Epithelial-mesenchymal transition in oral squamous cell carcinoma triggered by transforming growth factor-β1 is Snail family-dependent and correlates with matrix metalloproteinase-2 and -9 expressions

International Journal of Oncology

Volumn 37, Issue 3, 2010, Pages 663-668

  Qiao, Bin ^a   Johnson, Newell W ^a   Gao, Jin ^a  

^a GRIFFITH UNIVERSITY   (Australia)

Author keywords

Epithelial mesenchymal transition; Matrix metalloproteinase 2; Metalloproteinase 9; Oral squamous cell carcinoma; Snail family; Transforming growth factor 1

Indexed keywords

GELATINASE A; GELATINASE B; TRANSCRIPTION FACTOR SLUG; TRANSCRIPTION FACTOR SNAIL; TRANSFORMING GROWTH FACTOR BETA1;

ARTICLE; CANCER CELL CULTURE; CELL INVASION; DOWN REGULATION; ENZYME ACTIVITY; ENZYME ASSAY; EPITHELIAL MESENCHYMAL TRANSITION; HUMAN; HUMAN CELL; IMMUNOCYTOCHEMISTRY; IMMUNOPHENOTYPING; IN VITRO STUDY; MOUTH CARCINOMA; ORAL SQUAMOUS CELL CARCINOMA; PRIORITY JOURNAL; PROTEIN EXPRESSION; REAL TIME POLYMERASE CHAIN REACTION; SIGNAL TRANSDUCTION; SQUAMOUS CELL CARCINOMA; UPREGULATION; WESTERN BLOTTING; WOUND HEALING;

ANIMALS; CARCINOMA, SQUAMOUS CELL; CELL LINE, TUMOR; EPITHELIAL-MESENCHYMAL TRANSITION; FLUORESCENT ANTIBODY TECHNIQUE; GENE EXPRESSION REGULATION, NEOPLASTIC; HUMANS; IMMUNOHISTOCHEMISTRY; MATRIX METALLOPROTEINASE 2; MATRIX METALLOPROTEINASE 9; MOUTH NEOPLASMS; RECOMBINANT PROTEINS; TRANSCRIPTION FACTORS; TRANSFORMING GROWTH FACTOR BETA1;

EID: 77956533018     PISSN: 10196439     EISSN: 17912423     Source Type: Journal    
DOI: 10.3892/ijo-00000715     Document Type: Article

References (33)

