOXB7 gene induces bFGF expression, increases cell proliferation and reduces growth factor dependence. Oncogene 16: 3285-3289, 1998.
17. Care A, Silvani A, Meccia E, Mattia G, Stoppacciaro A, Parmiani G, Peschle C and Colombo MP: HOXB7 constitutively activates basic fibroblast growth factor in melanomas. Mol Cell Biol 16: 4842-4851, 1996.
18. Chen H, Lee JS, Liang X, Zhang H, Zhu T, Zhang Z, et al: Hoxb7 inhibits transgenic HER-2/neu-induced mouse mammary tumor onset but promotes progression and lung metastasis. Cancer Res 68: 3637-3644, 2008.
19. Rubin E, Wu X, Zhu T, Cheung JC, Chen H, Lorincz A, Pandita RK, Sharma GG, Ha HC, Gasson J, Hanakahi LA, Pandita TK and Sukumar S: A role for the HOXB7 homeo-domain protein in DNA repair. Cancer Res 67: 1527-1535, 2007.
20. Anneroth G, Batsakis J and Luna M: Review of the literature and a recommended system of malignancy grading in oral squamous cell carcinomas. Scand J Dent Res 95: 229-249, 1987.
21. Coletta RD, Christensen K, Reichenberger KJ, Lamb J, Micomonaco D, Huang L, Wolf DM, Müller-Tidow C, Golub TR, Kawakami K and Ford HL: The Six1 homeoprotein stimulates tumorigenesis by reactivation of cyclin A1. Proc Natl Acad Sci USA 101: 6478-6483, 2004.
22. Yaron Y, McAdara JK, Lynch M, Hughes E and Gasson JC: Identification of novel functional regions important for the activity of HOXB7 in mammalian cells. J Immunol 166: 5058-5067, 2001.
23. Martelli-Junior H, Cotrim P, Graner E, Sauk JJ and Coletta RD: Effect of transforming growth factor-beta1, interleukin-6, and interferon-gamma on the expression of type I collagen, heat shock protein 47, matrix metalloproteinase (MMP)-1 and MMP-2 by fibroblasts from normal gingiva and hereditary gingival fibromatosis. J Periodontol 74: 296-306, 2003.
24. Yamamoto M, Takai D and Yamamoto F: Comprehensive expression profiling of highly homologous 39 hox genes in 26 different human adult tissues by the modified systematic multiplex RT-pCR method reveals tissue-specific expression pattern that suggests an important role of chromosomal structure in the regulation of hox gene expression in adult tissues. Gene Expr 11: 199-210, 2003.
25. Zecchin KG, Seidinger AL, Chiaratti MR, Degasperi GR, Meirelles FV, Castilho RF and Vercesi AE: High Bcl-2/Bax ratio in Walker tumor cells protects mitochondria but does not prevent H2O2-induced apoptosis via calcineurin pathways. J Bioenerg Biomembr 39: 186-194, 2007.
26. Bondos SE, Tan XX and Matthews KS: Physical and genetic interactions link hox function with diverse transcription factors and cell signaling proteins. Mol Cell Proteomics 5: 824-834, 2006.
27. Taghon T, Thys K, De Smedt M, Weerkamp F, Staal FJ, Plum J and Leclercq G: Homeobox gene expression profile in human hematopoietic multipotent stem cells and T-cell progenitors: implications for human T-cell development. Leukemia 17: 1157-1163, 2003.
28. Garin E, Lemieux M, Coulombe Y, Robinson GW and Jeannotte L: Stromal Hoxa5 function controls the growth and differentiation of mammary alveolar epithelium. Dev Dyn 235: 1858-1871, 2006.
29. Lu Z, Hardt J and Kim JJ: Global analysis of genes regulated by HOXA10 in decidualization reveals a role in cell proliferation. Mol Hum Reprod 14: 357-366, 2008.
30. Kongsuwan K, Webb E, Housiaux P and Adams JM: Expression of multiple homeobox genes within diverse mammalian haemopoietic lineages. EMBO J 7: 2131-2138, 1988.
31. Christensen KL, Patrick AN, McCoy EL and Ford HL: The six family of homeobox genes in development and cancer. Adv Cancer Res 101: 93-126, 2008.
32. Cillo C, Cantile M, Faiella A and Boncinelli E: Homeobox genes in normal and malignant cells. J Cell Physiol 188: 161-169, 2001.
33. Care A, Felicetti F, Meccia E, Bottero L, Parenza M, Stoppacciaro A, Peschle C and Colombo MP: HOXB7: a key factor for tumor-associated angiogenic switch. Cancer Res 61: 6532-6539, 2001.
34. Wu X, Chen H, Parker B, Rubin E, Zhu T, Lee JS, Argani P and Sukumar S: HOXB7, a homeodomain protein, is overexpressed in breast cancer and confers epithelial-mesenchymal transition. Cancer Res 66: 9527-9534, 2006.
35. Srebrow A, Friedmann Y, Ravanpay A, Daniel CW and Bissell MJ: Expression of Hoxa-1 and Hoxb-7 is regulated by extracellular matrix-dependent signals in mammary epithelial cells. J Cell Biochem 69: 377-391, 1998.