1. Warnakulasuriya S: Global epidemiology of oral and oropharyngeal cancer. Oral Oncol 45: 309-316, 2009.
2. Shah JP and Gil Z: Current concepts in management of oral cancer-surgery. Oral Oncol 45: 394-401, 2009.
3. Ha PK, Chang SS, Glazer CA, Califano JA and Sidransky D: Molecular techniques and genetic alterations in head and neck cancer. Oral Oncol 45: 335-339, 2009.
4. Molinolo AA, Amornphimoltham P, Squarize CH, Castilho RM, Patel V and Gutkind JS: Dysregulated molecular networks in head and neck carcinogenesis. Oral Oncol 45: 324-334, 2009.
5. Micalizzi DS and Ford HL: Epithelial-mesenchymal transition in development and cancer. Future Oncol 5: 1129-1143, 2009.
6. Padua D and Massagué J: Roles of TGFβ in metastasis. Cell Res 19: 89-102, 2009.
7. Dasgupta S, Bhattacharya-Chatterjee M, O'Malley BW Jr and Chatterjee SK: Tumor metastasis in an orthotopic murine model of head and neck cancer: possible role of TGF-beta 1 secreted by the tumor cells. J Cell Biochem 97: 1036-1051, 2006.
8. Valcourt U, Kowanetz M, Niimi H, Heldin CH and Moustakas A: TGF-beta and the Smad signaling pathway support transcriptomic reprogramming during epithelial-mesenchymal cell transition. Mol Biol Cell 16: 1987-2002, 2005.
9. Xu J, Lamouille S and Derynck R: TGF-beta-induced epithelial to mesenchymal transition. Cell Res 19: 156-172, 2009.
10. Lin MH, Liu SY, Su HJ and Liu YC: Functional role of matrix metalloproteinase 28 in the oral squamous cell carcinoma. Oral Oncol 42: 907-913, 2006.
11. Sterz CM, Kulle C, Dakic B, et al: A basal-cell-like compartment in head and neck squamous cell carcinomas represents the invasive front of the tumor and is expressing MMP-9. Oral Oncol 46: 116-122, 2010.
12. Radisky DC, Levy DD, Littlepage LE, et al: Rac1b and reactive oxygen species mediate MMP-3-induced EMT and genomic instability. Nature 436: 123-127, 2005.
13. Orlichenko LS and Radisky DC: Matrix metalloproteinases stimulate epithelial-mesenchymal transition during tumor development. Clin Exp Metastasis 25: 593-600, 2008.
14. Liu Y, El-Naggar S, Darling DS, Higashi Y and Dean DC: Zeb1 links epithelial-mesenchymal transition and cellular senescence. Development 135: 579-588, 2008.
15. Rosivatz E, Becker I, Specht K, et al: Differential expression of the epithelial-mesenchymal transition regulators snail, SIP1, and twist in gastric cancer. Am J Pathol 161: 1881-1891, 2002.
16. Skrzypczak J, Wirstlein P, Mikolajczyk M, Ludwikowski G and Zak T: TGF superfamily and MMP2, MMP9, TIMP1 genes expression in the endometrium of women with impaired reproduction. Folia Histochem Cytobiol 45 (Suppl. 1): S143-S148, 2007.
17. Gordon KJ, Kirkbride KC, How T and Blobe GC: Bone morphogenetic proteins induce pancreatic cancer cell invasiveness through a Smad1-dependent mechanism that involves matrix metalloproteinase-2. Carcinogenesis 30: 238-248, 2009.
18. Agra IM, Carvalho AL, Pinto CA, Martins EP, Filho JG, Soares FA and Kowalski LP: Biological markers and prognosis in recurrent oral cancer after salvage surgery. Arch Otolaryngol Head Neck Surg 134: 743-749, 2008.
19. Dang D, Yang Y, Li X, et al: Matrix metalloproteinases and TGFbeta1 modulate oral tumor cell matrix. Biochem Biophys Res Commun 316: 937-942, 2004.
20. Moreno-Bueno G, Portillo F and Cano A: Transcriptional regulation of cell polarity in EMT and cancer. Oncogene 27: 6958-6969, 2008.
21. Turley EA, Veiseh M, Radisky DC and Bissell MJ: Mechanisms of disease: epithelial-mesenchymal transition - does cellular plasticity fuel neoplastic progression? Nat Clin Pract Oncol 5: 280-290, 2008.
22. Joseph MJ, Dangi-Garimella S, Shields MA, Diamond ME, Sun L, Koblinski JE and Munshi HG: Slug is a downstream mediator of transforming growth factor-beta1-induced matrix metalloproteinase-9 expression and invasion of oral cancer cells. J Cell Biochem 108: 726-736, 2009.
23. Zhou BP, Deng J, Xia W, Xu J, Li YM, Gunduz M and Hung MC: Dual regulation of Snail by GSK-3beta-mediated phosphorylation in control of epithelial-mesenchymal transition. Nat Cell Biol 6: 931-940, 2004.
24. Hoshino H, Miyoshi N, Nagai K, et al: Epithelial-mesenchymal transition with expression of SNAI1-induced chemoresistance in colorectal cancer. Biochem Biophys Res Commun 390: 1061-1065, 2009.
25. Muratani M and Tansey WP: How the ubiquitin-proteasome system controls transcription. Nat Rev Mol Cell Biol 4: 192-201, 2003. (Pubitemid 36288041)
26. Thiery JP: Epithelial-mesenchymal transitions in tumour progression. Nat Rev Cancer 2: 442-454, 2002.
27. Sun L, Diamond ME, Ottaviano AJ, Joseph MJ, Ananthanarayan V and Munshi HG: Transforming growth factor-beta 1 promotes matrix metalloproteinase-9- mediated oral cancer invasion through snail expression. Mol Cancer Res 6: 10-20, 2008.
28. Jin H, Yu Y, Zhang T, et al: Snail is critical for tumor growth and metastasis of ovarian carcinoma. Int J Cancer 126: 2102-2111, 2010.
29. Min C, Eddy SF, Sherr DH and Sonenshein GE: NF-kappaB and epithelial to mesenchymal transition of cancer. J Cell Biochem 104: 733-744, 2008.
30. Yoshizaki T, Sato H and Furukawa M: Recent advances in the regulation of matrix metalloproteinase 2 activation: from basic research to clinical implication (Review). Oncol Rep 9: 607-611, 2002.
31. Wu Y, Deng J, Rychahou PG, Qiu S, Evers BM and Zhou BP: Stabilization of snail by NF-kappaB is required for inflammation-induced cell migration and invasion. Cancer Cell 15: 416-428, 2009.
32. Kwan JA, Schulze CJ, Wang W, et al: Matrix metalloproteinase-2 (MMP-2) is present in the nucleus of cardiac myocytes and is capable of cleaving poly (ADP-ribose) polymerase (PARP) in vitro. FASEB J 18: 690-692, 2004.
33. Ip YC, Cheung ST and Fan ST: Atypical localization of membrane type 1-matrix metalloproteinase in the nucleus is associated with aggressive features of hepatocellular carcinoma. Mol Carcinog 46: 225-230, 2007.